Morphine increases plasma immunoreactive atrial natriuretic peptide levels in humans.

abstract：:The spectral interference caused by haemoglobin in the calcium-cresolphthalein complexone reaction was investigated. The results show that the nature of the haemoglobin derivative in the reaction mixture influences the degree of interference; in turn, the derivative formed depends on the order in which the sample and ...

journal_title：Annals of clinical biochemistry

authors： Corns CM

更新日期：1990-03-01 00:00:00

abstract：:A radioimmoassay for digoxin is described which uses commercially available reagents. Two assay procedures are used, one for batch assays, and another, which needs a 5 minute incubation only, for 'stat' assays. The methods are shown to be simple, rapid, precise and inexpensive and the batch procedure compared well wit...

journal_title：Annals of clinical biochemistry

authors： Moore RA,Turner M,Cousins J,Gales M

更新日期：1985-03-01 00:00:00

abstract：BACKGROUND:Analysis of copper and zinc in serum is commonly performed using atomic absorption spectrometry (AAS); however, these methods are often not readily available in smaller laboratories. Randox colorimetric assays for copper and zinc in serum were evaluated on the Thermo Electron Data Pro analyser against flame ...

journal_title：Annals of clinical biochemistry

authors： Beckett JM,Hartley TF,Ball MJ

更新日期：2009-07-01 00:00:00

abstract：:Serum osteocalcin did not show any response to the onset of osteosarcoma in Paget's disease of bone whereas serum alkaline phosphatase increased rapidly. This suggests that osteocalcin is not useful in the diagnosis and management of Paget's osteosarcoma and does not reflect the same osteoblastic processes in bone as ...

journal_title：Annals of clinical biochemistry

authors： Davie MW,Worsfold M,Sharp CA

更新日期：1991-03-01 00:00:00

abstract：:Direct assays have been described for the estimation of progesterone in serum and saliva. Both methods showed good inter-assay precision over a year, and the serum assay is now being used routinely in clinical laboratories. A highly significant correlation was obtained for progesterone concentrations in matched serum ...

journal_title：Annals of clinical biochemistry

authors： Webley GE,Edwards R

更新日期：1985-11-01 00:00:00

abstract：:Plasma creatine kinase (CK) activity and lean body mass (LBM) (by anthropometry) were measured in 120 women (20-82 years) and 70 men (20-82 years). Plasma CK activity and LBM was higher in men than in women. In men plasma CK activity was significantly correlated (product moment correlation coefficient) with LBM and ne...

journal_title：Annals of clinical biochemistry

authors： Swaminathan R,Ho CS,Donnan SP

更新日期：1988-07-01 00:00:00

abstract：:A patient with sepsis and jaundice was admitted for diagnosis and treatment. Associated biochemical changes included increased C-reactive protein, conjugated bilirubin and gamma-glutamyltransferase, the duration of which was protracted. High urine coproporphyrin isomer-1 and immunostaining of liver tissue suggested Du...

journal_title：Annals of clinical biochemistry

authors： Devgun MS,El-Nujumi AM,O'Dowd GJ,Barbu V,Poupon R

更新日期：2012-11-01 00:00:00

abstract：:We have made an evaluation of glycosylated haemoglobin measurements by affinity chromatography in a paediatric population. Age-related reference values for non-diabetic infants and children are reported. A poor correlation (r = 0.24) was found between glycosylated haemoglobin values in 26 insulin-dependent diabetic ch...

journal_title：Annals of clinical biochemistry

authors： van Heyningen C,Hanid TK,Hopkinson I

更新日期：1986-07-01 00:00:00

abstract：BACKGROUND:In humans, leptin circulates in a free form and is also bound to macromolecules. The aim of the present study was to compare a rapid acid-ethanol precipitation (AEP) method of measuring bound leptin with the more laborious gel exclusion chromatography (GEC) reference procedure. Serum samples collected from h...

journal_title：Annals of clinical biochemistry

authors： Jamieson NB,McMillan DC,Brown DJ,Wallace AM

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND:Neuroendocrine tumours are slow growing tumours known to secrete a variety of vasoactive peptides which give rise to symptoms of the carcinoid syndrome. The diagnosis and monitoring of patients with neuroendocrine tumours is undertaken in many centres using 24 h urinary measurement of 5-hydroxyindoleacetic a...

