Abstract:
BACKGROUND:The reported efficacy and safety of some biologic agents for psoriasis vary between Caucasians and Asians. Few reports of etanercept exist in psoriasis patients within the Asia-Pacific region. OBJECTIVES:The study aims to report our clinical experience of etanercept in the treatment of patients with moderate-to-severe psoriasis in Taiwan. METHODS:A retrospective analysis of 59 patients with moderate-to-severe psoriasis who received etanercept was conducted in a tertiary referral center. RESULTS:Etanercept therapy resulted in a reduction of mean Psoriasis Area and Severity Index (PASI) of 47% at week 12 and 61% at week 24. After 12 weeks of treatment, 48%, 26%, and 3.4% of the patients achieved at least PASI50, 75 and 90 response, respectively. At week 24, the proportion of patients achieving at least PASI50, 75 and 90 response was 59%, 37%, and 14%, respectively. Etanercept efficacy in achieving PASI75 improvement was, however, lower than that reported in previous pivotal placebo-controlled trials. No cases of active tuberculosis, viral hepatitis or malignancies were observed during the observation period. CONCLUSION:Our case series demonstrated the efficacy and safety of etanercept for the management of moderate-to-severe psoriasis in Taiwan.
journal_name
Int J Dermatoljournal_title
International journal of dermatologyauthors
Chiu HY,Wang TS,Cho YT,Tsai TFdoi
10.1111/j.1365-4632.2011.05273.xsubject
Has Abstractpub_date
2013-06-01 00:00:00pages
673-80issue
6eissn
0011-9059issn
1365-4632journal_volume
52pub_type
杂志文章abstract:BACKGROUND:Although disease severity, gender, body weight, and previous treatments have all been reported to affect clinical response of psoriasis vulgaris to narrowband ultraviolet B (NB-UVB) therapy, little information about possible local (lesional) influencing factors is available. OBJECTIVE:To assess correlations...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.13983
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journal_title:International journal of dermatology
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journal_title:International journal of dermatology
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journal_title:International journal of dermatology
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journal_title:International journal of dermatology
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更新日期:2006-06-01 00:00:00
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更新日期:2015-06-01 00:00:00
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doi:10.1111/j.1365-4362.1995.tb04659.x
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更新日期:1994-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2016-10-01 00:00:00
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更新日期:1984-12-01 00:00:00
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更新日期:1981-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2016-11-01 00:00:00