Extracorporeal treatment of cast nephropathy.


:Acute kidney injury (AKI) is common in patients with multiple myeloma (MM), most commonly caused by cast nephropathy resulting from precipitation of free light chains (FLC) in renal tubules. AKI may be irreversible and require dialysis and predicts a poor prognosis. Reduction in serum FLC concentration is thought to be associated with improved likelihood of kidney function recovery in MM patients with AKI. Plasma exchange (PE), by removing circulating FLC, has been used as a treatment modality to improve kidney function in MM, although its efficacy remains uncertain. Extracorporeal treatment with extended high cutoff hemodialysis (HCO-HD) has also recently been studied as a potentially more effective means of FLC removal. Both PE and HCO-HD may be beneficial in some patients, but only when used as adjuncts to successful chemotherapy. Further research is necessary to establish the specific efficacy of each of these extracorporeal methods in the treatment of cast nephropathy.


Semin Dial


Seminars in dialysis


Gakhar B,Kobrin S,Berns JS




Has Abstract


2011-01-01 00:00:00












  • Percutaneous technique of presternal peritoneal dialysis catheter placement.

    abstract::Presternally exiting peritoneal dialysis (PD) catheters have been described as advantageous compared to abdominally exiting catheters with regard to infection, wound healing, and other complications. Placement of such catheters has only been described with open surgical techniques and not by percutaneous means. In thi...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章


    authors: Sreenarasimhaiah VP,Margassery SK,Martin KJ,Bander SJ

    更新日期:2004-09-01 00:00:00

  • Dialysate leaks in peritoneal dialysis.

    abstract::Dialysate leakage represents a major noninfectious complication of peritoneal dialysis (PD). An exit-site leak refers to the appearance of any moisture around the PD catheter identified as dialysate; however, the spectrum of dialysate leaks also includes any dialysate loss from the peritoneal cavity other than via the...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Leblanc M,Ouimet D,Pichette V

    更新日期:2001-01-01 00:00:00

  • The effect of chronic renal failure on hepatic drug metabolism and drug disposition.

    abstract::There is abundant evidence that chronic renal failure (CRF) and end-stage renal disease (ESRD) alter drug disposition by affecting protein and tissue binding and reducing systemic clearance of renally cleared drugs. What is not fully appreciated is that CRF can significantly reduce nonrenal clearance and alter the bio...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Dreisbach AW,Lertora JJ

    更新日期:2003-01-01 00:00:00

  • Pulmonary hypertension in hemodialysis patients: an unrecognized threat.

    abstract::Pulmonary hypertension (PH) is a progressive, fatal pulmonary circulatory disease that accompanies many conditions (including left to right side shunt) with compensatory elevated cardiac output. PH also complicates chronic hemodialysis (HD) therapy immediately after the creation of an arteriovenous (AV) access, even b...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Yigla M,Abassi Z,Reisner SA,Nakhoul F

    更新日期:2006-09-01 00:00:00

  • Doing More Than Caring About Quality.

    abstract::The treatment of chronically ill patients with end stage renal disease (ESRD) receiving dialysis therapies has advanced greatly over the years and accomplished many successes in prolonging the life of patients with ESRD, yet has had considerable failures due to the inability to compensate for all functions of the kidn...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章


    authors: Maddux FW

    更新日期:2016-03-01 00:00:00

  • Hyperhomocysteinemia in uremia--a red flag in a disrupted circuit.

    abstract::Hyperhomocysteinemia is an independent cardiovascular risk factor, according to most observational studies and to studies using the Mendelian randomization approach, utilizing the common polymorphism C677T of methylene tetrahydrofolate reductase. In contrast, the most recent secondary preventive intervention studies, ...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Perna AF,Ingrosso D,Violetti E,Luciano MG,Sepe I,Lanza D,Capasso R,Ascione E,Raiola I,Lombardi C,Stenvinkel P,Massy Z,De Santo NG

    更新日期:2009-07-01 00:00:00

  • The pathogenesis of hemodialysis vascular access failure and systemic therapies for its prevention: Optimism unfulfilled.

