Abstract:
:The presence of low pKa N-hydroxylamines is beneficial in peptide chemistry as they reduce some base-mediated side reactions. Here we evaluated the applicability and buffering capacity of Ethyl 2-cyano-2-(hydroxyimino) acetate (Oxyma) in the prevention of aspartimide/piperidide formation and Pro-based overcoupling and compared it with the performance of HOBt and HOAt. In addition, the compatibility of these additives with the highly acid-labile 2-chlorotrityl chloride resin is examined.
journal_name
Biopolymersjournal_title
Biopolymersauthors
Subirós-Funosas R,El-Faham A,Albericio Fdoi
10.1002/bip.21713subject
Has Abstractpub_date
2012-01-01 00:00:00pages
89-97issue
2eissn
0006-3525issn
1097-0282journal_volume
98pub_type
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