Monascus purpureus induced apoptosis on gastric cancer cell by scavenging mitochondrial reactive oxygen species.

abstract：:It has been reported that levels of soluble intercellular adhesion molecule-1 (ICAM-1) in the blood are elevated in hepatocellular carcinoma patients. In the present study, serial observations of the localization of ICAM-1 in the liver were made by light and electron microscopy in rats with carcinogen-induced cancer. ...

journal_title：Journal of clinical biochemistry and nutrition

authors： Matsuoka S,Matsumura H,Arakawa Y,Nakamura H,Nirei K,Yamagami H,Ogawa M,Nakajima N,Amaki S,Tanaka N,Moriyama M

更新日期：2009-09-01 00:00:00

abstract：:Nitric oxide (NO), produced by inducible NO synthase (iNOS) during infection, plays a crucial role in host defense mechanisms. Salmonella typhimurium infection in mice is associated with excessive production of NO from iNOS as a host defense response. An important cytoprotective and antimicrobial function of NO is med...

journal_title：Journal of clinical biochemistry and nutrition

authors： Okamoto T,Khan S,Oyama K,Fujii S,Sawa T,Akaike T

更新日期：2010-01-01 00:00:00

abstract：:The fatty acid composition of serum phospholipids were analyzed in 20 patients with alcoholic liver cirrhosis (11 with malnutrition and 9 with acceptable nutritional status); 25 healthy age and sex-matched adults were used as controls. Cirrhotic patients showed higher levels of palmitic acid and total saturated fatty ...

journal_title：Journal of clinical biochemistry and nutrition

authors： Ristić-Medić D,Takić M,Vučić V,Kandić D,Kostić N,Glibetić M

更新日期：2013-07-01 00:00:00

abstract：:The pathophysiology of hypertension or stroke is associated with an excess of ROS generation in the vascular system, and results in induction of various pathological cascades of cerebrovascular damage. We have demonstrated that electron spin resonance methods using a spin trap or spin probe will be useful for understa...

journal_title：Journal of clinical biochemistry and nutrition

authors： Lee MC

更新日期：2013-01-01 00:00:00

abstract：:Gastroesophageal reflux disease (GERD) is common in patients with many chronic diseases, but has not been well recognized in rheumatoid arthritis (RA). We investigated the prevalence of GERD symptoms in 278 outpatients with RA and their association with such clinical factors as age, sex, height, weight, body mass inde...

journal_title：Journal of clinical biochemistry and nutrition

authors： Nampei A,Shi K,Ebina K,Tomita T,Sugamoto K,Yoshikawa H,Hirao M,Hashimoto J

更新日期：2013-03-01 00:00:00

abstract：:Cardiovascular disease is a major cause of death among hemodialysis patients. Hyperphosphatemia induces cardiovascular disease through vascular endothelial dysfunction and calcification. Repetition of a short-term excessive-phosphorus (P) diet causes transient elevations in plasma P and subsequent vascular endothelial...

journal_title：Journal of clinical biochemistry and nutrition

authors： Tani M,Tanaka S,Takamiya K,Sakaue M,Ito M

更新日期：2020-03-01 00:00:00

abstract：:Osteoclasts play a major role in bone resorption. Several functional food components, such as soy isoflavones and carotenoids, are reported to inhibit osteoclast formation. However, the cooperative effect of functional foods or their constituents on bone metabolism has not been clarified. This study aimed to investiga...

journal_title：Journal of clinical biochemistry and nutrition

authors： Tadaishi M,Nishide Y,Tousen Y,Kruger MC,Ishimi Y

更新日期：2014-03-01 00:00:00

abstract：:Bach1 is a transcriptional repressor of heme oxygenase-1 (HO-1, a.k.a. HSP-32), which is an inducible enzyme and has anti-oxidation/anti-inflammatory properties shown in various models of organ injuries. Since oxidative stress plays a pivotal role in the pathogenesis of nonalcoholic steatohepatitis (NASH), HO-1 induct...