journal_title：Annals of clinical biochemistry

authors： Adaway JE,Dobson R,Walsh J,Cuthbertson DJ,Monaghan PJ,Trainer PJ,Valle JW,Keevil BG

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:Ascorbic acid can interfere with methodologies involving redox reactions, while comprehensive studies on main chemistry analysers have not been reported. We therefore attempted to determine the interference of ascorbic acid with analytes on the Beckman Synchron LX20. METHODS:Various concentrations of ascorb...

journal_title：Annals of clinical biochemistry

authors： Meng QH,Irwin WC,Fesser J,Massey KL

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:Emergency abdominal surgery carries considerable postoperative morbidity and mortality. Hypovolaemia is considered to be a cause of renal hypoperfusion, which is associated with a decreased clearance of serum urea and creatinine. This study examines whether the perioperative serum urea and creatinine concent...

journal_title：Annals of clinical biochemistry

authors： Harten J,Hay A,McMillan DC,McArdle CS,O'Reilly DS,Kinsella J

更新日期：2006-07-01 00:00:00

abstract：:The influence of the glucose concentration in urines being assayed as part of a pancreolauryl test was investigated. Paired patient urines (n = 5) were assayed at 60 degrees and 70 degrees C, before and after spiking to 5% glucose. The influence of assay temperature alone was assessed using glucose-free paired patient...

journal_title：Annals of clinical biochemistry

authors： Trewick AL

更新日期：1998-03-01 00:00:00

abstract：:The total cost of a haematology and clinical chemistry laboratory, including external and hospital costs, was studied in a district general hospital in The Netherlands. The main conclusion is that the number of samples analysed is the most important cost-setting factor, but that reduction in the number of requests doe...

journal_title：Annals of clinical biochemistry

authors： Leijten JF,van der Geer F,Scholten MN,Goldschmidt HM

更新日期：1984-03-01 00:00:00

abstract：:Many techniques for the estimation of specific proteins measure light scattered by, or the turbidity of, suspensions of antigen:antibody aggregates formed in fluid-phase reactions. Although the shapes of reaction curves obtained are well documented, interpretation of the data in relation to the laws of light scatterin...

journal_title：Annals of clinical biochemistry

authors： Deverill I,Lock RJ

更新日期：1983-07-01 00:00:00

abstract：:A p-iodophenol-enhanced luminescent end-point has been incorporated into a commercially available heterogeneous competitive enzyme immunoassay for digoxin based on a horseradish peroxidase-digoxin conjugate. The luminescent end-point could be completed in less than 1 min and significantly reduced overall assay time. R...

journal_title：Annals of clinical biochemistry

authors： Coyle PM,Thorpe GH,Kricka LJ,Whitehead TP

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:Serum ornithine carbamoyltransferase is a diagnostic marker of hepatic disorders due to its localization in periportal mitochondria. METHODS:We have developed a new method for the determination of serum ornithine carbamoyltransferase. It is based on the reverse reaction of ornithine carbamoyltransferase, us...

journal_title：Annals of clinical biochemistry

authors： Ishikawa H,Matsuzawa T,Ohashi K,Nagamura Y

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:Extraction followed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis is the method of choice when it comes to the accurate quantification of 25-OH-vitamin D in blood samples. It is generally assumed that the addition of exogenous internal standard allows for the determination of the endo...

journal_title：Annals of clinical biochemistry

authors： Lankes U,Elder PA,Lewis JG,George P

更新日期：2015-01-01 00:00:00

abstract：:We describe a new electrochemical method for the determination of erythrocyte acetylcholinesterase activity (EC 3.1.1.7) and plasma cholinesterase (EC 3.1.1.8) activity, based on the measurements of pH variation due to release of acetic acid from acetylcholine. The major advantages of the differential pH procedure are...

journal_title：Annals of clinical biochemistry

authors： Barenghi L,Ceriotti F,Luzzana M,Ripamonti M,Mosca A,Bonini PA

更新日期：1986-09-01 00:00:00

abstract：:Improvement in the control of diabetic patients is aided by a knowledge of blood glucose levels during a 'normal' (non-hospitalised) day. We have devised a 5 microliter capillary tube collection system as a 'kit' for home use by diabetics. Blood collected into 5 microliter capillary tubes is washed into a protein prec...

