Etanercept use for psoriasis in Taiwan: a case series study.

Abstract:

BACKGROUND:The reported efficacy and safety of some biologic agents for psoriasis vary between Caucasians and Asians. Few reports of etanercept exist in psoriasis patients within the Asia-Pacific region. OBJECTIVES:The study aims to report our clinical experience of etanercept in the treatment of patients with moderate-to-severe psoriasis in Taiwan. METHODS:A retrospective analysis of 59 patients with moderate-to-severe psoriasis who received etanercept was conducted in a tertiary referral center. RESULTS:Etanercept therapy resulted in a reduction of mean Psoriasis Area and Severity Index (PASI) of 47% at week 12 and 61% at week 24. After 12 weeks of treatment, 48%, 26%, and 3.4% of the patients achieved at least PASI50, 75 and 90 response, respectively. At week 24, the proportion of patients achieving at least PASI50, 75 and 90 response was 59%, 37%, and 14%, respectively. Etanercept efficacy in achieving PASI75 improvement was, however, lower than that reported in previous pivotal placebo-controlled trials. No cases of active tuberculosis, viral hepatitis or malignancies were observed during the observation period. CONCLUSION:Our case series demonstrated the efficacy and safety of etanercept for the management of moderate-to-severe psoriasis in Taiwan.

journal_name

Int J Dermatol

authors

Chiu HY,Wang TS,Cho YT,Tsai TF

doi

10.1111/j.1365-4632.2011.05273.x

subject

Has Abstract

pub_date

2013-06-01 00:00:00

pages

673-80

issue

6

eissn

0011-9059

issn

1365-4632

journal_volume

52

pub_type

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