    abstract::In patients receiving hemodialysis, the provision of safe and effective vascular access using an arteriovenous fistula or graft is regarded as a critical priority by patients and health professionals. Vascular access failure is associated with morbidity and mortality, such that strategies to prevent these outcomes are...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Viecelli AK,Mori TA,Roy-Chaudhury P,Polkinghorne KR,Hawley CM,Johnson DW,Pascoe EM,Irish AB

    更新日期:2018-05-01 00:00:00

  • A survey of current procedural practices of Australian and New Zealand nephrologists.

    abstract::The aim of this study was to describe the range and extent of current procedural practices of Nephrologists and trainees in Australia and New Zealand with a specific focus on renal biopsy. A web-based survey was constructed based on a 2009 pilot survey conducted by the authors. The survey was distributed by email. A t...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章


    authors: Ritchie AG,Saunders J,Baer R,May S,Australian and New Zealand Special Interest Group in Interventional Nephrology Research Collaboration.

    更新日期:2013-11-01 00:00:00

  • A multicentre analysis of the outcome of arteriovenous fistula in maintenance haemodialysis.

    abstract:INTRODUCTION:Arteriovenous fistulas (AVF) are the preferred choice for vascular access in hemodialysis. We aim to identify factors that may contribute to AVF failure. METHODS:Data regarding AVF survival were collected from 441 patients. All AVFs were either radial or brachial, of the end-to-side variety. Parameters st...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章


    authors: Jothi S,Kg H,Lesley N,Vijayan M,Haridas Anupama S,Mathew M,Parthasarathy R,Sundarajan S,P N,Kumaraswamy L,Abraham G

    更新日期:2020-09-01 00:00:00

  • Bone Disorders in Chronic Kidney Disease: An Update in Diagnosis and Management.

    abstract::Renal osteodystrophy (ROD) is a bone disorder that occurs in chronic kidney disease (CKD) patients and is associated with 2- to 14-fold increased fracture risk compared to the general population. Risk of fractures is also increased in kidney transplant recipients especially within the first 5 years after transplantati...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Babayev R,Nickolas TL

    更新日期:2015-11-01 00:00:00

  • Evidence-based review of gastrointestinal bleeding in the chronic kidney disease patient.

    abstract::Patients with end-stage renal disease are more likely to suffer from gastrointestinal (GI) problems, including bleeding from upper and lower sources. Peptic ulcer disease is the most common cause of upper GI bleeding, and although there is some debate in the literature regarding whether the frequency of ulcer disease ...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Kalman RS,Pedrosa MC

    更新日期:2015-01-01 00:00:00

  • Hyperkalemia in hemodialysis patients.

    abstract::Hyperkalemia contributes significantly to high mortality among ESRD patients. Excess intake and inadequate removal are the most common etiologies in HD patients. Although dialysis is the definitive treatment, classical medical therapy must be employed as a temporizing measure to acutely lower serum potassium. Reducing...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Pani A,Floris M,Rosner MH,Ronco C

    更新日期:2014-11-01 00:00:00

  • Conservative treatment of the uremic syndrome.

    abstract::In addition to extracorporeal renal replacement strategies, which in chronic kidney disease (CKD) are largely reserved for the treatment of end-stage kidney failure, conservative measures can be taken to reduce concentration, effects, or both concentration and effects of uremic retention solutes. In this overview, we ...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Vanholder R,Argilés A,Beige J,Brunet P,Drüeke TB,Fliser D,Herget-Rosenthal S,Hörl WH,Jörres A,Perna A,Rodriguez-Portillo M,Spasovski G,Stegmayr B,Stenvinkel P,Wanner C,Wiecek A,Massy ZA

    更新日期:2009-07-01 00:00:00

  • Dietary vitamin D intake in advanced CKD/ESRD.

    abstract::In healthy individuals, vitamin D produced in the skin or derived from nutritional sources is converted to 25-hydroxyvitamin D (25[OH]D) in the liver, and then 1,25-dihydroxyvitamin D (1,25[OH](2)D) by 1 alpha-hydroxylase in the kidney. Chronic kidney disease (CKD) is accompanied by a progressive decline in the abilit...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Bhan I,Hewison M,Thadhani R

