Effect of Insulin Treatment or Zinc Supplementation on Vitamin A Status in Streptozotocin-Induced Diabetic Rats.

Abstract:

:A Using streptozotocin-induced diabetic rats, we examined the effects of zinc supplementation and insulin treatment on the metabolic availability of vitamin A. All diabetic animals exhibited an elevated plasma glucose (>18 mmol/liter) level within 48 h of intravenous streptozotocin injection. The untreated diabetic rats exhibited a reduction in body weight gain, with a 50% increase in daily food intake. In diabetic animals treated with insulin for 4 weeks, the plasma glucose, body weight gain, and daily food intake were comparable to those of the non-diabetic controls. The plasma concentration of vitamin A was significantly reduced in the diabetic animals, whereas the hepatic content of vitamin A in them was significantly elevated. Treatment with implantable insulin resulted in both plasma and liver concentrations of vitamin A returning to the control non-diabetic levels. Dietary zinc supplementation (120 µg/g diet for 4 weeks) failed to improve the plasma concentration of vitamin A. These results suggest that the impaired metabolic availability of vitamin A in the presence of diabetes is caused by insulin deficiency.

journal_name

J Clin Biochem Nutr

authors

Tuitoek P,Lakey J,Rajotte R,Ziari S,Tsin A,Basu T

doi

10.3164/jcbn.19.165

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

165-173

eissn

0912-0009

issn

1880-5086

journal_volume

19

pub_type

杂志文章
  • Effectiveness of tolvaptan monotherapy and low-dose furosemide/tolvaptan combination therapy for hepatoprotection and diuresis in a rat cirrhotic model.

    abstract::Spironolactone and furosemide, which are used to treat ascites associated with decompensated cirrhosis, are ineffective in treating refractory ascites. Hence, combination therapy with tolvaptan, a vasopressin V2 receptor antagonist, has been approved in Japan. Tolvaptan monotherapy and combination therapy with furosem...

    journal_title:Journal of clinical biochemistry and nutrition

    pub_type: 杂志文章

    doi:10.3164/jcbn.16-122

    authors: Tanabe N,Takami T,Fujisawa K,Matsumoto T,Yamamoto N,Sakaida I

    更新日期:2017-07-01 00:00:00

  • Cooperative effects of soy isoflavones and carotenoids on osteoclast formation.

    abstract::Osteoclasts play a major role in bone resorption. Several functional food components, such as soy isoflavones and carotenoids, are reported to inhibit osteoclast formation. However, the cooperative effect of functional foods or their constituents on bone metabolism has not been clarified. This study aimed to investiga...

    journal_title:Journal of clinical biochemistry and nutrition

    pub_type: 杂志文章

    doi:10.3164/jcbn.13-94

    authors: Tadaishi M,Nishide Y,Tousen Y,Kruger MC,Ishimi Y

    更新日期:2014-03-01 00:00:00

  • Association between body shape index and small dense LDL particles in a cohort of mediterranean women: findings from Progetto ATENA.

    abstract::Small dense LDL particles (sd-LDL) and body shape index (ABSI), were evaluated in 228 women, living in Naples, Italy (Progetto ATENA). Serum cholesterol, HDL-cholesterol, LDL-cholesterol, triglycerides, insulin, HOMA, Apo B, hs-CPR and sd-LDL were measured. LDL particle separation was performed by Lipoprint System: se...

    journal_title:Journal of clinical biochemistry and nutrition

    pub_type: 杂志文章

    doi:10.3164/jcbn.17-13

    authors: Gentile M,Iannuzzo G,Mattiello A,Rubba F,Panico S,Rubba P

    更新日期:2017-09-01 00:00:00

  • The effects of moderate exercise on secretory IgA production in mice depends on dietary carbohydrate intake.

    abstract::Secretory immunoglobulin A (sIgA) is produced from intestinal mucosa and is essential in preventing infection. We analyzed the influence of moderate exercise on intestinal sIgA production and antioxidative function under different carbohydrate nutritional conditions. Thirty-six mice were fed an experimental diet for 1...

    journal_title:Journal of clinical biochemistry and nutrition

    pub_type: 杂志文章

    doi:10.3164/jcbn.15-21

    authors: Shibuya T,Kaburagi T,Nagai R,Oshiro S

    更新日期:2015-07-01 00:00:00

  • Extensive Analysis of Elastase-Induced Pulmonary Emphysema in Rats: ALP in the Lung, a New Biomarker for Disease Progression?

    abstract::It is accepted that pulmonary exposure of rodents to porcine pancreatic elastase (ELT) induces lesions that morphologically resemble human emphysema. Nonetheless, extensive analysis of this model has rarely been conducted. The present study was designed to extensively examine the effects of ELT on lung inflammation, c...

