Crystal structure of cyclic (APGVGV)2, an analog of elastin, and a suggested mechanism for elongation/contraction of the molecule.

abstract：:The interaction of the immunogenic peptide of human hepatitis B virus (HBV) preS(120-145), including B and T epitopes, with phospholipid vesicles has been studied by fluorescence techniques and CD. In addition, interaction of three lipopeptides derived from preS(120-145) containing stearoyl, cholanoyl, and tripalmitoy...

journal_title：Biopolymers

authors： Cajal Y,Rabanal F,Alsina MA,Reig F

更新日期：1996-05-01 00:00:00

abstract：:We present a method for analysis of a fitness landscape of a biopolymer with significantly epistatic sites. The analysis is based on a quasi-additive fitness model. The fitness model is constructed with additive terms conducted by "site-fitness" and epistatic terms conducted by "pair-fitness," where the site-fitness i...

journal_title：Biopolymers

authors： Aita T,Hamamatsu N,Nomiya Y,Uchiyama H,Shibanaka Y,Husimi Y

更新日期：2002-07-05 00:00:00

abstract：:The linear viscoelastic and rheological properties of high molecular weight ovine submaxillary mucin (OSM) solution have been investigated in terms of the Newtonian steady-flow viscosity [eta(gamma)], the complex oscillatory viscosity [eta*(omega)], and the storage and loss shear moduli [G'(omega) and G"(omega)]. It w...

journal_title：Biopolymers

authors： Soby LM,Jamieson AM,Blackwell J,Jentoft N

更新日期：1990-08-15 00:00:00

abstract：:The thermal conformational transitions of two sonicated samples of schizophyllan were studied in water-dimethylsulfoxide (DMSO) mixtures by high-sensitivity differential scanning calorimetry (DSC). Two transitions were observed over most of the range of solvent compositions. These were assigned to an internal change o...

journal_title：Biopolymers

authors： Kitamura S,Kuge T

更新日期：1989-02-01 00:00:00

abstract：:A three-dimensional model of DNA/RNA triple helix that contains a poly(L-deoxyadenosine) (L-dA) chain is proposed based on computer-assisted model building and energy calculations. The model building was performed by a new method that systematically searches possible conformations of nucleotide units in the helical ch...

journal_title：Biopolymers

authors： Tomioka N,Itai A

更新日期：1992-12-01 00:00:00

abstract：:The present study characterizes the unfolding and folding processes of recombinant manganese peroxidase. This enzyme contains five disulfide bonds, two calcium ions, and one heme prosthetic group. Circular dichroism in the far UV was used to monitor global changes of the protein secondary structure, whereas UV-visible...

journal_title：Biopolymers

authors： Banci L,Bartalesi I,Ciofi-Baffoni S,Tien M

更新日期：2003-01-01 00:00:00

abstract：:Proteins and nucleic acids are able to adopt their native conformation and perform their biological role only in the presence of water with which they actively interact in a mutually modifying way. Traditionally, hydrophobic effect has been considered to be the major factor stabilizing biopolymeric structures. However...

journal_title：Biopolymers

authors： Chalikian TV

更新日期：2003-12-01 00:00:00

abstract：:The hinge region links the antigen binding Fab part to the constant Fc domain in immunoglobulins. For the hinge peptide derivative [AcThr(OtBu)-Cys-Pro-Pro-Cys-Pro-Ala-ProNH2]2 the assignment of the 1H and 13C resonances was achieved by two-dimensional nmr techniques: total correlation spectroscopy (TOCSY), nuclear Ov...

journal_title：Biopolymers

authors： Kessler H,Mronga S,Müller G,Moroder L,Huber R

更新日期：1991-09-01 00:00:00

abstract：:Photon correlation spectroscopy has been used to study the translational (D0) and internal dynamics of monodisperse linear and polydisperse superhelical plasmid-DNAs. Scattering vector dependent correlation functions were measured and analyzed with the inverse Laplace transform CONTIN written by S. Provencher. For sca...

journal_title：Biopolymers

authors： Seils J,Dorfmüller T

更新日期：1991-06-01 00:00:00

abstract：:Lung cancer is usually fatal once it becomes metastatic. However, in order to develop metastases, a tumor usually invades the basal membrane and enters the vascular or lymphatic system. In this study, a three-dimensional artificial membrane using collagen type I, one of the main components of basal membranes, was esta...

