Abstract:
OBJECTIVE:Metabolic syndrome (MetS) is associated with uncontrolled blood pressure (BP), despite use of aggressive therapy. This study was performed to assess whether the use of different classes of antihypertensive drugs might influence this association. METHODS:We evaluated risk of uncontrolled BP (BP ≥ 140/90 mmHg under antihypertensive treatment) at the time of the last available visit, after a mean follow-up of 5 years in 4612 hypertensive patients without prevalent cardiovascular disease (43% women, 53 ± 11 years) from the Campania Salute Network. RESULTS:At the time of the first visit, prevalence of MetS was associated with 43% increased risk of follow-up uncontrolled BP, independent of significant confounders and without a significant impact of specific classes of antihypertensive medications. At the time of the last available visit, patients with MetS had more often uncontrolled BP, despite more aggressive treatment. After adjusting for demographics, risk factors and number of antihypertensive medications, risk of uncontrolled BP was reduced with increased prescription of diuretics [DRTs; odds ratio (OR) 0.73, 95% confidence interval (CI) 0.62-0.86], renin-angiotensin system blockers [RAS-blockers (Angiotensin-converting enzyme-inhibitors or angiotensin receptor blockers); OR 0.77, 95% CI 0.66-0.91] and statins (OR 0.79, 95% 0.68-0.92, all P < 0.05), without significant impact of the other classes of medications. CONCLUSION:Despite the use of increased number of medications, hypertensive patients with MetS are at higher risk of uncontrolled BP. Among classes of antihypertensive medications, increased prescriptions of DRTs, RAS-blockers and also statins decrease the probability of poor BP control.
journal_name
J Hypertensjournal_title
Journal of hypertensionauthors
De Marco M,de Simone G,Izzo R,Mancusi C,Sforza A,Giudice R,Trimarco B,De Luca Ndoi
10.1097/HJH.0b013e32834e1edasubject
Has Abstractpub_date
2012-01-01 00:00:00pages
188-93issue
1eissn
0263-6352issn
1473-5598journal_volume
30pub_type
杂志文章abstract::Hypertension was induced in marmosets by ligating the minor branch of one renal artery. The blood pressure (BP), measured by a tail-cuff method, increased to hypertensive levels within 4-5 weeks and the maximum increases occurred after 4-15 weeks (BP, mean +/- s.e.m. was 120 +/- 3 and 152 +/- 6 mmHg before and 10 week...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-198712000-00015
更新日期:1987-12-01 00:00:00
abstract::Exogenous sex hormone use, including oral contraceptives, post-menopausal hormonal therapy and anabolic steroids, has been associated with blood pressure changes in both sexes, but little is known about the relationship between blood pressure and endogenous sex hormones. We examined this relationship in men in the Ran...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:
更新日期:1988-04-01 00:00:00
abstract:BACKGROUND:Cathepsin L (CTSL1) catalyzes the formation of peptides that influence blood pressure (BP). Naturally occurring genetic variation or targeted ablation of the Ctsl1 locus in mice yield cardiovascular pathology. Here, we searched for genetic variation across the human CTSL1 locus and probed its functional effe...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e328356b86a
更新日期:2012-10-01 00:00:00
abstract:AIM:We determined whether left ventricular hypertrophy (LVH) which exceeds that predicted from workload [inappropriate LV mass (LVM(inappr))] is associated with reduced left ventricle (LV) systolic chamber function independent of and more closely than absolute or indexed left ventricular mass (LVM). METHODS:In 626 ran...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e32835a8696
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:To test the hypothesis that in the stroke-prone spontaneously hypertensive rat (SHRSP), the pressor effect of selective dietary chloride loading depends on a positive external sodium balance. METHODS:In 43 male SHRSP fed a Japanese style diet containing a low normal amount of NaCl (0.4%), we compared the eff...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e3283316cfc
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVES:Previous studies have demonstrated that the time rate of blood pressure (BP) variation was associated with early carotid atherosclerosis, independent of peripheral and central BP levels. We evaluated the association between the rate of BP variation, derived from ambulatory BP monitoring (ABPM) data analysis,...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e3283454ff4
更新日期:2011-06-01 00:00:00
abstract::The concentrations of neuropeptide Y immunoreactivity (NPY-ir) were measured in the cortex and cervical, thoracic and lumbar spinal cord of 8-, 18- and 31-week-old normotensive Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR). This peptide was measured using a highly sensitive and specific radio-immun...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-198608000-00012
更新日期:1986-08-01 00:00:00
abstract:OBJECTIVE:Insulin-mediated vasodilation has been shown to be impaired with hypertension and aggravated by dietary sodium restriction. Whether vascular insulin resistance in this setting could be improved by antihypertensive therapy was unknown. Therefore, we determined the effect of therapy with an angiotensin-converti...
