Abstract:
:Anti-VEGF (vascular endothelial growth factor) therapy with the monoclonal antibody bevacizumab can cause gastrointestinal (GI) perforations. In recent years it became apparent that GI perforations also occur during treatment with antiangiogenic tyrosine kinase inhibitors (TKIs). It is of clinical importance to consider (vague) abdominal complaints during antiangiogenic treatment as a sign of a GI perforation. To illustrate this serious complication, we report four cases of antiangiogenic treatment related GI perforations. In three cases this was due to antiangiogenic TKI treatment. Reported risk factors of GI perforations due to bevacizumab include the presence of a primary tumor in situ and recent history of endoscopy or abdominal radiotherapy. Pathology assessments of surgical removal of the perforated intestinal part reveal that perforations are predominantly seen at the tumor or anastomotic site, in case of carcinomatosis or diverticulitis or when GI obstruction or an intra-abdominal abscess is present. Whether the same risk factors may be involved in antiangiogenic TKI related GI perforations is unknown. The underlying mechanisms responsible for GI perforation during antiangiogenic treatment is unknown, but disturbance of host cell homeostasis of immune cells as well as platelet-endothelial cell interactions may play an important role. In conclusion, while clinical awareness that antiangiogenic treatment can cause GI perforations is critical for current medical practice, it is also very important to get more insight in its underlying mechanisms so that this life-threatening complication may be prevented in the near future.
journal_name
Angiogenesisjournal_title
Angiogenesisauthors
Walraven M,Witteveen PO,Lolkema MP,van Hillegersberg R,Voest EE,Verheul HMdoi
10.1007/s10456-010-9197-6subject
Has Abstractpub_date
2011-05-01 00:00:00pages
135-41issue
2eissn
0969-6970issn
1573-7209journal_volume
14pub_type
杂志文章,评审相关文献
ANGIOGENESIS文献大全abstract::Therapeutic over-expression of vascular endothelial growth factor (VEGF) can be used to treat ischemic conditions. However, VEGF can induce either normal or aberrant angiogenesis depending on its dose in the microenvironment around each producing cell in vivo, which limits its clinical usefulness. The goal herein was ...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-012-9304-y
更新日期:2013-01-01 00:00:00
abstract::Transmembrane-4 L-six family member-1 (TM4SF1) is a small plasma membrane glycoprotein that regulates cell motility and proliferation. TM4SF1 is an attractive cancer target because of its high expression in both tumor cells and on the vascular endothelial cells lining tumor blood vessels. We generated mouse monoclonal...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-014-9437-2
更新日期:2014-10-01 00:00:00
abstract::During embryonic development, the lymphatic system emerges by transdifferentiation from the cardinal vein. Although lymphatic and blood vasculature share a close molecular and developmental relationship, they display distinct features and functions. However, even after terminal differentiation, transitions between blo...
journal_title:Angiogenesis
pub_type: 临床试验,杂志文章
doi:10.1007/s10456-012-9264-2
更新日期:2012-06-01 00:00:00
abstract::A missense mutation from arginine to tryptophan at residue 849 in the kinase domain of Tie2 (Tie2-R849W) is commonly identified in familial venous malformations. The mechanistic action of Tie2-R849W variant expression on angiogenic cascades including smooth muscle cell recruitment, however, remains elusive. To avoid c...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-012-9313-x
更新日期:2013-01-01 00:00:00
abstract::Vascular endothelial growth factors (VEGFs) regulate blood and lymph vessel development upon activation of three receptor tyrosine kinases (VEGFRs). The extracellular domain of VEGFRs consists of seven Ig-homology domains, of which D2-3 form the ligand-binding site, while the membrane proximal domains D4-7 are involve...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-018-9606-9
更新日期:2018-08-01 00:00:00
abstract::Vascular endothelial (VE) cadherin is a key component of endothelial adherens junctions (AJs) and plays an important role in maintaining vascular integrity. Endocytosis of VE-cadherin regulates junctional strength and a decrease of surface VE-cadherin reduces vascular stability. However, disruption of AJs is also a re...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-018-9638-1
更新日期:2019-02-01 00:00:00
