Ferulic Acid: therapeutic potential through its antioxidant property.

Abstract:

:There has been considerable public and scientific interest in the use of phytochemicals derived from dietary components to combat human diseases. They are naturally occurring substances found in plants. Ferulic acid (FA) is a phytochemical commonly found in fruits and vegetables such as tomatoes, sweet corn and rice bran. It arises from metabolism of phenylalanine and tyrosine by Shikimate pathway in plants. It exhibits a wide range of therapeutic effects against various diseases like cancer, diabetes, cardiovascular and neurodegenerative. A wide spectrum of beneficial activity for human health has been advocated for this phenolic compound, at least in part, because of its strong antioxidant activity. FA, a phenolic compound is a strong membrane antioxidant and known to positively affect human health. FA is an effective scavenger of free radicals and it has been approved in certain countries as food additive to prevent lipid peroxidation. It effectively scavenges superoxide anion radical and inhibits the lipid peroxidation. It possesses antioxidant property by virtue of its phenolic hydroxyl group in its structure. The hydroxy and phenoxy groups of FA donate electrons to quench the free radicals. The phenolic radical in turn forms a quinone methide intermediate, which is excreted via the bile. The past few decades have been devoted to intense research on antioxidant property of FA. So, the present review deals with the mechanism of antioxidant property of FA and its possible role in therapeutic usage against various diseases.

journal_name

J Clin Biochem Nutr

authors

Srinivasan M,Sudheer AR,Menon VP

doi

10.3164/jcbn.40.92

subject

Has Abstract

pub_date

2007-03-01 00:00:00

pages

92-100

issue

2

eissn

0912-0009

issn

1880-5086

journal_volume

40

pub_type

杂志文章
  • Possible adaptogenic effects of Momordica charantia on high-intensity training-induced alteration in the hypothalamic-pituitary-adrenal axis.

    abstract::This study investigated the effects of a drink supplement containing Momordica charantia extract from bitter melon on physical fitness and levels of stress hormones during a four-week exercise training program in a hot environment. Ten male tennis players were orally administrated in a four-week (100 ml, 6 times a day...

    journal_title:Journal of clinical biochemistry and nutrition

    pub_type: 杂志文章

    doi:10.3164/jcbn.20-96

    authors: Yook JS,Kwak JJ,Jeong WM,Song YH,Hijioka Y,Honda Y,Kim SE,Ha MS

    更新日期:2020-11-01 00:00:00

  • Endoscopic and histological features of the large intestine in patients with atopic dermatitis.

    abstract::Although atopic dermatitis is known to be closely associated with food antigens, the actual changes in the gastrointestinal tract have not been clarified. The aim of this study was to investigate the macroscopic and histological features of the large intestine in patients with atopic dermatitis. We studied 15 outpatie...

    journal_title:Journal of clinical biochemistry and nutrition

    pub_type: 杂志文章

    doi:10.3164/jcbn.40.24

    authors: Arisawa T,Arisawa S,Yokoi T,Kuroda M,Hirata I,Nakano H

    更新日期:2007-01-01 00:00:00

  • Intercorrelations of lipoprotein subfractions and their covariation with lifestyle factors in healthy men.

    abstract::So far, little is known about the effect of nutrition and lifestyle on the composition of circulating lipoprotein subfractions. In the current study, we measured the correlations among physical activity, nutrient intake, smoking, body-mass index (BMI), and age with the concentration of triglycerides, cholesterol, phos...

    journal_title:Journal of clinical biochemistry and nutrition

    pub_type: 杂志文章

    doi:10.3164/jcbn.13-78

    authors: Parlesak A,Eckoldt J,Winkler K,Bode CJ,Schäfer C

    更新日期:2014-05-01 00:00:00

  • Iron regulation by hepatocytes and free radicals.

    abstract::Iron is an essential metallic microelement for life. However, iron overload is toxic. The liver serves an important role as a storehouse for iron in the body. About 20-25 mg of iron is required each day for hemoglobin synthesis. To maintain iron homeostasis, transferrin and transferrin receptors are primarily involved...

    journal_title:Journal of clinical biochemistry and nutrition

    pub_type: 杂志文章

    doi:10.3164/jcbn.10-76

    authors: Takami T,Sakaida I

    更新日期:2011-03-01 00:00:00

  • Cooperative effects of soy isoflavones and carotenoids on osteoclast formation.

    abstract::Osteoclasts play a major role in bone resorption. Several functional food components, such as soy isoflavones and carotenoids, are reported to inhibit osteoclast formation. However, the cooperative effect of functional foods or their constituents on bone metabolism has not been clarified. This study aimed to investiga...

