Extracorporeal treatment of cast nephropathy.


:Acute kidney injury (AKI) is common in patients with multiple myeloma (MM), most commonly caused by cast nephropathy resulting from precipitation of free light chains (FLC) in renal tubules. AKI may be irreversible and require dialysis and predicts a poor prognosis. Reduction in serum FLC concentration is thought to be associated with improved likelihood of kidney function recovery in MM patients with AKI. Plasma exchange (PE), by removing circulating FLC, has been used as a treatment modality to improve kidney function in MM, although its efficacy remains uncertain. Extracorporeal treatment with extended high cutoff hemodialysis (HCO-HD) has also recently been studied as a potentially more effective means of FLC removal. Both PE and HCO-HD may be beneficial in some patients, but only when used as adjuncts to successful chemotherapy. Further research is necessary to establish the specific efficacy of each of these extracorporeal methods in the treatment of cast nephropathy.


Semin Dial


Seminars in dialysis


Gakhar B,Kobrin S,Berns JS




Has Abstract


2011-01-01 00:00:00












  • A multicentre analysis of the outcome of arteriovenous fistula in maintenance haemodialysis.

    abstract:INTRODUCTION:Arteriovenous fistulas (AVF) are the preferred choice for vascular access in hemodialysis. We aim to identify factors that may contribute to AVF failure. METHODS:Data regarding AVF survival were collected from 441 patients. All AVFs were either radial or brachial, of the end-to-side variety. Parameters st...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章


    authors: Jothi S,Kg H,Lesley N,Vijayan M,Haridas Anupama S,Mathew M,Parthasarathy R,Sundarajan S,P N,Kumaraswamy L,Abraham G

    更新日期:2020-09-01 00:00:00

  • Doppler ultrasound: a powerful tool for vascular access surveillance.

    abstract::National Kidney Foundation Kidney Disease Outcomes Quality Initiative (NKF KDOQI) guidelines recommend Doppler ultrasound (DU) for surveillance of vascular access (VA), but trials have not been unanimous about its benefit on VA patency. The aim of this study was to evaluate the accuracy of DU for patency, as well as t...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章


    authors: Guedes Marques M,Ibeas J,Botelho C,Maia P,Ponce P

    更新日期:2015-03-01 00:00:00

  • The economic burden of geriatric ESRD.

    abstract::The elderly represent the fastest growing segment of incident patients entering end-stage renal disease (ESRD). Increasingly, social scientists and caregivers are faced with changing models of care, which will challenge traditional patterns of patient acceptance into costly medical therapies. This paper analyzes the o...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章


    authors: Parker TF 3rd

    更新日期:2012-11-01 00:00:00

  • Euvolemia-A critical target in the management of acute kidney injury.

    abstract::It has been clearly established that critically ill patients with sepsis require prompt fluid resuscitation. The optimal amount of fluid and when to taper this resuscitation is less clear. There is a growing evidence that fluid overload leads to acute kidney injury, and increased morbidity and mortality. A clinician's...

    journal_title:Seminars in dialysis

    pub_type: 社论,评审


    authors: Colbert GB,Szerlip HM

    更新日期:2019-01-01 00:00:00

  • Longitudinal assessment of hemodynamic endpoints in predicting arteriovenous fistula maturation.

    abstract::Arteriovenous fistula (AVF) nonmaturation is currently a significant clinical problem; however, the mechanisms responsible for this have remained unanswered. Previous work by our group and others has suggested that anatomical configuration and the corresponding hemodynamic endpoints could have an important role in AVF...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章


    authors: Rajabi-Jagahrgh E,Krishnamoorthy MK,Roy-Chaudhury P,Succop P,Wang Y,Choe A,Banerjee RK

    更新日期:2013-03-01 00:00:00

  • Immunosuppressive management of dialysis patients with recently failed transplants.

    abstract::Over the past decade, patients returning to dialysis after a failed transplant comprised of 5-10% of the annual number of dialysis initiations in the United States, whereas retransplant candidates account for 5.0-13% of the annual deceased donor wait-list additions. The United States Renal Data System (USRDS) database...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Pham PT,Pham PC