    更新日期:2010-07-01 00:00:00

  • Metastatic complications of bloodstream infections in hemodialysis patients.

    abstract::Bacteremia is a common infectious complication in hemodialysis patients. Metastatic sites of infection including infective endocarditis, vertebral osteomyelitis, spinal epidural abscess, and septic arthritis occur relatively frequently. These complications are associated with increased morbidity and mortality in hemod...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Lewis SS,Sexton DJ

    更新日期:2013-01-01 00:00:00

  • Renal osteodystrophy, phosphate homeostasis, and vascular calcification.

    abstract::New advances in the pathogenesis of renal osteodystrophy (ROD) change the perspective from which many of its features and treatment are viewed. Calcium, phosphate, parathyroid hormone (PTH), and vitamin D have been shown to be important determinants of survival associated with kidney diseases. Now ROD dependent and in...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Hruska KA,Saab G,Mathew S,Lund R

    更新日期:2007-07-01 00:00:00

  • Thigh grafts: a preferable alternative to catheters when upper extremity access sites are exhausted.

    abstract::Hemodialysis patients with failed upper extremity (arm) access sites comprise 5-10% of the dialysis population. In these patients, arm vessels are either unsuitable for access placement due to trauma or peripheral vascular disease, or have been exhausted following dialysis usage. Synthetic grafts in the lower extremit...

    journal_title:Seminars in dialysis

    pub_type: 社论


    authors: Abreo KD,Ram SJ

    更新日期:2009-09-01 00:00:00

  • The body mass index paradox and an obesity, inflammation, and atherosclerosis syndrome in chronic kidney disease.

    abstract::The association of high body mass index (BMI) with better survival in chronic kidney disease (CKD) is considered a "risk factor paradox" or "reverse epidemiology." Since malnutrition is a powerful predictor of death and cardiovascular disease is its leading cause, it has been suggested that malnutrition and atheroscle...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Beddhu S

    更新日期:2004-05-01 00:00:00

  • Role of parathyroid hormone and therapy with active vitamin D sterols in renal osteodystrophy.

    abstract::Renal osteodystrophy (ROD) represents a spectrum of bone lesions ranging from a high-turnover to a low-turnover state. The expression of the histologic bone lesions is modulated by parathyroid hormone (PTH), vitamin D, calcium, phosphorus, and aluminum that act as major regulators of osteoblastic activity and bone for...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Hernandez JD,Wesseling K,Salusky IB

    更新日期:2005-07-01 00:00:00

  • The association of hepatitis C infection with the onset of CKD and progression into ESRD.

    abstract::Hepatitis C virus (HCV) infection is not only an important cause of chronic liver disease, but extrahepatic manifestations are common and include chronic kidney disease (CKD). HCV is classically associated with cryoglobulinemic glomerulonephritis in the context of mixed cryoglobulinemia syndrome, but other glomerular ...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Henson JB,Sise ME

    更新日期:2019-03-01 00:00:00

  • Is there an established hemoglobin target range for patients undergoing chronic dialysis?

    abstract::Anemia is a common complication of advanced chronic kidney disease (CKD). Treatment with erythropoiesis-stimulating agents (ESAs) remains a common approach in managing anemia of CKD. The 2012 Kidney Disease Improving Global Outcomes Clinical Practice Guideline for Anemia in CKD suggests avoiding ESA therapy use to mai...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Shah HH,Fishbane S

    更新日期:2018-07-01 00:00:00

  • Use of androgens in patients with renal failure.

    abstract::Anabolic steroids have been used for the treatment of the anemia of chronic renal failure for more than 25 years. Due to concerns over adverse effects, their use historically has been limited to nandrolone decanoate given to men, usually over age 50, who have intact kidneys. The introduction of epoetin alfa in 1989 ha...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Johnson CA

    更新日期:2000-01-01 00:00:00

  • Minerals in dialysis therapy: an introduction.

