Sympathetic overactivity in dialysis patients-Underappreciated and clinically consequential.

Abstract:

:Cardiovascular morbidity and mortality remain frustratingly common in dialysis patients. A dearth of established evidence-based treatment calls for alternative therapeutic avenues to be embraced. Sympathetic hyperactivity, predominantly due to afferent nerve signaling from the diseased native kidneys, has been established to be prognostic in the dialysis population for over 15 years. Despite this, tangible therapeutic interventions have, to date, been unsuccessful and the outlook for patients remains poor. This narrative review summarizes established experimental and clinical data, highlighting recent developments, and proposes why interventions to ameliorate sympathetic hyperactivity may well be beneficial for this high-risk population.

journal_name

Semin Dial

journal_title

Seminars in dialysis

authors

Hoye NA,Wilson LC,Jardine DL,Walker RJ

doi

10.1111/sdi.12756

subject

Has Abstract

pub_date

2019-05-01 00:00:00

pages

255-265

issue

3

eissn

0894-0959

issn

1525-139X

journal_volume

32

pub_type

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