    journal_title:Journal of clinical biochemistry and nutrition

    pub_type: 杂志文章

    doi:10.3164/jcbn.13-94

    authors: Tadaishi M,Nishide Y,Tousen Y,Kruger MC,Ishimi Y

    更新日期:2014-03-01 00:00:00

  • Prevalence of gastroesophageal reflux disease symptoms and related factors in patients with rheumatoid arthritis.

    abstract::Gastroesophageal reflux disease (GERD) is common in patients with many chronic diseases, but has not been well recognized in rheumatoid arthritis (RA). We investigated the prevalence of GERD symptoms in 278 outpatients with RA and their association with such clinical factors as age, sex, height, weight, body mass inde...

    journal_title:Journal of clinical biochemistry and nutrition

    pub_type: 杂志文章

    doi:10.3164/jcbn.12-83

    authors: Nampei A,Shi K,Ebina K,Tomita T,Sugamoto K,Yoshikawa H,Hirao M,Hashimoto J

    更新日期:2013-03-01 00:00:00

  • Kangen-karyu raises surface body temperature through oxidative stress modification.

    abstract::Kangen-karyu, a prescription containing six herbs, has been shown to achieve its pharmacological effect through oxidative stress-dependent pathways in animal models. The aim of this study is to investigate the relationship between the antioxidative effect and pharmacological mechanisms of Kangen-karyu, specifically it...

    journal_title:Journal of clinical biochemistry and nutrition

    pub_type: 杂志文章

    doi:10.3164/jcbn.15-135

    authors: Hirayama A,Okamoto T,Kimura S,Nagano Y,Matsui H,Tomita T,Oowada S,Aoyagi K

    更新日期:2016-05-01 00:00:00

  • Selenoprotein P as an in vivo redox regulator: disorders related to its deficiency and excess.

    abstract::Selenoprotein P (encoded by SELENOP) contains the essential trace element selenium in the form of selenocysteine, which is an analog of cysteine that contains selenium instead of sulfur. Selenoprotein P is a major selenium-containing protein in human plasma and is mainly synthesized in the liver. It functions as a sel...

    journal_title:Journal of clinical biochemistry and nutrition

    pub_type: 杂志文章,评审

    doi:10.3164/jcbn.19-31

    authors: Saito Y

    更新日期:2020-01-01 00:00:00

  • Effects of prolonged high phosphorus diet on phosphorus and calcium balance in rats.

    abstract::The amount of phosphorus contained in food as food additives is currently increasing and a high intake of phosphorus can cause various diseases. To determine the effects of a prolonged high phosphorus diet, here we investigated the phosphorus and calcium balance and expression of type IIa sodium-dependent phosphate tr...

    journal_title:Journal of clinical biochemistry and nutrition

    pub_type: 杂志文章

    doi:10.3164/jcbn.40.221

    authors: Tani Y,Sato T,Yamanaka-Okumura H,Yamamoto H,Arai H,Sawada N,Genjida K,Taketani Y,Takeda E

    更新日期:2007-05-01 00:00:00

  • Genetic Polymorphisms of Molecules Associated with Innate Immune Responses, TRL2 and MBL2 Genes in Japanese Subjects with Functional Dyspepsia.

    abstract::Inflammatory changes in the gastric mucosa are commonly observed in Japanese patients with functional dyspepsia (FD). However, detailed data regarding the possible association between the genetic factors of inflammation related molecules and FD are not available. Toll like receptor 2 (TLR2) and mannan-binding lectin (...

    journal_title:Journal of clinical biochemistry and nutrition

    pub_type: 杂志文章

    doi:10.3164/jcbn.10-40

    authors: Tahara T,Shibata T,Wang F,Yamashita H,Hirata I,Arisawa T

    更新日期:2010-11-01 00:00:00

  • Maslinic acid in olive fruit alleviates mild knee joint pain and improves quality of life by promoting weight loss in the elderly.

    abstract::Consumption of olives (Olea europaea L.) is associated with a low incidence of inflammation-related diseases. Olive fruit is rich in bioactive pentacyclic triterpenoids, mainly maslinic acid. This study, a randomized, double-blind, and placebo-controlled trial, examined the effects of an orally administered maslinic a...

    journal_title:Journal of clinical biochemistry and nutrition

    pub_type: 杂志文章

    doi:10.3164/jcbn.16-40

    authors: Fukumitsu S,Villareal MO,Aida K,Hino A,Hori N,Isoda H,Naito Y

    更新日期:2016-11-01 00:00:00

  • Effects of n-3 Fatty Acids Supplementation on Plasma Phospholipids Fatty Acid Composition in Patients with Obstructive Jaundice- a Pilot Study.

