Challenges in the swallowing mechanism: nonobstructive dysphagia in the era of high-resolution manometry and impedance.

Abstract:

:Esophageal high-resolution manometry (HRM) improves the management of patients with nonobstructive dysphagia. It has increased the diagnostic yield for detecting achalasia and defined three clinically relevant achalasia subtypes. Esophagogastric junction (EGJ) outflow obstruction, defined as an impaired EGJ relaxation in association with some preserved peristalsis, might also represent an achalasia variant in some cases. Using the concept of distal latency, the criteria for defining distal esophageal spasm, have been revised as the occurrence of premature distal contractions. Finally, the combination of HRM and impedance monitoring allows for a functional definition of weak peristalsis associated with incomplete bolus transit.

authors

Roman S,Kahrilas PJ

doi

10.1016/j.gtc.2011.09.006

subject

Has Abstract

pub_date

2011-12-01 00:00:00

pages

823-35, ix-x

issue

4

eissn

0889-8553

issn

1558-1942

pii

S0889-8553(11)00083-5

journal_volume

40

pub_type

杂志文章,评审
  • Gastrointestinal manifestations of AIDS.

    abstract::As the AIDS epidemic continues to grow, it becomes increasingly important that physicians are aware of the gastrointestinal and abdominal diseases specific to this group of patients. Most AIDS patients exhibit gastrointestinal symptoms at some time during the course of their disease. Clinical AIDS is often determined ...

    journal_title:Gastroenterology clinics of North America

    pub_type: 杂志文章,评审

    doi:

    authors: Yee J,Wall SD

    更新日期:1995-06-01 00:00:00

  • Early postoperative and postgastrectomy syndromes. Diagnosis, management, and prevention.

    abstract::The evaluation and treatment of patients after operations on the foregut is a challenge for physicians and surgeons. The early postoperative period is an especially important interval because the very survival of the patient as well as the success of the surgical intervention depends on the correct interpretation of t...

    journal_title:Gastroenterology clinics of North America

    pub_type: 杂志文章,评审

    doi:

    authors: Donahue PE

    更新日期:1994-06-01 00:00:00

  • Microbiology of Helicobacter pylori.

    abstract::The new genus name Helicobacter was first published in October 1989. H. pylori is a unipolar, multiflagellate, gently spiral organism found on the human gastric mucosa, but in culture and under unfavorable conditions, coccoidal forms emerge, which may be indicative of a dormant state. The biology and metabolism of H. ...

    journal_title:Gastroenterology clinics of North America

    pub_type: 杂志文章,评审

    doi:

    authors: Goodwin CS,Worsley BW

    更新日期:1993-03-01 00:00:00

  • Complications of reflux esophagitis and their medical management.

    abstract::It is shortsighted to consider only the esophageal manifestations and complications of esophageal reflux. That such reflux can directly affect not only the lung but also the oropharynx and larynx, both by direct acid contact and reflex neurologic mechanisms, has been demonstrated repeatedly. The task of the future wil...

    journal_title:Gastroenterology clinics of North America

    pub_type: 杂志文章,评审

    doi:

    authors: Kozarek RA

    更新日期:1990-09-01 00:00:00

  • The role of genetics in IBS.

    abstract::Irritable bowel syndrome (IBS) is a common disorder that has been shown to aggregate in families and to affect multiple generations, but not in a manner consistent with a major Mendelian effect. Relatives of an individual with IBS are 2 to 3 times as likely to have IBS, with both genders being affected. To date, more ...

    journal_title:Gastroenterology clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/j.gtc.2010.12.011

    authors: Saito YA

    更新日期:2011-03-01 00:00:00

  • Molecular diagnostic techniques for viral hepatitis.

    abstract::The five different viruses that cause human viral hepatitis, A, B, C, D, and E share the unique property of hepatotropism. Identification of the nucleic acid sequences of each of these viruses, coupled with the application of recombinant DNA technology, has resulted in the rapid development of molecular diagnostic tec...

    journal_title:Gastroenterology clinics of North America

    pub_type: 杂志文章,评审

    doi:

    authors: Hu KQ,Vierling JM

    更新日期:1994-09-01 00:00:00

  • The role of capsule endoscopy in evaluating inflammatory bowel disease.

