Quercetin induced NUPR1-dependent autophagic cell death by disturbing reactive oxygen species homeostasis in osteosarcoma cells.

abstract：:This study aimed to consider the significance of breast milk in preventing oxidative stress by comparing total antioxidant capacity (TAC) in breast milk and formula milk for premature infants, demonstrating the relationship between TAC in breast milk and postnatal age in days. We used the biological anti-oxidant poten...

journal_title：Journal of clinical biochemistry and nutrition

authors： Ezaki S,Ito T,Suzuki K,Tamura M

更新日期：2008-03-01 00:00:00

abstract：:Consumption of olives (Olea europaea L.) is associated with a low incidence of inflammation-related diseases. Olive fruit is rich in bioactive pentacyclic triterpenoids, mainly maslinic acid. This study, a randomized, double-blind, and placebo-controlled trial, examined the effects of an orally administered maslinic a...

journal_title：Journal of clinical biochemistry and nutrition

authors： Fukumitsu S,Villareal MO,Aida K,Hino A,Hori N,Isoda H,Naito Y

更新日期：2016-11-01 00:00:00

abstract：:The fatty acid composition of serum phospholipids were analyzed in 20 patients with alcoholic liver cirrhosis (11 with malnutrition and 9 with acceptable nutritional status); 25 healthy age and sex-matched adults were used as controls. Cirrhotic patients showed higher levels of palmitic acid and total saturated fatty ...

journal_title：Journal of clinical biochemistry and nutrition

authors： Ristić-Medić D,Takić M,Vučić V,Kandić D,Kostić N,Glibetić M

更新日期：2013-07-01 00:00:00

abstract：:Omega-3 fatty acids intake is important to maintain muscle mass. However, the relationship between omega-3 fatty acids intake and sarcopenia in elderly patients with type 2 diabetes has been unclear. We used the brief-type self-administered diet history questionnaire for the assessment of habitual food and nutrient in...

journal_title：Journal of clinical biochemistry and nutrition

authors： Okamura T,Hashimoto Y,Miki A,Kaji A,Sakai R,Iwai K,Osaka T,Ushigome E,Hamaguchi M,Yamazaki M,Fukui M

更新日期：2020-05-01 00:00:00

abstract：:Intestinal ischemia/reperfusion injury is a severe disease associated with a high mortality. The mechanisms that cause ischemia/reperfusion injury are complex and many factors are involved in the injury formation process; however, the only available treatment is surgical intervention. Recent studies demonstrated that ...

journal_title：Journal of clinical biochemistry and nutrition

authors： Nadatani Y,Watanabe T,Shimada S,Otani K,Tanigawa T,Fujiwara Y

更新日期：2018-07-01 00:00:00

abstract：:In a variety of experimental models, dietary phytochemicals have been demonstrated to exhibit pronounced and versatile bioactivities. Importantly, the possibility of such phytochemicals for human application has been supported in part by epidemiological surveys, which have demonstrated that frequent ingestion of veget...

journal_title：Journal of clinical biochemistry and nutrition

authors： Murakami A

更新日期：2018-03-01 00:00:00

abstract：:Reduced coenzyme Q(10) (CoQ(10)H(2)) is known as a potent antioxidant in biological systems. However, it is not yet known whether CoQ(9)H(2) could act as an antioxidant in human cells. The aim of this study is to assess whether exogenously added CoQ(9) can protect human liver cells against injuries induced by a water-...

journal_title：Journal of clinical biochemistry and nutrition

authors： Kusumoto C,Kinugawa T,Morikawa H,Teraoka M,Nishida T,Murawaki Y,Yamada K,Matsura T

更新日期：2010-05-01 00:00:00

abstract：:This study aimed to investigate the effects of abundant breast milk intake on rats model of oxygen-induced retinopathy (OIR). Neonatal Sprague-Dawley rats were randomly assigned to expand litters of 7 pups/litter (7-rats group) and 14 pups/litter (14-rats group). They were exposed to 80% oxygen from postnatal day (P) ...