abstract::Intermittent Hypoxia (IH) that develops in neovascularized solid tumours has been described to positively influence the tumour growth by modulating the behaviour of cancer cells as well as of endothelial cells. However, the molecular mechanisms regulated by IH still remain poorly understood. In this work, the effects ...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-009-9156-2
更新日期:2009-01-01 00:00:00
abstract::Angiogenesis is a complex process involving coordinated steps of endothelial cell activation, proliferation, migration, tube formation and capillary sprouting with participation of intracellular signaling pathways. Regulation of angiogenesis carries tremendous potential for cancer therapy. Our earlier studies showed t...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-005-9024-7
更新日期:2005-01-01 00:00:00
abstract::Angiogenesis is necessary for the continued growth of solid tumors, invasion and metastasis. Several studies clearly showed that heme oxygenase-1 (HO-1) plays an important role in angiogenesis. In this study, we used the vital microscope system, transparent skinfold model, lung colonization model and transduced pancre...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1023/a:1025803600840
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:The term "intramuscular hemangioma capillary type" (IHCT) refers to a fast-flow vascular lesion that is classified as a tumor, although its phenotype overlaps with arteriovenous malformation (AVM). The purpose of this study was to identify somatic mutations in IHCT. METHODS:Affected tissue specimens were ob...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-019-09678-w
更新日期:2019-11-01 00:00:00
abstract::Anti-angiogenesis is likely to develop into a novel therapeutic approach for patients with solid malignancies. Most current clinical trials evaluate anti-angiogenic drugs aimed primarily against single angiogenesis stimulators. Here, we show that a single solid malignancy, i.e., a human embryonal rhabdomyosarcoma, pro...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1023/a:1016045012466
更新日期:2001-01-01 00:00:00
abstract::CM101, an anti-pathoangiogenic polysaccharide derived from group B streptococcus, has been shown to inhibit inflammatory angiogenesis and accelerate wound healing in a mouse model and minimize scarring/gliosis following spinal cord injury. To evaluate the in vivo effects of CM101 on cutaneous wound healing in the pig,...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1023/a:1016752925761
更新日期:2001-01-01 00:00:00
abstract::Chemokine (C-C motif) receptor-2 (CCR2) regulates arteriogenesis and angiogenesis, facilitating the MCP-1-dependent recruitment of growth factor-secreting bone marrow-derived cells (BMCs). Here, we tested the hypothesis that the BMC-specific expression of CCR2 is also required for new arteriole formation via capillary...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-009-9157-1
更新日期:2009-01-01 00:00:00
abstract::Matrix Gla protein (MGP) is an antagonist of bone morphogenetic proteins and expressed in vascular endothelial cells. Lack of MGP causes vascular abnormalities in multiple organs in mice. The objective of this study is to define the role of MGP in early endothelial differentiation. We find that expression of endotheli...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-015-9484-3
更新日期:2016-01-01 00:00:00
abstract::In this study we investigated the control of the angiogenic/haemorrhagic phenotype of oestrogen-induced rat pituitary tumours of an F1 hybrid (F1) of Fischer 344 (F344) (tumour susceptible) and Brown Norway (tumour resistant) strains. F1 forms a pituitary tumour upon chronic oestrogen treatment, but microvessel count ...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1023/a:1021550211921
更新日期:2002-01-01 00:00:00
abstract::Receptor tyrosine kinase c-Kit and its ligand stem cell factor (SCF) regulate resident vascular wall cells and recruit circulating progenitors. We tested whether SCF may be induced by oxidized palmitoyl-arachidonoyl-phosphatidylcholine (OxPAPC) known to accumulate in atherosclerotic vessels. Gene expression analysis d...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-017-9590-5
更新日期:2018-05-01 00:00:00
abstract::The semaphorins and plexins comprise a family of cysteine-rich proteins implicated in control of nerve growth and development and regulation of the immune response. Our group and others have found that Semaphorin 4D (SEMA4D) and its receptor, Plexin-B1, play an important role in tumor-induced angiogenesis, with some n...
