Abstract:
:There has been considerable public and scientific interest in the use of phytochemicals derived from dietary components to combat human diseases. They are naturally occurring substances found in plants. Ferulic acid (FA) is a phytochemical commonly found in fruits and vegetables such as tomatoes, sweet corn and rice bran. It arises from metabolism of phenylalanine and tyrosine by Shikimate pathway in plants. It exhibits a wide range of therapeutic effects against various diseases like cancer, diabetes, cardiovascular and neurodegenerative. A wide spectrum of beneficial activity for human health has been advocated for this phenolic compound, at least in part, because of its strong antioxidant activity. FA, a phenolic compound is a strong membrane antioxidant and known to positively affect human health. FA is an effective scavenger of free radicals and it has been approved in certain countries as food additive to prevent lipid peroxidation. It effectively scavenges superoxide anion radical and inhibits the lipid peroxidation. It possesses antioxidant property by virtue of its phenolic hydroxyl group in its structure. The hydroxy and phenoxy groups of FA donate electrons to quench the free radicals. The phenolic radical in turn forms a quinone methide intermediate, which is excreted via the bile. The past few decades have been devoted to intense research on antioxidant property of FA. So, the present review deals with the mechanism of antioxidant property of FA and its possible role in therapeutic usage against various diseases.
journal_name
J Clin Biochem Nutrjournal_title
Journal of clinical biochemistry and nutritionauthors
Srinivasan M,Sudheer AR,Menon VPdoi
10.3164/jcbn.40.92subject
Has Abstractpub_date
2007-03-01 00:00:00pages
92-100issue
2eissn
0912-0009issn
1880-5086journal_volume
40pub_type
杂志文章abstract::This study investigated the effects of a drink supplement containing Momordica charantia extract from bitter melon on physical fitness and levels of stress hormones during a four-week exercise training program in a hot environment. Ten male tennis players were orally administrated in a four-week (100 ml, 6 times a day...
journal_title:Journal of clinical biochemistry and nutrition
pub_type: 杂志文章
doi:10.3164/jcbn.20-96
更新日期:2020-11-01 00:00:00
abstract::Although atopic dermatitis is known to be closely associated with food antigens, the actual changes in the gastrointestinal tract have not been clarified. The aim of this study was to investigate the macroscopic and histological features of the large intestine in patients with atopic dermatitis. We studied 15 outpatie...
journal_title:Journal of clinical biochemistry and nutrition
pub_type: 杂志文章
doi:10.3164/jcbn.40.24
更新日期:2007-01-01 00:00:00
abstract::So far, little is known about the effect of nutrition and lifestyle on the composition of circulating lipoprotein subfractions. In the current study, we measured the correlations among physical activity, nutrient intake, smoking, body-mass index (BMI), and age with the concentration of triglycerides, cholesterol, phos...
journal_title:Journal of clinical biochemistry and nutrition
pub_type: 杂志文章
doi:10.3164/jcbn.13-78
更新日期:2014-05-01 00:00:00
abstract::Iron is an essential metallic microelement for life. However, iron overload is toxic. The liver serves an important role as a storehouse for iron in the body. About 20-25 mg of iron is required each day for hemoglobin synthesis. To maintain iron homeostasis, transferrin and transferrin receptors are primarily involved...
journal_title:Journal of clinical biochemistry and nutrition
pub_type: 杂志文章
doi:10.3164/jcbn.10-76
更新日期:2011-03-01 00:00:00
abstract::Osteoclasts play a major role in bone resorption. Several functional food components, such as soy isoflavones and carotenoids, are reported to inhibit osteoclast formation. However, the cooperative effect of functional foods or their constituents on bone metabolism has not been clarified. This study aimed to investiga...
journal_title:Journal of clinical biochemistry and nutrition
pub_type: 杂志文章
doi:10.3164/jcbn.13-94
更新日期:2014-03-01 00:00:00
abstract::Gastroesophageal reflux disease (GERD) is common in patients with many chronic diseases, but has not been well recognized in rheumatoid arthritis (RA). We investigated the prevalence of GERD symptoms in 278 outpatients with RA and their association with such clinical factors as age, sex, height, weight, body mass inde...
