The role of genetics in IBS.

Abstract:

:Irritable bowel syndrome (IBS) is a common disorder that has been shown to aggregate in families and to affect multiple generations, but not in a manner consistent with a major Mendelian effect. Relatives of an individual with IBS are 2 to 3 times as likely to have IBS, with both genders being affected. To date, more than 100 genetic variants in more than 60 genes from various pathways have been studied in a number of candidate gene studies, with several positive associations reported. These findings suggest that there may be distinct, as well as shared, molecular underpinnings for IBS and its subtypes.

authors

Saito YA

doi

10.1016/j.gtc.2010.12.011

subject

Has Abstract

pub_date

2011-03-01 00:00:00

pages

45-67

issue

1

eissn

0889-8553

issn

1558-1942

pii

S0889-8553(10)00135-4

journal_volume

40

pub_type

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