Abstract:
:Coenzyme Q10 (CoQ10) is synthesized in almost all human tissues and presumably involved in age-related alterations and diseases. Here, we examined the impact of aging and sex on the serum CoQ10 status in 860 European adults ranging in age from 18 to 82 years. We identified an inverse U-shaped relationship between CoQ10 concentration and age. Women showed lower cholesterol-adjusted CoQ10 levels than men, irrespective of age. As observed in both sexes, the decrease in CoQ10 concentration in older subjects was accompanied by a shift in the redox status in favour of the oxidized form. A strong positive correlation was found for total CoQ10 and cholesterol concentrations (Spearman's, p≤1E-74). We found strong negative correlations between total (Spearman's, p≤1E-07) and between cholesterol-adjusted CoQ10 concentration (Spearman's, p≤1E-14) and the proportion of the oxidized form of CoQ10. These correlations were not dependent on age and sex and were attenuated by supplementation with 150 mg/day reduced CoQ10 for 14 days. Overall, our results are useful to define risk groups with critical CoQ10 status in humans. In particular, older subjects were characterized by impaired CoQ10 status due to their lowered serum CoQ10 concentration and concomitant decrease of CoQ10 redox capacity.
journal_name
J Clin Biochem Nutrjournal_title
Journal of clinical biochemistry and nutritionauthors
Niklowitz P,Onur S,Fischer A,Laudes M,Palussen M,Menke T,Döring Fdoi
10.3164/jcbn.15-73subject
Has Abstractpub_date
2016-05-01 00:00:00pages
240-5issue
3eissn
0912-0009issn
1880-5086pii
jcbn15-73journal_volume
58pub_type
杂志文章abstract::Nitric oxide (NO), produced by inducible NO synthase (iNOS) during infection, plays a crucial role in host defense mechanisms. Salmonella typhimurium infection in mice is associated with excessive production of NO from iNOS as a host defense response. An important cytoprotective and antimicrobial function of NO is med...
journal_title:Journal of clinical biochemistry and nutrition
pub_type: 杂志文章
doi:10.3164/jcbn.SR09-70
更新日期:2010-01-01 00:00:00
abstract::We investigated the effects of treatment with antibodies against tumor necrosis factor (TNF)-α on energy metabolism, nutritional status, serum cytokine levels in patients with Crohn's disease (CD). Twelve patients were enrolled. Resting energy expenditure (REE) levels were measured by indirect calorimetry. Crohn's dis...
journal_title:Journal of clinical biochemistry and nutrition
pub_type: 杂志文章
doi:10.3164/jcbn.13-18
更新日期:2013-09-01 00:00:00
abstract::Mammals have the biological clocks with approximately 24 h-rhythm. Energy metabolism including glucose metabolism is regulated by the biological clocks. Glucose metabolism is affected by not only meal volume and its energy but also meal timing. We have reported that cacao liquor procyanidin-rich extract (CLPr) amelior...
journal_title:Journal of clinical biochemistry and nutrition
pub_type: 杂志文章
doi:10.3164/jcbn.20-45
更新日期:2020-07-01 00:00:00
abstract::Although carbon monoxide derived from heme oxygenase has been reported to exert diverse biological actions in mammals, macromolecules responsible for its direct reception and functional outcomes of the gas binding remain largely unknown. Based on our previous results in vivo suggesting carbon monoxide serves as an inh...
journal_title:Journal of clinical biochemistry and nutrition
pub_type: 杂志文章
doi:10.3164/jcbn.11-011FR
更新日期:2011-01-01 00:00:00
abstract::Anticancer drugs have been reported to damage the intestinal mucosa. We evaluated the effects of caloric intake on the mucosal morphology and immune cells in rats treated with 5-fluorouracil (5-FU). Rats were received a liquid diet plus 5-FU treatment for 8 days as follows: Low calorie group (25 kcal/day with 5-FU), N...
