Lipid abnormalities associated with end-stage renal disease.


:Patients undergoing chronic renal replacement therapy have a high incidence of dyslipidemia. In general, there are increased concentrations of triglyceride-rich apolipoprotein B-containing particles. These elevations lead to increased levels of non-high-density lipoprotein (HDL) levels. This pattern is further modified by the method of dialysis (peritoneal versus hemodialysis) and comorbidities such as diabetes. End-stage renal disease patients also demonstrate increased levels of lipoprotein(a) (Lp(a)) and oxidized low-density lipoprotein (LDL)both of which are highly atherogenic. This review focuses on the pathogenesis of these lipid abnormalities and their role in the atherosclerotic process.


Semin Dial


Seminars in dialysis


Liu J,Rosner MH




Has Abstract


2006-01-01 00:00:00














  • How I do it: endovascular treatment of arteriovenous graft pseudoaneurysms-watch out for the mouth.

    abstract::We present a case of arteriovenous graft pseudoaneurysms treated endovascularly with stent grafts and make suggestions regarding the technique of evaluating the pseudoaneurysms and choosing the proper location to deploy the stent grafts to maximize the outcomes and minimize the length of the graft covered by the stent...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章


    authors: Florescu MC,Fillaus JA,Plumb TJ

    更新日期:2014-03-01 00:00:00

  • Vancomycin use in patients requiring hemodialysis: a literature review.

    abstract::Vancomycin, a glycopeptide antibiotic, has remained a popular antimicrobial agent throughout the past five decades, and is often included in empiric antibiotic regimens. With gram-positive coverage, it has found a niche in the treatment of methicillin-resistant Staphylococcus aureus. Although vancomycin has been in ex...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Pallotta KE,Manley HJ

    更新日期:2008-01-01 00:00:00

  • Role of parathyroid hormone and therapy with active vitamin D sterols in renal osteodystrophy.

    abstract::Renal osteodystrophy (ROD) represents a spectrum of bone lesions ranging from a high-turnover to a low-turnover state. The expression of the histologic bone lesions is modulated by parathyroid hormone (PTH), vitamin D, calcium, phosphorus, and aluminum that act as major regulators of osteoblastic activity and bone for...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Hernandez JD,Wesseling K,Salusky IB

    更新日期:2005-07-01 00:00:00

  • Ultrapure dialysate.

    abstract::To prevent pyrogenic reactions during hemodialysis, it is recommended that bacteria and endotoxin in dialysate not exceed 100-200 colony forming units (CFU)/ml and 0.25-2 endotoxin units (EU)/ml, respectively. While these limits are adequate to prevent acute pyrogenic reactions, data are accumulating to suggest they m...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Ward RA

    更新日期:2004-11-01 00:00:00

  • Extracorporeal treatment for tricyclic antidepressant poisoning: recommendations from the EXTRIP Workgroup.

    abstract::The Extracorporeal Treatments In Poisoning (EXTRIP) workgroup was formed to provide recommendations on the use of extracorporeal treatments (ECTR) in poisoning. Here, the workgroup presents its results for tricyclic antidepressants (TCAs). After an extensive literature search, using a predefined methodology, the subgr...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Yates C,Galvao T,Sowinski KM,Mardini K,Botnaru T,Gosselin S,Hoffman RS,Nolin TD,Lavergne V,Ghannoum M,EXTRIP workgroup.

    更新日期:2014-07-01 00:00:00

  • Highlights and hotspots of protein glycation in end-stage renal disease.

    abstract::Analysis of tissues, plasma, urine, other body fluids, and dialysate for glycation adducts has revealed the presence of two major forms: glycation adduct residues of proteins and related glycated amino acids--called glycation free adducts. The major effect on protein glycation in uremia is loss of clearance of glycati...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Thornalley PJ,Rabbani N

    更新日期:2009-07-01 00:00:00

  • We Do Too Many Parathyroidectomies for Calciphylaxis.

