Abstract:
:Hypertension among patients on hemodialysis is common, difficult to diagnose and often inadequately controlled. Although specific blood pressure (BP) targets in this particular population are not yet established, meta-analyses of randomized trials showed that deliberate BP-lowering with antihypertensive drugs improves clinical outcomes in hemodialysis patients. BP-lowering in these individuals should initially utilize nonpharmacological strategies aiming to control sodium and volume overload. Accordingly, restricting dietary sodium intake, eliminating intradialytic sodium gain via individualized dialysate sodium prescription, optimally assessing and managing dry-weight and providing a sufficient duration of dialysis are first-line treatment considerations to control BP. If BP remains uncontrolled despite the adequate management of volume, antihypertensive therapy is the next consideration. Contrary to nonhemodialysis populations, emerging clinical-trial evidence suggests that among those on hemodialysis, β-blockers are more effective than agents blocking the renin-angiotensin-system (RAS) in reducing BP levels and protecting from serious adverse cardiovascular complications. Accordingly, β-blockade is our first-line approach in pharmacotherapy of hypertension. Long-acting calcium-channel-blockers and RAS-blockers are our next considerations, taking into account the comorbidities and the overall risk profile of each individual patient. Additional research efforts, mainly randomized trials, are clearly warranted in order to elucidate aspects of management that remain elusive in hypertensive dialysis patients.
journal_name
Semin Dialjournal_title
Seminars in dialysisauthors
Georgianos PI,Agarwal Rdoi
10.1111/sdi.12741subject
Has Abstractpub_date
2018-11-01 00:00:00pages
557-562issue
6eissn
0894-0959issn
1525-139Xjournal_volume
31pub_type
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journal_title:Seminars in dialysis
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journal_title:Seminars in dialysis
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更新日期:2015-03-01 00:00:00
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journal_title:Seminars in dialysis
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journal_title:Seminars in dialysis
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journal_title:Seminars in dialysis
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journal_title:Seminars in dialysis
pub_type: 杂志文章,评审
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更新日期:2009-07-01 00:00:00
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journal_title:Seminars in dialysis
pub_type: 杂志文章,评审
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更新日期:2016-01-01 00:00:00
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journal_title:Seminars in dialysis
pub_type: 杂志文章
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更新日期:2003-11-01 00:00:00
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journal_title:Seminars in dialysis
pub_type: 杂志文章
doi:10.1111/j.1525-139X.2007.00397.x
更新日期:2008-03-01 00:00:00
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journal_title:Seminars in dialysis
pub_type: 杂志文章
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更新日期:2006-03-01 00:00:00
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journal_title:Seminars in dialysis
pub_type: 杂志文章
doi:10.1111/sdi.12183
更新日期:2014-03-01 00:00:00
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journal_title:Seminars in dialysis
pub_type: 杂志文章,评审
doi:10.1111/sdi.12756
更新日期:2019-05-01 00:00:00
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journal_title:Seminars in dialysis
pub_type: 社论,评审
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更新日期:2014-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2004-01-01 00:00:00
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journal_title:Seminars in dialysis
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Seminars in dialysis
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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更新日期:2016-11-01 00:00:00
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journal_title:Seminars in dialysis
pub_type: 杂志文章,随机对照试验
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journal_title:Seminars in dialysis
pub_type: 杂志文章
doi:10.1111/j.1525-139X.2010.00788.x
更新日期:2010-11-01 00:00:00
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journal_title:Seminars in dialysis
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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更新日期:2020-12-09 00:00:00
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journal_title:Seminars in dialysis
pub_type: 杂志文章,评审
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更新日期:2018-05-01 00:00:00
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journal_title:Seminars in dialysis
pub_type: 社论
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