Morning pressor surge, blood pressure variability, and arterial stiffness in essential hypertension.

Abstract:

OBJECTIVE:An excess morning blood pressure surge (MBPS) may portend an increased cardiovascular risk, but the mechanisms thereof have been little investigated. The link between MBPS, short-term blood pressure (BP) variability, and arterial stiffness has not been entirely defined. METHODS:In 602 consecutive untreated hypertensive patients (48 ± 12 years, 61% men, office BP 149/93 ± 17/10 mmHg), we measured carotid-femoral pulse wave velocity (cf-PWV, SphygmoCor) and 24-h ambulatory BP. Using self-reported sleep and wake times, MBPS was defined as sleep-trough (ST-MBPS), prewaking, rising. Short-term BP variability was calculated as weighted 24-h SBP SD and average real variability of 24-h SBP (ARV), that is, average of absolute differences between consecutive SBP readings. RESULTS:ST-MBPS (r = 0.16, P < 0.001) and rising MBPS (r = 0.12, P = 0.003) showed a direct correlation with cf-PWV, whereas prewaking MBPS had no such relation (r = 0.06, P = 0.14). Only ST-MBPS was independently associated with cf-PWV (t = 1.96, P = 0.04) after adjustment for age, sex, height, office mean arterial pressure, heart rate, and renal function. This association was lost after further adjustment for weighted 24-h SBP SD (P = 0.13) or ARV (P = 0.24). ARV was a significant mediator of the relationship between ST-MBPS and cf-PWV (P = 0.003). CONCLUSION:In untreated hypertension, ST-MBPS has a direct relation with aortic stiffness, which is mediated by an increased ARV. The adverse effects of MBPS may be partly explained by its link with arterial stiffness, mediated by short-term SBP variability.

journal_name

J Hypertens

journal_title

Journal of hypertension

authors

Pucci G,Battista F,Anastasio F,Schillaci G

doi

10.1097/HJH.0000000000001153

subject

Has Abstract

pub_date

2017-02-01 00:00:00

pages

272-278

issue

2

eissn

0263-6352

issn

1473-5598

pii

00004872-201702000-00013

journal_volume

35

pub_type

杂志文章
  • Angiotensin-converting enzyme inhibitor/angiotensin II receptor blockers and pneumonia risk among stroke patients.

    abstract:OBJECTIVE:To investigate the effect of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers on pneumonia hospitalization in patients with stroke history in Taiwan. METHODS:We conducted a case-crossover study using the National Health Insurance Research Database in Taiwan during the period from...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e328357a87a

    authors: Liu CL,Shau WY,Wu CS,Lai MS

    更新日期:2012-11-01 00:00:00

  • Diastolic blood pressure drop after standing as a clinical sign for increased mortality in older falls clinic patients.

    abstract:BACKGROUND:Orthostatic hypotension, postprandial hypotension, and carotid sinus hypersensitivity are hypotensive syndromes with high prevalence in older people. However, their pathophysiology and prognostic significance remain largely unknown. METHODS:In a retrospective cohort study of 313 consecutive patients visitin...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e328352b9fd

    authors: Lagro J,Laurenssen NC,Schalk BW,Schoon Y,Claassen JA,Olde Rikkert MG

    更新日期:2012-06-01 00:00:00

  • Seasonal trends of blood pressure during pregnancy in Japan: the babies and their parents' longitudinal observation in Suzuki Memorial Hospital in Intrauterine Period study.

    abstract:OBJECTIVE:Blood pressure (BP) increases both in winter and in the last trimester of pregnancy. Some interaction seems to exist between season and gestational age. The present study observed home BP values during pregnancy with adjustment for seasonal variation and gestational age. METHODS:We observed 10353 home BP mea...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e32831364a7

    authors: Metoki H,Ohkubo T,Watanabe Y,Nishimura M,Sato Y,Kawaguchi M,Hara A,Hirose T,Obara T,Asayama K,Kikuya M,Yagihashi K,Matsubara Y,Okamura K,Mori S,Suzuki M,Imai Y,BOSHI Study Group.

