Treatment of acute diarrhea with Saccharomyces boulardii in infants.

Abstract:

OBJECTIVE:The aim of the study was to determine whether an oral treatment with a commercial pharmaceutical product containing Saccharomyces boulardii would reduce the duration of diarrhea in infants with acute diarrhea. PATIENTS AND METHODS:In the present double-blind, placebo-controlled study, 186 infants, 6 to 48 months old and hospitalized within 72 hours after the onset of acute diarrhea in 2 hospitals in Goiânia, Goiás, Brazil, were randomly assigned to receive twice per day for 5 days 200 mg of a commercial pharmaceutical product containing 4 × 10 viable cells of S boulardii or a placebo. Stool samples were submitted to search for rotavirus. Among the 176 infants who completed the trial, those treated with S boulardii (90) showed a reduction in diarrhea duration (P < 0.05) when compared with the placebo group (86). RESULTS:The present study shows a reduction in diarrhea duration when S boulardii was given to children within 72 hours after the onset of acute diarrhea. CONCLUSIONS:The present study suggests a complementary treatment of acute diarrhea in infants with daily oral doses of S boulardii.

authors

Corrêa NB,Penna FJ,Lima FM,Nicoli JR,Filho LA

doi

10.1097/MPG.0b013e31822b7ab0

subject

Has Abstract

pub_date

2011-11-01 00:00:00

pages

497-501

issue

5

eissn

0277-2116

issn

1536-4801

journal_volume

53

pub_type

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