Reduction of interleukin-1β induced matrix metalloproteinase-3 release by extracts of six plants: inhibitory screening of 35 traditional medicinal plants.

abstract：:Heat shock protein 90 (Hsp90) is a ubiquitously expressed ATP-dependent molecular chaperone across all species that helps to the correct the folding of many proteins related to important signaling pathways. Tumor cells expressing Hsp90 have more ATP-binding affinity than normal cells. Many correlative inhibitors have ...

journal_title：Immunopharmacology and immunotoxicology

authors： Huyan T,Li Q,Dong DD,Yang H,Zhang J,Huang QS,Yin DC,Shang P

更新日期：2016-01-01 00:00:00

abstract：:Several abnormalities of the immune system have been reported in association with clinical and experimental iron overload. To dissect further such abnormalities, changes in lymphocyte subsets were evaluated in iron-loaded male Sprague-Dawley rats. The iron-loading protocol consisted of a total dose of irondextran (1.5...

journal_title：Immunopharmacology and immunotoxicology

authors： Cardier JE,Romano E,Soyano A

更新日期：1997-02-01 00:00:00

abstract：:We previously showed that formation of pulmonary granulomas in mice in response to a mycobacterial glycolipid, trehalose 6,6'-dimycolate (TDM) is due to the action of TNF-α and not of IFN-γ. However, the mechanisms of formation and maintenance of pulmonary granulomas are not yet clear. The purpose of the present study...

journal_title：Immunopharmacology and immunotoxicology

authors： Saitoh T,Yano I,Kumazawa Y,Takimoto H

更新日期：2012-10-01 00:00:00

abstract：:To evaluate the safety of two probiotic bacterial strains, Lactobacillus casei strain Shirota (LcS) and Bifidobacterium breve strain Yakult (BbY), these probiotics were orally administered to Lewis rats with experimental autoimmune encephalomyelitis (EAE), the experimental model of human multiple sclerosis. We examine...

journal_title：Immunopharmacology and immunotoxicology

authors： Kobayashi T,Kato I,Nanno M,Shida K,Shibuya K,Matsuoka Y,Onoue M

更新日期：2010-03-01 00:00:00

abstract：:Although investigations to date have demonstrated the ability of the monocyte/macrophage to synthesize complement components, only a limited number of studies on complement synthesis by nonhepatic tissue cells have been reported. To begin to fill this gap in our knowledge we have recently evaluated the ability of lung...

journal_title：Immunopharmacology and immunotoxicology

authors： Rothman BL,Contrino J,Merrow M,Despins A,Kennedy T,Kreutzer DL

更新日期：1994-11-01 00:00:00

abstract：:A competitive enzyme-linked immunosorbent assay (ELISA) with generated mouse anti-consensus interferon (CIFN) antibody was developed for quantitative determination of pegylated consensus interferon (PEG-CIFN) in rhesus monkey serum. The operational concentrations of the original assay were determined using the chessbo...

journal_title：Immunopharmacology and immunotoxicology

authors： Cao J,Du Y,Tian H,Gao XD,Yao WB

更新日期：2009-01-01 00:00:00

abstract：:Chronic administration of oxytetracycline (OXT) (incorporated at a level of 0.05 g per kg of feed for 50 days) to pigeons, significantly decreased total leukocyte and lymphocyte counts, increased heterophil:lymphocyte ratio and lysosomal enzyme activity, and decreased reticuloendothelial system function compared with ...

journal_title：Immunopharmacology and immunotoxicology

authors： Al-Ankari AS

更新日期：2005-01-01 00:00:00

abstract：AIM:To assess the immunogenicity of Peginterferon alpha-2 b(Pegberon) and its effect on the efficacy and safety in phase III clinical trial, by comparing it with the control drug Pegasys. METHODS:770 patients were recruited in total. 509 were treated with Pegberon plus ribavirin and 261 were treated with Pegasys plus ...

journal_title：Immunopharmacology and immunotoxicology

authors： Zhou W,Lu D,Liao X,Zhuang L,Sun L

更新日期：2018-02-01 00:00:00

abstract：:Plants have been shown to possess a number of beneficial anticancer and immunomodulatory properties. In this study the possible in vitro antitumor activity and immunomodulatory effects of five species of Euphorbia, an important genus of Euphorbiaceae, including E. petiolata, E. hebecarpa, E. osyridea, E. microciadia, ...

journal_title：Immunopharmacology and immunotoxicology

authors： Amirghofran Z,Malek-hosseini S,Gholmoghaddam H,Kalalinia F

更新日期：2011-03-01 00:00:00

abstract：:To probe into the mechanism of immunosuppression of FTY720, the authors study the cell cycle arrest effects of large-dose FTY720 on lymphocytes in mouse skin transplantation models and the expression of cell cycle-related factors in cell cycle regulation system in mouse skin allograft models using flow cytometry, Immu...