journal_title：Journal of clinical biochemistry and nutrition

authors： Matsubara M,Saito Y,Nakanishi-Ueda T,Ueda T,Hisamitsu T,Koide R,Takahashi H

更新日期：2014-09-01 00:00:00

abstract：:Osteoclasts play a major role in bone resorption. Several functional food components, such as soy isoflavones and carotenoids, are reported to inhibit osteoclast formation. However, the cooperative effect of functional foods or their constituents on bone metabolism has not been clarified. This study aimed to investiga...

journal_title：Journal of clinical biochemistry and nutrition

authors： Tadaishi M,Nishide Y,Tousen Y,Kruger MC,Ishimi Y

更新日期：2014-03-01 00:00:00

abstract：:Daily salt intake can be estimated by measuring sodium and creatinine concentrations in spot urine. Excessive salt intake is risk factor for gastric cancer. We examined the correlation between estimated salt intake from spot urine and risk of gastric cancer. This study included gastric cancer patients who underwent tr...

journal_title：Journal of clinical biochemistry and nutrition

authors： Goto A,Nishikawa J,Ito S,Hideura E,Shirasawa T,Hamabe K,Hashimoto S,Okamoto T,Yanai H,Sakaida I

更新日期：2020-01-01 00:00:00

abstract：:In this study, we examined whether compound 48/80 (C48/80), a mast cell degranulator, causes hepatic oxidative damage in rats. Serum and liver biochemical parameters were determined 0.5, 3 or 6 h after a single treatment with C48/80 (0.75 mg/kg). Serum histamine and serotonin levels increased 0.5 h after C48/80 treatm...

journal_title：Journal of clinical biochemistry and nutrition

authors： Ohta Y,Yashiro K,Ohashi K,Horikoshi Y,Kusumoto C,Matsura T

更新日期：2017-05-01 00:00:00

abstract：:Glutathione, the most abundant intracellular antioxidant, protects cells against reactive oxygen species induced oxidative stress and regulates intracellular redox status. We found that rice peptides increased intracellular glutathione levels in human hepatoblastoma HepG2 cells. Acetaminophen is a commonly used analge...

journal_title：Journal of clinical biochemistry and nutrition

authors： Kawakami K,Moritani C,Uraji M,Fujita A,Kawakami K,Hatanaka T,Suzaki E,Tsuboi S

更新日期：2017-03-01 00:00:00

abstract：:Biomedical evidence in the last 20 years has shown that the consumption of partially hydrolyzed guar gum may influence lipid and/or carbohydrate metabolism at many levels. Since intestine represents the first interface to interact with dietary partially hydrolyzed guar gum in vivo, we evaluated gene expression profile...

journal_title：Journal of clinical biochemistry and nutrition

authors： Yasukawa Z,Naito Y,Takagi T,Mizushima K,Tokunaga M,Ishihara N,R Juneja L,Yoshikawa T

更新日期：2012-07-01 00:00:00

abstract：:We investigated the effects of treatment with antibodies against tumor necrosis factor (TNF)-α on energy metabolism, nutritional status, serum cytokine levels in patients with Crohn's disease (CD). Twelve patients were enrolled. Resting energy expenditure (REE) levels were measured by indirect calorimetry. Crohn's dis...

journal_title：Journal of clinical biochemistry and nutrition

authors： Nishida N,Sasaki M,Kurihara M,Ichimaru S,Wakita M,Bamba S,Andoh A,Fujiyama Y,Amagai T

更新日期：2013-09-01 00:00:00

abstract：:The effects of inulin on the microbial composition and faecal characteristics in 36 healthy, formula-fed infants (average age 7.7 months) given 3 different daily dosages of native inulin (0.75 g/day, 1.00 g/day, and 1.25 g/day) were studied. At all levels of inulin consumption, a significant (p<0.05) reduction of pote...

