Alleviation of non-islet cell tumour hypoglycaemia by growth hormone therapy is associated with changes in IGF binding protein-3.

abstract：:The immunosuppressive agent mycophenolate mofetil is a prodrug for the active compound mycophenolic acid. Following organ transplantation, it is used mostly in combination with other immunosuppressive drugs, but it has also been used as primary therapy. Although in the pivotal clinical studies the drug was given in fi...

journal_title：Annals of clinical biochemistry

authors： Holt DW

更新日期：2002-05-01 00:00:00

abstract：:We developed a new simple assay for potassium ion in serum using urea amidolyase (UAL) from yeast sp. The method is based on activation of the enzyme by potassium ion. We eliminated endogenous ammonium ion by use of glutamate dehydrogenase (GLDH), and then monitored the production of ammonium ion by UAL, urea, ATP, bi...

journal_title：Annals of clinical biochemistry

authors： Kimura S,Iyama S,Yamaguchi Y,Hayashi S,Fushimi R,Amino N

更新日期：1997-07-01 00:00:00

abstract：:The spectral interference caused by haemoglobin in the calcium-cresolphthalein complexone reaction was investigated. The results show that the nature of the haemoglobin derivative in the reaction mixture influences the degree of interference; in turn, the derivative formed depends on the order in which the sample and ...

journal_title：Annals of clinical biochemistry

authors： Corns CM

更新日期：1990-03-01 00:00:00

abstract：:We studied the serum protein binding of 3H-labelled progesterone, oestradiol and testosterone, and five 125I-labelled analogues of these steroids. All tracers investigated appeared to be bound by proteins in every serum sample tested. The addition of blocking agents caused a substantial reduction in serum protein bind...

journal_title：Annals of clinical biochemistry

authors： Micallef JV,Hayes MM,Latif A,Ahsan R,Sufi SB

更新日期：1995-11-01 00:00:00

abstract：:Background Measured (MO) and calculated osmotic concentrations (CO) and the osmotic gap (OG) are commonly used in the investigation of electrolyte and volume disturbances as well as in cases of suspected volatile ingestion. Methods We compared 38 published formulae for CO with MO on a large data-set ( n = 9466) and ad...

journal_title：Annals of clinical biochemistry

authors： Wilgen U,Pretorius CJ,Ungerer JP

更新日期：2018-01-01 00:00:00

abstract：:Mass spectrometry has for many years enabled us to rapidly identify and quantify many different compounds in biological samples. The equipment is currently available in specialist centres investigating metabolic disorders and in toxicology laboratories. Improvements in sample introduction and refinements in the mass s...

journal_title：Annals of clinical biochemistry

authors： Honour JW

更新日期：2003-11-01 00:00:00

abstract：BACKGROUND:The relationship between plasma angiopoietin-like protein 3 (ANGPTL3), and lipoprotein lipase (LPL) activity and hepatic triglyceride lipase (HTGL) activity has not been investigated in the metabolism of remnant lipoproteins (RLPs) and high-density lipoprotein (HDL) in human plasma. METHODS:ANGPTL3, LPL act...

journal_title：Annals of clinical biochemistry

authors： Nakajima K,Kobayashi J,Mabuchi H,Nakano T,Tokita Y,Nagamine T,Imamura S,Ai M,Otokozawa S,Schaefer EF

更新日期：2010-09-01 00:00:00

abstract：:A total of 3227 urine specimens were analysed to investigate the applicability of a firefly luciferase assay of microbial adenosine triphosphate (ATP) for the rapid screening of bacteriuria in clinical specimens. Urine sediment, dipslide culture, and three plate cultures were also investigated in the majority of the u...

journal_title：Annals of clinical biochemistry

authors： Ruokonen A,Koskinen M,Leinonen M,Tiilikainen A,Vihko R

更新日期：1982-11-01 00:00:00

abstract：:Smoking is a major risk factor for periodontal disease, causing bone and tooth loss. Effective management of many oral conditions requires accurate information about smoking. We describe a disposable, 10-min, near-patient saliva test to monitor cigarette smoking. A plastic device contains the dried reagents to measure...

journal_title：Annals of clinical biochemistry

authors： Cope G,Nayyar P,Holder R,Brock G,Chapple I

更新日期：2000-09-01 00:00:00

abstract：:A recently introduced turbidimetric immunoassay using shell/core particles for determination of myoglobin (Turbiquant Myoglobin, Behringwerke, Marburg, Germany) was evaluated on the Behring Turbitimer analyzer. Intra-assay CV varied between 1.0% and 3.2%; interassay CV was between 2.0% and 3.6%. Linear results were ob...