    更新日期:2011-05-01 00:00:00

  • Epidemiology and demographic aspects of treated end-stage renal disease in the elderly.

    abstract::Over the last 10 years an increasing number of patients worldwide have started dialysis or had transplantation. Many are elderly with complex comorbid conditions. Registries across the world all show a rapid and dramatic increase in the number of older patients accepted for renal replacement therapy. In addition, the ...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章


    authors: Krishnan M,Lok CE,Jassal SV

    更新日期:2002-03-01 00:00:00

  • Is surgical salvage of arteriovenous grafts feasible after unsuccessful percutaneous mechanical thrombectomy?

    abstract::Treatment of thrombosed dialysis ateriovenous (AV) grafts in the radiology interventional suite requires percutaneous mechanical thrombectomy, along with angioplasty of the underlying stenotic lesion. We analyzed the anatomic reasons for unsuccessful percutaneous thrombectomy of AV grafts, and assessed the feasibility...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章


    authors: Maya ID,Smith T,Young CJ,Allon M

    更新日期:2008-03-01 00:00:00

  • The impact of arteriovenous fistulae on the myocardium: the impact of creation and ligation in the transplant era.

    abstract::Cardiac hypertrophy is a relatively common complication seen in patients with advanced chronic kidney disease (CKD) and end-stage renal disease (ESRD). Moreover, cardiac hypertrophy is even more frequently seen in patients with ESRD who have an arteriovenous (AV) access. There has been substantial evidence pertaining ...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Duque JC,Gomez C,Tabbara M,Alfonso CE,Li X,Vazquez-Padron RI,Asif A,Lenz O,Briones PL,Salman LH

    更新日期:2015-05-01 00:00:00

  • Accuracy of ultrasound in the detection of inflow stenosis of arteriovenous fistulae: results of a prospective study.

    abstract::While vascular ultrasound (US) has been highlighted to detect vascular access stenosis, its accuracy in the identification of inflow stenosis (IS) (anastomosis and/or juxta-anastomotic area) compared with the gold standard (angiography) has not been evaluated. One hundred three consecutive fistulae referred for interv...

    journal_title:Seminars in dialysis

    pub_type: 临床试验,杂志文章


    authors: Salman L,Ladino M,Alex M,Dhamija R,Merrill D,Lenz O,Contreras G,Asif A

    更新日期:2010-01-01 00:00:00

  • Vancomycin use in patients requiring hemodialysis: a literature review.

    abstract::Vancomycin, a glycopeptide antibiotic, has remained a popular antimicrobial agent throughout the past five decades, and is often included in empiric antibiotic regimens. With gram-positive coverage, it has found a niche in the treatment of methicillin-resistant Staphylococcus aureus. Although vancomycin has been in ex...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Pallotta KE,Manley HJ

    更新日期:2008-01-01 00:00:00

  • Long-term outcomes and management considerations after parathyroidectomy in the dialysis patient.

    abstract::Parathyroidectomy (PTX) remains an important intervention for dialysis patients with poorly controlled secondary hyperparathyroidism (SHPT), though there are only retrospective and observational data that show a mortality benefit to this procedure. Potential consequences that we seek to avoid after PTX include persist...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Kakani E,Sloan D,Sawaya BP,El-Husseini A,Malluche HH,Rao M

    更新日期:2019-11-01 00:00:00

  • Temperature control by the blood temperature monitor.

    abstract::The rationale of temperature control during hemodialysis (HD) is to prevent heat accumulation, which increases body temperature and enhances hypotensive susceptibility. Treatments where thermal energy is neither delivered nor removed from the patient through the extracorporeal circulation (so-called extracorporeal the...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Schneditz D,Ronco C,Levin N

    更新日期:2003-11-01 00:00:00

  • Do ketoanalogues still have a role in delaying dialysis initiation in CKD predialysis patients?