journal_title：Immunopharmacology and immunotoxicology

authors： Li QY,Chi YY,Liu SQ

更新日期：2008-01-01 00:00:00

abstract：:Experiments were performed to analyze the possible effect of the immunomodulating agent Pidotimod (3-L-pyroglutamyl-L-thiazolidine-4-carboxylic acid) on mouse Natural Killer (NK) cell activity and glucocorticoid hormone(GCH)-induced thymocyte apoptosis. The results indicate that in vivo treatment with Pidotimod (200 m...

journal_title：Immunopharmacology and immunotoxicology

authors： Migliorati G,D'Adamio L,Coppi G,Nicoletti I,Riccardi C

更新日期：1992-01-01 00:00:00

abstract：:We examined the effects of interferon (IFN)beta-1a on interleukin (IL)-12p70 and IL-10 secretion in 27 Relapsing Remitting Multiple Sclerosis (RRMS) patients, divided in responders and non-responders. In responders, IFNbeta-1a does not change the IL-12p70 concentrations, but it leads to a remarkable increase in the IL...

journal_title：Immunopharmacology and immunotoxicology

authors： Carrieri PB,Ladogana P,Di Spigna G,de Leva MF,Petracca M,Montella S,Buonavolontà L,Florio C,Postiglione L

更新日期：2008-01-01 00:00:00

abstract：CONTEXT:Multiple organ dysfunction syndrome (MODS) is a major cause of death in critically patients. It has been hypothesized that inactivation or removal of pro-inflammatory molecules may prevent or reverse MODS. OBJECTIVE:The purpose of this paper was to investigate the efficacy of continuous veno-venous hemodiafilt...

journal_title：Immunopharmacology and immunotoxicology

authors： Chen J,Liu J,Yu C,Wen H

更新日期：2012-12-01 00:00:00

abstract：:The immune effects of acebutolol, a beta-blocker, are investigated in various strains of mice. In 6-12 weeks old C57Bl/6 female mice, an increase in the number of immunoglobulin secreting cells is observed only at the age of 9 weeks. At that age, such an effect is seen neither in C57Bl/6 male mice nor in female mice f...

journal_title：Immunopharmacology and immunotoxicology

authors： In S,Lulé J,Fournié GJ

更新日期：1990-01-01 00:00:00

abstract：:We reported recently that a novel immunomodulator, 7-thia-8-oxoguanosine (7T8OG)2 inhibited formation of pulmonary melanoma metastases (1), prevented against viral infection in mice (2) and potentiated the efficacy of a weakly immunogenic leukemia vaccine (3). Since certain tumor metastases and virus infected cells ar...

journal_title：Immunopharmacology and immunotoxicology

authors： Sharma BS,Mhaskar S,Balazs L,Siaw M

更新日期：1992-01-01 00:00:00

abstract：:Abstract Alpinetin, a flavonoid compound extracted from the seeds of Alpinia katsumadai Hayata, has been known to possess antibacterial, anti-inflammatory and other important therapeutic activities. In the current study, we investigated alpinetin for its immunosuppressive effect on activation and cytokines secretion o...

journal_title：Immunopharmacology and immunotoxicology

authors： Guan S,Fang B,Song B,Xiong Y,Lu J

更新日期：2014-08-01 00:00:00

abstract：:Objective: Apigenin is a natural flavonoid compound extracted from Matricaria chamomilla. We evaluated the anti-inflammatory effects of apigenin in this study using the Lipopolysaccharide (LPS)-stimulated BV2 microglia.Methods: BV2 cells were treated with apigenin for 1 h and then treated with LPS. The inflammatory cy...

journal_title：Immunopharmacology and immunotoxicology

authors： Chen P,Huo X,Liu W,Li K,Sun Z,Tian J

更新日期：2020-02-01 00:00:00

abstract：:We have developed an in vitro system to model the interactions of drugs used to treat transplant rejection. This system consists of stimulation of human lymphocytes with a primary mitogen (anti-T-cell receptor complex antibodies (OKT3 or wt31)) and treatment with a primary immunosuppressive drug (ISD) (Cyclosporine A ...

journal_title：Immunopharmacology and immunotoxicology

authors： Weaver JL,Pine PS,Aszalos A

更新日期：1994-05-01 00:00:00

abstract：:A human THP-1 monocyte cell line culture system has been utilized to observe the effect of granulocyte macrophage colony stimulating factor (GM-CSF) supplementation with lipopolysaccharide (LPS) of oral microorganisms to stimulate monocyte/macrophage functional activity. LPS of oral microorganisms, Fusobacterium nucle...

journal_title：Immunopharmacology and immunotoxicology

authors： Baqui AA,Meiller TF,Turng BF,Kelley JI,Falkler WA Jr

更新日期：1998-11-01 00:00:00

abstract：:Inflammatory bowel diseases are characterized by disabilities in gastrointestinal system and defects in mucosal immune system. Statins are 3-hydroxy-3-methyl glutaryl coenzyme A reductase inhibitor and are used to treat hypercholesterolemia in patients with coronary artery and atherosclerotic diseases. Recent studies ...