journal_title:Journal of clinical biochemistry and nutrition
pub_type: 杂志文章
doi:10.3164/jcbn.08-264
更新日期:2009-07-01 00:00:00
abstract::Nephrotoxicity is defined as renal dysfunction that arises as result of exposure to external agents such as drugs and environmental chemicals. The present work was undertaken to carry out the phytochemical study and nephroprotective activity of methanolic extract of Casuarina equisetifolia leaves in gentamicin-induced...
journal_title:Journal of clinical biochemistry and nutrition
pub_type: 杂志文章
doi:10.3164/jcbn.13-19
更新日期:2013-11-01 00:00:00
abstract::Recently, it has been reported that α-tocopherol (α-Toc) is effective for amelioration of liver damage. However, it is unknown whether other vitamin E analogs are effective. In this study, we investigated the effects of γ-tocopherol (γ-Toc) and tocotrienols (T3) in rats with fatty liver. Rats fed a vitamin E-deficient...
journal_title:Journal of clinical biochemistry and nutrition
pub_type: 杂志文章
doi:10.3164/jcbn.10-35
更新日期:2010-09-01 00:00:00
abstract::There has been considerable public and scientific interest in the use of phytochemicals derived from dietary components to combat human diseases. They are naturally occurring substances found in plants. Ferulic acid (FA) is a phytochemical commonly found in fruits and vegetables such as tomatoes, sweet corn and rice b...
journal_title:Journal of clinical biochemistry and nutrition
pub_type: 杂志文章
doi:10.3164/jcbn.40.92
更新日期:2007-03-01 00:00:00
abstract::Reactive oxygen species attack several living organs and induce cell death. Previously, we found axonal/dendrite degeneration before the induction of cell death in hydrogen peroxide-treated neuroblastoma: N1E-115 cells and primary neurons. This phenomenon may be connected with membrane oxidation, microtubule destabili...
journal_title:Journal of clinical biochemistry and nutrition
pub_type: 杂志文章
doi:10.3164/jcbn.18-31
更新日期:2019-01-01 00:00:00
abstract::Ubiquinol-10 (QH(2)), the reduced form of Coenzyme Q(10) (CoQ(10)) serves as a potent antioxidant of lipid membranes. Because many antioxidants reveal potent anti-inflammatory effects, the influence of QH(2) on lipopolysaccharide (LPS)-induced pro-inflammatory cytokines and chemokines were determined in the human mono...
journal_title:Journal of clinical biochemistry and nutrition
pub_type: 杂志文章
doi:10.3164/jcbn.08-182
更新日期:2009-01-01 00:00:00
abstract::We investigated the effects of anticancer agents on peripheral blood mononuclear cells for the purpose of providing data to support new translational chemoimmunotherapy regimens. Peripheral-blood mononuclear cells were treated with one of four anticancer agents (5-fluorouracil, irinotecan, cisplatin, and gemcitabine) ...
journal_title:Journal of clinical biochemistry and nutrition
pub_type: 杂志文章
doi:10.3164/jcbn.12-60
更新日期:2013-01-01 00:00:00
abstract::It is accepted that pulmonary exposure of rodents to porcine pancreatic elastase (ELT) induces lesions that morphologically resemble human emphysema. Nonetheless, extensive analysis of this model has rarely been conducted. The present study was designed to extensively examine the effects of ELT on lung inflammation, c...
journal_title:Journal of clinical biochemistry and nutrition
pub_type: 杂志文章
doi:10.3164/jcbn.09-87
更新日期:2010-03-01 00:00:00
abstract::Resistance to anti-fungal drugs has become the main cause for increasing incidence rate of Candida infections in pediatric intensive care units (PICU). Zinc supplementation has been shown to exhibit beneficial effects on many pediatric illnesses. This study aimed to investigate the efficacy of zinc supplementation on ...
journal_title:Journal of clinical biochemistry and nutrition
pub_type: 杂志文章
doi:10.3164/jcbn.18-74
更新日期:2019-03-01 00:00:00
abstract::Antioxidant supplementations are commonly used as an ergogenic aid for physical exercise despite its limited evidence. The study aimed to investigate the effects of a polyphenol mixture and vitamins on exercise endurance capacity. Seventy regularly exercising male participants were randomly assigned to receive oligome...