    abstract::Nutritional and immunological status of patients with obstructive jaundice is usually severely altered, with high mortality rates. The n-3 polyunsaturate fatty acids (PUFA), particularly eicosapentaenoic acid (EPA, 20:5 n-3), posess potent immunomodulatory activities. Thus, our aim was to compare the plasma phospholip...

    journal_title:Journal of clinical biochemistry and nutrition

    pub_type: 杂志文章

    doi:10.3164/jcbn.09-54

    authors: Popovic T,Ranic M,Bulajic P,Milicevic M,Arsic A,Vucic V,Glibetic M

    更新日期:2009-11-01 00:00:00

  • Variable classifications of glycemic index determined by glucose meters.

    abstract::THE STUDY EVALUATED AND COMPARED THE DIFFERENCES OF GLUCOSE RESPONSES, INCREMENTAL AREA UNDER CURVE (IAUC), GLYCEMIC INDEX (GI) AND THE CLASSIFICATION OF GI VALUES BETWEEN MEASURED BY BIOCHEMICAL ANALYZER (FUJI AUTOMATIC BIOCHEMISTRY ANALYZER (FAA)) AND THREE GLUCOSE METERS: Accue Chek Advantage (AGM), BREEZE 2 (BGM),...

    journal_title:Journal of clinical biochemistry and nutrition

    pub_type: 杂志文章

    doi:10.3164/jcbn.10-08

    authors: Lin MH,Wu MC,Lin J

    更新日期:2010-07-01 00:00:00

  • Dioscorea japonica extract down-regulates prostaglandin E2 synthetic pathway and induces apoptosis in lung cancer cells.

    abstract::Prostaglandin E2 plays a role in an array of pathophysiological responses, including inflammation, carcinogenesis and so on. Prostaglandin E2 is synthesized from arachidonic acid by the enzymes cyclooxygenase and prostaglandin E synthase. In some pathological conditions, the isozymes cyclooxygenase-2 and microsomal pr...

    journal_title:Journal of clinical biochemistry and nutrition

    pub_type: 杂志文章

    doi:10.3164/jcbn.14-25

    authors: Suzuki-Yamamoto T,Tanaka S,Tsukayama I,Takafuji M,Hanada T,Arakawa T,Kawakami Y,Kimoto M,Takahashi Y

    更新日期:2014-11-01 00:00:00

  • Different gastoroesophageal reflux symptoms of middle-aged to elderly asthma and chronic obstructive pulmonary disease (COPD) patients.

    abstract::Symptomatic differences and the impact of gastroesophageal reflux disease (GERD) have not been clarified in patients with asthma and chronic obstructive pulmonary disease (COPD). The purpose of this study is to assess the differences of GERD symptoms among asthma, COPD, and disease control patients, and determine the ...

    journal_title:Journal of clinical biochemistry and nutrition

    pub_type: 杂志文章

    doi:10.3164/jcbn.11-75

    authors: Shimizu Y,Dobashi K,Kusano M,Mori M

    更新日期:2012-03-01 00:00:00

  • Intestinal Peyer's patches prevent tumorigenesis in Apc (Min/+) mice.

    abstract::Peyer's patches are nodules that play a central role in intestinal immunity. Few studies demonstrate the relationship between the number of Peyer's patches and intestinal polyps. Here we identify a statistically significant inverse correlation between the quantity of Peyer's patches and of the development of intestina...

    journal_title:Journal of clinical biochemistry and nutrition

    pub_type: 杂志文章

    doi:10.3164/jcbn.14-115

    authors: Fujimoto K,Fujii G,Sakurai H,Yoshitome H,Mutoh M,Wada M

    更新日期:2015-01-01 00:00:00

  • Recent effectiveness of proton pump inhibitors for severe reflux esophagitis: the first multicenter prospective study in Japan.

    abstract::Proton pump inhibitors are the first-line treatment for reflux esophagitis. Because severe reflux esophagitis has very low prevalence in Japan, little is known about the effectiveness of proton pump inhibitors in these patients. This prospective multicenter study assessed the effectiveness of proton pump inhibitors fo...

    journal_title:Journal of clinical biochemistry and nutrition

    pub_type: 杂志文章

    doi:10.3164/jcbn.14-144

    authors: Mizuno H,Matsuhashi N,Sakaguchi M,Inoue S,Nakada K,Higuchi K,Haruma K,Joh T

    更新日期:2015-11-01 00:00:00

  • Effect of Insulin Treatment or Zinc Supplementation on Vitamin A Status in Streptozotocin-Induced Diabetic Rats.