    journal_title:Journal of clinical biochemistry and nutrition

    pub_type: 杂志文章

    doi:10.3164/jcbn.09-87

    authors: Inoue K,Koike E,Yanagisawa R,Takano H

    更新日期:2010-03-01 00:00:00

  • Monascus purpureus induced apoptosis on gastric cancer cell by scavenging mitochondrial reactive oxygen species.

    abstract::Monascus purpureus is a red dye derived from yeast rice and has been used as color additives for food in East Asia. Monascus purpureus consists of several bioactive components. Some of these components work as a radical scavenger, thus monascus purpureus would also eliminate reactive oxygen species. Cancer cells maint...

    journal_title:Journal of clinical biochemistry and nutrition

    pub_type: 杂志文章

    doi:10.3164/jcbn.17-27

    authors: Kurokawa H,Ito H,Matsui H

    更新日期:2017-11-01 00:00:00

  • Intestinal Peyer's patches prevent tumorigenesis in Apc (Min/+) mice.

    abstract::Peyer's patches are nodules that play a central role in intestinal immunity. Few studies demonstrate the relationship between the number of Peyer's patches and intestinal polyps. Here we identify a statistically significant inverse correlation between the quantity of Peyer's patches and of the development of intestina...

    journal_title:Journal of clinical biochemistry and nutrition

    pub_type: 杂志文章

    doi:10.3164/jcbn.14-115

    authors: Fujimoto K,Fujii G,Sakurai H,Yoshitome H,Mutoh M,Wada M

    更新日期:2015-01-01 00:00:00

  • Changes of energy metabolism, nutritional status and serum cytokine levels in patients with Crohn's disease after anti-tumor necrosis factor-α therapy.

    abstract::We investigated the effects of treatment with antibodies against tumor necrosis factor (TNF)-α on energy metabolism, nutritional status, serum cytokine levels in patients with Crohn's disease (CD). Twelve patients were enrolled. Resting energy expenditure (REE) levels were measured by indirect calorimetry. Crohn's dis...

    journal_title:Journal of clinical biochemistry and nutrition

    pub_type: 杂志文章

    doi:10.3164/jcbn.13-18

    authors: Nishida N,Sasaki M,Kurihara M,Ichimaru S,Wakita M,Bamba S,Andoh A,Fujiyama Y,Amagai T

    更新日期:2013-09-01 00:00:00

  • Effects of n-3 Fatty Acids Supplementation on Plasma Phospholipids Fatty Acid Composition in Patients with Obstructive Jaundice- a Pilot Study.

    abstract::Nutritional and immunological status of patients with obstructive jaundice is usually severely altered, with high mortality rates. The n-3 polyunsaturate fatty acids (PUFA), particularly eicosapentaenoic acid (EPA, 20:5 n-3), posess potent immunomodulatory activities. Thus, our aim was to compare the plasma phospholip...

    journal_title:Journal of clinical biochemistry and nutrition

    pub_type: 杂志文章

    doi:10.3164/jcbn.09-54

    authors: Popovic T,Ranic M,Bulajic P,Milicevic M,Arsic A,Vucic V,Glibetic M

    更新日期:2009-11-01 00:00:00

  • Endoscopic and histological features of the large intestine in patients with atopic dermatitis.

    abstract::Although atopic dermatitis is known to be closely associated with food antigens, the actual changes in the gastrointestinal tract have not been clarified. The aim of this study was to investigate the macroscopic and histological features of the large intestine in patients with atopic dermatitis. We studied 15 outpatie...

    journal_title:Journal of clinical biochemistry and nutrition

    pub_type: 杂志文章

    doi:10.3164/jcbn.40.24

    authors: Arisawa T,Arisawa S,Yokoi T,Kuroda M,Hirata I,Nakano H

    更新日期:2007-01-01 00:00:00

  • Possible adaptogenic effects of Momordica charantia on high-intensity training-induced alteration in the hypothalamic-pituitary-adrenal axis.

    abstract::This study investigated the effects of a drink supplement containing Momordica charantia extract from bitter melon on physical fitness and levels of stress hormones during a four-week exercise training program in a hot environment. Ten male tennis players were orally administrated in a four-week (100 ml, 6 times a day...

    journal_title:Journal of clinical biochemistry and nutrition

    pub_type: 杂志文章

    doi:10.3164/jcbn.20-96

    authors: Yook JS,Kwak JJ,Jeong WM,Song YH,Hijioka Y,Honda Y,Kim SE,Ha MS

    更新日期:2020-11-01 00:00:00

  • Partially hydrolyzed guar gum affects the expression of genes involved in host defense functions and cholesterol absorption in colonic mucosa of db/db male mice.