    更新日期:2008-12-01 00:00:00

  • Alterations in erythrocyte Na+,K+-cotransport in normal and hypertensive human pregnancy.

    abstract::Many physiological variables known or thought to affect erythrocyte Na+,K+-cotransport are altered in pregnancy. The interrelationships of Na+,K+-cotransport and pregnancy were therefore examined. Values were elevated by more than 30% in both second and third trimesters with a return towards non-pregnant levels in the...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:

    authors: Gallery ED,Esber RP,Brown MA,Hawkins MR,Ross M

    更新日期:1988-02-01 00:00:00

  • Alcohol intake and cardiovascular mortality in hypertensive patients: report from the Department of Health Hypertension Care Computing Project.

    abstract:OBJECTIVE:To determine the benefits and risks of drinking alcohol in treated hypertensives. DESIGN:A prospective study of 6,369 hypertensives (3,161 men) attending primarily hospital clinics in the UK. METHODS:Relative risks both for drinkers compared with non-drinkers and for level of alcohol consumption were calcul...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-199509000-00004

    authors: Palmer AJ,Fletcher AE,Bulpitt CJ,Beevers DG,Coles EC,Ledingham JG,Petrie JC,Webster J,Dollery CT

    更新日期:1995-09-01 00:00:00

  • Drug compliance among hypertensive patients in Tabuk, Saudi Arabia.

    abstract:OBJECTIVE:To estimate the compliance rate and associated factors among a population of hypertensive subjects registered in hospitals and primary health care centres. DESIGN:A prospective study carried out on a sample of hypertensive subjects. METHOD:Compliance with treatment by the study sample was measured using the...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-199715050-00013

    authors: Khalil SA,Elzubier AG

    更新日期:1997-05-01 00:00:00

  • Crucial importance of using a sliding calliper to measure distance for carotid-femoral pulse wave velocity assessment.

    abstract:BACKGROUND AND OBJECTIVES:In the past, different methods have been used to measure the carotid-femoral distance for the assessment of pulse wave velocity (PWV). However, the latest consensus published advises to use 80% of the direct straight carotid-femoral distance (D(0.8)) using either a flexible tape or a sliding c...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e32835e2a2f

    authors: Levi-Marpillat N,Desamericq G,Akakpo S,Affes-Ayadi H,Tropeano AI,Millasseau S,Macquin-Mavier I

    更新日期:2013-05-01 00:00:00

  • Controlled analysis of blood pressure sensitivity to sodium intake: interactions with hypertension type.

    abstract:OBJECTIVE:The contribution of salt intake to the pathogenesis of hypertension holds longstanding interest. Recent studies employed the sensitivity of blood pressure (BP) to salt intake as an intermediate phenotype. The validity of this approach relative to the homogeneity of sodium-sensitive hypertension was investigat...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,多中心研究

    doi:10.1097/00004872-200305000-00020

    authors: Hurwitz S,Fisher ND,Ferri C,Hopkins PN,Williams GH,Hollenberg NK

    更新日期:2003-05-01 00:00:00

  • Predictive power of home blood pressure and clinic blood pressure in hypertensive patients with impaired glucose metabolism and diabetes.

    abstract:OBJECTIVES:We evaluated the predictive power of home blood pressure and clinic blood pressure based on the long-term cardiovascular outcome in hypertensive patients with and without impaired glucose metabolism (IGM). METHOD:The multicentre Hypertension Objective Treatment Based on Measurement by Electrical Devices Blo...

    journal_title:Journal of hypertension

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1097/HJH.0b013e328361732c

    authors: Noguchi Y,Asayama K,Staessen JA,Inaba M,Ohkubo T,Hosaka M,Satoh M,Kamide K,Awata T,Katayama S,Imai Y,HOMED-BP study group.