    abstract::Calciphylaxis, a disorder of dermal arteriolar calcification with a distinct predilection for patients with advanced kidney disease, remains an enigmatic condition that challenges clinicians. Observations regarding positive associations between levels of circulating parathyroid hormone (PTH) and the risk of calciphyla...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章


    authors: Nigwekar SU,Sprague SM

    更新日期:2016-07-01 00:00:00

  • Accuracy of ultrasound in the detection of inflow stenosis of arteriovenous fistulae: results of a prospective study.

    abstract::While vascular ultrasound (US) has been highlighted to detect vascular access stenosis, its accuracy in the identification of inflow stenosis (IS) (anastomosis and/or juxta-anastomotic area) compared with the gold standard (angiography) has not been evaluated. One hundred three consecutive fistulae referred for interv...

    journal_title:Seminars in dialysis

    pub_type: 临床试验,杂志文章


    authors: Salman L,Ladino M,Alex M,Dhamija R,Merrill D,Lenz O,Contreras G,Asif A

    更新日期:2010-01-01 00:00:00

  • Similar outcomes of catheters implanted by nephrologists and surgeons: analysis of the Brazilian peritoneal dialysis multicentric study.

    abstract::A good catheter implantation technique is important to allow for effective peritoneal access function and long-term technique survival. Studies regarding results obtained by nephrologists in comparison with surgeons have been limited to small single-center experiences. Thus, the objective of this study was to explore ...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,多中心研究


    authors: de Moraes TP,Campos RP,de Alcântara MT,Chula D,Vieira MA,Riella MC,Olandowski M,Divino-Filho JC,Pecoits-Filho R,Investigators of BRAZPD.

    更新日期:2012-09-01 00:00:00

  • We Wait Too Long to Refer Patients for Transplantation.

    abstract::Late referral of patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD) for evaluation of kidney transplantation is common. Even though renal transplantation offers a clear survival benefit to patients with advanced CKD and ESRD and should be considered the renal replacement therapy of choice, n...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章


    authors: Peev V

    更新日期:2016-07-01 00:00:00

  • Sympathetic overactivity in dialysis patients-Underappreciated and clinically consequential.

    abstract::Cardiovascular morbidity and mortality remain frustratingly common in dialysis patients. A dearth of established evidence-based treatment calls for alternative therapeutic avenues to be embraced. Sympathetic hyperactivity, predominantly due to afferent nerve signaling from the diseased native kidneys, has been establi...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Hoye NA,Wilson LC,Jardine DL,Walker RJ

    更新日期:2019-05-01 00:00:00

  • Long-term outcomes and management considerations after parathyroidectomy in the dialysis patient.

    abstract::Parathyroidectomy (PTX) remains an important intervention for dialysis patients with poorly controlled secondary hyperparathyroidism (SHPT), though there are only retrospective and observational data that show a mortality benefit to this procedure. Potential consequences that we seek to avoid after PTX include persist...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Kakani E,Sloan D,Sawaya BP,El-Husseini A,Malluche HH,Rao M

    更新日期:2019-11-01 00:00:00

  • Treatment of nephrogenic systemic fibrosis: limited options but hope for the future.

    abstract::Nephrogenic systemic fibrosis has now been linked to gadolinium-based contrast exposure in those with compromised kidney function. When present, symptoms can be quite devastating for the patient including severe pain and immobility. Unfortunately there is a lack of a universally effective therapy at this time and the ...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Linfert DR,Schell JO,Fine DM

    更新日期:2008-03-01 00:00:00

  • Sonography of Arteriovenous Fistulas and Grafts.

    abstract::Arteriovenous fistulas (AVFs) and arteriovenous grafts (AVGs) are the vascular accesses of choice for long-term hemodialysis. Strategies to establish and maintain functioning AVFs and AVGs are essential. In addition to clinical evaluation, ultrasound plays a critical role in the evaluation and maintenance of AVFs and ...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Pietryga JA,Little MD,Robbin ML

    更新日期:2017-07-01 00:00:00

  • Withholding and withdrawing renal support in acute kidney injury.