journal_title:Journal of clinical biochemistry and nutrition
pub_type: 杂志文章
doi:10.3164/jcbn.12-83
更新日期:2013-03-01 00:00:00
abstract::Kangen-karyu, a prescription containing six herbs, has been shown to achieve its pharmacological effect through oxidative stress-dependent pathways in animal models. The aim of this study is to investigate the relationship between the antioxidative effect and pharmacological mechanisms of Kangen-karyu, specifically it...
journal_title:Journal of clinical biochemistry and nutrition
pub_type: 杂志文章
doi:10.3164/jcbn.15-135
更新日期:2016-05-01 00:00:00
abstract::Selenoprotein P (encoded by SELENOP) contains the essential trace element selenium in the form of selenocysteine, which is an analog of cysteine that contains selenium instead of sulfur. Selenoprotein P is a major selenium-containing protein in human plasma and is mainly synthesized in the liver. It functions as a sel...
journal_title:Journal of clinical biochemistry and nutrition
pub_type: 杂志文章,评审
doi:10.3164/jcbn.19-31
更新日期:2020-01-01 00:00:00
abstract::The amount of phosphorus contained in food as food additives is currently increasing and a high intake of phosphorus can cause various diseases. To determine the effects of a prolonged high phosphorus diet, here we investigated the phosphorus and calcium balance and expression of type IIa sodium-dependent phosphate tr...
journal_title:Journal of clinical biochemistry and nutrition
pub_type: 杂志文章
doi:10.3164/jcbn.40.221
更新日期:2007-05-01 00:00:00
abstract::Inflammatory changes in the gastric mucosa are commonly observed in Japanese patients with functional dyspepsia (FD). However, detailed data regarding the possible association between the genetic factors of inflammation related molecules and FD are not available. Toll like receptor 2 (TLR2) and mannan-binding lectin (...
journal_title:Journal of clinical biochemistry and nutrition
pub_type: 杂志文章
doi:10.3164/jcbn.10-40
更新日期:2010-11-01 00:00:00
abstract::Consumption of olives (Olea europaea L.) is associated with a low incidence of inflammation-related diseases. Olive fruit is rich in bioactive pentacyclic triterpenoids, mainly maslinic acid. This study, a randomized, double-blind, and placebo-controlled trial, examined the effects of an orally administered maslinic a...
journal_title:Journal of clinical biochemistry and nutrition
pub_type: 杂志文章
doi:10.3164/jcbn.16-40
更新日期:2016-11-01 00:00:00
abstract::Nutritional and immunological status of patients with obstructive jaundice is usually severely altered, with high mortality rates. The n-3 polyunsaturate fatty acids (PUFA), particularly eicosapentaenoic acid (EPA, 20:5 n-3), posess potent immunomodulatory activities. Thus, our aim was to compare the plasma phospholip...
journal_title:Journal of clinical biochemistry and nutrition
pub_type: 杂志文章
doi:10.3164/jcbn.09-54
更新日期:2009-11-01 00:00:00
abstract::THE STUDY EVALUATED AND COMPARED THE DIFFERENCES OF GLUCOSE RESPONSES, INCREMENTAL AREA UNDER CURVE (IAUC), GLYCEMIC INDEX (GI) AND THE CLASSIFICATION OF GI VALUES BETWEEN MEASURED BY BIOCHEMICAL ANALYZER (FUJI AUTOMATIC BIOCHEMISTRY ANALYZER (FAA)) AND THREE GLUCOSE METERS: Accue Chek Advantage (AGM), BREEZE 2 (BGM),...
journal_title:Journal of clinical biochemistry and nutrition
pub_type: 杂志文章
doi:10.3164/jcbn.10-08
更新日期:2010-07-01 00:00:00
abstract::Prostaglandin E2 plays a role in an array of pathophysiological responses, including inflammation, carcinogenesis and so on. Prostaglandin E2 is synthesized from arachidonic acid by the enzymes cyclooxygenase and prostaglandin E synthase. In some pathological conditions, the isozymes cyclooxygenase-2 and microsomal pr...