journal_title：Annals of clinical biochemistry

authors： Williams CP,Davies GK,Child DF

更新日期：1981-09-01 00:00:00

abstract：:591 patients with a history of coronary heart disease had one or more biochemical markers of tobacco smoking measured. 26% were self reported smokers and a further 4% were apparent 'smoking deceivers'. The urinary nicotine metabolite concentration is an excellent marker for tobacco smoking; breath CO would be a suitab...

journal_title：Annals of clinical biochemistry

authors： Archbold GP,Cupples ME,McKnight A,Linton T

更新日期：1995-03-01 00:00:00

abstract：:The standard colorimetric methods most often used for the measurement of serum unsaturated iron binding capacity (UIBC) are subject to gross interference by iron dextran. This paper describes a brief evaluation of an alternative radiometric assay for serum UIBC, based on a commercially available kit method, but incorp...

journal_title：Annals of clinical biochemistry

authors： Kind CN

更新日期：1988-05-01 00:00:00

abstract：:The application of a DC plasma emission spectrometer to the measurement of copper, zinc and magnesium in serum and urine is reported. Each assay requires only a simple dilution in 1% nitric acid. Comparisons with standard atomic absorption techniques showed good analytical agreement, especially for copper and magnesiu...

journal_title：Annals of clinical biochemistry

authors： Roberts NB,Fairclough D,McLoughlin S,Taylor WH

更新日期：1985-09-01 00:00:00

abstract：:Wernicke's encephalopathy is caused by thiamine deficiency and has a range of presenting features, including gait disturbance, altered cognitive state, nystagmus and other eye movement disorders. In the past, Wernicke's encephalopathy was described almost exclusively in the alcohol-dependent population. However, in cu...

journal_title：Annals of clinical biochemistry

authors： Kohnke S,Meek CL

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND AND METHODS:We report a case of insulinoma in which the diagnosis was very challenging as some of the biochemical data were consistently equivocal. In order to assess the relative reliability of the analytical tests, retrospective biochemical data on 45 other cases of histologically confirmed insulinoma were...

journal_title：Annals of clinical biochemistry

authors： Chammas NK,Teale JD,Quin JD

更新日期：2003-11-01 00:00:00

abstract：:Serum retinol-binding protein (RBP), with a biological half-life of less than 12 h, is a useful indicator of liver or kidney dysfunction. An automated immunoturbidimetric assay for the measurement of RBP has been developed using the Cobas-BIO centrifugal analyser and commercially available materials. Serum samples wit...

journal_title：Annals of clinical biochemistry

authors： Bankson DD,Rifai N,Silverman LM

更新日期：1988-05-01 00:00:00

abstract：BACKGROUND:Adding or incorporating clinical interpretative comments on biochemistry results is widespread in UK laboratories; although this consumes considerable human resource, there is still little evidence to suggest that it is either effective or appreciated by our clinical colleagues. I therefore decided to survey...

journal_title：Annals of clinical biochemistry

authors： Barlow IM

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:The high-dose hook effect is a well-known phenomenon of two-site immunoassays including those for human chorionic gonadotrophin (hCG). We investigated the occurrence of a high-dose hook effect in six routinely available hCG assays using a sample with a total hCG concentration of approximately 3,600,000 IU/L....

journal_title：Annals of clinical biochemistry

authors： Al-Mahdili HA,Jones GR

更新日期：2010-07-01 00:00:00

abstract：:Most UK clinical laboratories use alkaline phosphatase (ALP) methods similar to that proposed by the International Federation of Clinical Chemistry (IFCC), based on the use of 2-amino-2-methyl-1-propanol (AMP) buffer. We present evidence of significant differences in results produced by apparently similar commercial A...

journal_title：Annals of clinical biochemistry

authors： Lamb EJ,Browne M,John WG,Price CP

更新日期：1998-01-01 00:00:00

abstract：:The hypoglycaemia caused by non-islet cell tumours is often associated with an increase in plasma insulin-like activity. In many cases there is a relative if not always absolute increase in plasma insulin-like growth factor II (IGF-II). Growth hormone (GH) secretion is almost invariably depressed as is the plasma insu...

journal_title：Annals of clinical biochemistry

authors： Teale JD,Blum WF,Marks V

更新日期：1992-05-01 00:00:00