    abstract::Management of critically ill patients with acute kidney injury (AKI) is mainly limited to supportive therapy, with dialysis as one of the main components. Whether or not to offer dialysis and when to withdraw dialysis is a one of the many choices physicians face in daily clinical practice. Withholding or withdrawing r...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Claure-Del Granado R,Mehta RL

    更新日期:2011-03-01 00:00:00

  • Role of leptin in reverse epidemiology in chronic kidney disease.

    abstract::Leptin is mainly produced by adipocytes and metabolized in the kidney. Leptin is taken up into the central nervous system by a saturable transport system, and controls appetite in rodents and in healthy subjects. Leptin acts on peripheral tissue and increases the inflammatory response by stimulating the production of ...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Scholze A,Tepel M

    更新日期:2007-11-01 00:00:00

  • The Use of Calcimimetics for the Treatment of Secondary Hyperparathyroidism: A 10 Year Evidence Review.

    abstract::Until the discovery of calcimimetics, the management of secondary hyperparathyroidism (SHPT) relied exclusively on treatment with phosphate binders, vitamin D derivatives or surgical parathyroidectomy with limited success. The therapeutic use of calcimimetic agents, together with a better understanding of the pivotal ...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Rodríguez M,Goodman WG,Liakopoulos V,Messa P,Wiecek A,Cunningham J

    更新日期:2015-09-01 00:00:00

  • Temperature control by the blood temperature monitor.

    abstract::The rationale of temperature control during hemodialysis (HD) is to prevent heat accumulation, which increases body temperature and enhances hypotensive susceptibility. Treatments where thermal energy is neither delivered nor removed from the patient through the extracorporeal circulation (so-called extracorporeal the...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Schneditz D,Ronco C,Levin N

    更新日期:2003-11-01 00:00:00

  • We Underdose Antibiotics in Patients on CRRT.

    abstract::Appropriate antibiotic dosing in critically ill, infected, patients receiving continuous renal replacement therapy (CRRT) is crucial to improve patient outcomes. Severe sepsis and septic shock result in changes in pharmacokinetic parameters, including increased volume of distribution, hypoalbuminemia, and changes in r...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Shaw AR,Chaijamorn W,Mueller BA

    更新日期:2016-07-01 00:00:00

  • Anemia management in cancer patients with chronic kidney disease.

    abstract::Cancer and kidney disease are linked by causality and comorbidities. Observational data show an increased risk of malignancy as renal function declines. Erythropoietin stimulating agents (ESAs), which are the cornerstone therapy for anemia patients with chronic kidney disease and cancer, are associated with increased ...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Latcha S

    更新日期:2019-11-01 00:00:00

  • Platelet dysfunction and end-stage renal disease.

    abstract::Patients with end-stage renal disease (ESRD) develop hemostatic disorders mainly in the form of bleeding diatheses. Hemorrhage can occur at cutaneous, mucosal, or serosal sites. Retroperitoneal or intracranial hemorrhages also occur. Platelet dysfunction is the main factor responsible for hemorrhagic tendencies in adv...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Kaw D,Malhotra D

    更新日期:2006-07-01 00:00:00

  • Dialysis membrane and modality in acute renal failure: understanding discordant meta-analyses.

    abstract::Meta-analyses of the published literature are increasingly being used, allowing similar clinical trials to be combined quantitatively, thereby increasing the precision of the estimation of treatment effect. Four meta-analyses were recently published comparing the impact of dialysis membranes or dialysis modality on cl...

    journal_title:Seminars in dialysis

    pub_type: 社论,评审


    authors: Teehan GS,Liangos O,Lau J,Levey AS,Pereira BJ,Jaber BL

    更新日期:2003-09-01 00:00:00

  • Alternate night nocturnal hemodialysis: the Australian experience.

    abstract::Alternate night nocturnal hemodialysis (HD) is a popular modality in Australia. This modality grew out of a desire to increase the availability and accessibility of nocturnal HD without incurring excessive costs. It has proven popular with staff, patients, and administrators. There are limited data to support the bene...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章


    authors: Kerr PG,Agar JW,Hawley CM

    更新日期:2011-11-01 00:00:00

  • Hyperhomocysteinemia in uremia--a red flag in a disrupted circuit.

