Abstract:
:Cardiovascular disease is a leading cause of mortality among patients with diabetes, and heart failure exists even in the absence of coronary disease. Myocardial metabolism is altered in the diabetic heart as a result of changes in substrate availability secondary to insulin resistance. The nuclear receptor peroxisome proliferator activated receptor-alpha (PPARα) and PPAR-gamma coactivator-1alpha (PGC-1α) play important roles in transcriptional regulation of myocardial metabolism and contribute significantly to the changes that occur in the diabetic heart. This review summarizes the role of PPARα and PGC-1α in myocardial metabolism in the normal heart and in the diabetic heart.
journal_name
Pediatr Cardioljournal_title
Pediatric cardiologyauthors
Duncan JGdoi
10.1007/s00246-011-9889-8subject
Has Abstractpub_date
2011-03-01 00:00:00pages
323-8issue
3eissn
0172-0643issn
1432-1971journal_volume
32pub_type
杂志文章,评审abstract::Plastic bronchitis (PB) is a poorly understood disease that can complicate any underlying pulmonary disease. However, it appears to most often occur in patients with surgically palliated congenital heart disease, particularly after the Fontan procedure. Few data exist about the prevalence and etiology of PB in this po...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-012-0430-5
更新日期:2013-02-01 00:00:00
abstract::A 2100-g neonate underwent a two-ventricular surgical repair of a right ventricle-dominant unbalanced atrioventricular septal defect associated with the heterotaxy syndrome and sinus node dysfunction. Postoperative congestive heart failure persisted despite bradycardia management by temporary ventricular pacing. Spect...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s002469900446
更新日期:1999-05-01 00:00:00
abstract::This study aimed to clarify the characteristics of pulmonary arterial resistance (Rp)-compliance (Cp) coupling in individuals with Down syndrome (DS), who have increased risks of pulmonary arterial hypertension (PAH). We performed cardiac catheterization before and after corrective surgery in 85 DS infants and 85 cont...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-019-02080-9
更新日期:2019-04-01 00:00:00
abstract::Cardiopulmonary bypass (CPB) reduces coagulation factor levels through hemodilution and consumption. Differences in CPB-induced alterations of factor XIII (FXIII) levels in children with cyanotic and acyanotic congenital heart defects (CHDs) are not well characterized. FXIII activity (determined by Berichrom assay), p...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-014-0903-9
更新日期:2014-10-01 00:00:00
abstract::Exercise testing can highlight repolarisation abnormalities in adults with coronary artery disease. Late after Kawasaki disease (KD), increased QT dispersion (QTd) has been reported on resting ECG in children, but there are no reported studies of QTd during exercise. Our objective was to determine the pattern of QTd r...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-012-0201-3
更新日期:2012-06-01 00:00:00
abstract::A 4-year-old girl had the insidious onset of congestive heart failure without apparent cause. Evaluation by echocardiography, thallous chloride TI 201 scintigraphy, and angiography suggested the presence of either a neoplasm or restrictive cardiomyopathy with a localized mass effect on the left ventricle. Pathological...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/BF02312963
更新日期:1982-01-01 00:00:00
abstract::Contrary to acquired arteriovenous fistulas, the congenital malformations are very rare. Here we report a case of congenital arteriovenous fistula forming a communication between the right subclavian artery to subclavian vein. To our knowledge, there is no similar case in which an infant has been successfully operated...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s002460010056
更新日期:2000-05-01 00:00:00
abstract::Nesiritide is a synthetic form of B-type natriuretic peptide. It is approved for the treatment of acute exacerbations of congestive heart failure in hospitalized adult patients. It is currently under investigation for use in other settings and other patient populations. This article describes administration of nesirit...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-006-0064-6
更新日期:2007-05-01 00:00:00
abstract::Fetal echocardiography has impacted the fetus with congenital heart disease in many important ways. Advances in fetal echocardiography have allowed for more accurate and earlier detection of cardiac abnormalities. In turn, the prenatal diagnosis of cardiac abnormalities has improved the care and outcome of selected fe...
journal_title:Pediatric cardiology
pub_type: 杂志文章,评审
doi:10.1007/s00246-003-0593-1
更新日期:2004-05-01 00:00:00
abstract::Inferior sinus venosus defects (SVDs) are rare imperfections located in the inferior portion of the atrial septum, leading to an overriding inferior vena cava (IVC) and an interatrial connection. These defects have increased risk of anomalous pulmonary venous return (PAPVR) and often are confused with secundum atrial ...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-012-0449-7
更新日期:2013-02-01 00:00:00
abstract::Congenitally corrected transposition of the great arteries is a rare anomaly that is thought to arise from a defect in looping of the primitive cardiac tube. Cor triatriatum is another rare congenital cardiac anomaly due to faulty incorporation of the common pulmonary vein into the left atrium. We present a rare case ...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-011-9912-0
更新日期:2011-04-01 00:00:00
abstract::Computed tomographic angiography (CTA) and cardiac catheterization are useful adjuncts to echocardiography for delineating cardiovascular anatomy in pediatric patients. These studies require ionizing radiation, and it is paramount to understand the amount of radiation pediatric patients receive when these tests are pe...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-012-0486-2
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND:This study applied tissue Doppler imaging and color tissue Doppler imaging to study atrial function changes in patients with hypertrophic cardiomyopathy (HCM). The profile of the segmental atrial velocities and the strain rate were determined and compared with those of normal matched control subjects. METHO...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-007-9112-0
更新日期:2008-03-01 00:00:00
abstract::An atrial septal aneurysm (ASA) is an increasingly recognized entity that involves septal tissue significantly bulging into either atria instead of remaining in a relatively neutral position. ASAs may be described based on the length of the segment of atrial septal tissue involved as well as the distance and direction...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-018-2017-2