    abstract::Capsule endoscopy is a relatively new technology available in the investigation of IBD. Its place in the algorithm of evaluating IBD is being refined. Capsule endoscopy has the ability to visualize the entire SB with very few complications. It is a sensitive test for the diagnosis of mucosal changes, but should be vie...

    journal_title:Gastroenterology clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/j.gtc.2012.01.005

    authors: de Melo SW Jr,Di Palma JA

    更新日期:2012-06-01 00:00:00

  • Treatment of Ulcerative Colitis with Steroids (in Whom, How Long, What Dose, What Form).

    abstract::Corticosteroids are a nonspecific immune modulator used in the treatment of ulcerative colitis. Topical and systemic forms of corticosteroids have been shown to be effective in induction of clinical remission and remain first-line therapy for acute severe ulcerative colitis. A large proportion of patients experience a...

    journal_title:Gastroenterology clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/j.gtc.2020.08.001

    authors: George LA,Cross RK

    更新日期:2020-12-01 00:00:00

  • Screening and treatment for hepatocellular carcinoma.

    abstract::Surveillance for hepatocellular carcinoma (HCC) has become routine despite a lack of evidence of efficacy. Suitable candidates for surveillance include patients with cirrhosis and some subsets of noncirrhotic chronic hepatitis B carriers. The best surveillance testis ultrasonography at 6- to 12-month intervals. Serolo...

    journal_title:Gastroenterology clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/j.gtc.2004.04.012

    authors: Sherman M,Takayama Y

    更新日期:2004-09-01 00:00:00

  • Diagnosis of irritable bowel syndrome.

    abstract::Because there are no reliable biological or laboratory markers associated with the condition, the diagnosis of irritable bowel syndrome(IBS) is based on patient descriptions of common symptoms such as abdominal pain accompanied by changes in stool form or frequency and associated symptoms such as bloating and distensi...

    journal_title:Gastroenterology clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/j.gtc.2005.03.001

    authors: Cash BD,Chey WD

    更新日期:2005-06-01 00:00:00

  • Computed tomography and magnetic resonance imaging evaluation of liver cancer.

    abstract::Focal liver lesions occur commonly and with varying histology, each requiring radically different management. There are a multitude of imaging modalities currently being used for detecting and characterizing focal liver neoplasms. The primary modalities include ultrasonography, computed tomography (CT), magnetic reson...

    journal_title:Gastroenterology clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/s0889-8553(02)00028-6

    authors: Harisinghani MG,Hahn PF

    更新日期:2002-09-01 00:00:00

  • Steroids in pediatric eosinophilic esophagitis.

    abstract::Swallowed fluticasone and oral viscous budesonide are effective first-line therapies for eosinophilic esophagitis in children. Side effects are minimal without evidence of Cushing syndrome, as seen in treatment with systemic corticosteroids. New studies on alternative delivery systems and different corticosteroids (eg...

    journal_title:Gastroenterology clinics of North America

    pub_type: 杂志文章

    doi:10.1016/j.gtc.2014.02.008

    authors: Contreras EM,Gupta SK

    更新日期:2014-06-01 00:00:00

  • Clostridium difficile and inflammatory bowel disease.

    abstract::The past decade has seen an alarming increase in the burden of disease associated with Clostridium difficile. Several studies have now demonstrated an increasing incidence of C difficile infection in patients with inflammatory bowel disease (IBD) with a more severe course of disease compared with the non-IBD populatio...

    journal_title:Gastroenterology clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/j.gtc.2009.07.003

    authors: Ananthakrishnan AN,Issa M,Binion DG

    更新日期:2009-12-01 00:00:00

  • Hepatitis B: Current Status of Therapy and Future Therapies.

    abstract::Despite the availability of a protective vaccine for over 3 decades, the number of persons with chronic hepatitis B virus (HBV) infection remains high. These persons are at risk for cirrhosis and hepatocellular carcinoma. Current treatment is effective at inhibiting viral replication and reducing complications of chro...