    abstract::A Using streptozotocin-induced diabetic rats, we examined the effects of zinc supplementation and insulin treatment on the metabolic availability of vitamin A. All diabetic animals exhibited an elevated plasma glucose (>18 mmol/liter) level within 48 h of intravenous streptozotocin injection. The untreated diabetic ra...

    journal_title:Journal of clinical biochemistry and nutrition

    pub_type: 杂志文章

    doi:10.3164/jcbn.19.165

    authors: Tuitoek P,Lakey J,Rajotte R,Ziari S,Tsin A,Basu T

    更新日期:1995-01-01 00:00:00

  • Zinc supplementation reduces Candida infections in pediatric intensive care unit: a randomized placebo-controlled clinical trial.

    abstract::Resistance to anti-fungal drugs has become the main cause for increasing incidence rate of Candida infections in pediatric intensive care units (PICU). Zinc supplementation has been shown to exhibit beneficial effects on many pediatric illnesses. This study aimed to investigate the efficacy of zinc supplementation on ...

    journal_title:Journal of clinical biochemistry and nutrition

    pub_type: 杂志文章

    doi:10.3164/jcbn.18-74

    authors: Xie J,Zhu L,Zhu T,Jian Y,Ding Y,Zhou M,Feng X

    更新日期:2019-03-01 00:00:00

  • Prospective multi-center trial for the efficacy of ecabet sodium on the relief of dyspepsia in korean patients with chronic gastritis.

    abstract::Anti-peptic and anti-inflammatory actions of ecabet sodium might be beneficial in either improving gastritis or relieving dyspeptic symptoms. This study was designed to evaluate the clinical efficacy of ecabet sodium on dyspeptic symptoms and to elucidate the molecular mechanism attributable to symptom relief in patie...

    journal_title:Journal of clinical biochemistry and nutrition

    pub_type: 杂志文章

    doi:10.3164/jcbn.2007022

    authors: Yang Kim H,Hahm KB,Choi MG,Rew JS,Seol SY,Chun HJ,Lee OY,Hong WS

    更新日期:2007-11-01 00:00:00

  • Effects of Citric Acid and l-Carnitine on Physical Fatigue.

    abstract::We examined the effects of citric acid and l-carnitine administration on physical fatigue. In a double-blind, placebo-controlled, 3-way crossover study, 18 healthy volunteers were randomized to oral citric acid (2,700 mg/day), l-carnitine (1,000 mg/day), or placebo for 8 days. The fatigue-inducing physical task consis...

    journal_title:Journal of clinical biochemistry and nutrition

    pub_type: 杂志文章

    doi:10.3164/jcbn.2007032

    authors: Sugino T,Aoyagi S,Shirai T,Kajimoto Y,Kajimoto O

    更新日期:2007-11-01 00:00:00

  • Sex difference: an important issue to consider in epidemiological and clinical studies dealing with serum paraoxonase-1.

    abstract::The aim of this study was to evaluate the influence of sex on serum paraoxonase-1 (PON1) activities and on its relationship with cardiovascular disease risk factors such as overall and central obesity. Arylesterase and lactonase activities of PON1 were assessed in 374 women and 92 men. Both arylesterase and lactonase ...

    journal_title:Journal of clinical biochemistry and nutrition

    pub_type: 杂志文章

    doi:10.3164/jcbn.18-73

    authors: Trentini A,Bellini T,Bonaccorsi G,Cavicchio C,Hanau S,Passaro A,Cervellati C

    更新日期:2019-05-01 00:00:00

  • Bach1 gene ablation reduces steatohepatitis in mouse MCD diet model.

    abstract::Bach1 is a transcriptional repressor of heme oxygenase-1 (HO-1, a.k.a. HSP-32), which is an inducible enzyme and has anti-oxidation/anti-inflammatory properties shown in various models of organ injuries. Since oxidative stress plays a pivotal role in the pathogenesis of nonalcoholic steatohepatitis (NASH), HO-1 induct...

    journal_title:Journal of clinical biochemistry and nutrition

    pub_type: 杂志文章

    doi:10.3164/jcbn.09-122GFR

    authors: Inoue M,Tazuma S,Kanno K,Hyogo H,Igarashi K,Chayama K

    更新日期:2011-03-01 00:00:00

  • Non-specific protein modifications may be novel mechanism underlying bioactive phytochemicals.

    abstract::In a variety of experimental models, dietary phytochemicals have been demonstrated to exhibit pronounced and versatile bioactivities. Importantly, the possibility of such phytochemicals for human application has been supported in part by epidemiological surveys, which have demonstrated that frequent ingestion of veget...