journal_title:Journal of clinical biochemistry and nutrition
pub_type: 杂志文章
doi:10.3164/jcbn.14-25
更新日期:2014-11-01 00:00:00
abstract::Symptomatic differences and the impact of gastroesophageal reflux disease (GERD) have not been clarified in patients with asthma and chronic obstructive pulmonary disease (COPD). The purpose of this study is to assess the differences of GERD symptoms among asthma, COPD, and disease control patients, and determine the ...
journal_title:Journal of clinical biochemistry and nutrition
pub_type: 杂志文章
doi:10.3164/jcbn.11-75
更新日期:2012-03-01 00:00:00
abstract::Peyer's patches are nodules that play a central role in intestinal immunity. Few studies demonstrate the relationship between the number of Peyer's patches and intestinal polyps. Here we identify a statistically significant inverse correlation between the quantity of Peyer's patches and of the development of intestina...
journal_title:Journal of clinical biochemistry and nutrition
pub_type: 杂志文章
doi:10.3164/jcbn.14-115
更新日期:2015-01-01 00:00:00
abstract::Proton pump inhibitors are the first-line treatment for reflux esophagitis. Because severe reflux esophagitis has very low prevalence in Japan, little is known about the effectiveness of proton pump inhibitors in these patients. This prospective multicenter study assessed the effectiveness of proton pump inhibitors fo...
journal_title:Journal of clinical biochemistry and nutrition
pub_type: 杂志文章
doi:10.3164/jcbn.14-144
更新日期:2015-11-01 00:00:00
abstract::A Using streptozotocin-induced diabetic rats, we examined the effects of zinc supplementation and insulin treatment on the metabolic availability of vitamin A. All diabetic animals exhibited an elevated plasma glucose (>18 mmol/liter) level within 48 h of intravenous streptozotocin injection. The untreated diabetic ra...
journal_title:Journal of clinical biochemistry and nutrition
pub_type: 杂志文章
doi:10.3164/jcbn.19.165
更新日期:1995-01-01 00:00:00
abstract::Resistance to anti-fungal drugs has become the main cause for increasing incidence rate of Candida infections in pediatric intensive care units (PICU). Zinc supplementation has been shown to exhibit beneficial effects on many pediatric illnesses. This study aimed to investigate the efficacy of zinc supplementation on ...
journal_title:Journal of clinical biochemistry and nutrition
pub_type: 杂志文章
doi:10.3164/jcbn.18-74
更新日期:2019-03-01 00:00:00
abstract::Anti-peptic and anti-inflammatory actions of ecabet sodium might be beneficial in either improving gastritis or relieving dyspeptic symptoms. This study was designed to evaluate the clinical efficacy of ecabet sodium on dyspeptic symptoms and to elucidate the molecular mechanism attributable to symptom relief in patie...
journal_title:Journal of clinical biochemistry and nutrition
pub_type: 杂志文章
doi:10.3164/jcbn.2007022
更新日期:2007-11-01 00:00:00
abstract::We examined the effects of citric acid and l-carnitine administration on physical fatigue. In a double-blind, placebo-controlled, 3-way crossover study, 18 healthy volunteers were randomized to oral citric acid (2,700 mg/day), l-carnitine (1,000 mg/day), or placebo for 8 days. The fatigue-inducing physical task consis...
journal_title:Journal of clinical biochemistry and nutrition
pub_type: 杂志文章
doi:10.3164/jcbn.2007032
更新日期:2007-11-01 00:00:00
abstract::The aim of this study was to evaluate the influence of sex on serum paraoxonase-1 (PON1) activities and on its relationship with cardiovascular disease risk factors such as overall and central obesity. Arylesterase and lactonase activities of PON1 were assessed in 374 women and 92 men. Both arylesterase and lactonase ...