journal_title：Biopolymers

authors： Yang Y,Sulé-Suso J,Sockalingum GD,Kegelaer G,Manfait M,El Haj AJ

更新日期：2005-08-15 00:00:00

abstract：:A natural rubber was identified and characterized for the first time in the latex of the perennial Mediterranean shrub Euphorbia characias. Four different methods, i.e., acetone, acetic acid, trichloroacetic acid, and Triton® X-100, followed by successive treatments with cyclohexane/ethanol, were employed to extract t...

journal_title：Biopolymers

authors： Spanò D,Pintus F,Mascia C,Scorciapino MA,Casu M,Floris G,Medda R

更新日期：2012-08-01 00:00:00

abstract：:Synthetic RNA poly[r(A-T)] has been synthesized and its CD spectral properties compared to those of poly[r(A-U)], poly[d(A-T)], and poly[d(A-U)] in various salt and ethanolic solutions. The CD spectra of poly[r(A-T)] in an aqueous buffer and of poly[d(A-T)] in 70.8% v/v ethanol are very similar, suggesting that they b...

journal_title：Biopolymers

authors： Vorlícková M,Kypr J,Jovin TM,Planck M

更新日期：1990-02-05 00:00:00

abstract：:Reactive oxygen species (ROS) have generated a great deal of interest in the clinical field since experimental studies showed the involvement of these species in carcinogenesis. This paper reports the detection of ROS during the decomposition of H2O2 in the presence of samples obtained from tissues of 16 patients with...

journal_title：Biopolymers

authors： Kładny J,Lichszteld K,Kołecki J

更新日期：2004-08-05 00:00:00

abstract：:Substance P, one of the mammalian tachykinins, is known to interact strongly with lipid bilayers and this interaction may play a role in the receptor-peptide recognition process. The conformation of substance P bound to vesicles consisting of perdeuterated phosphatidylcholine has been investigated by means of two-dime...

journal_title：Biopolymers

authors： Augé S,Bersch B,Tropis M,Milon A

更新日期：2000-10-15 00:00:00

abstract：:Dehydrophenylalanine, ΔPhe, is the most commonly studied α,β-dehydroamino acid. In nature, further modifications of the α,β-dehydroamino acids were found, for example, replacement of the C-terminal amide group by oxazole ring. The conformational properties of oxazole-dehydrophenylalanine residue (ΔPhe-Ozl), both isome...

journal_title：Biopolymers

authors： Staś M,Bujak M,Broda MA,Siodłak D

更新日期：2016-05-01 00:00:00

abstract：:We have previously proposed a model for the delta-opioid receptor binding conformation of the high affinity tetrapeptide Tyr-c[D-Cys-Phe-D-Pen]OH (JOM-13) based on experimental and theoretical conformational analysis of this peptide and a correlation of conformational preferences of further conformationally restricted...

journal_title：Biopolymers

authors： Mosberg HI,Dua RK,Pogozheva ID,Lomize AL

更新日期：1996-09-01 00:00:00

abstract：:The oxidation of methionine to methionine sulfoxide both in vivo and in vitro can lead to the loss of biological activity in a variety of proteins. This loss of activity can be reversed by an enzyme called methionine sulfoxide reductase. The gene for this enzyme has been cloned and sequenced from a variety of prokaryo...

journal_title：Biopolymers

authors： Brot N,Weissbach H

更新日期：2000-01-01 00:00:00

abstract：:Recent advances in the application of solid state nmr spectroscopy to uniformly aligned biopolymers have opened a window through which to view the detailed structure of biological macromolecules that are unable to be seen with standard techniques for structure determination such as x-ray diffraction. Atomic resolution...

journal_title：Biopolymers

authors： Nicholson LK,Asakura T,Demura M,Cross TA

更新日期：1993-05-01 00:00:00

abstract：:The indirect solvent-induced effect on the free energy of binding of biopolymers is examined within the framework of classical statistical mechanics. We focus specifically on the role of the solute-solvent hydrogen bonding. In particular, we have estimated the first order solvent effect on the indirect interaction bet...

journal_title：Biopolymers

authors： Ben-Naim A,Ting KL,Jernigan RL

更新日期：1990-05-01 00:00:00

abstract：:Calculations of the normal mode spectrum of a netropsin-DNA complex, an isolated DNA helix of the same sequence, and a free netropsin molecule were carried out and compared with observations. We find that the frequency of modes of the complex that are primarily vibrations localized to the helix are relatively unchange...