journal_title：Annals of clinical biochemistry

authors： Delanghe J,Chapelle JP,el Allaf M,De Buyzere M

更新日期：1991-09-01 00:00:00

abstract：:This review describes the development and application of a novel test to determine levels of human immunoreactive trypsin, an enzyme produced solely by the pancreas, in biological fluids. Being organ-specific, the assay of immunoreactive trypsin should be an ideal marker of pancreatic function, and this is supported b...

journal_title：Annals of clinical biochemistry

authors： Stagg BH,Wood TP

更新日期：1979-05-01 00:00:00

abstract：:Serum concentrations of total thyroid hormones, thyroid hormone binding proteins, free thyroid hormones and thyroid stimulating hormone (TSH) were measured in a large group of healthy normal subjects (n = 218) to determine the influence of age and sex on tests of thyroid function. No effect of age on measurements of t...

journal_title：Annals of clinical biochemistry

authors： Franklyn JA,Ramsden DB,Sheppard MC

更新日期：1985-09-01 00:00:00

abstract：:A microtiter plate based Dual Analyte enzyme-immunoassay method for the simultaneous measurement of alpha-fetoprotein (AFP) and Free-beta human chorionic gonadotrophin (hCG) was evaluated. This rapid assay, which has application in both Neural Tube Defect screening and Down's screening, shows good precision with betwe...

journal_title：Annals of clinical biochemistry

authors： Macri JN,Spencer K,Anderson R

更新日期：1992-07-01 00:00:00

abstract：BACKGROUND:Current guidelines document persistent rectal bleeding as an alarm symptom in patients presenting to primary care. We studied whether a faecal immunochemical test could assist in their assessment. METHODS:From December 2015, faecal immunochemical tests were routinely available to primary care when assessing...

journal_title：Annals of clinical biochemistry

authors： Digby J,Strachan JA,McCann R,Steele RJ,Fraser CG,Mowat C

更新日期：2020-07-01 00:00:00

abstract：:A simple and improved method of continuous-flow analysis for total and direct bilirubin in serum is described. Advantages of the method are: small serum and reagent volumes; the use of less concentrated caffeine solution in the accelerator; the substitution of distilled water for hydrochloric acid in the direct biliru...

journal_title：Annals of clinical biochemistry

authors： Lolekha PH

更新日期：1980-09-01 00:00:00

abstract：:Measurement of urine-free (unconjugated) cortisol (UFC) excretion is widely used in the investigation of hypercortisolaemia. We have measured 24 h UFC excretion in normal healthy individuals using a radioimmunoassay (RIA) method claimed to be suitable for unextracted urine. Significantly higher rates of excretion were...

journal_title：Annals of clinical biochemistry

authors： Lamb EJ,Noonan KA,Burrin JM

更新日期：1994-09-01 00:00:00

abstract：:A bloodspot assay for testosterone has been developed using an antiserum raised against testosterone-3-carboxymethyloxime-bovine serum albumin (T-3 CMO-BSA) conjugate and 125I-T-3CMO-histamine tracer. The method has a detection limit of 0.4 nmol/L with between-batch precision of less than 15% for testosterone values b...

journal_title：Annals of clinical biochemistry

authors： Walker J,Hughes IA,Wood PJ

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND:Lysophosphatidic acid (LPA) plays important roles in a variety of biological responses, especially in the area of vascular biology, and the determination of its plasma concentration is believed to be important. Several mechanisms are known to be involved in the metabolism of LPA. METHODS:To identify factors...

journal_title：Annals of clinical biochemistry

authors： Hosogaya S,Yatomi Y,Nakamura K,Ohkawa R,Okubo S,Yokota H,Ohta M,Yamazaki H,Koike T,Ozaki Y

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:Ischaemia-modified albumin (IMA) is a relatively new marker of ischaemia. IMA has not been studied previously in pleural effusions due to congestive heart failure (CHF). The aim of our study was to assess the diagnostic value of IMA in the pleural fluid (PF) and serum for the identification of pleural effusi...

journal_title：Annals of clinical biochemistry

authors： Ozsu S,Gulsoy A,Karahan SC,Mentese A,Nuhoglu I,Ozlu T

更新日期：2011-01-01 00:00:00

abstract：:Thyroglobulin (Tg) is a tumour marker for differentiated thyroid cancer. Interpretation requires a knowledge of the current thyrotropin (TSH) concentration as secretion is TSH-dependent. While a raised serum Tg may be indicative of residual or recurrent thyroid cancer, trauma to the thyroid (e.g. surgical, biopsy or d...