更新日期:2019-01-01 00:00:00
abstract::Congenital diverticulum of the ventricle is a rare disease, but most cases of congenital left ventricular diverticula are asymptomatic. We present a child with congenital left ventricular diverticulum whose routine electrocardiographic examination showed T-wave inversion in inferior and V4 to V6 leads. He was successf...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-010-9719-4
更新日期:2010-08-01 00:00:00
abstract::Coronary artery fistula (CAF) is a rare congenital anomaly that can be complicated by endocarditis, myocardial infarction, or coronary aneurysms. This article reviews the clinical characteristics and surgical outcome of 10 patients with CAF in Rajae Heart Center. From 1990 to 2000, 10 patients (age, 6 months to 15 yea...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-004-0656-y
更新日期:2005-07-01 00:00:00
abstract::Radiation exposure from pediatric cardiac catheterization may be substantial, although published estimates vary. We sought to report patient radiation dose across a range of diagnostic and interventional cases in a modern, high-volume pediatric catheterization laboratory. We retrospectively reviewed diagnostic and int...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-014-0869-7
更新日期:2014-06-01 00:00:00
abstract::Percutaneous balloon aortic valvuloplasty was attempted in an eight-month-old infant with severe aortic valve stenosis. The procedure resulted in a fall in the resting transvalvular systolic pressure gradient from 106 mmHg to 40 mmHg and no aortic regurgitation. Clinical and Doppler echocardiography findings suggest p...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/BF02282747
更新日期:1985-01-01 00:00:00
abstract::Anomalous origin of left pulmonary artery (ALPA) from aorta with atrial septal defect (ASD) is a rare congenital cardiac malformation. We report a case of ALPA from the aorta with ASD in a 1.8-kg baby. Repair was needed at an early age due to progressive congestive heart failure. Surgical correction was performed with...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-008-9234-z
更新日期:2008-07-01 00:00:00
abstract::In this article we report the first case of Q fever endocarditis in a 13 years old child with a percutaneous pulmonary Melody® valve. The patient had a new onset of Melody valve dysfunction associated with the combination of hepatosplenomegaly and pancytopenia but was afebrile. Although blood cultures were negative, w...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-017-1723-5
更新日期:2018-01-01 00:00:00
abstract::Echocardiography has previously been of limited use in visualizing the aorta in neonates and infants. Using a new technique--right parasternal scanning--the aortic arch and brachiocephalic vessels were studied in 50 children under 18 months of age. Complete visualization was accomplished in 47 patients including those...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/BF02426973
更新日期:1982-01-01 00:00:00
abstract::The aim of the study is to identify reliable quantitative fetal echocardiographic predictors for postnatal development of coarctation (CoA). In this retrospective study, we included 65 fetuses with a prenatally suspected, isolated CoA, born 2010-2018. Dimensions of the cardiac structures, aortic, and ductal arches exp...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-020-02509-6
更新日期:2020-12-23 00:00:00
abstract::The COVID-19 pandemic has had devastating direct consequences on the health of affected patients. It has also had a significant impact on the ability of unaffected children to be physically active. We evaluated the effect of deconditioning from social distancing and school shutdowns implemented during the COVID-19 pan...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-020-02513-w
更新日期:2021-01-04 00:00:00
abstract::Digoxin has been an effective treatment for fetal supraventricular tachycardia (SVT), but second-line therapy remains more controversial. Thirty-seven cases of fetal SVT were identified that received digoxin as first-line therapy. Seventeen fetuses (46%) converted to and maintained normal sinus rhythm. Flecainide was ...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s002460010279
更新日期:2001-11-01 00:00:00
abstract::Arrhythmias in pregnancy are becoming more common given more available and effective medical, ablation and device treatment options. Several changes associated with pregnancy, increased blood volume, cardiac output, and heart rate secondary to an increased sympathetic state, facilitate more frequent occurrences of arr...
journal_title:Pediatric cardiology
pub_type: 杂志文章,评审
doi:10.1007/s00246-015-1232-3
更新日期:2015-10-01 00:00:00
abstract::Angiotensin-converting enzyme inhibitors (ACEi) are commonly used for pediatric cardiology patients. However, studies examining their safety for neonates with cardiac disease are scarce. The current study aimed to test the hypothesis that ACEi-mediated nephrotoxicity occurs in neonates and may be underappreciated in t...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-013-0813-2
更新日期:2014-03-01 00:00:00
abstract::The aim of this study was to clarify the association of clinical characteristics of unexplained syncope with the outcome of the head-up tilt test (HUT) in children. A total of 47 patients with unexplained syncope were classified into two groups according to their outcomes of HUT: the positive response group and the ne...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-003-0513-4
更新日期:2004-07-01 00:00:00
abstract::From 1981 through June 1989, 59 children had surgery for a complete atrioventricular (AV) canal defect at Oregon Health Sciences University. We compared the morbidity, mortality, and hemodynamic status of 47 children with and 12 without Down's syndrome through review of operative, clinical, and cardiac catheterization...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/BF00798209
更新日期:1992-04-01 00:00:00
abstract::The morphology and natural history of anomalous right ventricular muscle bundles (ARVMB) have been described in a number of postnatal studies. Whether this is a congenital or acquired cardiac lesion remains obscure. A fetal echocardiogram performed in a 32-week gestation mother showed a large ventricular septal defect...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/BF00795736
更新日期:1994-09-01 00:00:00
abstract::We report a patient with tricuspid atresia after total cavopulmonary connection who developed significant mitral valve regurgitation. Doppler myocardial echocardiography tracings showed "pseudonormalization" of diastolic velocities. After successful surgical reconstruction of the mitral valve, the diastolic myocardial...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-006-1283-6
更新日期:2006-07-01 00:00:00