Uremia-related metabolic cardiac risk factors in chronic kidney disease.

Abstract:

:Growing evidence has been gathered over the last 15 years regarding the role of nontraditional or uremia-related risk factors in the pathogenesis of atherosclerosis in subjects with renal failure. Among those factors, dyslipidemia, inflammation, hyperhomocysteinemia, and oxidant stress have been extensively studied. However, the clinical significance of many of these factors remains controversial in light of reported studies. In this article, the existing evidence regarding the role of uremia-related risk factors in the pathogenesis of atherosclerosis is reviewed, with special emphasis on prevalence, cardiac risk, and management in patients with chronic kidney disease (CKD). Consensus treatment recommendations are provided for risk factors for which there is evidence to support preventive or therapeutic interventions.

journal_name

Semin Dial

journal_title

Seminars in dialysis

authors

Madore F

doi

10.1046/j.1525-139x.2003.16031.x

subject

Has Abstract

pub_date

2003-03-01 00:00:00

pages

148-56

issue

2

eissn

0894-0959

issn

1525-139X

pii

16031

journal_volume

16

pub_type

杂志文章,评审
  • Eliminating the need for routine monthly postdialysis serum urea nitrogen measurement: A method for monitoring Kt/V and normalized protein catabolic rate using conductivity determined dialyzer clearance.

    abstract::Many dialysis machines can compute dialyzer sodium clearances at multiple time points during a dialysis treatment using conductivity. For a given treatment, the average dialyzer sodium clearance (K), when combined with treatment time (t), and the estimated urea distribution volume (V, usually based on either anthropom...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章

    doi:10.1111/sdi.12750

    authors: Daugirdas JT

    更新日期:2018-11-01 00:00:00

  • APD in the elderly.

    abstract::Few elderly patients with end-stage renal disease (ESRD) are treated with peritoneal dialysis (PD). Among dialysis patients >or=65 years of age reported by the U.S. Renal Data System (USRDS), the percentage treated with chronic peritoneal dialysis (CPD) is lower than in any other age group. To evaluate the effectivene...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章

    doi:10.1046/j.1525-139x.2002.00106.x

    authors: Kadambi P,Troidle L,Gorban-Brennan N,Kliger AS,Finkelstein FO

    更新日期:2002-11-01 00:00:00

  • Wishful Thinking: The Surprisingly Sparse Evidence for a Relationship between Oxidative Stress and Cardiovascular Disease in Hemodialysis Patients.

    abstract::The increased frequency of cardiovascular disease observed in hemodialysis patients is secondary to the combination of many traditional (age, male sex, hypertension, smoking, diabetes mellitus, and dyslipidemia) and novel and uremia-related (inflammation, uremic toxins, adipokine imbalance, coagulation disorders, prot...

    journal_title:Seminars in dialysis

    pub_type: 社论,评审

    doi:10.1111/sdi.12345

    authors: Bossola M,Tazza L

    更新日期:2015-05-01 00:00:00

  • Euvolemia-A critical target in the management of acute kidney injury.

    abstract::It has been clearly established that critically ill patients with sepsis require prompt fluid resuscitation. The optimal amount of fluid and when to taper this resuscitation is less clear. There is a growing evidence that fluid overload leads to acute kidney injury, and increased morbidity and mortality. A clinician's...

    journal_title:Seminars in dialysis

    pub_type: 社论,评审

    doi:10.1111/sdi.12753

    authors: Colbert GB,Szerlip HM

    更新日期:2019-01-01 00:00:00

  • The pathogenesis of hemodialysis vascular access failure and systemic therapies for its prevention: Optimism unfulfilled.

    abstract::In patients receiving hemodialysis, the provision of safe and effective vascular access using an arteriovenous fistula or graft is regarded as a critical priority by patients and health professionals. Vascular access failure is associated with morbidity and mortality, such that strategies to prevent these outcomes are...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审

    doi:10.1111/sdi.12658

    authors: Viecelli AK,Mori TA,Roy-Chaudhury P,Polkinghorne KR,Hawley CM,Johnson DW,Pascoe EM,Irish AB

    更新日期:2018-05-01 00:00:00

  • Identification of facilitators and barriers to home dialysis selection by canadian adults with ESRD.