    abstract::Hyperhomocysteinemia is an independent cardiovascular risk factor, according to most observational studies and to studies using the Mendelian randomization approach, utilizing the common polymorphism C677T of methylene tetrahydrofolate reductase. In contrast, the most recent secondary preventive intervention studies, ...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Perna AF,Ingrosso D,Violetti E,Luciano MG,Sepe I,Lanza D,Capasso R,Ascione E,Raiola I,Lombardi C,Stenvinkel P,Massy Z,De Santo NG

    更新日期:2009-07-01 00:00:00

  • Identification of facilitators and barriers to home dialysis selection by canadian adults with ESRD.

    abstract::Home dialysis (home HD or home PD) remains underutilized in most jurisdictions. Physicians, advanced-practice nurses, and policy makers working with chronic kidney disease populations can provide insights into patient, healthcare professional, and system-level barriers to home dialysis selection by suitable patients. ...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章


    authors: Osterlund K,Mendelssohn D,Clase C,Guyatt G,Nesrallah G

    更新日期:2014-03-01 00:00:00

  • Doppler ultrasound: a powerful tool for vascular access surveillance.

    abstract::National Kidney Foundation Kidney Disease Outcomes Quality Initiative (NKF KDOQI) guidelines recommend Doppler ultrasound (DU) for surveillance of vascular access (VA), but trials have not been unanimous about its benefit on VA patency. The aim of this study was to evaluate the accuracy of DU for patency, as well as t...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章


    authors: Guedes Marques M,Ibeas J,Botelho C,Maia P,Ponce P

    更新日期:2015-03-01 00:00:00

  • Dialysis vascular access management by interventional nephrology programs at University Medical Centers in the United States.

    abstract::The development of interventional nephrology has undoubtedly led to an improvement in patient care at many facilities across the United States. However, these services have traditionally been offered by interventional nephrologists in the private practice arena. While interventional nephrology was born in the private ...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章


    authors: Vachharajani TJ,Moossavi S,Salman L,Wu S,Dwyer AC,Ross J,Dukkipati R,Maya ID,Yevzlin AS,Agarwal A,Abreo KD,Work J,Asif A

    更新日期:2011-09-01 00:00:00

  • Iatrogenic Baclofen Neurotoxicity in ESRD: Recognition and Management.

    abstract::Baclofen is an oral derivative of gamma-aminobutyric acid (GABA) used to treat muscular spasticity from disorders of the central nervous system. However, it is also being used for a variety of other conditions such as musculoskeletal pain, myoclonus, and alcohol withdrawal. The elimination of baclofen is heavily depen...

    journal_title:Seminars in dialysis

    pub_type: 信件


    authors: Roberts JK,Westphal S,Sparks MA

    更新日期:2015-09-01 00:00:00

  • Euvolemia-A critical target in the management of acute kidney injury.

    abstract::It has been clearly established that critically ill patients with sepsis require prompt fluid resuscitation. The optimal amount of fluid and when to taper this resuscitation is less clear. There is a growing evidence that fluid overload leads to acute kidney injury, and increased morbidity and mortality. A clinician's...

    journal_title:Seminars in dialysis

    pub_type: 社论,评审


    authors: Colbert GB,Szerlip HM

    更新日期:2019-01-01 00:00:00

  • Influence of temporal variation in wall shear stress on intima-media thickening in arteriovenous fistulae.

    abstract::Arteriovenous fistula (AVF) failure is mainly due to venous stenosis characterized by significant amount of intima-media thickening (IMT), probably in the presence of negative (inward) remodeling. Our hypothesis is that the longitudinal changes in wall shear stress (WSS) within different configurations of AVF can infl...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章


    authors: Rajabi-Jagahrgh E,Krishnamoorthy MK,Wang Y,Choe A,Roy-Chaudhury P,Banerjee RK

    更新日期:2013-07-01 00:00:00