The association of hepatitis C infection with the onset of CKD and progression into ESRD.


:Hepatitis C virus (HCV) infection is not only an important cause of chronic liver disease, but extrahepatic manifestations are common and include chronic kidney disease (CKD). HCV is classically associated with cryoglobulinemic glomerulonephritis in the context of mixed cryoglobulinemia syndrome, but other glomerular diseases also occur and may be significantly under-recognized. HCV may cause glomerular disease by immune complex deposition; however, other potential mechanisms by which HCV promotes CKD include a direct cytopathic effect of the virus on renal tissue, and by its association with accelerated atherosclerosis, insulin resistance, and chronic inflammation. Epidemiologic studies show HCV infection confers an increased risk of incident CKD and accelerates progression of CKD to end-stage renal disease (ESRD) in the general population, as well as subpopulations including diabetic patients, those coinfected with human immunodeficiency virus (HIV), and kidney transplant recipients. Patients with CKD and HCV infection experience inferior clinical outcomes, including poorer quality of life and an increased risk of mortality. Treatment with interferon-based regimens is associated with decreased risk of incident CKD and ESRD, though prior studies are limited by the small number of patients with HCV and CKD who underwent treatment. With the advent of new, well-tolerated direct-acting antiviral combinations that are not cleared by the kidneys, it is possible to treat all genotypes of HCV infection in patients with CKD and ESRD. More data on the effect of direct-acting antivirals on CKD incidence and progression are necessary. However, there is every expectation that with improved access to HCV treatment, the burden of CKD in patients with HCV could significantly decline.


Semin Dial


Seminars in dialysis


Henson JB,Sise ME




Has Abstract


2019-03-01 00:00:00












  • Is there an established hemoglobin target range for patients undergoing chronic dialysis?

    abstract::Anemia is a common complication of advanced chronic kidney disease (CKD). Treatment with erythropoiesis-stimulating agents (ESAs) remains a common approach in managing anemia of CKD. The 2012 Kidney Disease Improving Global Outcomes Clinical Practice Guideline for Anemia in CKD suggests avoiding ESA therapy use to mai...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Shah HH,Fishbane S

    更新日期:2018-07-01 00:00:00

  • Consolidation in dialysis Markets-Causes, consequences, and the role of policy.

    abstract::The dialysis industry is one of the most highly concentrated healthcare sectors in the United States. Despite decades of growth in the number of patients with end-stage renal disease and in the size of dialysis markets, two large dialysis organizations currently care for more than two-thirds of the dialysis population...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章


    authors: Saeed MK,Ho V,Erickson KF

    更新日期:2020-01-01 00:00:00

  • Surface-area-normalized Kt/V: a method of rescaling dialysis dose to body surface area-implications for different-size patients by gender.

    abstract::Dialysis is measured as Kt/V, which scales the dose (Kt) to body water content (V). Scaling dialysis dose to body surface area (S(dub)) has been advocated, but the implications of such rescaling have not been examined. We developed a method of rescaling measured Kt/V to S(dub) and studied the effect of such alternativ...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章


    authors: Daugirdas JT,Depner TA,Greene T,Kuhlmann MK,Levin NW,Chertow GM,Rocco MV

    更新日期:2008-09-01 00:00:00

  • Tunneled Hemodialysis Catheter Removals by Non-Interventional Nephrologists: The University of Mississippi Experience.

    abstract::Bedside removal of tunneled hemodialysis catheters (TDC) by noninterventional Nephrologists has not been frequently performed or studied. We performed a retrospective review of bedside TDC removal at the University of Mississippi Medical Center between January, 2010 and June, 2013. We collected data on multiple patien...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章


    authors: Fülöp T,Rodríguez B,Kosztaczky BA,Gharaibeh KA,Lengvárszky Z,Dossabhoy NR,Tapolyai MB

    更新日期:2015-09-01 00:00:00

  • Sonography of Arteriovenous Fistulas and Grafts.