    journal_title:Gastroenterology clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/j.gtc.2020.01.003

    authors: Spyrou E,Smith CI,Ghany MG

    更新日期:2020-06-01 00:00:00

  • Surgical treatment of esophageal carcinoma.

    abstract::The view of surgical treatment of esophageal carcinoma is pessimistic. This is so because (1) most patients present late in the disease and are beyond the benefits of surgical therapy for cure, (2) resection is associated with a high operative mortality, and (3) the poor 5-year survival rates for surgical resection ci...

    journal_title:Gastroenterology clinics of North America

    pub_type: 杂志文章,评审

    doi:

    authors: Bremner RM,DeMeester TR

    更新日期:1991-12-01 00:00:00

  • Helical (spiral) computed tomography. Implications for imaging of the abdomen.

    abstract::Dramatic refinements in CT technology are resulting in improved evaluation of the liver, pancreas, and gastrointestinal tract. Further clinical trials are necessary to compare the relative merits of CT versus MR imaging and endoscopic ultrasonography in a wide variety of gastrointestinal diseases. ...

    journal_title:Gastroenterology clinics of North America

    pub_type: 杂志文章,评审

    doi:

    authors: Zeman RK,Silverman PM,Cooper C,Weltman DI,Ascher SM,Patt RH

    更新日期:1995-06-01 00:00:00

  • Histologic precursors of gastrointestinal tract malignancy.

    abstract::Precursor lesions in the GIT include flat dysplasias, adenomas, dysplasia superimposed on nonneoplastic polyps, endocrine cell dysplasia, ACF, and condyloma accuminatum. Interobserver variability can be a problem in reporting dysplasia, and ancillary techniques including flow cytometry, image analysis, proliferation m...

    journal_title:Gastroenterology clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/s0889-8553(02)00007-9

    authors: Haber MM

    更新日期:2002-06-01 00:00:00

  • Morphologic Subtypes of Hepatocellular Carcinoma.

    abstract::Hepatocellular carcinomas can be further divided into distinct subtypes that provide important clinical information and biological insights. These subtypes are distinct from growth patterns and are on based on morphologic and molecular findings. There are 12 reasonably well-defined subtypes as well as 6 provisional su...

    journal_title:Gastroenterology clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/j.gtc.2017.01.009

    authors: Torbenson MS

    更新日期:2017-06-01 00:00:00

  • COX-2 inhibitors. Are they nonsteroidal anti-inflammatory drugs with a better safety profile?

    abstract::In the treatment of arthritis, NSAIDs are some of the most commonly used drugs, although the prescription of such drugs has been questioned due to their inherent risks for gastrointestinal compromise, platelet effects, and the potential for renal toxicity with long-term use. With the availability of celecoxib and rofe...

    journal_title:Gastroenterology clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/s0889-8553(05)70226-0

    authors: Simon LS

    更新日期:2001-12-01 00:00:00

  • Corticosteroids for the management of ulcerative colitis and Crohn's disease.

    abstract::Corticosteroids are of proven value for the treatment of active ulcerative colitis and Crohn's disease, but are of little value for the maintenance of remission. The development of new steroid compounds with low systemic bioavailability should allow higher doses to be given for longer periods without risking serious a...

    journal_title:Gastroenterology clinics of North America

    pub_type: 杂志文章,评审

    doi:

    authors: Jewell DP

    更新日期:1989-03-01 00:00:00

  • Immunology of Helicobacter pylori and prospects for vaccine.

    abstract::Since the initial discovery of H. pylori by Marshall and Warren 17 years ago, much progress has been made in treating this infection. However, as we enter the millennium, H. pylori infection continues to be one of the most common infections of mankind. In addition, eradication of H. pylori still requires multiple anti...

    journal_title:Gastroenterology clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/s0889-8553(05)70137-0

    authors: Blanchard TG,Czinn SJ

    更新日期:2000-09-01 00:00:00

  • Colonic motility in health and disease.

    abstract::Being the final pathway for chyme and digestive residues, the colorectum influences bowel function critically. The most important and relevant symptoms of colonic dysfunction are diarrhea, constipation, urgency, and pain. Despite the effects of many investigators, over several decades, the motor physiology of the huma...

