Burden of dysthymia and comorbid illness in adults in a Canadian primary care setting: high rates of psychiatric illness in the offspring.


BACKGROUND:The burden of comorbid dysthymia and other comorbid psychiatric illnesses in a Canadian primary care setting was measured. Two groups of primary care patients: those who scored positive for comorbid dysthymia versus those who scored negative for any psychiatric disorder were compared. METHODS:This was a cross-sectional survey in a Health Service Organization (HSO) in Ontario, Canada. The subjects were patients of the HSO. The main outcome measures were: health status, mood, social adjustment, coping ability, children's psychiatric disorders, child development, family function, and health and social service utilization. RESULTS:Of the 6280 eligible adults who were patients at the HSO, 68.9% consented to be screened for psychiatric disorders; 5.1% screened positive for dysthymia, of which 90% had at least one comorbid psychiatric disorder. The following statistically significant differences were found between people with dysthymia and other comorbid psychiatric disorders versus people without any psychiatric disorder. People with dysthymia were more likely to have worse health status, worry more about their health, and report levels of pain that impaired their function; they had higher MADRS depression scores, lower social role function scores, lower social adjustment scores, and lower coping ability. More children of people with comorbid dysthymia met criteria for one or more childhood psychiatric disorders and there were more families with a parent with dysthymia that were dysfunctional. People with dysthymia used a greater proportion of health and social services, had higher per person annual health care costs (excluding hospital services), and had higher per person annual indirect costs (lost wages). CONCLUSION:This analysis demonstrated the burden of illness and costs that this disorder imposes on individuals, their families, and society as a whole.


J Affect Disord


Bell B,Chalklin L,Mills M,Browne G,Steiner M,Roberts J,Gafni A,Byrne C,Wallik D,Kraemer J,Webb M,Jamieson E,Whittaker S,Dunn E




Has Abstract


2004-01-01 00:00:00














  • User, carer and staff perspectives on anxiety in dementia: a qualitative study.

    abstract:BACKGROUND:Anxiety is extremely common in dementia and can lead to social exclusion, excess disability and associated problems including high physical dependency, problems in the patient/carer relationship, and increased cognitive and behavioural difficulties. Despite this, there is little research on the detection or ...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Qazi A,Spector A,Orrell M

    更新日期:2010-09-01 00:00:00

  • Suicidality among patients with asthma: A systematic review and meta-analysis.

    abstract:BACKGROUND:Asthma is associated with multiple psychiatric comorbidities. However, the relationship between asthma and suicidality has not be well established. METHODS:According to the PRISMA guidelines, protocol of the study was registered in the PROSPERO database (CRD42019123150). A systematic search of the PubMed, E...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,meta分析


    authors: Zhang Y,Cheng J,Li Y,He R,Choudhry AA,Jiang J,Pan P,Su X,Hu C

    更新日期:2019-09-01 00:00:00

  • Comparison of objective and subjective assessments of sleep time in subjects with bipolar disorder.

    abstract:INTRODUCTION:Sleep disturbance is a core feature of bipolar disorder. To date there are a limited number of studies that compare subjective and objective measures of sleep in populations of subjects with mood disorders. This study evaluated the relationship between subjective and objective measurements of total sleep t...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Gonzalez R,Tamminga C,Tohen M,Suppes T

    更新日期:2013-07-01 00:00:00

  • Lithium treatment at 52.

    abstract::The paper reviews briefly and comments in detail on selected events in the history of lithium treatment. The events include Cade's discovery of lithium's antimanic action, the discovery and establishment of its prophylactic action, the ensuing debate, amelioration and prevention of side effects and risks, use during p...

    journal_title:Journal of affective disorders

    pub_type: 历史文章,杂志文章,评审


    authors: Schou M

    更新日期:2001-12-01 00:00:00

  • A systematic review of prevention programs targeting depression, anxiety, and stress in university students.

    abstract:BACKGROUND:Given the prevalence of anxiety, depression, and stress among university students, it is important to assess the effectiveness of prevention programs for these problems. Beyond examining effect sizes, applying a common elements approach can enhance our understanding of which practice elements are most freque...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Rith-Najarian LR,Boustani MM,Chorpita BF

    更新日期:2019-10-01 00:00:00

  • Relationship of depression, chronic disease, self-rated health, and gender with health care utilization among community-living elderly.

