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Evaluation of the URIT-2900 automated hematology analyzer for screening of thalassemia and hemoglobinopathies in Southeast Asian populations.

Abstract：

BACKGROUND:The effectiveness of the URIT-2900 Hematology Analyzer for screening of hemoglobinopathies commonly found in Southeast Asian populations was examined. METHODS:Appropriate cut-off values of MCV and MCH for screening of α(0) and β thalassemias were derived from the receiver operator characteristic curve conducted initially on 279 subjects with various thalassemia genotypes. Validation was performed additionally in a cohort of another unrelated 313 subjects. RESULTS:The best cut off values of MCV and MCH were found to be 78fL and 27pg, respectively. Using these cut off values in combination with the dichlorophenolindophenol test in screening of α(0) thalassemia, β thalassemia and Hb E in a cohort study revealed 100% sensitivity, 79.6% specificity, 80.0% positive predictive value and 100% negative predictive value. CONCLUSION:The combined blood cell counting using the URIT-2900 Automated Hematology Analyzer and dichlorophenolindophenol test is suitable for population screening of thalassemia and hemoglobinopathies in Southeast Asia.

journal_name

Clin Biochem

journal_title

Clinical biochemistry

authors

Karnpean R,Pansuwan A,Fucharoen G,Fucharoen S

doi

10.1016/j.clinbiochem.2011.04.009

subject

Has Abstract

pub_date

2011-07-01 00:00:00

pages

889-93

issue

10-11

eissn

0009-9120

issn

1873-2933

pii

S0009-9120(11)00314-6

journal_volume

44

pub_type

杂志文章

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