Peroxisome proliferator activated receptor-alpha (PPARα) and PPAR gamma coactivator-1alpha (PGC-1α) regulation of cardiac metabolism in diabetes.

Abstract:

:Cardiovascular disease is a leading cause of mortality among patients with diabetes, and heart failure exists even in the absence of coronary disease. Myocardial metabolism is altered in the diabetic heart as a result of changes in substrate availability secondary to insulin resistance. The nuclear receptor peroxisome proliferator activated receptor-alpha (PPARα) and PPAR-gamma coactivator-1alpha (PGC-1α) play important roles in transcriptional regulation of myocardial metabolism and contribute significantly to the changes that occur in the diabetic heart. This review summarizes the role of PPARα and PGC-1α in myocardial metabolism in the normal heart and in the diabetic heart.

journal_name

Pediatr Cardiol

journal_title

Pediatric cardiology

authors

Duncan JG

doi

10.1007/s00246-011-9889-8

subject

Has Abstract

pub_date

2011-03-01 00:00:00

pages

323-8

issue

3

eissn

0172-0643

issn

1432-1971

journal_volume

32

pub_type

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