journal_title:Angiogenesis
pub_type: 杂志文章,收录出版
doi:10.1007/s10456-012-9268-y
更新日期:2012-09-01 00:00:00
abstract::Ocular angiogenesis is responsible for the majority of irreversible blindness in the developed world [1]. This debilitating complication affects all age groups and characterizes such diverse and widespread diseases as trachoma, retinopathy of prematurity, diabetic retinopathy, neovascular glaucoma and age-related macu...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1023/a:1009071601454
更新日期:1999-01-01 00:00:00
abstract::Both vasculogenesis and angiogenesis occur during normal placental vascular development. Additionally, the placenta undergoes a process of vascular mimicry (pseudo-vasculogenesis) where the placental extravillous trophoblast (EVT) that invade the spiral arteries convert from an epithelial to an endothelial phenotype d...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-012-9317-6
更新日期:2013-04-01 00:00:00
abstract::In the adult, new vessels and red blood cells form in response to hypoxia. Here, the oxygen-sensing system (PHD-HIF) has recently been put into focus, since the prolyl-hydroxylase domain proteins (PHD) and hypoxia-inducible factors (HIF) are considered as potential therapeutic targets to treat ischemia, cancers or age...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-015-9492-3
更新日期:2016-04-01 00:00:00
abstract::Although monotherapy with angiostatic drugs is still far from effective, there is abundant evidence that angiostatic therapy can improve the efficacy of conventional treatments like radiotherapy. This has instigated numerous efforts to optimize and clinically implement the combination of angiostatic drugs with radiati...
journal_title:Angiogenesis
pub_type: 历史文章,杂志文章,评审
doi:10.1007/s10456-017-9546-9
更新日期:2017-05-01 00:00:00
abstract::Immunostaining with endothelial and pericyte markers was used to evaluate the cellular composition of angiogenic sprouts in several types of tumors and in the developing retina. Confocal microscopy revealed that, in addition to conventional endothelial tubes heavily invested by pericytes, all tissues contained small p...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1023/B:AGEN.0000021401.58039.a9
更新日期:2003-01-01 00:00:00
abstract::Therapeutic angiogenesis is a promising strategy to promote the formation of new or collateral vessels for tissue regeneration and repair. Since changes in tissue oxygen concentrations are known to stimulate numerous cell functions, these studies have focused on the oxygen microenvironment and its role on the angiogen...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-009-9152-6
更新日期:2009-01-01 00:00:00
abstract::The plasminogen activation system has been implicated in angiogenesis and angiogenesis-dependent diseases such as cancer, atherosclerosis and ocular diseases. The identification and development of inhibitors of angiogenesis offer new possibilities for the treatment of these diseases. To clarify the role of proteins in...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1023/B:AGEN.0000029414.24060.fe
更新日期:2003-01-01 00:00:00
abstract::Human ribonuclease inhibitor (hRI) can inhibit angiogenesis by reversibly binding angiogenin, a member of the RNaseA superfamily, and by suppressing the expression of basic fibroblast growth factor (bFGF). Angiogenesis is necessary for the growth and metastasis of tumors. To study the links between hRI, angiogenesis, ...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-005-5714-4
更新日期:2005-01-01 00:00:00
abstract::Targeted ultrasound contrast imaging has the potential to become a reliable molecular imaging tool. A better understanding of the quantitative aspects of molecular ultrasound technology could facilitate the translation of this technique to the clinic for the purposes of assessing vascular pathology and detecting indiv...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-014-9447-0
更新日期:2015-01-01 00:00:00
abstract::Antiangiogenic therapy, specially sorafenib, has become the standard of care for patients with advanced hepatocellular carcinoma (HCC), however, the improvement in survival time is not satisfactory. Previous studies have found that, in some circumstances, antiangiogenic therapy promoted tumor metastasis and the mechan...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-013-9357-6
更新日期:2013-10-01 00:00:00
abstract::Endometriosis, defined as the presence of endometrial tissue outside the uterus, is an estrogen-dependent disease which causes pelvic pain and subfertility in women of reproductive age. The condition has a dramatic impact on the professional, social and marital life of sufferers. Direct and indirect evidence suggests ...
journal_title:Angiogenesis
pub_type: 杂志文章,评审
doi:10.1007/s10456-005-9005-x
更新日期:2005-01-01 00:00:00
abstract::Vascular endothelial growth factor receptor 2 (VEGFR-2) and α v ß 3 integrin are the most frequently addressed targets in molecular imaging of tumor angiogenesis. In preclinical studies, molecular imaging of angiogenesis has shown potential to detect and differentiate benign and malignant lesions of the breast. Thus, ...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-016-9499-4
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:Angiogenesis plays a pivotal role in neoplastic growth and metastasis formation. Vascular endothelial growth factor A (VEGFA) is a major player in physiological and tumour-induced angiogenesis and numerous human tumours have been show to overexpress VEGFA. Moreover increased VEGFA gene expression has been fo...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-013-9396-z
更新日期:2014-07-01 00:00:00