    abstract::Home dialysis (home HD or home PD) remains underutilized in most jurisdictions. Physicians, advanced-practice nurses, and policy makers working with chronic kidney disease populations can provide insights into patient, healthcare professional, and system-level barriers to home dialysis selection by suitable patients. ...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章

    doi:10.1111/sdi.12183

    authors: Osterlund K,Mendelssohn D,Clase C,Guyatt G,Nesrallah G

    更新日期:2014-03-01 00:00:00

  • We Wait Too Long to Refer Patients for Transplantation.

    abstract::Late referral of patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD) for evaluation of kidney transplantation is common. Even though renal transplantation offers a clear survival benefit to patients with advanced CKD and ESRD and should be considered the renal replacement therapy of choice, n...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章

    doi:10.1111/sdi.12497

    authors: Peev V

    更新日期:2016-07-01 00:00:00

  • Obesity as a barrier to kidney transplantation: Time to eliminate the body weight bias?

    abstract::There is clear evidence that survival rates following transplantation far exceed those for remaining on dialysis, regardless of body size measured by body mass index (BMI). Studies over the past 15 years also suggest little to no difference in long-term outcomes, including graft survival and mortality, irrespective of...

    journal_title:Seminars in dialysis

    pub_type: 社论

    doi:10.1111/sdi.12783

    authors: MacLaughlin HL,Campbell KL

    更新日期:2019-05-01 00:00:00

  • Impact of drugs on intradialytic hypotension: Antihypertensives and vasoconstrictors.

    abstract::Intradialytic hypotension (IDH) is a common complication of hemodialysis and is associated with numerous adverse outcomes including cardiovascular events, inadequate dialysis, loss of vascular access, and death. It is estimated that approximately 20%-30% of all dialysis sessions are affected by IDH. In seeking ways to...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审

    doi:10.1111/sdi.12633

    authors: Chang TI

    更新日期:2017-11-01 00:00:00

  • Reducing the risk of re-fracture in the dialysis population: is it time to consider therapy with PTH analogues?

    abstract::Dialysis patients are at high risk for fracture, with published rates in excess of a 20% probability of fracture over the next 10 years of dialysis. Unfortunately, there is no accepted methodology for quantifying this risk in advance of the first fracture; conventional bone densitometry performs unreliably in this rol...

    journal_title:Seminars in dialysis

    pub_type: 社论

    doi:10.1111/j.1525-139X.2010.00817.x

    authors: Jamal SA,Hodsman AB

    更新日期:2011-01-01 00:00:00

  • Dialysis membrane and modality in acute renal failure: understanding discordant meta-analyses.

    abstract::Meta-analyses of the published literature are increasingly being used, allowing similar clinical trials to be combined quantitatively, thereby increasing the precision of the estimation of treatment effect. Four meta-analyses were recently published comparing the impact of dialysis membranes or dialysis modality on cl...

    journal_title:Seminars in dialysis

    pub_type: 社论,评审

    doi:10.1046/j.1525-139x.2003.16071.x

    authors: Teehan GS,Liangos O,Lau J,Levey AS,Pereira BJ,Jaber BL

    更新日期:2003-09-01 00:00:00

  • Serum Parathyroid Hormone Concentrations and Clinical Outcomes in ESRD: A Call for Targeted Clinical Trials.

    abstract::Secondary hyperparathyroidism almost universally accompanies end-stage renal disease (ESRD). In some, but not all studies, elevated serum parathyroid hormone (PTH) concentrations are associated with increased fracture rates, cardiovascular disease, and mortality in ESRD. The serum concentration of PTH required for opt...

    journal_title:Seminars in dialysis

    pub_type: 社论

    doi:10.1111/sdi.12457

    authors: Zand L,Kumar R

    更新日期:2016-05-01 00:00:00

  • Sympathetic overactivity in dialysis patients-Underappreciated and clinically consequential.

    abstract::Cardiovascular morbidity and mortality remain frustratingly common in dialysis patients. A dearth of established evidence-based treatment calls for alternative therapeutic avenues to be embraced. Sympathetic hyperactivity, predominantly due to afferent nerve signaling from the diseased native kidneys, has been establi...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审

    doi:10.1111/sdi.12756

    authors: Hoye NA,Wilson LC,Jardine DL,Walker RJ

    更新日期:2019-05-01 00:00:00

  • Renal osteodystrophy, phosphate homeostasis, and vascular calcification.