journal_title：Journal of clinical biochemistry and nutrition

authors： K W Yap W,Mohamed S,Husni Jamal M,Diederick M,A Manap Y

更新日期：2008-11-01 00:00:00

abstract：:We previously reported that the plasma level of endotoxin and colonic expression of IgA in the mouse increased with obstructive jaundice induced by bile duct ligation (BDL). To elucidate the mechanism of the BDL-induced increase, we analyzed the effect of BDL on intestinal flora in wild type and inducible nitric oxide...

journal_title：Journal of clinical biochemistry and nutrition

authors： Hong JY,F Sato E,Nishikawa T,Hiramoto K,Inoue M

更新日期：2009-03-01 00:00:00

abstract：:We examined the effects of citric acid and l-carnitine administration on physical fatigue. In a double-blind, placebo-controlled, 3-way crossover study, 18 healthy volunteers were randomized to oral citric acid (2,700 mg/day), l-carnitine (1,000 mg/day), or placebo for 8 days. The fatigue-inducing physical task consis...

journal_title：Journal of clinical biochemistry and nutrition

authors： Sugino T,Aoyagi S,Shirai T,Kajimoto Y,Kajimoto O

更新日期：2007-11-01 00:00:00

abstract：:Serum alanine aminotransferase (ALT) concentration is the most commonly used marker for hepatocellular injury. We investigated the suitable cutoff value of serum ALT for the diagnosis or prediction of fatty liver. In 1578 Japanese adults (1208 men, 370 women; 35-69 years of age) who visited our center both in 2000 and...

journal_title：Journal of clinical biochemistry and nutrition

authors： Omagari K,Takamura R,Matsutake S,Ichimura M,Kato S,Morikawa S,Nagaoka S,Osabe M

更新日期：2011-11-01 00:00:00

abstract：:We investigated the effect of the sodium glucose cotransporter-2 inhibitor (SGLT-2i) luseogliflozin on skeletal muscle. Eight-week-old mice were fed a standard diet or the standard diet with added luseogliflozin for 8 weeks. The mice were divided into the following four genotype/dietary groups: Db/m mice without SGLT-...

journal_title：Journal of clinical biochemistry and nutrition

authors： Okamura T,Hashimoto Y,Osaka T,Fukuda T,Hamaguchi M,Fukui M

更新日期：2019-07-01 00:00:00

abstract：:Spironolactone and furosemide, which are used to treat ascites associated with decompensated cirrhosis, are ineffective in treating refractory ascites. Hence, combination therapy with tolvaptan, a vasopressin V2 receptor antagonist, has been approved in Japan. Tolvaptan monotherapy and combination therapy with furosem...

journal_title：Journal of clinical biochemistry and nutrition

authors： Tanabe N,Takami T,Fujisawa K,Matsumoto T,Yamamoto N,Sakaida I

更新日期：2017-07-01 00:00:00

abstract：:Vitamin E analog, such as α- and γ-tocopherol, can undergo ω-oxidation without cleavage of the chroman ring, and this pathway is responsible for generation of the major urinary vitamin E metabolite, carboxyethyl hydroxychroman. However, it is still unclear how carboxyethyl hydroxychroman is changed in various tissues ...

journal_title：Journal of clinical biochemistry and nutrition

authors： Kiyose C,Saito K,Yachi R,Muto C,Igarashi O

更新日期：2015-03-01 00:00:00

abstract：:Inflammatory changes in the gastric mucosa are commonly observed in Japanese patients with functional dyspepsia (FD). However, detailed data regarding the possible association between the genetic factors of inflammation related molecules and FD are not available. Toll like receptor 2 (TLR2) and mannan-binding lectin (...

journal_title：Journal of clinical biochemistry and nutrition

authors： Tahara T,Shibata T,Wang F,Yamashita H,Hirata I,Arisawa T

更新日期：2010-11-01 00:00:00

abstract：:Anticancer drugs have been reported to damage the intestinal mucosa. We evaluated the effects of caloric intake on the mucosal morphology and immune cells in rats treated with 5-fluorouracil (5-FU). Rats were received a liquid diet plus 5-FU treatment for 8 days as follows: Low calorie group (25 kcal/day with 5-FU), N...

