Abstract:
:Cells usually spread on a synthetic substrate through bonds between receptors and chemical groups on the substrate (ligands). Therefore, it is valuable to study the effects of the average number density of these chemical groups and the average distance between them to model and predict the cell behavior. Poly(ethylene glycol) [PEG] modified with peptide groups has been used widely in biomedical applications as a substrate material. In this study, a coarse-grained model is proposed for PEG to predict the average number density of ligands and the average distance between them. Molecular information such as initial molecular weight distribution, average molecular weight between cross-links, and average molecular weight between entanglements is used as input parameters. Based on simulation results, it is concluded that both entanglement and cross-link densities are required to create a network structure. The results suggest that an average initial molecular weight 2-3 times the average molecular weight between entanglements and a moderate cross-link density are sufficient to create a closed network structure with a high ligand density and a small average distance between them.
journal_name
Biotechnol Bioengjournal_title
Biotechnology and bioengineeringauthors
Eskandari M,Brey E,Cinar Adoi
10.1002/bit.22889subject
Has Abstractpub_date
2011-02-01 00:00:00pages
435-45issue
2eissn
0006-3592issn
1097-0290journal_volume
108pub_type
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