    abstract::Arteriovenous fistulas (AVFs) and arteriovenous grafts (AVGs) are the vascular accesses of choice for long-term hemodialysis. Strategies to establish and maintain functioning AVFs and AVGs are essential. In addition to clinical evaluation, ultrasound plays a critical role in the evaluation and maintenance of AVFs and ...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Pietryga JA,Little MD,Robbin ML

    更新日期:2017-07-01 00:00:00

  • The pathogenesis of hemodialysis vascular access failure and systemic therapies for its prevention: Optimism unfulfilled.

    abstract::In patients receiving hemodialysis, the provision of safe and effective vascular access using an arteriovenous fistula or graft is regarded as a critical priority by patients and health professionals. Vascular access failure is associated with morbidity and mortality, such that strategies to prevent these outcomes are...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Viecelli AK,Mori TA,Roy-Chaudhury P,Polkinghorne KR,Hawley CM,Johnson DW,Pascoe EM,Irish AB

    更新日期:2018-05-01 00:00:00

  • Iatrogenic Baclofen Neurotoxicity in ESRD: Recognition and Management.

    abstract::Baclofen is an oral derivative of gamma-aminobutyric acid (GABA) used to treat muscular spasticity from disorders of the central nervous system. However, it is also being used for a variety of other conditions such as musculoskeletal pain, myoclonus, and alcohol withdrawal. The elimination of baclofen is heavily depen...

    journal_title:Seminars in dialysis

    pub_type: 信件


    authors: Roberts JK,Westphal S,Sparks MA

    更新日期:2015-09-01 00:00:00

  • Intensive hemodialysis in the (nursing) home: the bright side of geriatric ESRD care?

    abstract::Elderly ESRD patients often lose functionality when they start dialysis, which may be due to a variety of clinical problems. We recently postulated that intensive (longer and/or more frequent) hemodialysis (HD) may be the ideal strategy to try to prevent these ESRD- and dialysis-related complications, including dialys...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章


    authors: Cornelis T,Kotanko P,Goffin E,van der Sande FM,Kooman JP,Chan CT

    更新日期:2012-11-01 00:00:00

  • Mycotic aneurysms and death in a hemodialysis patient.

    abstract::A patient with newly diagnosed end-stage renal disease (ESRD) received a femoral catheter for hemodialysis (HD). Shortly thereafter he developed fever, and blood cultures grew methicillin-resistant Staphylococcus aureus. The catheter was removed and the patient was treated with both vancomycin and rifampin; however, b...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章


    authors: Chang CS,Thajeb P,Chen HH,Wu CJ

    更新日期:2005-07-01 00:00:00

  • We Use Heparin as the Anticoagulant for CRRT.

    abstract::Continuous Renal Replacement Therapy (CRRT) usually requires anticoagulation to prevent clotting of the extracorporeal circuit. Interruptions due to filter clotting significantly reduce total therapy time and CRRT efficacy. Although heparin has traditionally been the most common anticoagulant used for CRRT, increasing...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章


    authors: Karakala N,Tolwani A

    更新日期:2016-07-01 00:00:00

  • Withholding and withdrawing renal support in acute kidney injury.

    abstract::Management of critically ill patients with acute kidney injury (AKI) is mainly limited to supportive therapy, with dialysis as one of the main components. Whether or not to offer dialysis and when to withdraw dialysis is a one of the many choices physicians face in daily clinical practice. Withholding or withdrawing r...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Claure-Del Granado R,Mehta RL

    更新日期:2011-03-01 00:00:00

  • Is surgical salvage of arteriovenous grafts feasible after unsuccessful percutaneous mechanical thrombectomy?

    abstract::Treatment of thrombosed dialysis ateriovenous (AV) grafts in the radiology interventional suite requires percutaneous mechanical thrombectomy, along with angioplasty of the underlying stenotic lesion. We analyzed the anatomic reasons for unsuccessful percutaneous thrombectomy of AV grafts, and assessed the feasibility...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章


    authors: Maya ID,Smith T,Young CJ,Allon M

    更新日期:2008-03-01 00:00:00

  • We Do Too Many Parathyroidectomies for Calciphylaxis.