journal_title:Journal of hypertension
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00004872-200101000-00015
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:Recent evidence suggests that central aortic blood pressure may be a better predictor of cardiovascular risk than peripheral blood pressure. The central SBP (cSBP) can be estimated from the late systolic shoulder of the radial pulse waveform. We compared the second systolic peak of the radial waveform (pSBP(...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/hjh.0b013e32832e0b58
更新日期:2009-09-01 00:00:00
abstract:OBJECTIVES:We aimed to determine the association of nonalcoholic fatty liver disease (NAFLD) with central and peripheral blood pressure (BP), in a general adolescent population and to examine whether associations are independent of adiposity. METHODS:Using cross-sectional data from a subsample (N = 1904) of a UK birth...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000000445
更新日期:2015-03-01 00:00:00
abstract:OBJECTIVE:To investigate cardiomyocyte hypertrophy and hormonal profile in cardiac hypertrophy resulting from sequentially applied overloads. METHODS:We studied Sprague-Dawley rats with renovascular hypertension (RV), where pressure overload predominates, or deoxycorticosterone acetate (DOCA)-salt (DS), where volume o...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e3282435b1e
更新日期:2007-09-01 00:00:00
abstract:BACKGROUND:Angiotensin II causes hypertension not only by direct constriction of vascular smooth muscle, but also by facilitating the release of noradrenaline from sympathetic terminals and by enhancing vascular noradrenaline sensitivity. AT1 receptor antagonists attenuate all these actions, but display some evidence o...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/01.hjh.0000179510.86265.63
更新日期:2005-10-01 00:00:00
abstract:OBJECTIVE:The pathogenesis of atherosclerosis, a chronic inflammatory disease, is influenced by the renin-angiotensin system and especially by angiotensin II subtype 1 (AT1) receptor activation. Although pro-inflammatory properties of angiotensin II as well as anti-inflammatory effects of AT1 receptor antagonists are w...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/01.hjh.0000242415.73406.17
更新日期:2006-09-01 00:00:00
abstract:OBJECTIVE:Prior to the discovery of chloride channel Kb with a variant threonine change to serine at position 481 (CLCNKB-T481S) there were no variants or clinical disorders associated with gain-of-function defects in thick ascending limb of the kidney channels or transporters. CLCNKB-T481S is a novel gain-of-function ...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/hjh.0b013e3283140c9e
更新日期:2009-02-01 00:00:00
abstract:BACKGROUND:Peroxisome proliferator-activated receptor (PPAR)-alpha has been implicated in the regulation of normal and pathological cellular functions, but the effect of specific gene silencing on PPARalpha-mediated function is not fully defined. AIM:This study evaluated the role of PPARalpha in hypertensive renal inj...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e328330b6d9
更新日期:2009-11-01 00:00:00
abstract:OBJECTIVE:Coronary heart disease (CHD) risk factors have been consistently related to an increase in carotid intima-media thickness (IMT) in selected populations. However, few studies were population-based and furthermore little attention has been given to the influence of CHD risk factors on IMT in low-risk population...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199917060-00004
更新日期:1999-06-01 00:00:00
abstract:BACKGROUND:Hypertension is associated with endothelial dysfunction characterized by decreased endothelium-dependent relaxations and increased endothelium-dependent contractions. Angiotensin converting enzyme inhibitors and thromboxane A2 receptor antagonists decreased the endothelium dysfunction in hypertensive animals...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199715060-00007
更新日期:1997-06-01 00:00:00
abstract:OBJECTIVE:To test the hypothesis that genetically determined alterations of maternal immune tolerance to a foetal semi-allograft are important for the pathogenesis of hypertensive disorders in pregnancy. DESIGN:A genetic association study was performed to analyse the impact of genetic polymorphisms known to be involve...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/01.hjh.0000188732.52722.5a
更新日期:2005-12-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to assess the role of transforming growth factor (TGF)-beta1 in the development of diabetes-associated mesenteric vascular hypertrophy and in the antitrophic effect of angiotensin converting enzyme inhibitors. DESIGN AND METHODS:Streptozotocin-induced diabetic and control Spragu...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199816110-00006
更新日期:1998-11-01 00:00:00
abstract::Although the blood vessels are exposed to high pressures in hypertension, the main complications of hypertension (stroke and myocardial infarction) are paradoxically thrombotic rather than haemorrhagic. In keeping with Virchow's triad, patients with hypertension do demonstrate abnormalities of vessel wall (endothelial...