journal_title:Journal of clinical biochemistry and nutrition
pub_type: 杂志文章
doi:10.3164/jcbn.11-46
更新日期:2012-03-01 00:00:00
abstract::Neutrophil accumulation within epithelial crypts and in the intestinal mucosa directly correlates with clinical disease activity and epithelial injury in ulcerative colitis (UC). Current advances have defined the mechanisms by which neutrophils are activated or migrate across mucosal epithelia. A better understanding ...
journal_title:Journal of clinical biochemistry and nutrition
pub_type: 杂志文章
doi:10.3164/jcbn.2007003
更新日期:2007-07-01 00:00:00
abstract::Changes in l-arginine metabolism, including increased arginase levels and decreased nitric oxide production, are involved in the pathophysiology of asthma. In this study, using an intranasal mite-induced NC/Nga mouse model of asthma, we examined whether administration of l-arginine ameliorated airway hyperresponsivene...
journal_title:Journal of clinical biochemistry and nutrition
pub_type: 杂志文章
doi:10.3164/jcbn.14-140
更新日期:2015-05-01 00:00:00
abstract::We investigated the effect of the sodium glucose cotransporter-2 inhibitor (SGLT-2i) luseogliflozin on skeletal muscle. Eight-week-old mice were fed a standard diet or the standard diet with added luseogliflozin for 8 weeks. The mice were divided into the following four genotype/dietary groups: Db/m mice without SGLT-...
journal_title:Journal of clinical biochemistry and nutrition
pub_type: 杂志文章
doi:10.3164/jcbn.18-114
更新日期:2019-07-01 00:00:00
abstract::The aim of the study was to evaluate the anti-obesity effects of two types of meju in diet induced obese C57BL/6J mice. Animals were randomly divided into 4 dietary group (n = 10); normal diet, high fat diet with 30% soybean, high fat diet with 30% traditional meju, high fat diet with 30% standardized meju. After 16 w...
journal_title:Journal of clinical biochemistry and nutrition
pub_type: 杂志文章
doi:10.3164/jcbn.13-52
更新日期:2014-01-01 00:00:00
abstract::Gastroesophageal reflux disease (GERD) is common in patients with many chronic diseases, but has not been well recognized in rheumatoid arthritis (RA). We investigated the prevalence of GERD symptoms in 278 outpatients with RA and their association with such clinical factors as age, sex, height, weight, body mass inde...
journal_title:Journal of clinical biochemistry and nutrition
pub_type: 杂志文章
doi:10.3164/jcbn.12-83
更新日期:2013-03-01 00:00:00
abstract::Monascus purpureus is a red dye derived from yeast rice and has been used as color additives for food in East Asia. Monascus purpureus consists of several bioactive components. Some of these components work as a radical scavenger, thus monascus purpureus would also eliminate reactive oxygen species. Cancer cells maint...
journal_title:Journal of clinical biochemistry and nutrition
pub_type: 杂志文章
doi:10.3164/jcbn.17-27
更新日期:2017-11-01 00:00:00
abstract::Consumption of olives (Olea europaea L.) is associated with a low incidence of inflammation-related diseases. Olive fruit is rich in bioactive pentacyclic triterpenoids, mainly maslinic acid. This study, a randomized, double-blind, and placebo-controlled trial, examined the effects of an orally administered maslinic a...
journal_title:Journal of clinical biochemistry and nutrition
pub_type: 杂志文章
doi:10.3164/jcbn.16-40
更新日期:2016-11-01 00:00:00
abstract::Functional gastrointestinal disorders (FGIDs), including functional dyspepsia (FD), are common chronic disorders even in the younger population. Physical activity is advocated for patients with FGIDs, although the evidence is insufficient. We investigated the association between the intensity of regular exercise and g...