journal_title：Annals of clinical biochemistry

authors： Clark P,Franklyn J

更新日期：2012-07-01 00:00:00

abstract：:Sequential measurements of plasma alkaline phosphatase activity were made in 84 pre-term infants delivered before 38 weeks gestation. In 67% of infants, without evidence of rickets but in whom three or more measurements were made and the peak activity was less than 10 times the adult reference range, the activity rose...

journal_title：Annals of clinical biochemistry

authors： Walters EG,Murphy JF,Henry P,Gray OP,Elder GH

更新日期：1986-11-01 00:00:00

abstract：:Mitochondrial acetoacetyl-CoA thiolase deficiency (or beta-ketothiolase deficiency) is a rare metabolic disorder characterized by acute episodes of severe acidosis and ketosis. A case is presented of an 18-month-old boy who presented with vomiting and diarrhoea and was found to be markedly acidotic. When the acidosis ...

journal_title：Annals of clinical biochemistry

authors： Tilbrook LK,Slater J,Agarwal A,Cyriac J

更新日期：2008-09-01 00:00:00

abstract：:Serum amyloid A protein (SAA) is a sensitive acute phase reactant. We developed a method for the rapid measurement of human SAA in serum by kinetic nephelometry of anti-SAA antibody-coated latex agglutination. Measurement takes less than 6 min using an automated analyser. Standardization of the assay employs SAA-enric...

journal_title：Annals of clinical biochemistry

authors： Yamada T,Nomata Y,Sugita O,Okada M

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:Current guidelines define acute myocardial infarction (AMI) by the rise and/or fall of cardiac troponin with ≥1 value above the 99th percentile. Past troponin assays have been unreliable at the lower end of the range. Highly sensitive assays have therefore been developed to increase the clinical sensitivity ...

journal_title：Annals of clinical biochemistry

authors： Aldous SJ,Florkowski CM,Crozier IG,Elliott J,George P,Lainchbury JG,Mackay RJ,Than M,Flaws DF,Borowsky J

更新日期：2011-05-01 00:00:00

abstract：:Measurement of genetically altered DNA shed from tumours into the circulation can potentially provide a new generation of blood-based cancer biomarkers. Compared with tissue DNA biomarkers which require surgery or biopsy, samples for circulating tumour DNA assays can be obtained with minimal inconvenience and at lower...

journal_title：Annals of clinical biochemistry

authors： Duffy MJ

更新日期：2019-01-01 00:00:00

abstract：:A patient with sepsis and jaundice was admitted for diagnosis and treatment. Associated biochemical changes included increased C-reactive protein, conjugated bilirubin and gamma-glutamyltransferase, the duration of which was protracted. High urine coproporphyrin isomer-1 and immunostaining of liver tissue suggested Du...

journal_title：Annals of clinical biochemistry

authors： Devgun MS,El-Nujumi AM,O'Dowd GJ,Barbu V,Poupon R

更新日期：2012-11-01 00:00:00

abstract：:We examined the reproducibility of oral glucose tolerance tests (OGTT) using the World Health Organization criterion in 212 Chinese subjects (male 149, female 63) who underwent two 75 g OGTTs within a 6-week period. The overall reproducibility was 65.6% (139/212) of which 74 subjects had normal glucose tolerance, 24 h...

journal_title：Annals of clinical biochemistry

authors： Ko GT,Chan JC,Woo J,Lau E,Yeung VT,Chow CC,Cockram CS

更新日期：1998-01-01 00:00:00

abstract：:We have made an evaluation of glycosylated haemoglobin measurements by affinity chromatography in a paediatric population. Age-related reference values for non-diabetic infants and children are reported. A poor correlation (r = 0.24) was found between glycosylated haemoglobin values in 26 insulin-dependent diabetic ch...

journal_title：Annals of clinical biochemistry

authors： van Heyningen C,Hanid TK,Hopkinson I

更新日期：1986-07-01 00:00:00

abstract：:Serum retinol-binding protein (RBP), with a biological half-life of less than 12 h, is a useful indicator of liver or kidney dysfunction. An automated immunoturbidimetric assay for the measurement of RBP has been developed using the Cobas-BIO centrifugal analyser and commercially available materials. Serum samples wit...

journal_title：Annals of clinical biochemistry

authors： Bankson DD,Rifai N,Silverman LM

更新日期：1988-05-01 00:00:00

abstract：:This paper summarises the views of the authors on the provision of a prolactin assay service. We discuss the pathophysiology of prolactin secretion and the clinical indications that arise from that. We cover the rather complex issue of the definition of normal and elevated prolactin levels. From these considerations, ...

journal_title：Annals of clinical biochemistry

authors： Jeffcoate SL,Bacon RR,Beastall GH,Diver MJ,Franks S,Seth J

更新日期：1986-11-01 00:00:00