    abstract::Early versus later start of dialysis is still a matter of debate. Low-protein diets have been used for many decades to delay dialysis initiation. Protein-restricted diets (0.3-0.6 g protein/kg/day) supplemented with essential amino acids and ketoanalogues (sVLPD) can be offered, in association with pharmacological tre...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Aparicio M,Bellizzi V,Chauveau P,Cupisti A,Ecder T,Fouque D,Garneata L,Lin S,Mitch W,Teplan V,Yu X,Zakar G

    更新日期:2013-11-01 00:00:00

  • The other side of the coin: impact of toxin generation and nutrition on the uremic syndrome.

    abstract::Both the morbidity of the uremic syndrome and the generation of uremic toxins are attributed to malnutrition. If protein intake and catabolism result in the generation of solutes, then nutritional intake should be related directly to toxicity. On the other hand, inadequate nutrition has been linked to inflammation and...

    journal_title:Seminars in dialysis

    pub_type: 社论


    authors: Vanholder R,Glorieux G,Lameire N

    更新日期:2002-09-01 00:00:00

  • The role of continuous renal replacement therapy in the treatment of poisoning.

    abstract::Extracorporeal elimination of drugs and toxins is a critical component in the management of poisonings, though specific techniques and indications remain a matter of debate. Conventional hemodialysis is frequently the treatment of choice because of its widespread availability and proven effectiveness for certain drugs...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Goodman JW,Goldfarb DS

    更新日期:2006-09-01 00:00:00

  • Dialysis access failure: an indication for immediate kidney transplantation.

    abstract::In the United States, presently there are more than 50,000 patients with end-stage renal disease (ESRD) awaiting a cadaveric kidney and each year less than a quarter receive kidney transplantation. Although the real incidence in unknown, a significant number of these patients die due to lack of dialysis access. While ...

    journal_title:Seminars in dialysis

    pub_type: 社论


    authors: Laskow DA,Ahsan N

    更新日期:2002-01-01 00:00:00

  • Convective therapies for removal of middle molecular weight uremic toxins in end-stage renal disease: a review of the evidence.

    abstract::The increasing number of patients requiring renal replacement therapy poses a challenge to maintain quality of care in the setting of limited resources. The commonly used modalities include hemodialysis and peritoneal dialysis, and using a "urea-centric" model to increase the clearance of small molecular weight uremic...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Thomas G,Jaber BL

    更新日期:2009-11-01 00:00:00

  • How do calcimimetics fit into the management of parathyroid hormone, calcium, and phosphate disturbances in dialysis patients?

    abstract::As suggested by its American brand name (Sensipar), the calcimimetic cinacalcet sensitizes the parathyroid cells to the extracellular calcium signal, suppressing parathyroid hormone (PTH) release and synthesis and preventing parathyroid cell proliferation. This primary PTH suppression decreases the release of calcium ...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Shahapuni I,Mansour J,Harbouche L,Maouad B,Benyahia M,Rahmouni K,Oprisiu R,Bonne JF,Monge M,El Esper N,Presne C,Moriniere P,Choukroun G,Fournier A

    更新日期:2005-05-01 00:00:00

  • The relationship of soluble klotho level with uremic cardiomyopathy and ecocardiographic parameters in hemodialysis patients.

    abstract::There are studies reporting that soluble kltho (sKlotho) deficiency plays a role in cardiovascular disease in addition to traditional risk factors such as diabetes, hypertension, anemia, smoking, and excessive volume burden. Our aim in this study was to investigate the relationship of sKlotho with uremic cardiomyopath...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章


    authors: Erkus E,Buyukterzı Z,Karakose S,Kurku H,Kurtgoz PO,Topal M,Guney I

    更新日期:2020-11-30 00:00:00

  • Blood Pressure Management in Hemodialysis Patients: What We Know And What Questions Remain.

    abstract::Despite having thousands of blood pressure (BP) readings on individual dialysis patients over the course of a year, our knowledge about the optimal assessment of BP, the mechanisms underlying hypertension and its management remain incomplete. Observational studies reveal that BP is lower at home than when measured in ...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Miskulin DC,Weiner DE

    更新日期:2017-05-01 00:00:00

  • The effect of chronic renal failure on hepatic drug metabolism and drug disposition.