    abstract:BACKGROUND:We investigated the interactive effects of depressive symptoms and chronic diseases on health care utilization among elderly people and explored the potential moderating effect of gender and the mediating effect of self-rated health (SRH) on the association between depressive symptoms and health care utiliza...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Han KM,Ko YH,Yoon HK,Han C,Ham BJ,Kim YK

    更新日期:2018-12-01 00:00:00

  • Meta-analytic review of the effects of a single dose of intranasal oxytocin on threat processing in humans.

    abstract:BACKGROUND:Heightened threat sensitivity is a transdiagnostic feature in several psychiatric disorders. The neuropeptide oxytocin has been shown to reduce fear related behaviours and facilitated fear extinction in animals. These findings have led to increasing interest to explore the effects of intranasal oxytocin on t...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,meta分析,评审


    authors: Leppanen J,Ng KW,Kim YR,Tchanturia K,Treasure J

    更新日期:2018-01-01 00:00:00

  • Inflammatory cytokines influence measures of white matter integrity in Bipolar Disorder.

    abstract:BACKGROUND:Bipolar Disorder (BD) is associated with elevated biomarkers of cell-mediated immune activation and inflammation and with signs of widespread disruption of white matter (WM) integrity in adult life. Consistent findings in animal models link WM damage in inflammatory diseases of the brain and serum levels of ...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Benedetti F,Poletti S,Hoogenboezem TA,Mazza E,Ambrée O,de Wit H,Wijkhuijs AJ,Locatelli C,Bollettini I,Colombo C,Arolt V,Drexhage HA

    更新日期:2016-09-15 00:00:00

  • Internet-delivered treatment for young adults with anxiety and depression: Evaluation in routine clinical care and comparison with research trial outcomes.

    abstract:INTRODUCTION:Mood and anxiety disorders typically emerge in adolescence and early adult life, but young adults are often reluctant to seek treatment. The Mood Mechanic course is a transdiagnostic internet-delivered psychological intervention for symptoms of depression and anxiety, targeted at people aged 18-24 years. T...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Staples LG,Dear BF,Johnson B,Fogliati V,Gandy M,Fogliati R,Nielssen O,Titov N

    更新日期:2019-09-01 00:00:00

  • Forecasting state-level premature deaths from alcohol, drugs, and suicides using Google Trends data.

    abstract:BACKGROUND:Vital statistics on the number of, alcohol-induced death (AICD) drug-induced death (DICD), and suicides at the local-level are only available after a substantial lag of up to two years after the events occur. We (1) investigate how well Google Trends search data explain variation in state-level rates in the ...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Parker J,Cuthbertson C,Loveridge S,Skidmore M,Dyar W

    更新日期:2017-04-15 00:00:00

  • New pathways of increased cardiovascular risk in depression: a pilot study on the association of high-sensitivity C-reactive protein with pro-atherosclerotic markers in patients with depression.

    abstract:BACKGROUND:An elevation of inflammatory markers such as high-sensitivity C-reactive protein (hs-CRP) can be found in patients with depressive disorders. Inflammatory processes are known to influence atherosclerosis and might also mediate the link between depression and diabetes. The present study aimed at comparing hs-...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Zahn D,Petrak F,Uhl I,Juckel G,Neubauer H,Hägele AK,Wiltfang J,Herpertz S

    更新日期:2013-04-25 00:00:00

  • The association of HTR2A polymorphisms with obsessive-compulsive disorder and its subtypes: A meta-analysis.

    abstract:BACKGROUND:Genetic risk factors that contribute to obsessive-compulsive disorder (OCD) have yet to be elucidated. Historically, serotonergic dysfunction has been implicated. Evidence from the literature points towards the serotonin receptor 2A gene (HTR2A) as a primary candidate. Our meta-analysis investigated whether ...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,评审


    authors: Mattina GF,Samaan Z,Hall GB,Steiner M

    更新日期:2020-10-01 00:00:00

  • Duration and stability of the rapid-cycling course: a long-term personal follow-up of 109 patients.

    abstract:BACKGROUND:Recognition by the DSM-IV of rapid cyclicity as a course specifier has raised the question of the stability and long-term outcome of rapid-cycling (RC) patients. Data on this topic is sparse and often inconsistent. To our knowledge, these are the first personally followed patients over the long term, dealing...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Koukopoulos A,Sani G,Koukopoulos AE,Minnai GP,Girardi P,Pani L,Albert MJ,Reginaldi D

    更新日期:2003-01-01 00:00:00

  • Biopsychosocial factors related to depression in aged care residents.