journal_title：Journal of clinical biochemistry and nutrition

authors： Murakami M,Sato N,Tashiro K,Nakamura T,Masunaga H

更新日期：2009-07-01 00:00:00

abstract：:Changes in l-arginine metabolism, including increased arginase levels and decreased nitric oxide production, are involved in the pathophysiology of asthma. In this study, using an intranasal mite-induced NC/Nga mouse model of asthma, we examined whether administration of l-arginine ameliorated airway hyperresponsivene...

journal_title：Journal of clinical biochemistry and nutrition

authors： Zhang R,Kubo M,Murakami I,Setiawan H,Takemoto K,Inoue K,Fujikura Y,Ogino K

更新日期：2015-05-01 00:00:00

abstract：:Nitidine chloride (NC), a natural, bioactive, phytochemical alkaloid derived from the roots of Zanthoxylum nitidum, has been reported to exhibit anti-tumor activity against various types of cancer. However, the potential therapeutic role of NC in human cervical cancer has not yet been studied. We are the first to repo...

journal_title：Journal of clinical biochemistry and nutrition

authors： Kwon HJ,Kim LH,Ahn CH,Yang IH,Hong KO,Doo Hong S,Shin JA,Cho SD

更新日期：2019-11-01 00:00:00

abstract：:We investigated the effects of anticancer agents on peripheral blood mononuclear cells for the purpose of providing data to support new translational chemoimmunotherapy regimens. Peripheral-blood mononuclear cells were treated with one of four anticancer agents (5-fluorouracil, irinotecan, cisplatin, and gemcitabine) ...

journal_title：Journal of clinical biochemistry and nutrition

authors： Sakai H,Kokura S,Ishikawa T,Tsuchiya R,Okajima M,Matsuyama T,Adachi S,Katada K,Kamada K,Uchiyama K,Handa O,Takagi T,Yagi N,Naito Y,Yoshikawa T

更新日期：2013-01-01 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) plays a crucial role in cancer metastasis. In this study, we evaluated the effect of heat treatment on tumor growth factor-β1 (TGF-β1)-induced EMT in pancreatic cancer cells and tried to ascertain the mechanism related to any observed effects. Human pancreatic cancer cell lines ...

journal_title：Journal of clinical biochemistry and nutrition

authors： Kimura-Tsuchiya R,Ishikawa T,Kokura S,Mizushima K,Adachi S,Okajima M,Matsuyama T,Okayama T,Sakamoto N,Katada K,Kamada K,Uchiyama K,Handa O,Takagi T,Yagi N,Naito Y,Itoh Y

更新日期：2014-07-01 00:00:00

abstract：:Overexpression of IGF-1R has been demonstrated in gastrointestinal cancers, and its expression is reported as the result of the loss of tumor suppressors. IL-16 is involved in the pathophysiological process of chronic inflammatory diseases. The aim of this study is to determine the changes in the expression of IGF-1R ...

journal_title：Journal of clinical biochemistry and nutrition

authors： Nakajima N,Kozu K,Kobayashi S,Nishiyama R,Okubo R,Akai Y,Moriyama M,Kinukawa N

更新日期：2016-07-01 00:00:00

abstract：:Effects of soy isoflavones, genistein and daidzein, on the hepatic gene expression profile and indices for lipid metabolism were compared in rats. In the first experiment (Expt. 1), animals were fed diets containing 2 g/kg of either genistein or daidzein, or a control diet free of isoflavone for 14 days. In the second...

journal_title：Journal of clinical biochemistry and nutrition

authors： Takahashi Y,Odbayar TO,Ide T

更新日期：2009-05-01 00:00:00

abstract：:The aim of the study was to evaluate the anti-obesity effects of two types of meju in diet induced obese C57BL/6J mice. Animals were randomly divided into 4 dietary group (n = 10); normal diet, high fat diet with 30% soybean, high fat diet with 30% traditional meju, high fat diet with 30% standardized meju. After 16 w...

journal_title：Journal of clinical biochemistry and nutrition

authors： Bae CR,Kwon DY,Cha YS

更新日期：2014-01-01 00:00:00