Sustained molecular response following a failed attempt of tyrosine kinase inhibitor discontinuation & the effects on growth in a child with chronic myeloid leukemia: not always a short story.

Abstract:

:We report a patient who developed chronic myelogenous leukemia (CML) at 12 months of age. She was treated aggressively with stem cell transplant (SCT), interferon, donor lymphocytes and imatinib, with subsequent molecular progression. She received dasatinib, achieving a complete molecular response. Dasatinib was discontinued at 3 years but she had a molecular recurrence. Dasatinib was restarted and continued for 5 additional years with a second major molecular remission (MMR). While on dasatinib therapy she suffered growth failure and was treated with concurrent growth hormone (GH). After discontinuing dasatinib and GH, catch-up growth continues and she remains in MMR. Discontinuation of TKI therapy and the toxicity of long-term TKI therapy is discussed.

journal_name

Pediatr Hematol Oncol

authors

Triche L,Yarbrough A,Roth M,Ying A,Wells R

doi

10.1080/08880018.2020.1751755

subject

Has Abstract

pub_date

2020-08-01 00:00:00

pages

375-379

issue

5

eissn

0888-0018

issn

1521-0669

journal_volume

37

pub_type

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