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Relationship between the estimates of desaturase activities and cardiometabolic phenotypes in Koreans.

Abstract：

:In the present study, we evaluated the relationships of estimated desaturase activities with cardiometabolic risk factors including abdominal obesity, atherogenic lipoprotein phenotype and inflammation in Koreans. Ninety-three healthy volunteers participated in this cross-sectional study. LDL particle size was determined using gradient gel electrophoresis and inflammatory markers including C-reactive protein, soluble intercellular adhesion molecule-1, and adiponectin were measured. Stearoyl-coA desaturase, delta-6 desaturase and delta-5 desaturase were estimated as precursor to fatty acid ratios. The results showed that stearoyl-coA desaturase was correlated with body mass index (r = 0.235, p<0.05), triglyceride (r = 0.261, p<0.001), and HDL-cholesterol (r = -0.226, p<0.05). Stearoyl-coA desaturase was associated with only triglyceride (r = 0.283, p<0.01). Delta-6 desaturase was correlated with body mass index (r = 0.236, p<0.05), waist circumference (r = 0.218, p<0.05), triglyceride (r = 0.399, p<0.001), C-reactive protein (r = 0.333, p<0.001), soluble intercellular adhesion molecule-1 (r = 0.229, p<0.05), HDL-cholesterol (r = -0.325, p<0.01), LDL particle size (r = -0.297, p<0.01) and adiponectin (r = -0.233, p<0.05). In contrast, delta-5 desaturase was correlated with body mass index (r = -0.324, p<0.01), waist circumference (r = -0.276, p<0.01), triglyceride (r = -0.329, p<0.01), C-reactive protein (r = -0.215, p<0.05), HDL-cholesterol (r = 0.262, p<0.05) and LDL particle size (r = 0.278, p<0.01). Stepwise multiple regression analysis revealed that delta-6 desaturase (p<0.01) together with waist circumference (p<0.001) were found to be independent factors for determining plasma levels of C-reactive protein (R(2) = 0.230). Estimated desaturase activities are closely associated with the features of cardiometabolic risk in Koreans.

journal_name

J Clin Biochem Nutr

journal_title

Journal of clinical biochemistry and nutrition

authors

Do HJ,Chung HK,Moon J,Shin MJ

doi

10.3164/jcbn.10-147

subject

Has Abstract

pub_date

2011-09-01 00:00:00

pages

131-5

issue

eissn

0912-0009

issn

1880-5086

pii

jcbn10-147

journal_volume

pub_type

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Relationship between the estimates of desaturase activities and cardiometabolic phenotypes in Koreans.