    journal_title:Gastroenterology clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/s0889-8553(05)70369-1

    authors: O'Brien MD,Phillips SF

    更新日期:1996-03-01 00:00:00

  • Diet options of obesity: fad or famous?

    abstract::This article highlights the different dietary approaches that have evolved and become popular over the past few years. Whether these are fads or truly represent important changes in the way peo-ple eat and that ultimately will lead to a lower rate of obesity and improved health is impossible to know. ...

    journal_title:Gastroenterology clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/j.gtc.2004.12.007

    authors: Balart LA

    更新日期:2005-03-01 00:00:00

  • Gastric bypass.

    abstract::The success of gastric bypass probably depends on factors other than merely the restrictive size of the gastric pouch and outlet. Postoperative dumping and a mild degree of malabsorption derived from the redirection of intestinal contents contribute to long-term success. Thus, gastric bypass combines some elements of ...

    journal_title:Gastroenterology clinics of North America

    pub_type: 杂志文章

    doi:

    authors: Flickinger EG,Sinar DR,Swanson M

    更新日期:1987-06-01 00:00:00

  • Probiotics in Inflammatory Bowel Disease.

    abstract::Evidence indicates that the gut microbiota and/or interactions between the microbiota and the host immune system are involved in the pathogenesis of inflammatory bowel disease (IBD). Strategies that target the microbiota have emerged as potential therapies and, of these, probiotics have gained the greatest attention. ...

    journal_title:Gastroenterology clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/j.gtc.2017.08.003

    authors: Abraham BP,Quigley EMM

    更新日期:2017-12-01 00:00:00

  • Traveler's diarrhea.

    abstract::A variety of infectious enteric pathogens (bacterial, viral, and protozoal) can lead to a systemic diarrheal illness in international travelers traveling from industrialized countries to developing areas of the world. Many of the agents that lead to this syndrome have been identified, and their mode of transmission ha...

    journal_title:Gastroenterology clinics of North America

    pub_type: 杂志文章,评审

    doi:

    authors: Chak A,Banwell JG

    更新日期:1993-09-01 00:00:00

  • Update on Therapeutic Drug Monitoring in Crohn's Disease.

    abstract::In patients with Crohn's disease on biologic medications, the use of therapeutic drug monitoring leads to a personalized approach to optimize treatment. Using an algorithmic approach, measurement of drug concentrations and anti-drug antibodies can be used to improve treatment outcomes. Therapeutic drug concentrations ...

    journal_title:Gastroenterology clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/j.gtc.2017.05.014

    authors: Heron V,Afif W

    更新日期:2017-09-01 00:00:00

  • Fecal markers: calprotectin and lactoferrin.

    abstract::Overall, fecal markers have been found to be more accurate than serum markers. However, fecal markers are not specific for IBD and may be elevated in a range of organic conditions. Fecal calprotectin and lactoferrin can still differentiate inflammatory disease from functional bowel disorders. Comparison studies have f...

    journal_title:Gastroenterology clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/j.gtc.2012.01.007

    authors: Abraham BP,Kane S

    更新日期:2012-06-01 00:00:00

  • Biology of the Microbiome 1: Interactions with the Host Immune Response.

    abstract::The intestinal immune system is intimately connected with the vast diversity of microbes present within the gut and the diversity of food components that are consumed daily. The discovery of novel molecular mechanisms, which mediate host-microbe-nutrient communication, have highlighted the important roles played by mi...

    journal_title:Gastroenterology clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/j.gtc.2016.09.004

    authors: Smolinska S,Groeger D,O'Mahony L

    更新日期:2017-03-01 00:00:00

  • Nutrition support in severe acute pancreatitis.

    abstract::Nutritional support can improve the outcome from severe acute pancreatitis in two ways: first by providing the building blocks for tissue repair and recovery, and second, by modulating the inflammatory response and preventing organ failure, both of which are responsible for most of the morbidity and mortality associat...

    journal_title:Gastroenterology clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/j.gtc.2007.03.009

    authors: O'Keefe SJ,Sharma S

    更新日期:2007-06-01 00:00:00