    abstract::The 180 l of glomerular filtrate formed each day contain some 1100 g (2.5 pounds) of sodium chloride, of which only 5-10 g are excreted in the urine--95% is reabsorbed by the tubules. Some 425 g (nearly a pound) of sodium bicarbonate and 145 g of glucose are filtered, and more than 99% of both are reabsorbed. Also fil...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章


    authors: Weisberg LS,Zanger R

    更新日期:2010-11-01 00:00:00

  • A case of uremia-associated pleural effusion in a peritoneal dialysis patient.

    abstract::The development of pleural effusions in ESRD patients is a relatively common occurrence. Uremia, currently a rare cause of effusion, can lead to the development of hemorrhagic pleural fluid collections in patients who are underdialyzed. Uremic pleural effusions should be considered when common etiologies of effusions ...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章


    authors: Krishnan M,Choi M

    更新日期:2001-05-01 00:00:00

  • Sympathetic nervous system function and dysfunction in chronic hemodialysis patients.

    abstract::Adequate sympathetic nervous system activation is essential for the compensatory mechanisms of blood pressure maintenance during the hemodialysis (HD) procedure. Chronic sympathetic nervous system overactivity, however, may lead to the development of hypertension and cardiovascular disease in HD patients. The present ...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Rubinger D,Backenroth R,Sapoznikov D

    更新日期:2013-05-01 00:00:00

  • Extracorporeal treatment for tricyclic antidepressant poisoning: recommendations from the EXTRIP Workgroup.

    abstract::The Extracorporeal Treatments In Poisoning (EXTRIP) workgroup was formed to provide recommendations on the use of extracorporeal treatments (ECTR) in poisoning. Here, the workgroup presents its results for tricyclic antidepressants (TCAs). After an extensive literature search, using a predefined methodology, the subgr...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Yates C,Galvao T,Sowinski KM,Mardini K,Botnaru T,Gosselin S,Hoffman RS,Nolin TD,Lavergne V,Ghannoum M,EXTRIP workgroup.

    更新日期:2014-07-01 00:00:00

  • Methods of assessment of volume status and intercompartmental fluid shifts in hemodialysis patients: implications in clinical practice.

    abstract::Determining dry weight and assessing extracellular fluid volume in hemodialysis (HD) patients is one of the greatest challenges to practicing nephrologists. The clinical examination has limited accuracy, so different strategies have been investigated to aid in this evaluation. Biochemical markers of volume overload (A...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Ishibe S,Peixoto AJ

    更新日期:2004-01-01 00:00:00

  • A novel technique for tethered dialysis catheter removal using the laser sheath.

    abstract::Traction and cutdown techniques can successfully remove a tunneled dialysis catheter (TDC) in a great majority of patients. However, these methods may not be successful in patients with catheters that are tethered or attached to the central veins or the atrium. A forceful application of traction can lead to catheter b...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章


    authors: Carrillo RG,Garisto JD,Salman L,Merrill D,Asif A

    更新日期:2009-11-01 00:00:00

  • Obesity as a barrier to kidney transplantation: Time to eliminate the body weight bias?

    abstract::There is clear evidence that survival rates following transplantation far exceed those for remaining on dialysis, regardless of body size measured by body mass index (BMI). Studies over the past 15 years also suggest little to no difference in long-term outcomes, including graft survival and mortality, irrespective of...

    journal_title:Seminars in dialysis

    pub_type: 社论


    authors: MacLaughlin HL,Campbell KL

    更新日期:2019-05-01 00:00:00

  • Comments on plasma parathyroid hormone levels and their relationship to bone histopathology among patients undergoing dialysis.

    abstract::Measurements of the concentration of parathyroid hormone (PTH) in serum or plasma are used widely for the initial diagnostic assessment of patients with renal bone disease, to monitor disease progression, and to gauge responses to treatment. Several analytical methods are used to measure plasma PTH levels, and a varie...

    journal_title:Seminars in dialysis

    pub_type: 社论,评审


    authors: Goodman WG

    更新日期:2007-01-01 00:00:00