journal_title:Journal of clinical biochemistry and nutrition
pub_type: 杂志文章
doi:10.3164/jcbn.18-73
更新日期:2019-05-01 00:00:00
abstract::Bach1 is a transcriptional repressor of heme oxygenase-1 (HO-1, a.k.a. HSP-32), which is an inducible enzyme and has anti-oxidation/anti-inflammatory properties shown in various models of organ injuries. Since oxidative stress plays a pivotal role in the pathogenesis of nonalcoholic steatohepatitis (NASH), HO-1 induct...
journal_title:Journal of clinical biochemistry and nutrition
pub_type: 杂志文章
doi:10.3164/jcbn.09-122GFR
更新日期:2011-03-01 00:00:00
abstract::In a variety of experimental models, dietary phytochemicals have been demonstrated to exhibit pronounced and versatile bioactivities. Importantly, the possibility of such phytochemicals for human application has been supported in part by epidemiological surveys, which have demonstrated that frequent ingestion of veget...
journal_title:Journal of clinical biochemistry and nutrition
pub_type: 杂志文章,评审
doi:10.3164/jcbn.17-113
更新日期:2018-03-01 00:00:00
abstract::Intestinal ischemia/reperfusion injury is a severe disease associated with a high mortality. The mechanisms that cause ischemia/reperfusion injury are complex and many factors are involved in the injury formation process; however, the only available treatment is surgical intervention. Recent studies demonstrated that ...
journal_title:Journal of clinical biochemistry and nutrition
pub_type: 杂志文章,评审
doi:10.3164/jcbn.17-137
更新日期:2018-07-01 00:00:00
abstract::The present study was conducted to assess the association between 25-hydroxyvitamin D [25(OH)D], estimated glomerular filtration rate (eGFR) and urine microalbumin/creatinine ratio (uACR) in Korean adults. Data on 4,948 adults aged ≥20 years from the Korean National Health and Nutrition Examination Survey V-3 (2012) w...
journal_title:Journal of clinical biochemistry and nutrition
pub_type: 杂志文章
doi:10.3164/jcbn.17-69
更新日期:2018-01-01 00:00:00
abstract::Vitamin E analog, such as α- and γ-tocopherol, can undergo ω-oxidation without cleavage of the chroman ring, and this pathway is responsible for generation of the major urinary vitamin E metabolite, carboxyethyl hydroxychroman. However, it is still unclear how carboxyethyl hydroxychroman is changed in various tissues ...
journal_title:Journal of clinical biochemistry and nutrition
pub_type: 杂志文章
doi:10.3164/jcbn.14-107
更新日期:2015-03-01 00:00:00
abstract::Omega-3 fatty acids intake is important to maintain muscle mass. However, the relationship between omega-3 fatty acids intake and sarcopenia in elderly patients with type 2 diabetes has been unclear. We used the brief-type self-administered diet history questionnaire for the assessment of habitual food and nutrient in...
journal_title:Journal of clinical biochemistry and nutrition
pub_type: 杂志文章
doi:10.3164/jcbn.19-85
更新日期:2020-05-01 00:00:00
abstract::Although the accumulation of advanced glycation end-products (AGEs) of the Maillard reaction in our body is reported to increase with aging and is enhanced by the pathogenesis of lifestyle-related diseases such as diabetes, routine measurement of AGEs is not applied to regular clinical diagnoses due to the lack of con...
journal_title:Journal of clinical biochemistry and nutrition
pub_type: 杂志文章
doi:10.3164/jcbn.15-132
更新日期:2016-03-01 00:00:00
abstract::Effects of soy isoflavones, genistein and daidzein, on the hepatic gene expression profile and indices for lipid metabolism were compared in rats. In the first experiment (Expt. 1), animals were fed diets containing 2 g/kg of either genistein or daidzein, or a control diet free of isoflavone for 14 days. In the second...
journal_title:Journal of clinical biochemistry and nutrition
pub_type: 杂志文章
doi:10.3164/jcbn.08-211
更新日期:2009-05-01 00:00:00