Abstract：
BACKGROUND:Few studies have prospectively examined the relationships of sleep with symptoms and functioning in bipolar disorder. METHODS:The present study examined concurrent and prospective associations between total sleep time (TST) and sleep variability (SV) with symptom severity and functioning in a cohort of DSM-IV bipolar patients (N = 468) participating in the National Institute of Mental Health Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD), all of whom were recovered at study entry. RESULTS:Concurrent associations at study entry indicated that shorter TST was associated with increased mania severity, and greater SV was associated with increased mania and depression severity. Mixed-effects regression modeling was used to examine prospective associations in the 196 patients for whom follow-up data were available. Consistent with findings at study entry, shorter TST was associated with increased mania severity, and greater SV was associated with increased mania and depression severity over 12 months. DISCUSSION:These findings highlight the importance of disrupted sleep patterns in the course of bipolar illness.
journal_name
J Affect Disordjournal_title
Journal of affective disordersauthors
Gruber J,Miklowitz DJ,Harvey AG,Frank E,Kupfer D,Thase ME,Sachs GS,Ketter TAdoi
10.1016/j.jad.2011.05.016subject
Has Abstractpub_date
2011-11-01 00:00:00pages
416-20issue
1-3eissn
0165-0327issn
1573-2517pii
S0165-0327(11)00262-Xjournal_volume
134pub_type
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