Disaccharidases activity in the intestinal mucosa after methotrexate therapy.

abstract：:Adolescence is characterized by inter-related physiologic and emotional development. It is a particularly vulnerable period of life culminating into emergence as an adult. The majority of malignant bone tumors in pediatrics affect the adolescent patient. As a part of the treatment, amputation may be required for cure....

journal_title：Pediatric hematology and oncology

authors： Jaffe N,Zietz H

更新日期：2004-09-01 00:00:00

abstract：:Bloodstream infections (BSI) represent one of the most serious complications in patients in the hematology-oncology unit. In this study, the prevalence, distribution, drug sensitivity profiles, and clinical outcome of BSI were analyzed in pediatric patients with hematological malignancies. Patients admitted to the ped...

journal_title：Pediatric hematology and oncology

authors： Chen S,Liu S,Yuan X,Mai H,Lin J,Wen F

更新日期：2019-11-01 00:00:00

abstract：:The aim of this study was to identify genes distinctively expressed or suppressed in childhood leukemia with different prognoses, using cDNA microarray and quantitative reverse transcription-polymerase chain reaction (RT-PCR). The expression levels of the selected genes by cDNA microarray were quantified in primary le...

journal_title：Pediatric hematology and oncology

authors： Hattori H,Matsuzaki A,Suminoe A,Koga Y,Tashiro K,Hara T

更新日期：2006-03-01 00:00:00

abstract：:Neuroblastoma is the most common solid tumor in childhood and is the most frequent neural crest tumor (NCT). More than 90% of the patients excrete high levels of vanilmandelic acid (VMA) and homovanillic acid (HVA) in the urine. Original biochemical methods for measuring these two metabolites of catecholamines employe...

journal_title：Pediatric hematology and oncology

authors： Gregianin LJ,McGill AC,Pinheiro CM,Brunetto AL

更新日期：1997-05-01 00:00:00

abstract：:The Department of Oncology at Hospital Infantil de México Federico Gómez (HIMFG) was the first unit in our country, and one of the first in Latin America, to specialize in the management of children with cancer. The HIMFG is part of the National Institutes of Health of Mexico, and is a reference hospital with research...

journal_title：Pediatric hematology and oncology

authors： Medina-Sanson A,Martínez-Avalos A,Gallegos-Castorena S,Juárez-Villegas LE,González-Montalvo P,Perales-Arroyo A,Gallegos-González E,Ayometzi-Ouchi MT

更新日期：2002-09-01 00:00:00

abstract：:Twelve cases of neuroblastoma (NB) (7 boys and 5 girls) and 4 cases of primitive peripheral neuroectodermal tumor (PNET) (3 boys and 1 girl) were investigated for the presence of apoptosis and retinoic acid receptor (RAR) by immunhistochemical method. The apoptotic index in NB was zero or 1% in 8 children and relative...

journal_title：Pediatric hematology and oncology

authors： Farid P,Babosa M,Hauser P,Schuler D,Szende B

更新日期：2000-06-01 00:00:00

abstract：PURPOSE:To describe clinical and CT features of L-asparaginase-associated pancreatitis (L-AP) and to correlate CT grades with clinical parameters. METHODS:A total of 16 children (M:F = 9:7; mean age, 8.1 years) who developed L-AP after L-asparaginase (L-asp) treatment and underwent abdominal CT scan were included. We ...

journal_title：Pediatric hematology and oncology

authors： Oh HJ,Im SA,Lee JW,Chung NG,Cho B

更新日期：2014-10-01 00:00:00

abstract：:Signaling between leukemia cells and nonhematopoietic cells in the bone marrow microenvironment contributes to leukemia cell growth and survival. This complicated extrinsic mechanism of chemotherapy resistance relies on a number of pathways and factors, some of which have yet to be determined. Research on cell-cell cr...

journal_title：Pediatric hematology and oncology

authors： Sison EAR,Kurre P,Kim YM

更新日期：2017-01-01 00:00:00

abstract：:The increased incidence of malignancies, especially acute leukemia, in Down syndrome has been clearly established. The association of Hodgkin's disease with Down syndrome has not been extensively documented, and only a few cases have been reported. We present here a case report of Hodgkin's disease in an 11-year-old f...

journal_title：Pediatric hematology and oncology

authors： Kusumakumary P,Jyothirmayi R,Chellam VG,Krishnan NM

更新日期：1996-09-01 00:00:00

abstract：:The acquired form of pure red cell aplasia (PRCA) presents either as an acute self-limited disease, predominantly seen in children, or as a chronic illness more frequently seen in adults with rare spontaneous remissions. A 14-year-old boy presented with pallor, without hepatosplenomegaly, jaundice, lymphadenopathy, pe...