    更新日期:2013-08-01 00:00:00

  • Moxonidine-induced central sympathoinhibition improves prognosis in rats with hypertensive heart failure.

    abstract:OBJECTIVES:Enhanced central sympathetic outflow is an indicator of the prognosis of heart failure. Although the central sympatholytic drug moxonidine is an established therapeutic strategy for hypertension, its benefits for hypertensive heart failure are poorly understood. In the present study, we investigated the effe...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e328364a2a1

    authors: Honda N,Hirooka Y,Ito K,Matsukawa R,Shinohara K,Kishi T,Yasukawa K,Utsumi H,Sunagawa K

    更新日期:2013-11-01 00:00:00

  • C-reactive protein, an 'intermediate phenotype' for inflammation: human twin studies reveal heritability, association with blood pressure and the metabolic syndrome, and the influence of common polymorphism at catecholaminergic/beta-adrenergic pathway loc

    abstract:BACKGROUND:C-reactive protein (CRP) both reflects and participates in inflammation, and its circulating concentration marks cardiovascular risk. Here we sought to understand the role of heredity in determining CRP secretion. METHODS:CRP, as well as multiple facets of the metabolic syndrome, were measured in a series o...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e328011753e

    authors: Wessel J,Moratorio G,Rao F,Mahata M,Zhang L,Greene W,Rana BK,Kennedy BP,Khandrika S,Huang P,Lillie EO,Shih PA,Smith DW,Wen G,Hamilton BA,Ziegler MG,Witztum JL,Schork NJ,Schmid-Schönbein GW,O'Connor DT

    更新日期:2007-02-01 00:00:00

  • Impact of malignant arterial hypertension on the heart.

    abstract:OBJECTIVES:To assess the consequences of malignant hypertension and its evolution with antihypertensive treatment. BACKGROUND:Malignant hypertension can be considered as a model of the effects of very high blood pressure and renin-angiotensin levels on target organs. However, the consequences on the heart have been li...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e3283430b12

    authors: Gosse P,Coulon P,Papaioannou G,Litalien J,Lemetayer P

    更新日期:2011-04-01 00:00:00

  • Additional salutary effects of the combination of exercise training and an angiotensin-converting enzyme inhibitor on the left ventricular function of spontaneously hypertensive rats.

    abstract:OBJECTIVES:To investigate whether the combination of exercise training with the angiotensin-converting enzyme inhibitor lisinopril will have an additional beneficial effect on left ventricular function in spontaneously hypertensive rats. DESIGN:Twelve-week-old male rats were assigned to treadmill running (Ht-Ex; 20 m/...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/hjh.0b013e328329fb55

    authors: Ziada AM

    更新日期:2009-06-01 00:00:00

  • The importance of blood pressure variability in rat aortic and left ventricular hypertrophy produced by sinoaortic denervation.

    abstract:OBJECTIVE:The main objective was to examine the role of hemodynamics in rat aortic and left ventricular hypertrophy produced by sinoaortic denervation (SAD). DESIGN AND METHODS:Rats were examined at different times after SAD or sham operation (Sham). Hemodynamics were recorded continuously in conscious unrestrained ra...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-200209000-00033

    authors: Miao CY,Su DF

    更新日期:2002-09-01 00:00:00

  • Socioeconomic status, education, and aortic stiffness progression over 5 years: the Whitehall II prospective cohort study.

    abstract:OBJECTIVE:The inverse association between socioeconomic status (SES) and cardiovascular disease (CVD) risk is well documented. Aortic stiffness assessed by aortic pulse wave velocity (PWV) is a strong predictor of CVD events. However, no previous study has examined the effect of SES on arterial stiffening over time. Th...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000001057

    authors: Trudel X,Shipley MJ,McEniery CM,Wilkinson IB,Brunner EJ

    更新日期:2016-10-01 00:00:00

  • Effects of angiotensin converting enzyme inhibition on endothelium-dependent vasodilatation in essential hypertensive patients.

    abstract:BACKGROUND:Essential hypertension is characterized by an impairment of endothelium-dependent vasodilatation. OBJECTIVE:To test whether antihypertensive treatment with the angiotensin converting enzyme inhibitor lisinopril can improve vasodilatation in response to endothelium-dependent agonists in essential hypertensiv...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-199816040-00006

    authors: Taddei S,Virdis A,Ghiadoni L,Mattei P,Salvetti A

    更新日期:1998-04-01 00:00:00

  • Pulse pressure as a risk factor for cardiovascular events in the MRC Mild Hypertension Trial.