    abstract:BACKGROUND:While depression is common in residential aged care settings, there is an absence of research into factors that may be associated with this condition. This pilot study examined the relationship between depression and multiple biopsychosocial factors among residents of aged care facilities. METHODS:Participa...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Davison TE,McCabe MP,Knight T,Mellor D

    更新日期:2012-12-15 00:00:00

  • Eighteen months of drug treatment for depression: predicting relapse and recovery.

    abstract:BACKGROUND:The clinically relevant outcomes in treating depression are persistent recovery, relapse, and treatment resistance. METHOD:175 outpatients treated with antidepressants for 6 months were assessed for major depression. Those who had recovered were prospectively monitored for one year to study rates of relapse...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,随机对照试验


    authors: Mulder RT,Frampton CM,Luty SE,Joyce PR

    更新日期:2009-04-01 00:00:00

  • Efficacy and tolerability of antidepressants for sub-threshold depression and for mild major depressive disorder.

    abstract:BACKGROUND:It is commonly assumed that robust evidence exists for the lack of efficacy of antidepressants at the milder end of the depression severity spectrum. In light of specific limitations of existing reviews, we assess if antidepressants are efficacious and tolerable for sub-threshold or mild major depressive dis...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,评审


    authors: Cameron IM,Reid IC,MacGillivray SA

    更新日期:2014-09-01 00:00:00

  • Prevalence and correlates of DSM-5 eating disorders in patients with bipolar disorder.

    abstract:OBJECTIVE:To determine prevalence rates and clinical correlates of current DSM-5 eating disorders in patients with bipolar disorder (BP). METHODS:Prevalence rates of current DSM-5- and DSM-IV-defined binge eating disorder (BED), bulimia nervosa (BN), and anorexia nervosa (AN) were assessed with the Eating Disorder Dia...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: McElroy SL,Crow S,Blom TJ,Biernacka JM,Winham SJ,Geske J,Cuellar-Barboza AB,Bobo WV,Prieto ML,Veldic M,Mori N,Seymour LR,Bond DJ,Frye MA

    更新日期:2016-02-01 00:00:00

  • Clonazepam augmentation of antidepressants: does it distinguish unipolar from bipolar depression?

    abstract:BACKGROUND:The authors compared the effect of clonazepam supplement treatment on unipolar depression and bipolar depression. METHODS:A total of 38 protracted depression patients with unipolar depression (n = 19) or bipolar depression (n = 19) were treated with 3.0 mg clonazepam for 4 weeks. RESULTS:In the unipolar de...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Morishita S,Aoki S

    更新日期:2002-09-01 00:00:00

  • Suicide and history of childhood trauma among street youth.

    abstract:BACKGROUND:Street youth represent a marginalized population marked by early mortality and elevated risk for suicide. It is not known to what extent childhood abuse and neglect predispose to suicide in this difficult-to-study population. This study is among the first to examine the relationship between childhood trauma ...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Hadland SE,Marshall BD,Kerr T,Qi J,Montaner JS,Wood E

    更新日期:2012-02-01 00:00:00

  • Secular trends in psychiatric diagnoses of suicide victims.

    abstract::Post-mortem psychiatric diagnoses are compared in two cohorts of male suicides from St. Louis (1956-1957) (Robins, 1981) and San Diego (1981-1982) (Rich et al., 1986). Similar structured interviews and diagnostic criteria had been used in both assessments. Substance/alcohol abuse has remained the major diagnosis in su...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Carlson GA,Rich CL,Grayson P,Fowler RC

    更新日期:1991-02-01 00:00:00

  • The relationship between temperament and sexual orientation.

    abstract:BACKGROUND:The relationship between temperament and sexual orientation has been poorly characterized. We have used the Affective and Emotional Composite Temperament (AFECT) model to evaluate this association in a large population sample. METHODS:Data from 16,571 subjects between 21 and 45 years old (mean age=29.1±6.3 ...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Guerim LD,de Carvalho HW,Lara DR

    更新日期:2015-04-01 00:00:00

  • The effectiveness of four empirically supported psychotherapies for primary care depression and anxiety: A systematic review and meta-analysis.

    abstract:BACKGROUND:Depressive and anxiety disorders are highly prevalent and detrimental in primary care settings. However, there are gaps in the literature concerning effectiveness and generalizability of empirically supported interventions and treatment of both depression and anxiety in primary care settings. The aim of this...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,meta分析


    authors: Zhang A,Franklin C,Jing S,Bornheimer LA,Hai AH,Himle JA,Kong D,Ji Q

    更新日期:2019-02-15 00:00:00

  • Anterior cingulate cortex, insula and amygdala seed-based whole brain resting-state functional connectivity differentiates bipolar from unipolar depression.