journal_title：Immunopharmacology and immunotoxicology

authors： Aktunc E,Kayhan B,Arasli M,Gun BD,Barut F

更新日期：2011-12-01 00:00:00

abstract：:Snakebites in rural areas of tropical and subtropical regions are commonly treated with medicinal plants. In this report, we have studied the ability of Anacardium occidentale bark extract to neutralize enzymatic as well as pharmacological effects induced by Vipera russelii venom. The extract neutralized the viper ven...

journal_title：Immunopharmacology and immunotoxicology

authors： Ushanandini S,Nagaraju S,Nayaka SC,Kumar KH,Kemparaju K,Girish KS

更新日期：2009-01-01 00:00:00

abstract：:In the present study, we investigated the possibility that the WNT/β-catenin pathway plays a role in inflammatory responses both in an human inflammatory condition and in an in vitro inflammation model. First, we analyzed gene expression patterns of the peripheral blood cells from asthma patients compared with those f...

journal_title：Immunopharmacology and immunotoxicology

authors： Lee H,Bae S,Choi BW,Yoon Y

更新日期：2012-02-01 00:00:00

abstract：:Disodium cromoglycate (DSCG) has been shown to inhibit the release of mediators from mast cells. In the present study, the effect of DSCG on active anaphylactic reaction was studied in mice. DSCG dose-dependently inhibited the active systemic anaphylactic reaction and serum immunoglobulin (Ig)E production induced by i...

journal_title：Immunopharmacology and immunotoxicology

authors： Seo SB,Park SJ,Park ST,Cho CC,Park BH,Lee SJ,Kim HM,Kajiuchi T,Shin TY

更新日期：2001-05-01 00:00:00

abstract：:N-nitrozodimethyloamine (NDMA) is a carcinogenic compound that can be formed in vivo. NDMA is synthesized from precursors-amines and nitrosating agents. Nitrosating agents are formed through the reaction of oxide, reactive oxygen species and nitric oxide (NO). Human neutrophils (PMN) are an important source of the mos...

journal_title：Immunopharmacology and immunotoxicology

authors： Jabłoński J,Jabłońska E,Iwanowska J,Marcińczyk M,Moniuszko-Jakoniuk J

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVE:To establish the clearance of cervical human papillomavirus (HPV) infection following postoperative immunotherapy with inosine pranobex in women receiving surgical treatment of established high-grade squamous intraepithelial lesion (HSIL) of the uterine cervix. MATERIALS AND METHODS:Over the six-year study p...

journal_title：Immunopharmacology and immunotoxicology

authors： Kovachev SM

更新日期：2020-08-01 00:00:00

abstract：:In the present study, we introduce a new class of organometallic compound, the Biphosphinic Palladacycle Complex [Pd (C2, N-S(-)(dmpa)(dppf)] Cl (BPC), as an angiotensin-I converting-enzyme inhibitor (ACEI) with hematological regulation properties. When BPC was assayed as a competitive inhibitor over the hydrolysis of...

journal_title：Immunopharmacology and immunotoxicology

authors： Caires AC,Oliveira CR,Smith MC,Hemerly JP,Juliano MA,Bincoletto C

更新日期：2004-01-01 00:00:00

abstract：:The modulatory effect of FK 506 and cyclosporin A (CsA) on the expression of inducible nitric oxide synthase (iNOS) in macrophages and mechanisms of their action were analysed. Isolated rat peritoneal macrophages were cultured for 12 or 24 h with or without lipopolysaccharide (LPS) (5 microg/ml) and in the absence or ...

journal_title：Immunopharmacology and immunotoxicology

authors： Strestíková P,Otová B,Filipec M,Masek K,Farghali H

更新日期：2001-02-01 00:00:00

abstract：BACKGROUND AND AIM:To probe into the effects of different doses of FK506 on endocrine function of pancreatic islets in Wistar rats. METHODS:Wistar rats were randomly divide into control group A (0mg/kg/d) and experimental group B (1mg/kg/d), C (3mg/kg/d), D (10mg/kg/d) treated with FK506. In an intraperitoneal glucose...

journal_title：Immunopharmacology and immunotoxicology

authors： Li F,Li Q

更新日期：2010-06-01 00:00:00

abstract：AIM:To determine the steady state concentration and the pharmacokinetics of Cyclosporine A (CsA) in heart transplant recipients. METHODS:A single dose of 100 mg CsA capsules twice daily was given to five heart transplant recipients of steady state. The concentrations of CsA in plasma were determined by streptavidin pe...

journal_title：Immunopharmacology and immunotoxicology

authors： Jin R,Duan H,Zhao C,Wang Z,Qu F

更新日期：2012-06-01 00:00:00

abstract：OBJECTIVES:Fingolimod (FIN) is used for multiple sclerosis treatment and has potential antiapoptotic and anti-inflammatory effects. We aimed at expanding our knowledge on various immunohistochemical markers for elucidating the possible mechanisms of action of fingolimod in the placenta and fetal lung and brain. METHOD...

journal_title：Immunopharmacology and immunotoxicology

authors： Yavuz A,Sezik M,Eris Yalcin S,Asci H,Ozmen O

更新日期：2020-12-01 00:00:00