journal_title:Journal of clinical biochemistry and nutrition
pub_type: 杂志文章
doi:10.3164/jcbn.16-29
更新日期:2016-09-01 00:00:00
abstract::Colon cancer prevalence is high worldwide. O-GlcNAcylation has been associated with tumor growth in various tissues, including the colon; however, its link to carcinogenesis is not fully understood. We investigated the association of O-GlcNAcylation with colon carcinogenesis using a 1,2-dimethylhydrazine/dextran sodiu...
journal_title:Journal of clinical biochemistry and nutrition
pub_type: 杂志文章
doi:10.3164/jcbn.17-106
更新日期:2018-05-01 00:00:00
abstract::In this study, we examined whether compound 48/80 (C48/80), a mast cell degranulator, causes hepatic oxidative damage in rats. Serum and liver biochemical parameters were determined 0.5, 3 or 6 h after a single treatment with C48/80 (0.75 mg/kg). Serum histamine and serotonin levels increased 0.5 h after C48/80 treatm...
journal_title:Journal of clinical biochemistry and nutrition
pub_type: 杂志文章
doi:10.3164/jcbn.16-89
更新日期:2017-05-01 00:00:00
abstract::We previously reported that type 2 diabetes risk, early impaired glucose tolerance and insulin resistance can be predicted by measuring the fasting levels of certain biomarkers. Here we validated these findings in randomly recruited healthy volunteers (n = 101) based on biomarker expression as well as various non-inva...
journal_title:Journal of clinical biochemistry and nutrition
pub_type: 杂志文章
doi:10.3164/jcbn.17-81
更新日期:2018-03-01 00:00:00
abstract::Geranylgeranoic acid, a 20-carbon polyprenoic acid (all-trans 3,7,11,15-tetramethyl-2,4,6,10,14-hexadecatetraenoic acid) and its derivatives were previously developed as synthetic "acyclic retinoids" for cancer chemoprevention. Recently, we demonstrated the natural occurrence of geranylgeranoic acid in various medicin...
journal_title:Journal of clinical biochemistry and nutrition
pub_type: 杂志文章
doi:10.3164/jcbn.10-110
更新日期:2011-07-01 00:00:00
abstract::We examined the effects of citric acid and l-carnitine administration on physical fatigue. In a double-blind, placebo-controlled, 3-way crossover study, 18 healthy volunteers were randomized to oral citric acid (2,700 mg/day), l-carnitine (1,000 mg/day), or placebo for 8 days. The fatigue-inducing physical task consis...
journal_title:Journal of clinical biochemistry and nutrition
pub_type: 杂志文章
doi:10.3164/jcbn.2007032
更新日期:2007-11-01 00:00:00
abstract::Parkinson's disease is a major neurodegenerative disease involving the selective degeneration of dopaminergic neurons and α-synuclein containing Lewy bodies formation in the substantia nigra. Although α-synuclein is a key molecule for both dopaminergic neuron death and the formation of inclusion bodies, the mechanism ...
journal_title:Journal of clinical biochemistry and nutrition
pub_type: 杂志文章
doi:10.3164/jcbn.D-11-00030
更新日期:2012-09-01 00:00:00
abstract::The aim of this study was to evaluate the influence of sex on serum paraoxonase-1 (PON1) activities and on its relationship with cardiovascular disease risk factors such as overall and central obesity. Arylesterase and lactonase activities of PON1 were assessed in 374 women and 92 men. Both arylesterase and lactonase ...
journal_title:Journal of clinical biochemistry and nutrition
pub_type: 杂志文章
doi:10.3164/jcbn.18-73
更新日期:2019-05-01 00:00:00
abstract::Nitidine chloride (NC), a natural, bioactive, phytochemical alkaloid derived from the roots of Zanthoxylum nitidum, has been reported to exhibit anti-tumor activity against various types of cancer. However, the potential therapeutic role of NC in human cervical cancer has not yet been studied. We are the first to repo...
journal_title:Journal of clinical biochemistry and nutrition
pub_type: 杂志文章
doi:10.3164/jcbn.19-28
更新日期:2019-11-01 00:00:00