    abstract::Calciphylaxis, a disorder of dermal arteriolar calcification with a distinct predilection for patients with advanced kidney disease, remains an enigmatic condition that challenges clinicians. Observations regarding positive associations between levels of circulating parathyroid hormone (PTH) and the risk of calciphyla...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章


    authors: Nigwekar SU,Sprague SM

    更新日期:2016-07-01 00:00:00

  • Management of hyperkalemia in dialysis patients.

    abstract::Hyperkalemia is common in patients with end-stage renal disease, and may result in serious electrocardiographic abnormalities. Dialysis is the definitive treatment of hyperkalemia in these patients. Intravenous calcium is used to stabilize the myocardium. Intravenous insulin and nebulized albuterol lower serum potassi...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Putcha N,Allon M

    更新日期:2007-09-01 00:00:00

  • We Wait Too Long to Refer Patients for Transplantation.

    abstract::Late referral of patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD) for evaluation of kidney transplantation is common. Even though renal transplantation offers a clear survival benefit to patients with advanced CKD and ESRD and should be considered the renal replacement therapy of choice, n...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章


    authors: Peev V

    更新日期:2016-07-01 00:00:00

  • Oral iron for patients receiving dialysis: what is the evidence?

    abstract::This review aims to summarize the available evidence of the effectiveness of oral iron in patients receiving dialysis. Four small randomized controlled trials (105 evaluated patients) compared oral iron supplements with placebo or no treatment; hemoglobin and ferritin levels did not differ significantly between groups...

    journal_title:Seminars in dialysis

    pub_type: 社论,评审


    authors: Hodson EM,Craig JC

    更新日期:2014-01-01 00:00:00

  • Niacin and related compounds for treating hyperphosphatemia in dialysis patients.

    abstract::Recent experimental and clinical studies suggest the possible utility of niacin (nicotinic acid, vitamin B3) and its metabolite nicotinamide as a means of lowering phosphate levels in dialysis patients via direct inhibition of the Na-Pi-2b sodium-dependent phosphate co-transporter in the GI tract. While the possibilit...

    journal_title:Seminars in dialysis

    pub_type: 社论


    authors: Berns JS

    更新日期:2008-05-01 00:00:00

  • We Underdose Antibiotics in Patients on CRRT.

    abstract::Appropriate antibiotic dosing in critically ill, infected, patients receiving continuous renal replacement therapy (CRRT) is crucial to improve patient outcomes. Severe sepsis and septic shock result in changes in pharmacokinetic parameters, including increased volume of distribution, hypoalbuminemia, and changes in r...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Shaw AR,Chaijamorn W,Mueller BA

    更新日期:2016-07-01 00:00:00

  • Experimental studies on computed tomographic peritoneography. Peritoneal and residual renal function tolerance to iodinated contrast media injected into the peritoneal cavity.

    abstract::Computed tomographic (CT) peritoneography has been widely used as reference standard to evaluate continuous ambulatory peritoneal dialysis-related complications. However, given the varying CT peritoneography approaches used across different institutions, there is no standard value for non-ionic iodinated contrast medi...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章


    authors: Bai J,Dong J,Shu J,Xu Y,Ding W,Chen J

    更新日期:2020-03-01 00:00:00

  • Hyperkalemia in hemodialysis patients.

    abstract::Hyperkalemia contributes significantly to high mortality among ESRD patients. Excess intake and inadequate removal are the most common etiologies in HD patients. Although dialysis is the definitive treatment, classical medical therapy must be employed as a temporizing measure to acutely lower serum potassium. Reducing...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Pani A,Floris M,Rosner MH,Ronco C

    更新日期:2014-11-01 00:00:00

  • How I do it: directional atherectomy for in-stent restenosis of a PTFE arteriovenous graft.

    abstract::We describe the use of directional atherectomy (DA) to restore patency of a thrombosed polytetrafluoroethylene arteriovenous graft with an in-stent restenosis at the venous anastomosis. Technically, the procedure described is not an atherectomy per se, but rather the removal of fibrosis and intimal hyperplasia with sh...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章


    authors: Yevzlin AS,Guttormsen B,Chan MR,Gimelli G

    更新日期:2008-05-01 00:00:00

  • Doppler ultrasound: a powerful tool for vascular access surveillance.