journal_title：Journal of clinical biochemistry and nutrition

authors： Inoue M,Tazuma S,Kanno K,Hyogo H,Igarashi K,Chayama K

更新日期：2011-03-01 00:00:00

abstract：:Although some studies have indicated a correlation between Helicobacter pylori infection and the risk of colorectal neoplasms, these findings have not been consistent and are controversial. This case-control study aimed to investigate the association between endoscopic gastric mucosal atrophy and colorectal polyp occu...

journal_title：Journal of clinical biochemistry and nutrition

authors： Kawahara Y,Kodama M,Mizukami K,Saito T,Hirashita Y,Sonoda A,Fukuda K,Matsunari O,Okamoto K,Ogawa R,Okimoto T,Murakami K

更新日期：2019-09-01 00:00:00

abstract：:The redox balance of coenzyme Q10 in human plasma is a good marker of oxidative stress because the reduced form of coenzyme Q10 (ubiquinol-10) is very sensitive to oxidation and is quantitatively converted to its oxidized form (ubiquinone-10). Here we describe an HPLC method for simultaneous detection of ubiquinol-10 ...

journal_title：Journal of clinical biochemistry and nutrition

authors： Nagase M,Yamamoto Y,Mitsui J,Tsuji S

更新日期：2018-11-01 00:00:00

abstract：:Reactive oxygen species attack several living organs and induce cell death. Previously, we found axonal/dendrite degeneration before the induction of cell death in hydrogen peroxide-treated neuroblastoma: N1E-115 cells and primary neurons. This phenomenon may be connected with membrane oxidation, microtubule destabili...

journal_title：Journal of clinical biochemistry and nutrition

authors： Fukui K,Okihiro S,Ohfuchi Y,Hashimoto M,Kato Y,Yoshida N,Mochizuki K,Tsumoto H,Miura Y

更新日期：2019-01-01 00:00:00

abstract：:Serum alanine aminotransferase (ALT) concentration is the most commonly used marker for hepatocellular injury. We investigated the suitable cutoff value of serum ALT for the diagnosis or prediction of fatty liver. In 1578 Japanese adults (1208 men, 370 women; 35-69 years of age) who visited our center both in 2000 and...

journal_title：Journal of clinical biochemistry and nutrition

authors： Omagari K,Takamura R,Matsutake S,Ichimura M,Kato S,Morikawa S,Nagaoka S,Osabe M

更新日期：2011-11-01 00:00:00

abstract：:The relationship between Helicobacter pylori (H. pylori) eradication therapy and the risk of developing gastroesophageal reflux disease (GERD) is controversial. We investigated the influence of H. pylori eradication on the risk of GERD by focusing on the quality of life (QOL) and evaluating reflux symptoms. Patients w...

journal_title：Journal of clinical biochemistry and nutrition

authors： Hirata K,Suzuki H,Matsuzaki J,Masaoka T,Saito Y,Nishizawa T,Iwasaki E,Fukuhara S,Okada S,Hibi T

更新日期：2013-03-01 00:00:00

abstract：:The amount of phosphorus contained in food as food additives is currently increasing and a high intake of phosphorus can cause various diseases. To determine the effects of a prolonged high phosphorus diet, here we investigated the phosphorus and calcium balance and expression of type IIa sodium-dependent phosphate tr...

journal_title：Journal of clinical biochemistry and nutrition

authors： Tani Y,Sato T,Yamanaka-Okumura H,Yamamoto H,Arai H,Sawada N,Genjida K,Taketani Y,Takeda E

更新日期：2007-05-01 00:00:00

abstract：:Gastrointestinal symptoms are a problematic issue for patients who take low-dose aspirin for long time. We conducted a pilot study to investigate the efficacy of combination therapy with proton pump inhibitor and rebamipide. This was a prospective, randomized, double-blind, placebo-controlled cross-over study. All the...

