Nesiritide for the treatment of pulmonary hypertension and cor pulmonale in an infant.

Abstract:

:Nesiritide is a synthetic form of B-type natriuretic peptide. It is approved for the treatment of acute exacerbations of congestive heart failure in hospitalized adult patients. It is currently under investigation for use in other settings and other patient populations. This article describes administration of nesiritide to an infant patient with severe pulmonary hypertension and cor pulmonale. No adverse reactions occurred during administration of the drug. Specifically, there was no hypertension, vomiting, arrhythmia, or changes in renal function. No changes in renal function occurred in the months subsequent to treatment. This case report illustrates that nesiritide can be safely administered to critically ill infants with pulmonary hypertension and cor pulmonale. Our patient experienced a decrease in pulmonary pressure and improved clinical condition during and after the infusion. However, further study is required to fully evaluate the safety and efficacy of nesiritide for these patients.

journal_name

Pediatr Cardiol

journal_title

Pediatric cardiology

authors

Reynolds EW,Conely ET,Vranicar M

doi

10.1007/s00246-006-0064-6

subject

Has Abstract

pub_date

2007-05-01 00:00:00

pages

229-33

issue

3

eissn

0172-0643

issn

1432-1971

journal_volume

28

pub_type

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