journal_title:Journal of hypertension
pub_type: 评论,社论,评审
doi:10.1097/00004872-199816070-00003
更新日期:1998-07-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to determine the optimal schedule for home blood pressure (HBP) measurement based on a clinical approach. METHODS:Four hundred and sixty-four participants underwent HBP measurement for 7 days (duplicate measurements in the morning and in the evening), ambulatory blood pressure (ABP)...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e328332fa5e
更新日期:2010-02-01 00:00:00
abstract:OBJECTIVE:Adenosine dilates rabbit renal arteries by an endothelium-dependent, nitric oxide (NO)- and prostaglandin-independent mechanism. The aim was to identify the responsible P1-purinoceptor subtype and to investigate the involvement of K+-channels. METHODS:Rabbit renal arteries were perfused with medium containin...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/00004872-199917121-00032
更新日期:1999-12-01 00:00:00
abstract:OBJECTIVE:To describe several emerging concepts regarding the biosynthesis, metabolism and biological roles of adenosine and to illustrate the possible significance of these ideas to vascular biology by proposing a hypothesis pertaining to the role of erythrocyte-derived adenosine deaminase in vaso-occlusive diseases a...
journal_title:Journal of hypertension
pub_type: 杂志文章,评审
doi:
更新日期:1996-01-01 00:00:00
abstract:OBJECTIVES:Acute hypertensive response (AHR) in acute stroke is associated with adverse outcomes; however, the underlying pathophysiology of the association is poorly understood and its prognostic impact in ischemic stroke remains unclear. We aimed to investigate the prognostic significance of AHR in patients with isch...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000002171
更新日期:2019-12-01 00:00:00
abstract:OBJECTIVE:To investigate the effect of angiotensin II on cyclooxygenase-2 (COX-2) expression in aortic adventitial fibroblasts from normotensive [Wistar-Kyoto (WKY)] rats and spontaneously hypertensive rats (SHRs). METHODS:Protein expression was determined by western blot, mRNA levels by real-time PCR, transcriptional...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/hjh.0b013e328317a730
更新日期:2009-01-01 00:00:00
abstract:INTRODUCTION:Several renal denervation (RDN) systems are currently under investigation for treatment of hypertension by ablation of renal sympathetic nerves. The procedural efficacy of devices, however, is variable and incompletely understood. This study aimed at investigating procedural and anatomical predictors of RD...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000001840
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:Little data is available concerning the prognostic implications of renal function abnormalities, their evolution over time and the effects of nifedipine on such abnormalities in patients with stable angina pectoris. METHODS:The previously published ACTION trial compared long-acting nifedipine GITS 60 mg onc...
journal_title:Journal of hypertension
pub_type: 杂志文章,随机对照试验
doi:10.1097/HJH.0b013e3281c49d93
更新日期:2007-08-01 00:00:00
abstract:OBJECTIVE:To evaluate the prognostic significance of cardiovascular risk factors including 24-h ambulatory blood pressure level and rhythm for all-cause mortality in type 2 diabetic patients. METHODS:In a prospective observational study, 104 patients with type 2 diabetes were followed: 51 patients with diabetic nephro...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0b013e3282f06428
更新日期:2007-12-01 00:00:00
abstract:OBJECTIVE:An excess morning blood pressure surge (MBPS) may portend an increased cardiovascular risk, but the mechanisms thereof have been little investigated. The link between MBPS, short-term blood pressure (BP) variability, and arterial stiffness has not been entirely defined. METHODS:In 602 consecutive untreated h...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000001153
更新日期:2017-02-01 00:00:00
abstract:OBJECTIVE:We aim to synthesize effects of repeated administration (≥3 days) of inorganic nitrate on blood pressure and arterial stiffness measures. METHODS:We conducted a systematic review and meta-analysis of randomized controlled trials with at least 3 days treatment of inorganic nitrate on blood pressure and arteri...
journal_title:Journal of hypertension
pub_type: 杂志文章
doi:10.1097/HJH.0000000000002524
更新日期:2020-11-01 00:00:00