    abstract::Biomedical evidence in the last 20 years has shown that the consumption of partially hydrolyzed guar gum may influence lipid and/or carbohydrate metabolism at many levels. Since intestine represents the first interface to interact with dietary partially hydrolyzed guar gum in vivo, we evaluated gene expression profile...

    journal_title:Journal of clinical biochemistry and nutrition

    pub_type: 杂志文章

    doi:10.3164/jcbn.11-104

    authors: Yasukawa Z,Naito Y,Takagi T,Mizushima K,Tokunaga M,Ishihara N,R Juneja L,Yoshikawa T

    更新日期:2012-07-01 00:00:00

  • A new insight into the apoptotic effect of nitidine chloride targeting Checkpoint kinase 2 in human cervical cancer in vitro.

    abstract::Nitidine chloride (NC), a natural, bioactive, phytochemical alkaloid derived from the roots of Zanthoxylum nitidum, has been reported to exhibit anti-tumor activity against various types of cancer. However, the potential therapeutic role of NC in human cervical cancer has not yet been studied. We are the first to repo...

    journal_title:Journal of clinical biochemistry and nutrition

    pub_type: 杂志文章

    doi:10.3164/jcbn.19-28

    authors: Kwon HJ,Kim LH,Ahn CH,Yang IH,Hong KO,Doo Hong S,Shin JA,Cho SD

    更新日期:2019-11-01 00:00:00

  • Polished rice as natural sources of cancer-preventing geranylgeranoic acid.

    abstract::Geranylgeranoic acid, a 20-carbon polyprenoic acid (all-trans 3,7,11,15-tetramethyl-2,4,6,10,14-hexadecatetraenoic acid) and its derivatives were previously developed as synthetic "acyclic retinoids" for cancer chemoprevention. Recently, we demonstrated the natural occurrence of geranylgeranoic acid in various medicin...

    journal_title:Journal of clinical biochemistry and nutrition

    pub_type: 杂志文章

    doi:10.3164/jcbn.10-110

    authors: Muraguchi T,Okamoto K,Mitake M,Ogawa H,Shidoji Y

    更新日期:2011-07-01 00:00:00

  • Cytoprotective effect of chlorogenic acid against α-synuclein-related toxicity in catecholaminergic PC12 cells.

    abstract::Parkinson's disease is a major neurodegenerative disease involving the selective degeneration of dopaminergic neurons and α-synuclein containing Lewy bodies formation in the substantia nigra. Although α-synuclein is a key molecule for both dopaminergic neuron death and the formation of inclusion bodies, the mechanism ...

    journal_title:Journal of clinical biochemistry and nutrition

    pub_type: 杂志文章

    doi:10.3164/jcbn.D-11-00030

    authors: Teraoka M,Nakaso K,Kusumoto C,Katano S,Tajima N,Yamashita A,Zushi T,Ito S,Matsura T

    更新日期:2012-09-01 00:00:00

  • Prevalence of gastroesophageal reflux disease symptoms and related factors in patients with rheumatoid arthritis.

    abstract::Gastroesophageal reflux disease (GERD) is common in patients with many chronic diseases, but has not been well recognized in rheumatoid arthritis (RA). We investigated the prevalence of GERD symptoms in 278 outpatients with RA and their association with such clinical factors as age, sex, height, weight, body mass inde...

    journal_title:Journal of clinical biochemistry and nutrition

    pub_type: 杂志文章

    doi:10.3164/jcbn.12-83

    authors: Nampei A,Shi K,Ebina K,Tomita T,Sugamoto K,Yoshikawa H,Hirao M,Hashimoto J

    更新日期:2013-03-01 00:00:00

  • Effect of Obstructive Jaundice and Nitric Oxide on the Profiles of Intestinal Bacterial Flora in Wild and iNOS Mice.

    abstract::We previously reported that the plasma level of endotoxin and colonic expression of IgA in the mouse increased with obstructive jaundice induced by bile duct ligation (BDL). To elucidate the mechanism of the BDL-induced increase, we analyzed the effect of BDL on intestinal flora in wild type and inducible nitric oxide...

    journal_title:Journal of clinical biochemistry and nutrition

    pub_type: 杂志文章

    doi:10.3164/jcbn.08-213

    authors: Hong JY,F Sato E,Nishikawa T,Hiramoto K,Inoue M

    更新日期:2009-03-01 00:00:00

  • Expression of intercellular adhesion molecule-1 in the livers of rats treated with diethylnitrosamine.