    abstract::National Kidney Foundation Kidney Disease Outcomes Quality Initiative (NKF KDOQI) guidelines recommend Doppler ultrasound (DU) for surveillance of vascular access (VA), but trials have not been unanimous about its benefit on VA patency. The aim of this study was to evaluate the accuracy of DU for patency, as well as t...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章


    authors: Guedes Marques M,Ibeas J,Botelho C,Maia P,Ponce P

    更新日期:2015-03-01 00:00:00

  • Management of the Dialysis Patient with Sickle Cell Disease.

    abstract::While patients with sickle cell disease currently constitute a very small minority of the US dialysis population (0.1%), there is anticipated growth of this group as the life expectancy of those with sickle cell disease (SCD) increases. SCD patients suffer a high burden of morbidity, which is enhanced by the presence ...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Boyle SM,Jacobs B,Sayani FA,Hoffman B

    更新日期:2016-01-01 00:00:00

  • Changing dialysate composition to optimize acid-base therapy.

    abstract::In response to rapid alkali delivery during hemodialysis, hydrogen ions (H+ ) are mobilized from body buffers and from stimulation of organic acid production in amounts sufficient to convert most of the delivered bicarbonate to CO2 and water. Release of H+ from nonbicarbonate buffers serves to back-titrate them to a m...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Sargent JA,Marano M,Marano S,Gennari FJ

    更新日期:2019-05-01 00:00:00

  • Temperature control by the blood temperature monitor.

    abstract::The rationale of temperature control during hemodialysis (HD) is to prevent heat accumulation, which increases body temperature and enhances hypotensive susceptibility. Treatments where thermal energy is neither delivered nor removed from the patient through the extracorporeal circulation (so-called extracorporeal the...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Schneditz D,Ronco C,Levin N

    更新日期:2003-11-01 00:00:00

  • Hemodialysis for the treatment of severe accidental hypothermia.

    abstract::Severe hypothermia is defined as a core body temperature <28°C and is associated with in-hospital mortality rates of 50% or higher. Delays in rewarming and slower rates of rewarming are the most important prognostic factors associated with increased mortality. Arrhythmias are the most common cause of mortality in pati...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章


    authors: Singh T,Hallows KR

    更新日期:2014-05-01 00:00:00

  • Cardiovascular adaptations associated with exercise in patients on hemodialysis.

    abstract::Patients on hemodialysis are physically inactive. Less than 50% of hemodialysis patients undertake exercise once a week and such patients have increased mortality compared to patients who undertake regular exercise. The reasons for physical inactivity and reduced functional capacity are complex and inter-related, with...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Graham-Brown MPM,Jardine MJ,Burton JO

    更新日期:2019-07-01 00:00:00

  • Antidiabetic Therapy in End-Stage Renal Disease.

    abstract::There has been substantial growth in the variety of available antidiabetic agents during the last decade and a half. The role of these newer agents in patients with diabetes and end-stage renal disease (ESRD) population, and their relative benefits and risks in this population compared to patients without ESRD are not...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Boyle SM,Simon B,Kobrin SM

    更新日期:2015-07-01 00:00:00

  • ESRD-induced dyslipidemia-Should management of lipid disorders differ in dialysis patients?

    abstract::Cardiovascular disease (CVD) is a major cause of morbidity and mortality worldwide. Although numerous modifiable risk factors in the pathogenesis of CVD and its associated mortality have been identified, dyslipidemia remains to be a key focus for therapy. In this regard, significant progress has been made in reducing ...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Moradi H,Streja E,Vaziri ND

    更新日期:2018-07-01 00:00:00

  • The effect of chronic renal failure on hepatic drug metabolism and drug disposition.

    abstract::There is abundant evidence that chronic renal failure (CRF) and end-stage renal disease (ESRD) alter drug disposition by affecting protein and tissue binding and reducing systemic clearance of renally cleared drugs. What is not fully appreciated is that CRF can significantly reduce nonrenal clearance and alter the bio...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Dreisbach AW,Lertora JJ

    更新日期:2003-01-01 00:00:00