Microbiome and intestinal ischemia/reperfusion injury.

Abstract:

:Intestinal ischemia/reperfusion injury is a severe disease associated with a high mortality. The mechanisms that cause ischemia/reperfusion injury are complex and many factors are involved in the injury formation process; however, the only available treatment is surgical intervention. Recent studies demonstrated that the intestinal microbiome plays a key role in intestinal ischemia/reperfusion injury and there are many factors associated with intestinal bacteria during the formation of the intestinal ischemia/reperfusion injury. Among the Toll-like receptors (TLR), TLR2, TLR4, and their adaptor protein, myeloid differentiation primary-response 88 (MyD88), have been reported to be involved in intestinal ischemia/reperfusion injury. Oxidative stress and nitric oxide are also associated with intestinal bacteria during the formation of the intestinal ischemia/reperfusion injury. This review focuses on our current understanding of the impact of the microbiome, including the roles of the TLRs, oxidative stress, and nitric oxide, on intestinal ischemia/reperfusion injury.

journal_name

J Clin Biochem Nutr

authors

Nadatani Y,Watanabe T,Shimada S,Otani K,Tanigawa T,Fujiwara Y

doi

10.3164/jcbn.17-137

subject

Has Abstract

pub_date

2018-07-01 00:00:00

pages

26-32

issue

1

eissn

0912-0009

issn

1880-5086

pii

jcbn17-137

journal_volume

63

pub_type

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