Neutrophil-dependent oxidative stress in ulcerative colitis.

Abstract:

:Neutrophil accumulation within epithelial crypts and in the intestinal mucosa directly correlates with clinical disease activity and epithelial injury in ulcerative colitis (UC). Current advances have defined the mechanisms by which neutrophils are activated or migrate across mucosal epithelia. A better understanding of this process will likely provide new insights into novel treatment strategies for UC. Especially, activated neutrophils produce reactive oxygen and nitrogen species within intestinal mucosa, which induce oxidative stress. In clinically, we have succeeded to develop a novel granulocytes adsorptive apheresis therapy for UC. In this article, we discuss current advances to define the role of neutrophils-dependent oxidative stress in UC.

journal_name

J Clin Biochem Nutr

authors

Naito Y,Takagi T,Yoshikawa T

doi

10.3164/jcbn.2007003

subject

Has Abstract

pub_date

2007-07-01 00:00:00

pages

18-26

issue

1

eissn

0912-0009

issn

1880-5086

journal_volume

41

pub_type

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