    abstract::It has been reported that levels of soluble intercellular adhesion molecule-1 (ICAM-1) in the blood are elevated in hepatocellular carcinoma patients. In the present study, serial observations of the localization of ICAM-1 in the liver were made by light and electron microscopy in rats with carcinogen-induced cancer. ...

    journal_title:Journal of clinical biochemistry and nutrition

    pub_type: 杂志文章

    doi:10.3164/jcbn.08-247

    authors: Matsuoka S,Matsumura H,Arakawa Y,Nakamura H,Nirei K,Yamagami H,Ogawa M,Nakajima N,Amaki S,Tanaka N,Moriyama M

    更新日期:2009-09-01 00:00:00

  • Quercetin induced NUPR1-dependent autophagic cell death by disturbing reactive oxygen species homeostasis in osteosarcoma cells.

    abstract::Osteosarcoma is a primary bone aggressive cancer, affecting adolescents worldwide. Quercetin (a natural polyphenolic compound) is a polyphenolic flavonoid compound found in a variety of plants. It has been demonstrated to exert cytostatic activity against a variety of human cancer, including the human osteosarcoma. Ho...

    journal_title:Journal of clinical biochemistry and nutrition

    pub_type: 杂志文章

    doi:10.3164/jcbn.19-121

    authors: Wu B,Zeng W,Ouyang W,Xu Q,Chen J,Wang B,Zhang X

    更新日期:2020-09-01 00:00:00

  • Influence of regular exercise on gastric emptying in healthy men: a pilot study.

    abstract::Functional gastrointestinal disorders (FGIDs), including functional dyspepsia (FD), are common chronic disorders even in the younger population. Physical activity is advocated for patients with FGIDs, although the evidence is insufficient. We investigated the association between the intensity of regular exercise and g...

    journal_title:Journal of clinical biochemistry and nutrition

    pub_type: 杂志文章

    doi:10.3164/jcbn.16-29

    authors: Matsuzaki J,Suzuki H,Masaoka T,Tanaka K,Mori H,Kanai T

    更新日期:2016-09-01 00:00:00

  • Ferulic Acid: therapeutic potential through its antioxidant property.

    abstract::There has been considerable public and scientific interest in the use of phytochemicals derived from dietary components to combat human diseases. They are naturally occurring substances found in plants. Ferulic acid (FA) is a phytochemical commonly found in fruits and vegetables such as tomatoes, sweet corn and rice b...

    journal_title:Journal of clinical biochemistry and nutrition

    pub_type: 杂志文章

    doi:10.3164/jcbn.40.92

    authors: Srinivasan M,Sudheer AR,Menon VP

    更新日期:2007-03-01 00:00:00

  • Zinc supplementation reduces Candida infections in pediatric intensive care unit: a randomized placebo-controlled clinical trial.

    abstract::Resistance to anti-fungal drugs has become the main cause for increasing incidence rate of Candida infections in pediatric intensive care units (PICU). Zinc supplementation has been shown to exhibit beneficial effects on many pediatric illnesses. This study aimed to investigate the efficacy of zinc supplementation on ...

    journal_title:Journal of clinical biochemistry and nutrition

    pub_type: 杂志文章

    doi:10.3164/jcbn.18-74

    authors: Xie J,Zhu L,Zhu T,Jian Y,Ding Y,Zhou M,Feng X

    更新日期:2019-03-01 00:00:00

  • A comparative analysis of genistein and daidzein in affecting lipid metabolism in rat liver.

    abstract::Effects of soy isoflavones, genistein and daidzein, on the hepatic gene expression profile and indices for lipid metabolism were compared in rats. In the first experiment (Expt. 1), animals were fed diets containing 2 g/kg of either genistein or daidzein, or a control diet free of isoflavone for 14 days. In the second...

    journal_title:Journal of clinical biochemistry and nutrition

    pub_type: 杂志文章

    doi:10.3164/jcbn.08-211

    authors: Takahashi Y,Odbayar TO,Ide T

    更新日期:2009-05-01 00:00:00

  • The relationship between vitamin D and estimated glomerular filtration rate and urine microalbumin/creatinine ratio in Korean adults.

    abstract::The present study was conducted to assess the association between 25-hydroxyvitamin D [25(OH)D], estimated glomerular filtration rate (eGFR) and urine microalbumin/creatinine ratio (uACR) in Korean adults. Data on 4,948 adults aged ≥20 years from the Korean National Health and Nutrition Examination Survey V-3 (2012) w...