journal_title：Journal of clinical biochemistry and nutrition

authors： Mizukami K,Murakami K,Hirashita Y,Hisamatsu A,Ogawa R,Uchida M,Nakagawa Y,Okimoto T,Kodama M,Fujioka T

更新日期：2012-11-01 00:00:00

abstract：:Plant sterols are used as food additives to reduce intestinal cholesterol absorption. They also increase fecal neutral sterol (FNS) excretion irrespective of the absorption inhibition. Intestine-mediated reverse cholesterol transport, or trans-intestinal cholesterol efflux (TICE), provides the major part of the increa...

journal_title：Journal of clinical biochemistry and nutrition

authors： Nakano T,Inoue I,Takenaka Y,Ikegami Y,Kotani N,Shimada A,Noda M,Murakoshi T

更新日期：2018-09-01 00:00:00

abstract：:Glutathione, the most abundant intracellular antioxidant, protects cells against reactive oxygen species induced oxidative stress and regulates intracellular redox status. We found that rice peptides increased intracellular glutathione levels in human hepatoblastoma HepG2 cells. Acetaminophen is a commonly used analge...

journal_title：Journal of clinical biochemistry and nutrition

authors： Kawakami K,Moritani C,Uraji M,Fujita A,Kawakami K,Hatanaka T,Suzaki E,Tsuboi S

更新日期：2017-03-01 00:00:00

abstract：:Previously, we identified four metabolites of (-)-epicatechin in blood and urine: (-)-epicatechin-3'-O-glucuronide (E3'G), 4'-O-methyl-(-)-epicatechin-3'-O-glucuronide (4'ME3'G), (-)-epicatechin-7-O-glucuronide (E7G), and 3'-O-methyl-(-)-epicatechin-7-O-glucuronide (3'ME7G) (Natsume et al. Free Radical Biol. Med. 34, ...

journal_title：Journal of clinical biochemistry and nutrition

authors： Natsume M,Osakabe N,Yasuda A,Osawa T,Terao J

更新日期：2008-01-01 00:00:00

abstract：:Secretory immunoglobulin A (sIgA) is produced from intestinal mucosa and is essential in preventing infection. We analyzed the influence of moderate exercise on intestinal sIgA production and antioxidative function under different carbohydrate nutritional conditions. Thirty-six mice were fed an experimental diet for 1...

journal_title：Journal of clinical biochemistry and nutrition

authors： Shibuya T,Kaburagi T,Nagai R,Oshiro S

更新日期：2015-07-01 00:00:00

abstract：:Functional gastrointestinal disorders (FGIDs), including functional dyspepsia (FD), are common chronic disorders even in the younger population. Physical activity is advocated for patients with FGIDs, although the evidence is insufficient. We investigated the association between the intensity of regular exercise and g...

journal_title：Journal of clinical biochemistry and nutrition

authors： Matsuzaki J,Suzuki H,Masaoka T,Tanaka K,Mori H,Kanai T

更新日期：2016-09-01 00:00:00

abstract：:Intestinal ischemia/reperfusion injury is a severe disease associated with a high mortality. The mechanisms that cause ischemia/reperfusion injury are complex and many factors are involved in the injury formation process; however, the only available treatment is surgical intervention. Recent studies demonstrated that ...

journal_title：Journal of clinical biochemistry and nutrition

authors： Nadatani Y,Watanabe T,Shimada S,Otani K,Tanigawa T,Fujiwara Y

更新日期：2018-07-01 00:00:00

abstract：:Parkinson's disease is a major neurodegenerative disease involving the selective degeneration of dopaminergic neurons and α-synuclein containing Lewy bodies formation in the substantia nigra. Although α-synuclein is a key molecule for both dopaminergic neuron death and the formation of inclusion bodies, the mechanism ...

journal_title：Journal of clinical biochemistry and nutrition

authors： Teraoka M,Nakaso K,Kusumoto C,Katano S,Tajima N,Yamashita A,Zushi T,Ito S,Matsura T