    abstract:OBJECTIVES:The aim of this study was to determine whether pulse pressure is a risk factor for coronary artery disease using data from the MRC trial of treatment of mild hypertension, and whether the effect of anti-hypertensive drug therapy on pulse pressure may be a determinant of outcome in treated patients. METHODS:...

    journal_title:Journal of hypertension

    pub_type: 临床试验,杂志文章

    doi:10.1097/00004872-199917080-00004

    authors: Millar JA,Lever AF,Burke V

    更新日期:1999-08-01 00:00:00

  • A reliable index for the prognostic significance of blood pressure variability.

    abstract:OBJECTIVES:This study presents a reliable index inspired by the total variability concept of real analysis in mathematics, called average real variability (ARV), for the prognostic significance of blood pressure variability (BPV) overcoming the pitfalls of the commonly used standard deviation (SD). BACKGROUND:Recent s...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/01.hjh.0000160205.81652.5a

    authors: Mena L,Pintos S,Queipo NV,Aizpúrua JA,Maestre G,Sulbarán T

    更新日期:2005-03-01 00:00:00

  • Low dose of telmisartan prevents ischemic brain damage with peroxisome proliferator-activated receptor-gamma activation in diabetic mice.

    abstract:BACKGROUND:Telmisartan is a unique AT1 receptor blocker with a peroxisome proliferator-activated receptor gamma (PPAR-gamma) agonistic action. Activation of PPAR-gamma could prevent inflammation and brain damage. METHOD:We investigated the beneficial effect of telmisartan on ischemic brain damage via PPAR-gamma activa...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e32833a551a

    authors: Iwanami J,Mogi M,Tsukuda K,Min LJ,Sakata A,Jing F,Iwai M,Horiuchi M

    更新日期:2010-08-01 00:00:00

  • Angiotensinogen genotype predicts abnormal renal hemodynamics in young hypertensive patients.

    abstract:OBJECTIVE:In essential hypertensive patients, blunted renal plasma flow responsiveness to angiotensin II suggests a pathologic increase in angiotensin II in the kidneys. This blunting has been associated with the angiotensinogen 235TT genotype. As several measures of renal function decline with age, we sought to determ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e3282ffb417

    authors: Patel TV,Williams GH,Fisher ND

    更新日期:2008-07-01 00:00:00

  • Ambulatory blood pressure monitoring and development of cardiovascular events in high-risk patients included in the Spanish ABPM registry: the CARDIORISC Event study.

    abstract:BACKGROUND AND AIM:Ambulatory blood pressure monitoring (ABPM) is superior to conventional BP measurement in predicting outcome, with baseline 24-h, daytime and night-time absolute values, as well as relative nocturnal decline, as powerful determinants of prognosis. We aimed to evaluate ABPM estimates on the appearance...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e328350bb40

    authors: de la Sierra A,Banegas JR,Segura J,Gorostidi M,Ruilope LM,CARDIORISC Event Investigators.

    更新日期:2012-04-01 00:00:00

  • Diurnal variation and repeatability of arterial stiffness and cardiac output measurements in the third trimester of uncomplicated pregnancy.

    abstract:AIM:To investigate same day repeated measures and diurnal variation of arterial stiffness, cardiac output (CO), stroke volume (SV) and total peripheral resistance (TPR) during the third trimester of normal pregnancy. METHODOLOGY:Pulse wave velocity (PWV) and augmentation index (AIx) were recorded using the Arteriograp...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000001482

    authors: Osman MW,Leone F,Nath M,Khalil A,Webb DR,Robinson TG,Mousa HA

    更新日期:2017-12-01 00:00:00

  • Dissociation between blood pressure reduction and fall in proteinuria in primary renal disease: a randomized double-blind trial.

    abstract:OBJECTIVE:Guidelines recommend lower threshold and goal blood pressure (BP) for patients with proteinuria. BP reduction could be accompanied by a different fall in proteinuria depending of the antihypertensive drug. The objective was to compare proteinuria reduction when BP is lowered to the same level with different d...

    journal_title:Journal of hypertension

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1097/00004872-200204000-00032

    authors: PROCOPA Study Group.

