FSH inhibits ovarian cancer cell apoptosis by up-regulating survivin and down-regulating PDCD6 and DR5.

abstract：:Tropomyosin receptor kinase (Trk) inhibitors are investigated as a novel targeted therapy in various cancers. We investigated the in vitro effects of the pan-Trk inhibitor GNF-5837 in human neuroendocrine tumor (NET) cells. The human neuroendocrine pancreatic BON1, bronchopulmonary NCI-H727 and ileal GOT1 cell lines w...

journal_title：Endocrine-related cancer

authors： Aristizabal Prada ET,Heinzle V,Knösel T,Nölting S,Spöttl G,Maurer J,Spitzweg C,Angele M,Schmidt N,Beuschlein F,Stalla GK,Blaser R,Kuhn KA,Auernhammer CJ

更新日期：2018-05-01 00:00:00

abstract：:Over the past years there have been significant advances in breast cancer treatment and early detection. For the first time, a decrease in cancer mortality has been observed. Recently, much progress has been made in the understanding of carcinogenesis partly due to available new technologies to detect early molecular ...

journal_title：Endocrine-related cancer

authors： Arun B,Hortobagyi GN

更新日期：2002-03-01 00:00:00

abstract：:Elevated expression of steroid receptor coactivator-3 (SRC-3), a member of the p160 family of nuclear receptor coactivators, has been implicated in tamoxifen resistance of breast tumors while the involvement of the two other members of this family, SRC-1 and SRC-2, is less well characterized. In this study, using smal...

journal_title：Endocrine-related cancer

authors： Karmakar S,Foster EA,Blackmore JK,Smith CL

更新日期：2010-12-21 00:00:00

abstract：:The expression of estrogen receptor α (ERα) in breast cancer identifies patients most likely to respond to endocrine treatment. The second ER, ERβ, is also expressed in breast tumors, but its function and therapeutic potential need further study. Although in vitro studies have established that ERβ opposes transcriptio...

journal_title：Endocrine-related cancer

authors： Jonsson P,Katchy A,Williams C

更新日期：2014-01-30 00:00:00

abstract：:Distant metastases from thyroid cancer of follicular origin are uncommon. Treatment includes levothyroxine administration, focal treatment modalities with surgery, external radiation therapy and thermal ablation, and radioiodine in patients with uptake of 131I in their metastases. Two-thirds of distant metastases beco...

journal_title：Endocrine-related cancer

authors： Berdelou A,Lamartina L,Klain M,Leboulleux S,Schlumberger M

更新日期：2018-04-01 00:00:00

abstract：:The aim of this study was to explore the pharmacological response to 4-hydroxy-tamoxifen (OH-Tam) and to estradiol (E2) in three cell lines: MVLN, a human breast carcinoma cell line derived from MCF-7, and two MVLN-derived OH-Tam-resistant (OTR) cell lines, called CL6.8 and CL6.32. The OH-Tam response in the OTR cells...

journal_title：Endocrine-related cancer

authors： Vendrell JA,Bieche I,Desmetz C,Badia E,Tozlu S,Nguyen C,Nicolas JC,Lidereau R,Cohen PA

更新日期：2005-03-01 00:00:00

abstract：:Medullary thyroid cancer (MTC) is a rare tumor arising from the calcitonin-producing parafollicular C cells of the thyroid gland, occurring either sporadically or alternatively in a hereditary form based on germline RET mutations in approximately one-third of cases. Historically, patients with advanced, metastasized M...

journal_title：Endocrine-related cancer

authors： Spitzweg C,Morris JC,Bible KC

更新日期：2016-06-01 00:00:00

abstract：:Malignant growth of small-cell lung carcinoma is promoted by various neuroendocrine autocrine/paracrine loops. Therefore, to interfere with this mitogenic process, it is crucial to elucidate the mechanisms involved. It is known that the oxytocin (OT) and vasopressin (VP) genes, normally transcriptionally restricted in...

journal_title：Endocrine-related cancer

authors： Péqueux C,Keegan BP,Hagelstein MT,Geenen V,Legros JJ,North WG

更新日期：2004-12-01 00:00:00

abstract：:Genetic alteration is the driving force for thyroid tumorigenesis and progression, based upon which novel approaches to the management of thyroid cancer can be developed. A recent important genetic finding in thyroid cancer is the oncogenic T1799A transversion mutation of BRAF (the gene for the B-type Raf kinase, BRAF...