    abstract::New advances in the pathogenesis of renal osteodystrophy (ROD) change the perspective from which many of its features and treatment are viewed. Calcium, phosphate, parathyroid hormone (PTH), and vitamin D have been shown to be important determinants of survival associated with kidney diseases. Now ROD dependent and in...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审

    doi:10.1111/j.1525-139X.2007.00300.x

    authors: Hruska KA,Saab G,Mathew S,Lund R

    更新日期:2007-07-01 00:00:00

  • Policies to promote timely referral for kidney transplantation.

    abstract::There are numerous patient, provider, and health system barriers to accessing kidney transplantation. Patient barriers such as sociocultural and clinical characteristics and provider factors such as provider knowledge and awareness of transplantation play important roles in facilitating transplant. Health system facto...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章

    doi:10.1111/sdi.12860

    authors: Patzer RE,Pastan SO

    更新日期:2020-01-01 00:00:00

  • Starting a home hemodialysis program.

    abstract::Home hemodialysis is not a new therapy; rather it is a therapy in which interest has been rekindled due to both the continually growing end-stage renal disease population and concern about poor outcomes in patients on conventional thrice-weekly in-center dialysis. The practical issues to be considered when starting a ...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审

    doi:10.1111/j.1525-139X.2007.00239.x

    authors: Moran J,Kraus M

    更新日期:2007-01-01 00:00:00

  • The failed renal transplant: in or out?

    abstract::With the increased number of renal transplants being performed in the United States, there are also increasing numbers of early and long-term allograft failures. Patients with failed allografts require reentry into the end-stage renal disease (ESRD) system. If an allograft is producing little in the way of morbidity, ...

    journal_title:Seminars in dialysis

    pub_type: 社论,评审

    doi:10.1111/j.1525-139X.2005.18306.x

    authors: Bennett WM

    更新日期:2005-05-01 00:00:00

  • Clinical features of patients undergoing hemodialysis with COVID-19.

    abstract::Hemodialysis patients are susceptible to coronavirus disease 2019 (COVID-19). The aim of this study was to describe the epidemiological, clinical characteristics, and mortality-related risk factors for those who undergoing hemodialysis with COVID-19. We conducted a retrospective study. A total of 49 hemodialysis patie...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章

    doi:10.1111/sdi.12928

    authors: Tian M,Li H,Yan T,Dai Y,Dong L,Wei H,Song X,Dong J,Cheng F,Li W

    更新日期:2020-10-29 00:00:00

  • Metastatic complications of bloodstream infections in hemodialysis patients.

    abstract::Bacteremia is a common infectious complication in hemodialysis patients. Metastatic sites of infection including infective endocarditis, vertebral osteomyelitis, spinal epidural abscess, and septic arthritis occur relatively frequently. These complications are associated with increased morbidity and mortality in hemod...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审

    doi:10.1111/sdi.12031

    authors: Lewis SS,Sexton DJ

    更新日期:2013-01-01 00:00:00

  • Comparison of peritoneal dialysis catheter insertion techniques by nephrologists: Surgical vs blind methods.

    abstract:BACKGROUND:The aim of the present study was to perform a comparative analysis of peritoneal dialysis catheter (PDC) insertion between blind and surgical methods by nephrologists. PATIENTS AND METHODS:The present study enrolled 249 peritoneal dialysis patients who received first-time PDC insertion. All PDC insertions w...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章

    doi:10.1111/sdi.12904

    authors: Kang SH,Park JW,Cho KH,Do JY

    更新日期:2020-07-23 00:00:00

  • Baxter Aurora dialysis system.

    abstract::With the recent focus on the benefits of more frequent dialysis, the Baxter Aurora dialysis system provides maximum flexibility for therapy prescription, including short daily treatments, long nocturnal treatments, hemodialysis, hemofiltration, and online hemodiafiltration, all in a compact, reliable, easy to use syst...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章

    doi:10.1111/j.0894-0959.2004.17215.x

    authors: Kelly TD

    更新日期:2004-03-01 00:00:00

  • Association between CRT(D)/ICD and renal insufficiency: A systematic review and meta-analysis.

    abstract::Cardiac resynchronization therapy with or without a defibrillator (CRT(D)) and implantable cardioverter defibrillator (ICD) may reduce the risk of arrhythmia or heart failure-specific mortality and improves the prognosis of patients with chronic kidney disease (CKD) or dialysis. The aim of this study was to perform a ...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审

    doi:10.1111/sdi.12937

    authors: Liu Y,Sun JY,Zhu YS,Li ZM,Li KL,Wang RX

    更新日期:2020-12-09 00:00:00

  • Role of parathyroid hormone and therapy with active vitamin D sterols in renal osteodystrophy.