journal_title：Biopolymers

authors： Chen YZ,Prohofsky EW

更新日期：1995-06-01 00:00:00

abstract：:We have previously described [K. M. Sullivan and D. M. J. Lilley (1986) Cell 47, 817-827] a set of sequences, called C-type inducing sequences, which cause cruciform extrusion by adjacent inverted repeats to occur by an abnormal kinetic pathway involving a large denatured region of DNA. In this paper we apply statisti...

journal_title：Biopolymers

authors： Schaeffer F,Yeramian E,Lilley DM

更新日期：1989-08-01 00:00:00

abstract：:Among the most exciting functional features of G-protein coupled receptors (GPCRs) that are coming into focus lately are those relating to the role and structural characteristics of their oligomerization (mostly homo- and heterodimers). The structural underpinnings of these novel functional insights are still not clea...

journal_title：Biopolymers

authors： Filizola M,Weinstein H

更新日期：2002-01-01 00:00:00

abstract：:Small-angle x-ray scattering was used for studying intermediate species, isolated after heat-induced aggregation of the A variant of bovine beta-lactoglobulin. The intermediates were separated in two fractions, the heated metastable dimer and heated metastable oligomers larger than the dimer. The pair distance distrib...

journal_title：Biopolymers

authors： Carrotta R,Arleth L,Pedersen JS,Bauer R

更新日期：2003-10-01 00:00:00

abstract：:While end capping in alpha-helices is well understood, the concept of capping a beta-hairpin is a relatively recent development; to date, favorable Coulombic interactions are the only example of sidechains at the termini influencing the overall stability of a beta-hairpin. While cross-strand hydrophobic residues gener...

journal_title：Biopolymers

authors： Eidenschink L,Crabbe E,Andersen NH

更新日期：2009-07-01 00:00:00

abstract：:Small disulfide-rich peptides are translated as larger precursors typically containing an N-terminal prepro sequence. In this study, we investigated the role of a propeptide in the oxidative folding of an extremely hydrophobic delta-conotoxin, PVIA. delta-Conotoxin PVIA (delta-PVIA) is a 29-amino acid neurotoxin stabi...

journal_title：Biopolymers

authors： Buczek P,Buczek O,Bulaj G

更新日期：2005-01-01 00:00:00

abstract：:A new triclinic crystal structure form of porcine pancreatic procarboxypeptidase B (PCPB) was obtained at higher resolution than the previously known tetragonal crystal structure. This new crystal polymorph has allowed for a corrected, accurate assignment of residues along the polypeptide chain based on the currently ...

journal_title：Biopolymers

authors： Fernández D,Boix E,Pallarès I,Avilés FX,Vendrell J

更新日期：2010-02-01 00:00:00

abstract：:Ribonuclease A is the archetype of a functionally diverse superfamily of vertebrate-specific ribonucleases. Inhibitors of its action have potential use in the elucidation of the in vivo roles of these enzymes and in the treatment of pathologies associated therewith. Derivatives of adenosine 5'-pyrophosphate are the mo...

journal_title：Biopolymers

authors： Holloway DE,Chavali GB,Leonidas DD,Baker MD,Acharya KR

更新日期：2009-12-01 00:00:00

abstract：:We developed dictionaries of two-, three-, and five-residue patterns in proteins and computed the average solvent accessibility of the central residues in their native proteins. These dictionaries serve as a look-up table for making subsequent predictions of solvent accessibility of amino acid residues. We find that p...

journal_title：Biopolymers

authors： Wang JY,Ahmad S,Gromiha MM,Sarai A

更新日期：2004-10-15 00:00:00

abstract：:For the controlled synthesis of even the simplest dipeptide, the N(alpha)-amino group of one of the amino acids and the C-terminal carboxyl group of the other should both be blocked with suitable protecting groups. Formation of the desired amide bond can now occur upon activation of the free carboxyl group. After coup...

journal_title：Biopolymers

authors： Albericio F

更新日期：2000-01-01 00:00:00

abstract：:The applicability of the FTIR attenuated total reflectance technique for in situ monitoring of plant physiological processes such as leaf senescence and aging has been examined. Difference spectra obtained by subtracting the spectrum of the young plant leaf from that of the older one revealed positive bands at 1650-15...

journal_title：Biopolymers

authors： Ivanova DG,Singh BR

更新日期：2003-01-01 00:00:00