    journal_title:Journal of clinical biochemistry and nutrition

    pub_type: 杂志文章

    doi:10.3164/jcbn.17-69

    authors: Kim SG,Kim GS,Lee JH,Moon AE,Yoon H

    更新日期:2018-01-01 00:00:00

  • l-Arginine administration attenuates airway inflammation by altering l-arginine metabolism in an NC/Nga mouse model of asthma.

    abstract::Changes in l-arginine metabolism, including increased arginase levels and decreased nitric oxide production, are involved in the pathophysiology of asthma. In this study, using an intranasal mite-induced NC/Nga mouse model of asthma, we examined whether administration of l-arginine ameliorated airway hyperresponsivene...

    journal_title:Journal of clinical biochemistry and nutrition

    pub_type: 杂志文章

    doi:10.3164/jcbn.14-140

    authors: Zhang R,Kubo M,Murakami I,Setiawan H,Takemoto K,Inoue K,Fujikura Y,Ogino K

    更新日期:2015-05-01 00:00:00

  • Sex difference: an important issue to consider in epidemiological and clinical studies dealing with serum paraoxonase-1.

    abstract::The aim of this study was to evaluate the influence of sex on serum paraoxonase-1 (PON1) activities and on its relationship with cardiovascular disease risk factors such as overall and central obesity. Arylesterase and lactonase activities of PON1 were assessed in 374 women and 92 men. Both arylesterase and lactonase ...

    journal_title:Journal of clinical biochemistry and nutrition

    pub_type: 杂志文章

    doi:10.3164/jcbn.18-73

    authors: Trentini A,Bellini T,Bonaccorsi G,Cavicchio C,Hanau S,Passaro A,Cervellati C

    更新日期:2019-05-01 00:00:00

  • Proteomic study on neurite responses to oxidative stress: search for differentially expressed proteins in isolated neurites of N1E-115 cells.

    abstract::Reactive oxygen species attack several living organs and induce cell death. Previously, we found axonal/dendrite degeneration before the induction of cell death in hydrogen peroxide-treated neuroblastoma: N1E-115 cells and primary neurons. This phenomenon may be connected with membrane oxidation, microtubule destabili...

    journal_title:Journal of clinical biochemistry and nutrition

    pub_type: 杂志文章

    doi:10.3164/jcbn.18-31

    authors: Fukui K,Okihiro S,Ohfuchi Y,Hashimoto M,Kato Y,Yoshida N,Mochizuki K,Tsumoto H,Miura Y

    更新日期:2019-01-01 00:00:00

  • Efficacy of rebamipide for low-dose aspirin-related gastrointestinal symptoms.

    abstract::Gastrointestinal symptoms are a problematic issue for patients who take low-dose aspirin for long time. We conducted a pilot study to investigate the efficacy of combination therapy with proton pump inhibitor and rebamipide. This was a prospective, randomized, double-blind, placebo-controlled cross-over study. All the...

    journal_title:Journal of clinical biochemistry and nutrition

    pub_type: 杂志文章

    doi:10.3164/jcbn.12-27

    authors: Mizukami K,Murakami K,Hirashita Y,Hisamatsu A,Ogawa R,Uchida M,Nakagawa Y,Okimoto T,Kodama M,Fujioka T

    更新日期:2012-11-01 00:00:00

  • A new paradigm for antimicrobial host defense mediated by a nitrated cyclic nucleotide.

    abstract::Nitric oxide (NO), produced by inducible NO synthase (iNOS) during infection, plays a crucial role in host defense mechanisms. Salmonella typhimurium infection in mice is associated with excessive production of NO from iNOS as a host defense response. An important cytoprotective and antimicrobial function of NO is med...

    journal_title:Journal of clinical biochemistry and nutrition

    pub_type: 杂志文章

    doi:10.3164/jcbn.SR09-70

    authors: Okamoto T,Khan S,Oyama K,Fujii S,Sawa T,Akaike T

    更新日期:2010-01-01 00:00:00

  • Hepatoprotective effects of rice-derived peptides against acetaminophen-induced damage in mice.

    abstract::Glutathione, the most abundant intracellular antioxidant, protects cells against reactive oxygen species induced oxidative stress and regulates intracellular redox status. We found that rice peptides increased intracellular glutathione levels in human hepatoblastoma HepG2 cells. Acetaminophen is a commonly used analge...

    journal_title:Journal of clinical biochemistry and nutrition

    pub_type: 杂志文章

    doi:10.3164/jcbn.16-44

    authors: Kawakami K,Moritani C,Uraji M,Fujita A,Kawakami K,Hatanaka T,Suzaki E,Tsuboi S

    更新日期:2017-03-01 00:00:00