    abstract::Renal osteodystrophy (ROD) represents a spectrum of bone lesions ranging from a high-turnover to a low-turnover state. The expression of the histologic bone lesions is modulated by parathyroid hormone (PTH), vitamin D, calcium, phosphorus, and aluminum that act as major regulators of osteoblastic activity and bone for...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审

    doi:10.1111/j.1525-139X.2005.18404.x

    authors: Hernandez JD,Wesseling K,Salusky IB

    更新日期:2005-07-01 00:00:00

  • Past, present, and future of quantified peritoneal dialysis.

    abstract::The role of peritoneal dialysis (PD) as a modality in renal replacement therapy has been well established. In this article we review various aspects in the evolution of PD, with special emphasis on adequacy. Until the late 1950s PD was still considered as a last resort in the treatment of terminal uremia. The introduc...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审

    doi:10.1046/j.1525-139x.2001.00071.x

    authors: Haq NU,Nolph KD

    更新日期:2001-07-01 00:00:00

  • Blood pressure control in conventional hemodialysis.

    abstract::Hypertension among patients on hemodialysis is common, difficult to diagnose and often inadequately controlled. Although specific blood pressure (BP) targets in this particular population are not yet established, meta-analyses of randomized trials showed that deliberate BP-lowering with antihypertensive drugs improves...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审

    doi:10.1111/sdi.12741

    authors: Georgianos PI,Agarwal R

    更新日期:2018-11-01 00:00:00

  • Diastolic heart failure in dialysis patients: mechanisms, diagnostic approach, and treatment.

    abstract::Heart failure (HF) is very common in the general population, and risk factors for HF, such as coronary artery disease, diabetes, obesity, and hypertension, are frequently present in patients with CKD. Therefore, HF is also an important cause of morbidity and mortality in this population. Diastolic heart failure (DHF),...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审

    doi:10.1111/j.1525-139X.2011.01011.x

    authors: Pecoits-Filho R,Bucharles S,Barberato SH

    更新日期:2012-01-01 00:00:00

  • Assessing the approach to a thrombosed AV graft.

    abstract::The patency of the vascular access (VA) is a fight for the attending nephrologist. A retrospective observational study was conducted to compare the success rate of surgical versus endovascular technique percutaneous transluminal angioplasty (PTA) for graft thrombosis treatment. Of 3008 patients, 22.1% patients were di...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章

    doi:10.1111/sdi.12189

    authors: Ponce P,Carvalho T,Messias H,Neves F,Lisbon VAC Interventional Nephrology Team.

    更新日期:2014-09-01 00:00:00

  • Intensive hemodialysis in the (nursing) home: the bright side of geriatric ESRD care?

    abstract::Elderly ESRD patients often lose functionality when they start dialysis, which may be due to a variety of clinical problems. We recently postulated that intensive (longer and/or more frequent) hemodialysis (HD) may be the ideal strategy to try to prevent these ESRD- and dialysis-related complications, including dialys...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章

    doi:10.1111/sdi.12011

    authors: Cornelis T,Kotanko P,Goffin E,van der Sande FM,Kooman JP,Chan CT

    更新日期:2012-11-01 00:00:00

  • Catheter thrombosis.

    abstract::Catheter malfunction due to poor flow is a common problem. When it occurs early, the cause is generally technical. Late occurrences are most often related to thrombus formation. Several types of thrombus may be seen, differing by location and supposed mechanism of formation. The most common offender, however, is the f...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审

    doi:10.1046/j.1525-139x.2001.00109.x

    authors: Beathard GA

    更新日期:2001-11-01 00:00:00

  • Mycotic aneurysms and death in a hemodialysis patient.

    abstract::A patient with newly diagnosed end-stage renal disease (ESRD) received a femoral catheter for hemodialysis (HD). Shortly thereafter he developed fever, and blood cultures grew methicillin-resistant Staphylococcus aureus. The catheter was removed and the patient was treated with both vancomycin and rifampin; however, b...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章

    doi:10.1111/j.1525-139X.2005.18323.x

    authors: Chang CS,Thajeb P,Chen HH,Wu CJ

    更新日期:2005-07-01 00:00:00