Abstract:
BACKGROUND:Recent evidence suggests that central aortic blood pressure may be a better predictor of cardiovascular risk than peripheral blood pressure. The central SBP (cSBP) can be estimated from the late systolic shoulder of the radial pulse waveform. We compared the second systolic peak of the radial waveform (pSBP(2)) with the central systolic pressure derived by a generalized transfer function in a large cohort, across a wide age range, of patients from the Anglo-Cardiff Collaborative Trial. We also compared pSBP(2) with the true cSBP measured by cardiac catheterization [invasively measured cSBP (cSBPi)]. METHODS:Noninvasive measurements were made by applanation tonometry using the SphygmoCor device. The aortic pressure waveform was derived from the radial waveform using a validated transfer function. Invasive measures of cSBPi were carried out in a group of 38 patients undergoing diagnostic cardiac angiography, and radial artery pressure waveforms were simultaneously recorded using the SphygmoCor device. RESULTS:Overall, there was a strong correlation (r = 0.99, P<0.001) and good agreement between pSBP(2) and the derived cSBP (mean difference +/- SD 1 +/- 4 mmHg). However, there was a systematic bias with a greater difference between these measures at lower average pressures. There was also a strong correlation and good agreement between the invasively measured cSBPi and pSBP(2) (r = 0.92, P<0.001, mean difference 2 +/- 6 mmHg). CONCLUSION:The second systolic shoulder of the peripheral pressure waveform approximates the cSBP in a large cohort of patients across a wide age range, but this may be inaccurate at low SBP values.
journal_name
J Hypertensjournal_title
Journal of hypertensionauthors
Hickson SS,Butlin M,Mir FA,Graggaber J,Cheriyan J,Khan F,Grace AA,Yasmin,Cockcroft JR,Wilkinson IB,McEniery CM,Anglo-Cardiff Collaboration Trial Investigators.doi
10.1097/hjh.0b013e32832e0b58subject
Has Abstractpub_date
2009-09-01 00:00:00pages
1784-8issue
9eissn
0263-6352issn
1473-5598journal_volume
27pub_type
杂志文章abstract:OBJECTIVES:To assess the impact of various criteria used to define hypertension in community surveys on estimates of prevalence, treatment and control. In particular, this paper examines the effect of using mean versus minimum values; one, two or three examinations; and three different blood pressure levels. DESIGN:A ...
journal_title:Journal of hypertension
pub_type: 杂志文章
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journal_title:Journal of hypertension
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pub_type: 杂志文章,meta分析,评审
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更新日期:2016-10-01 00:00:00
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更新日期:1999-07-01 00:00:00
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journal_title:Journal of hypertension
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journal_title:Journal of hypertension
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更新日期:1983-12-01 00:00:00
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journal_title:Journal of hypertension
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doi:10.1097/01.hjh.0000242395.07473.92
更新日期:2006-09-01 00:00:00
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journal_title:Journal of hypertension
pub_type: 杂志文章
doi:
更新日期:1988-04-01 00:00:00
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journal_title:Journal of hypertension
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doi:10.1097/HJH.0b013e328357a87a
更新日期:2012-11-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2002-10-01 00:00:00
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journal_title:Journal of hypertension
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更新日期:2014-05-01 00:00:00
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journal_title:Journal of hypertension
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:1986-12-01 00:00:00
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更新日期:1999-06-01 00:00:00
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更新日期:2016-02-01 00:00:00
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journal_title:Journal of hypertension
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更新日期:1991-04-01 00:00:00
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journal_title:Journal of hypertension
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更新日期:2005-04-01 00:00:00
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更新日期:2009-11-01 00:00:00