    更新日期:2002-04-01 00:00:00

  • Hypertension: evolving from standardized to individualized care.

    abstract::: The hypertension paradigm has contributed to a dramatic reduction in CVD mortality. This has been achieved by applying average results of population studies to identify a target population and design a common intervention to achieve a BP goal. Progressive lowering of the BP threshold has expanded the fraction of per...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000002375

    authors: Alderman MH,Blumenfeld JD

    更新日期:2020-07-01 00:00:00

  • Predicting high blood pressure in pregnancy: a multivariate approach.

    abstract:OBJECTIVE:To identify predictors of pregnancy-induced hypertension and pre-eclampsia in 212 nulliparous women before 20 weeks' gestation and at approximately 28 weeks' gestation. STUDY DESIGN:A randomized, prospective study in a teaching hospital. We performed standardized measurements of systolic and diastolic arteri...

    journal_title:Journal of hypertension

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004872-199816020-00013

    authors: Broughton Pipkin F,Sharif J,Lal S

    更新日期:1998-02-01 00:00:00

  • Blood pressure reduction and cardiovascular prevention: meta-regression using ordered categorical (ordinal) event data.

    abstract:BACKGROUND:Blood pressure (BP)-lowering trials studying efficacy mostly assesses binary outcome events, for example stroke/no stroke. Analysis of ordered categorical vascular events (e.g. three levels: fatal stroke/nonfatal stroke/no stroke) provides information on severity and is more powerful statistically than analy...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e32833c7a32

    authors: Geeganage CM,Tracy M,Bath MW,Bath PM

    更新日期:2010-10-01 00:00:00

  • Enhanced expression of Gi proteins in non-hypertrophic hearts from rats with hypertension-induced by L-NAME treatment.

    abstract:OBJECTIVE:The objective of the present studies is to investigate if the enhanced expression of Gs alpha protein and their mRNA observed in various models of hypertensive rats is due to the expressed hypertrophy or hypertension. METHODS:Hypertension, in Sprague-Dawley rats was induced by the oral administration of the ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-200018080-00013

    authors: Di Fusco F,Anand-Srivastava MB

    更新日期:2000-08-01 00:00:00

  • Weight status change from childhood to early adulthood and the risk of adult hypertension.

    abstract:OBJECTIVE:Overweight/obesity in childhood is suggested to increase risk of hypertension later in life. However, few studies have assessed the effect of trajectories of weight status from childhood to adulthood on adult hypertension. The present study aimed to assess the relationship between weight status change from ch...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000002016

    authors: Hou Y,Wang M,Yang L,Zhao M,Yan Y,Xi B

    更新日期:2019-06-01 00:00:00

  • Are coronary revascularization and myocardial infarction a homogeneous combined endpoint in hypertension trials? The Losartan Intervention For Endpoint reduction in hypertension study.

    abstract:OBJECTIVE:Construction of prognostically relevant endpoints for clinical trials in hypertension has increasingly included coronary revascularization with myocardial infarction (MI) as manifestations of coronary artery disease. However, whether coronary revascularization and MI predict other cardiovascular events simila...

    journal_title:Journal of hypertension

    pub_type: 临床试验,杂志文章

    doi:

    authors: Cicala S,de Simone G,Gerdts E,Dahlöf B,Lindholm LH,Kjeldsen SE,Devereux RB

    更新日期:2010-06-01 00:00:00

  • The electrophysiological characteristics of hypertrophied ventricular myocytes from the spontaneously hypertensive rat.

    abstract:OBJECTIVE:Previous studies on multicellular preparations have shown that hypertrophied cardiac muscle from the spontaneously hypertensive rat (SHR) has a prolonged action potential. The first aim of the present study was to determine whether the action potential of isolated left ventricular myocytes was similarly prolo...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-199306000-00005

    authors: Brooksby P,Levi AJ,Jones JV

    更新日期:1993-06-01 00:00:00