journal_title：Pediatric hematology and oncology

authors： Khalil A,Elhasid R,Ben Barak A,Ben Arush MW

更新日期：2010-10-01 00:00:00

abstract：:The endocrinological complications in β-thalassemia major patients do affect the life quality to a large extend. In this study, the endocrinological complications of 47 β-thalassemia patients, who have been followed-up at our hospital's pediatric hematology department, were evaluated. Out of β-thalassemia major cases ...

journal_title：Pediatric hematology and oncology

authors： Isik P,Yarali N,Tavil B,Demirel F,Karacam GB,Sac RU,Fettah A,Ozkasap S,Kara A,Tunc B

更新日期：2014-10-01 00:00:00

abstract：:This study evaluates the efficacy of heparinization in prolonging patency of arterial and central venous catheters in children. A randomized double-blind trial in a tertiary 10-bed pediatric intensive care unit was used to evaluate 300 children (age older than 4 weeks, younger than 18 years). Trial medication consiste...

journal_title：Pediatric hematology and oncology

authors： de Neef M,Heijboer H,van Woensel JB,de Haan RJ

更新日期：2002-12-01 00:00:00

abstract：:Although most common in tropical regions, population migration has meant that sickle cell disease is now one of the most prevalent genetic diseases worldwide. The issues and challenges faced by physicians and patients have been discussed by an international group of experts representing 4 key regions: the USA, Europe,...

journal_title：Pediatric hematology and oncology

authors： Vichinsky EP,Ohene-Frempong K,Thein SL,Lobo CL,Inati A,Thompson AA,Smith-Whitley K,Kwiatkowski JL,Swerdlow PS,Porter JB,Marks PW

更新日期：2011-03-01 00:00:00

abstract：:A major problem of hemophilia A (HA) treatment is the development of factor VIII (FVIII) inhibitor, which usually occurs shortly after initiating replacement therapy. Several studies showed the correlation between inhibitor development and polymorphisms in inflammatory and immune response genes of HA patients; however...

journal_title：Pediatric hematology and oncology

authors： Naderi N,Yousefi H,Mollazadeh S,Seyed Mikaeili A,Keshavarz Norouzpour M,Jazebi M,Moazezi Nekooi Asl SS,Namvar A,Azizi Saraji A,Agi E,Bolhassani A

更新日期：2019-02-01 00:00:00

abstract：:In an autopsy series of children with cancer, histopathologic myocardial changes caused by anthracyclines (A) were evaluated. The series comprised three groups: group A, 9 patients given A whose myocardial function had been evaluated before death; group B, 10 patients given A, but no lifetime echocardiographic evaluat...

journal_title：Pediatric hematology and oncology

authors： Pihkala J,Sariola H,Saarinen UM

更新日期：1994-05-01 00:00:00

abstract：:Three children with malignant solid tumors developed hyponatremia with renal sodium wasting associated with other signs of tubular dysfunction, such as hypokalemia or hypomagnesemia, a few days after cis-diammine dichloroplatinum (CDDP) administration. The normalization of serum electrolyte disturbances was obtained w...

journal_title：Pediatric hematology and oncology

authors： Vassal G,Rubie H,Kalifa C,Hartmann O,Lemerle J

更新日期：1987-01-01 00:00:00

abstract：:Patients with thalassemia intermedia (TI) experience many complications, of which the incidence varies greatly among cases. Considering the high prevalence of thalassemia in Iran, the study was carried out to determine the frequency of TI complications in Iranian patients and to find possible risk factors for each of ...

journal_title：Pediatric hematology and oncology

authors： Rafsanjani KA,Mafi N,Tafreshi RI

更新日期：2011-09-01 00:00:00

abstract：:The treatment of a child with a relapsed state acute leukemia after allogeneic stem cell transplantation (allo-SCT) is a challenge. The authors report about a child with an acute myelogenous leukemia (AML), which relapsed after allo-SCT despite immunological intervention. It was further treated with a second line chem...

journal_title：Pediatric hematology and oncology

authors： Hartwig M,Weigel S,Bernig T,Bader P,Dölken R,Beck J

更新日期：2007-03-01 00:00:00

abstract：:Fanconi's anemia is an autosomal recessive disorder characterized by progressive pancytopenia and congenital malformation of the skeleton. This study investigated the oral health status of 15 children with Fanconi's anemia, including oral lesions, gingival and periodontal status, and dental abnormalities. All children...

journal_title：Pediatric hematology and oncology

authors： Açikgöz A,Ozden FO,Fisgin T,Açikgöz G,Duru F,Yarali N,Albayrak D

更新日期：2005-09-01 00:00:00

abstract：:Malignant ectomesenchymoma (MEM) is a rare soft tissue tumor believed to arise from a pluripotent migratory neural crest cell and composed fo both a mesenchymal element and a neuroectodermal element. The authors report the case of an 11-month-old male who presented with a local abdominal MEM and systemic metastases in...