更新日期：2012-09-01 00:00:00

abstract：:Changes in l-arginine metabolism, including increased arginase levels and decreased nitric oxide production, are involved in the pathophysiology of asthma. In this study, using an intranasal mite-induced NC/Nga mouse model of asthma, we examined whether administration of l-arginine ameliorated airway hyperresponsivene...

journal_title：Journal of clinical biochemistry and nutrition

authors： Zhang R,Kubo M,Murakami I,Setiawan H,Takemoto K,Inoue K,Fujikura Y,Ogino K

更新日期：2015-05-01 00:00:00

abstract：:The present study was conducted to assess the association between 25-hydroxyvitamin D [25(OH)D], estimated glomerular filtration rate (eGFR) and urine microalbumin/creatinine ratio (uACR) in Korean adults. Data on 4,948 adults aged ≥20 years from the Korean National Health and Nutrition Examination Survey V-3 (2012) w...

journal_title：Journal of clinical biochemistry and nutrition

authors： Kim SG,Kim GS,Lee JH,Moon AE,Yoon H

更新日期：2018-01-01 00:00:00

abstract：:The aim of the study was to evaluate the anti-obesity effects of two types of meju in diet induced obese C57BL/6J mice. Animals were randomly divided into 4 dietary group (n = 10); normal diet, high fat diet with 30% soybean, high fat diet with 30% traditional meju, high fat diet with 30% standardized meju. After 16 w...

journal_title：Journal of clinical biochemistry and nutrition

authors： Bae CR,Kwon DY,Cha YS

更新日期：2014-01-01 00:00:00

abstract：:We examined the effects of citric acid and l-carnitine administration on physical fatigue. In a double-blind, placebo-controlled, 3-way crossover study, 18 healthy volunteers were randomized to oral citric acid (2,700 mg/day), l-carnitine (1,000 mg/day), or placebo for 8 days. The fatigue-inducing physical task consis...

journal_title：Journal of clinical biochemistry and nutrition

authors： Sugino T,Aoyagi S,Shirai T,Kajimoto Y,Kajimoto O

更新日期：2007-11-01 00:00:00

abstract：:Resistance to anti-fungal drugs has become the main cause for increasing incidence rate of Candida infections in pediatric intensive care units (PICU). Zinc supplementation has been shown to exhibit beneficial effects on many pediatric illnesses. This study aimed to investigate the efficacy of zinc supplementation on ...

journal_title：Journal of clinical biochemistry and nutrition

authors： Xie J,Zhu L,Zhu T,Jian Y,Ding Y,Zhou M,Feng X

更新日期：2019-03-01 00:00:00

abstract：:Symptomatic differences and the impact of gastroesophageal reflux disease (GERD) have not been clarified in patients with asthma and chronic obstructive pulmonary disease (COPD). The purpose of this study is to assess the differences of GERD symptoms among asthma, COPD, and disease control patients, and determine the ...

journal_title：Journal of clinical biochemistry and nutrition

authors： Shimizu Y,Dobashi K,Kusano M,Mori M

更新日期：2012-03-01 00:00:00

abstract：:In the past few decades, many types of functional factors have been identified in dietary foods; for example, flavonoids are major groups widely distributed in the plant kingdom. However, the absorption rates of the functional food factors are usually low, and many of these are difficult to be absorbed in the intact f...

journal_title：Journal of clinical biochemistry and nutrition

authors： Tsurusaki T,Sakakibara H,Aoshima Y,Yamazaki S,Sakono M,Shimoi K

更新日期：2013-05-01 00:00:00

abstract：:Although atopic dermatitis is known to be closely associated with food antigens, the actual changes in the gastrointestinal tract have not been clarified. The aim of this study was to investigate the macroscopic and histological features of the large intestine in patients with atopic dermatitis. We studied 15 outpatie...

journal_title：Journal of clinical biochemistry and nutrition

authors： Arisawa T,Arisawa S,Yokoi T,Kuroda M,Hirata I,Nakano H

更新日期：2007-01-01 00:00:00