Use of surveillance, epidemiology, and end results-medicare data to conduct case-control studies of cancer among the US elderly.

Abstract:

:Cancer is an important cause of morbidity in the elderly, and many medical conditions and treatments influence cancer risk. The Surveillance, Epidemiology, and End Results (SEER)-Medicare database can be used to conduct population-based case-control studies that elucidate the etiology of cancer among the US elderly. SEER-Medicare links data on malignancies ascertained through SEER cancer registries to claims from Medicare, the US government insurance program for people over age 65 years. Under one approach described herein, elderly cancer cases are ascertained from SEER data (1987-2005). Matched controls are selected from a 5% random sample of Medicare beneficiaries. Risk factors of interest, including medical conditions and procedures, are identified by using linked Medicare claims. Strengths of this design include the ready availability of data, representative sampling from the US elderly population, and large sample size (e.g., under one scenario: 1,176,950 cases, including 221,389 prostate cancers, 185,853 lung cancers, 138,041 breast cancers, and 124,442 colorectal cancers; and 100,000 control subjects). Limitations reflect challenges in exposure assessment related to Medicare claims: restricted range of evaluable risk factors, short time before diagnosis/selection for ascertainment, and inaccuracies in claims. With awareness of limitations, investigators have in SEER-Medicare data a valuable resource for epidemiologic research on cancer etiology.

journal_name

Am J Epidemiol

authors

Engels EA,Pfeiffer RM,Ricker W,Wheeler W,Parsons R,Warren JL

doi

10.1093/aje/kwr146

subject

Has Abstract

pub_date

2011-10-01 00:00:00

pages

860-70

issue

7

eissn

0002-9262

issn

1476-6256

pii

kwr146

journal_volume

174

pub_type

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