    journal_title:Journal of clinical biochemistry and nutrition

    pub_type: 杂志文章,评审

    doi:10.3164/jcbn.17-113

    authors: Murakami A

    更新日期:2018-03-01 00:00:00

  • Microbiome and intestinal ischemia/reperfusion injury.

    abstract::Intestinal ischemia/reperfusion injury is a severe disease associated with a high mortality. The mechanisms that cause ischemia/reperfusion injury are complex and many factors are involved in the injury formation process; however, the only available treatment is surgical intervention. Recent studies demonstrated that ...

    journal_title:Journal of clinical biochemistry and nutrition

    pub_type: 杂志文章,评审

    doi:10.3164/jcbn.17-137

    authors: Nadatani Y,Watanabe T,Shimada S,Otani K,Tanigawa T,Fujiwara Y

    更新日期:2018-07-01 00:00:00

  • The relationship between vitamin D and estimated glomerular filtration rate and urine microalbumin/creatinine ratio in Korean adults.

    abstract::The present study was conducted to assess the association between 25-hydroxyvitamin D [25(OH)D], estimated glomerular filtration rate (eGFR) and urine microalbumin/creatinine ratio (uACR) in Korean adults. Data on 4,948 adults aged ≥20 years from the Korean National Health and Nutrition Examination Survey V-3 (2012) w...

    journal_title:Journal of clinical biochemistry and nutrition

    pub_type: 杂志文章

    doi:10.3164/jcbn.17-69

    authors: Kim SG,Kim GS,Lee JH,Moon AE,Yoon H

    更新日期:2018-01-01 00:00:00

  • Changes in the concentrations of vitamin E analogs and their metabolites in rat liver and kidney after oral administration.

    abstract::Vitamin E analog, such as α- and γ-tocopherol, can undergo ω-oxidation without cleavage of the chroman ring, and this pathway is responsible for generation of the major urinary vitamin E metabolite, carboxyethyl hydroxychroman. However, it is still unclear how carboxyethyl hydroxychroman is changed in various tissues ...

    journal_title:Journal of clinical biochemistry and nutrition

    pub_type: 杂志文章

    doi:10.3164/jcbn.14-107

    authors: Kiyose C,Saito K,Yachi R,Muto C,Igarashi O

    更新日期:2015-03-01 00:00:00

  • Reduced dietary omega-3 fatty acids intake is associated with sarcopenia in elderly patients with type 2 diabetes: a cross-sectional study of KAMOGAWA-DM cohort study.

    abstract::Omega-3 fatty acids intake is important to maintain muscle mass. However, the relationship between omega-3 fatty acids intake and sarcopenia in elderly patients with type 2 diabetes has been unclear. We used the brief-type self-administered diet history questionnaire for the assessment of habitual food and nutrient in...

    journal_title:Journal of clinical biochemistry and nutrition

    pub_type: 杂志文章

    doi:10.3164/jcbn.19-85

    authors: Okamura T,Hashimoto Y,Miki A,Kaji A,Sakai R,Iwai K,Osaka T,Ushigome E,Hamaguchi M,Yamazaki M,Fukui M

    更新日期:2020-05-01 00:00:00

  • Non-invasive measurement of skin autofluorescence to evaluate diabetic complications.

    abstract::Although the accumulation of advanced glycation end-products (AGEs) of the Maillard reaction in our body is reported to increase with aging and is enhanced by the pathogenesis of lifestyle-related diseases such as diabetes, routine measurement of AGEs is not applied to regular clinical diagnoses due to the lack of con...

    journal_title:Journal of clinical biochemistry and nutrition

    pub_type: 杂志文章

    doi:10.3164/jcbn.15-132

    authors: Yamanaka M,Matsumura T,Ohno R,Fujiwara Y,Shinagawa M,Sugawa H,Hatano K,Shirakawa J,Kinoshita H,Ito K,Sakata N,Araki E,Nagai R

    更新日期:2016-03-01 00:00:00

  • A comparative analysis of genistein and daidzein in affecting lipid metabolism in rat liver.

    abstract::Effects of soy isoflavones, genistein and daidzein, on the hepatic gene expression profile and indices for lipid metabolism were compared in rats. In the first experiment (Expt. 1), animals were fed diets containing 2 g/kg of either genistein or daidzein, or a control diet free of isoflavone for 14 days. In the second...

    journal_title:Journal of clinical biochemistry and nutrition

    pub_type: 杂志文章

    doi:10.3164/jcbn.08-211

    authors: Takahashi Y,Odbayar TO,Ide T

    更新日期:2009-05-01 00:00:00