journal_title：Pediatric hematology and oncology

authors： Müller HL,Marx A,Trusen M,Schneider P,Kühl J

更新日期：2002-01-01 00:00:00

abstract：:Background: Preclinical studies show that TLR9 agonists can eradicate leukemia by induction of immune responses in vivo against AML and ALL. These studies demonstrated that TLR9 agonists induce an immediate NK response followed by adaptive T and B cells responses resulting in long term anti-leukemia immunity. Methods:...

journal_title：Pediatric hematology and oncology

authors： Ronsley R,Kariminia A,Ng B,Mostafavi S,Reid G,Subrt P,Hijiya N,Schultz KR

更新日期：2019-11-01 00:00:00

abstract：:Two children with inflammatory pseudotumor (IPT) of the lung are reported. Symptomless "cystic" lesions were present on routine chest x ray. Morphological study of these peculiar lesions included light microscopic, immunohistochemical, and ultrastructural analysis. Histologic appearance of the lesion varied from the f...

journal_title：Pediatric hematology and oncology

authors： Vujanić GM,Dojĉinov D

更新日期：1991-04-01 00:00:00

abstract：:The development of myeloid leukemias and myelodysplastic syndrome (MDS) is common in children with trisomy 8 mosaicism. However, the mechanisms by which the presence of an additional chromosome 8 translates to an increased risk of leukemias and MDS is currently unknown. The authors describe the analysis of stromal cel...

journal_title：Pediatric hematology and oncology

authors： Narendran A,Hawkins LM,Ganjavi H,Vanek W,Gee MF,Barlow JW,Johnson G,Malkin D,Freedman MH

更新日期：2004-04-01 00:00:00

abstract：:This study aimed to address the clinical impact of recombination-activating gene (RAG1) expression and tumor suppressor IKZF1 gene deletions in Philadelphia negative B-cell precursor acute lymphoblastic leukemia (B-ALL) patients. Fifty newly diagnosed pediatric Philadelphia negative B-ALL patients were included in thi...

journal_title：Pediatric hematology and oncology

authors： Aref S,Khaled N,Menshawy NE,Sabry M,Agder MA

更新日期：2020-08-01 00:00:00

abstract：:Since the mid-1960s intrathecal chemotherapy (methotrexate [MTX], cytarabine [Ara-C], or both, plus hydrocortisone) has constituted the standard approach to prophylaxis and treatment of central nervous system (CNS) leukemia and lymphoma. Intrathecal chemotherapy-related neurotoxicity has been described in a variable p...

journal_title：Pediatric hematology and oncology

authors： García-Tena J,López-Andreu JA,Ferrís J,Menor F,Mulas F,Millet E,Verdeguer A

更新日期：1995-07-01 00:00:00

abstract：:Increased susceptibility to infection is reported in patients with beta-thalassemia major due to toxic effect of iron on neutrophil functions and reticuloendothelial system dysfunction. This study investigated the association between the neutrophil apoptosis and frequency of infection episodes, desferrioxamine treatme...

journal_title：Pediatric hematology and oncology

authors： Oren H,Sahin B,Irken G,Ateş H,Duman M,Yilmaz S,Türker M,Atabay B,Yaprak I

更新日期：2003-04-01 00:00:00

abstract：:We report a patient who developed chronic myelogenous leukemia (CML) at 12 months of age. She was treated aggressively with stem cell transplant (SCT), interferon, donor lymphocytes and imatinib, with subsequent molecular progression. She received dasatinib, achieving a complete molecular response. Dasatinib was disco...

journal_title：Pediatric hematology and oncology

authors： Triche L,Yarbrough A,Roth M,Ying A,Wells R

更新日期：2020-08-01 00:00:00

abstract：:Most of the extragonadal teratomas are located in the sacrococygeal region. Teratoma with malignant sarcomatous differentiation is a rare form of germ cell tumor. The authors describe a 5-year-old-girl with sacrococygeal teratoma in which sarcomatous elements were observed. The patient was treated with complete surgic...

journal_title：Pediatric hematology and oncology

authors： Elli M,Pinarli FG,Kandemir B,Dagdemir A,Ceyhan M,Acar S

更新日期：2008-06-01 00:00:00

abstract：:The authors sought to determine prevalence, social, economic, and dietary patterns of young children (n = 20) identified as having vitamin B12 deficiency anemia after admission to their hospital in the last 3 years. The diagnosis of vitamin B12 deficiency was based on symptoms and clinical findings, findings on periph...

journal_title：Pediatric hematology and oncology

authors： Cetinkaya F,Yildirmak Y,Kutluk G,Erdem E

更新日期：2007-01-01 00:00:00

abstract：:Between 1973 and 1991, 10 patients with locally advanced [stages III and IV] nasopharyngeal carcinoma were treated at the Northern Israel Oncology Center. All patients were treated with wide-field irradiation to the primary tumor, including the base of skull, neck, and supraclavicular region. After 1984, 6 patients al...

journal_title：Pediatric hematology and oncology

authors： Arush MW,Stein ME,Rosenblatt E,Lavie R,Kuten A

更新日期：1995-05-01 00:00:00