    abstract:OBJECTIVE:The frontal-limbic circuit is hypothesized as sub-serving emotional regulation. We performed whole brain resting-state functional connectivity (rs-FC) analysis by studying the key hubs of frontal-limbic circuit: anterior cingulate cortex (ACC), bilateral insula subregions, bilateral amygdala (Amy) as seeds, s...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Yu H,Li ML,Li YF,Li XJ,Meng Y,Liang S,Li Z,Guo W,Wang Q,Deng W,Ma X,Coid J,Li DT

    更新日期:2020-09-01 00:00:00

  • Generic effectiveness measures: sensitivity to symptom change in anxiety disorders.

    abstract:OBJECTIVE:The purpose of this study was to compare a newly developed screening measure of disability, the WHODAS II, to three established generic effectiveness measures in terms of its sensitivity to symptom change in people with anxiety disorders. METHOD:Patients who had undergone treatment for social phobia or panic...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Perini SJ,Slade T,Andrews G

    更新日期:2006-02-01 00:00:00

  • The anaesthetic-ECT time interval with thiopentone-Impact on seizure quality.

    abstract:BACKGROUND:The time between anaesthetic induction and ECT stimulus administration has been hypothesised to significantly impact ictal EEG quality. In this study, our aim was to examine the effect of the time interval between anaesthetic induction and the ECT stimulus for ictal seizure quality in ECT sessions utilising ...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Taylor R,Hadzi-Pavlovic D,Nikolin S,Bull M,Wark H,Leyden J,Harper S,Martin D,Galvez V,Loo C

    更新日期:2019-06-01 00:00:00

  • Age-dependent symptomatology of depression in hospitalized patients and its implications for DSM-5.

    abstract:BACKGROUND:We investigated effects of current age and age at onset on symptomatology of depression with reference to proposed revisions in DSM-5. METHODS:The study entailed medical records of 326 inpatients diagnosed with major depressive disorder, including 520 depressive episodes, with 113 first episodes lifetime. S...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Wilkowska-Chmielewska J,Szelenberger W,Wojnar M

    更新日期:2013-08-15 00:00:00

  • Graph-theoretical analysis of resting-state fMRI in pediatric obsessive-compulsive disorder.

    abstract:BACKGROUND:fMRI graph theory reveals resting-state brain networks, but has never been used in pediatric OCD. METHODS:Whole-brain resting-state fMRI was acquired at 3T from 21 children with OCD and 20 age-matched healthy controls. BOLD connectivity was analyzed yielding global and local graph-theory metrics across 100 ...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Armstrong CC,Moody TD,Feusner JD,McCracken JT,Chang S,Levitt JG,Piacentini JC,O'Neill J

    更新日期:2016-03-15 00:00:00

  • Validation of the subscales of the Edinburgh Postnatal Depression Scale in a sample of women with unsettled infants.

    abstract:BACKGROUND:The Edinburgh Postnatal Depression Scale (EPDS) was developed as a uni-dimensional measure of depression, however there is evidence that it also measures anxiety. This study examined the factor structure of the EPDS and validity of the identified subscales. METHOD:309 women with infants aged up to 12 months...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Phillips J,Charles M,Sharpe L,Matthey S

    更新日期:2009-11-01 00:00:00

  • High fatality rates of late-life depression associated with cardiovascular disease.

    abstract::Sixty-two elderly depressives were located one year after discharge. Eight patients (13%) had died, 2.6 times higher than the expected mortality rate. Patients dying were more likely to have had a diagnosis of cardiovascular disease (P less than 0.001). ...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Rabins PV,Harvis K,Koven S

    更新日期:1985-09-01 00:00:00

  • Trajectories of maternal distress and risk of child developmental delays: Findings from the All Our Families (AOF) pregnancy cohort.

    abstract:BACKGROUND:Existing literature on the impact of the course of maternal distress symptoms in the perinatal period and beyond has mainly focused on one source of distress (e.g., anxiety or depression) and only selected aspects of child development. This study examined the relative impact of trajectories of maternal depre...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Mughal MK,Giallo R,Arnold PD,Kehler H,Bright K,Benzies K,Wajid A,Kingston D

    更新日期:2019-04-01 00:00:00