    abstract::There is abundant evidence that chronic renal failure (CRF) and end-stage renal disease (ESRD) alter drug disposition by affecting protein and tissue binding and reducing systemic clearance of renally cleared drugs. What is not fully appreciated is that CRF can significantly reduce nonrenal clearance and alter the bio...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Dreisbach AW,Lertora JJ

    更新日期:2003-01-01 00:00:00

  • Comments on plasma parathyroid hormone levels and their relationship to bone histopathology among patients undergoing dialysis.

    abstract::Measurements of the concentration of parathyroid hormone (PTH) in serum or plasma are used widely for the initial diagnostic assessment of patients with renal bone disease, to monitor disease progression, and to gauge responses to treatment. Several analytical methods are used to measure plasma PTH levels, and a varie...

    journal_title:Seminars in dialysis

    pub_type: 社论,评审


    authors: Goodman WG

    更新日期:2007-01-01 00:00:00

  • The medical-legal responsibilities of a dialysis unit medical director.

    abstract::The specialty of Nephrology, by virtue of its relationship with the dialysis procedure, is highly vulnerable to litigation. As is the case with all nephrologists, a dialysis unit medical director is not immune to medical malpractice suits, and can be held liable for any act of perceived or potential harm to any dialys...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Vaqar S,Murray B,Panesar M

    更新日期:2014-09-01 00:00:00

  • Conventional dialysis in the elderly: How lenient should our guidelines be?

    abstract::There has been a dramatic, worldwide expansion in life expectancy across the last century. This has resulted in a progressively more elderly and comorbid population. It is increasingly recognized that healthcare in this group needs to move to the concept of "adding life to years". Recognition and assessment of frailty...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Corbett RW,Brown EA

    更新日期:2018-11-01 00:00:00

  • Anemia management in cancer patients with chronic kidney disease.

    abstract::Cancer and kidney disease are linked by causality and comorbidities. Observational data show an increased risk of malignancy as renal function declines. Erythropoietin stimulating agents (ESAs), which are the cornerstone therapy for anemia patients with chronic kidney disease and cancer, are associated with increased ...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Latcha S

    更新日期:2019-11-01 00:00:00

  • Dialysis-related amyloidosis: pathogenesis focusing on AGE modification.

    abstract::Dialysis-related amyloidosis (DRA) is a serious complication in long-term dialysis patients, and presents with carpal tunnel syndrome, cystic bone lesions, destructive spondylarthropathy, diffuse arthritis and periarthritis, systemic organ involvement, and dialysis-related spinal canal stenosis (DSCS). Recently a new ...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Niwa T

    更新日期:2001-03-01 00:00:00

  • Iron and infection in hemodialysis patients.

    abstract::Intravenous iron is an important component of the treatment of anemia of end-stage renal disease (ESRD), but it is biologically plausible that iron could increase the risk of infection through impairment of neutrophil and T-cell function and promotion of microbial growth. Any such increase in risk would be particularl...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Ishida JH,Johansen KL

    更新日期:2014-01-01 00:00:00

  • What the non-nephrologist needs to know about dialysis.

    abstract::The End-Stage Renal Disease (ESRD) program now serves approximately 675,000 individuals in the United States at a cost of $26.1 billion to the Medicare system. Given the size of this population, healthcare providers from all disciplines will deliver care to patients on dialysis. Mortality remains high among patients o...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Foy M,Sperati CJ

    更新日期:2018-03-01 00:00:00

  • Wishful Thinking: The Surprisingly Sparse Evidence for a Relationship between Oxidative Stress and Cardiovascular Disease in Hemodialysis Patients.

    abstract::The increased frequency of cardiovascular disease observed in hemodialysis patients is secondary to the combination of many traditional (age, male sex, hypertension, smoking, diabetes mellitus, and dyslipidemia) and novel and uremia-related (inflammation, uremic toxins, adipokine imbalance, coagulation disorders, prot...

    journal_title:Seminars in dialysis

    pub_type: 社论,评审


    authors: Bossola M,Tazza L

    更新日期:2015-05-01 00:00:00