journal_title：Endocrine-related cancer

authors： Xing M

更新日期：2005-06-01 00:00:00

abstract：:Aromatase inhibitors (AIs) are one of the principal therapeutic approaches for estrogen receptor-positive (ER+) breast cancer in postmenopausal women. They block estrogen biosynthesis through aromatase inhibition, thus preventing tumour progression. Besides the therapeutic success of the third-generation AIs, acquired...

journal_title：Endocrine-related cancer

authors： Augusto TV,Correia-da-Silva G,Rodrigues CMP,Teixeira N,Amaral C

更新日期：2018-05-01 00:00:00

abstract：:Papillary (PTC) and follicular thyroid carcinoma (FTC) are known as differentiated thyroid carcinoma (DTC). Nevertheless, according to the UICC/AJCC (TNM) classification PTC and FTC are frequently analyzed as one cancer. The aim of this study is to show differences in outcome and specific prognostic factors in an iodi...

journal_title：Endocrine-related cancer

authors： Passler C,Scheuba C,Prager G,Kaczirek K,Kaserer K,Zettinig G,Niederle B

更新日期：2004-03-01 00:00:00

abstract：:Anaplastic thyroid cancer (ATC) is an aggressive malignancy with limited treatment options. We explored novel treatment modalities by targeting epigenetic modifications using inhibitors of BET (e.g. BRD4) activity. We evaluated the efficacy in the treatment of ATC of a novel BET inhibitor, PLX51107 (PLX), currently in...

journal_title：Endocrine-related cancer

authors： Zhu X,Park S,Lee WK,Cheng SY

更新日期：2019-09-01 00:00:00

abstract：:Numerous epidemiological observations point to sex differences in lung cancer etiology and progression. The present study was aimed at understanding the bases of these sex differences. To test the effect of estradiol on tumor progression, we used a mouse model based on conditional Kras expression and concurrent deleti...

journal_title：Endocrine-related cancer

authors： Hammoud Z,Tan B,Badve S,Bigsby RM

更新日期：2008-06-01 00:00:00

abstract：:Selection of novel molecular markers is an important goal of cancer genomics studies. The aim of our analysis was to apply the multivariate bioinformatical tools to rank the genes - potential markers of papillary thyroid cancer (PTC) according to their diagnostic usefulness. We also assessed the accuracy of benign/mal...

journal_title：Endocrine-related cancer

authors： Fujarewicz K,Jarzab M,Eszlinger M,Krohn K,Paschke R,Oczko-Wojciechowska M,Wiench M,Kukulska A,Jarzab B,Swierniak A

更新日期：2007-09-01 00:00:00

abstract：:Small-intestinal carcinoids (SIC) are the most common small-bowel malignancies. We sought to determine the risk of developing SIC before and after other primary malignancies (PM) and the prognosis of patients with SIC, with and without another PM. We used the Surveillance, Epidemiology, and End Results database to ide...

journal_title：Endocrine-related cancer

authors： Amin S,Warner RR,Itzkowitz SH,Kim MK

更新日期：2012-05-24 00:00:00

abstract：:Sialic acid immunoglobulin-like lectin (Siglec)-6 is a transmembrane receptor that binds leptin. Leptin is an obesity-associated peptide hormone overexpressed in gestational trophoblastic disease (GTD). GTD encompasses several placental abnormalities that range from benign to malignant. Among GTD, molar placentas are ...

journal_title：Endocrine-related cancer

authors： Rumer KK,Post MD,Larivee RS,Zink M,Uyenishi J,Kramer A,Teoh D,Bogart K,Winn VD

更新日期：2012-11-19 00:00:00

abstract：:The combination of pituitary adenomas (PA) and phaeochromocytomas (phaeo) or paragangliomas (PGL) is a rare event. Although these endocrine tumours may occur together by coincidence, there is mounting evidence that, in at least some cases, classical phaeo/PGL-predisposing genes may also play a role in pituitary tumori...

journal_title：Endocrine-related cancer

authors： O'Toole SM,Dénes J,Robledo M,Stratakis CA,Korbonits M

更新日期：2015-08-01 00:00:00

abstract：:We have reported a high prevalence of hypothyroidism in the cutaneous melanoma population, suggesting that the pathologic hormonal environment of hypothyroidism promotes melanoma growth. The objective of this study was to test the hypothesis that TSH, which circulates at elevated levels in hypothyroid individuals, sti...

journal_title：Endocrine-related cancer

authors： Ellerhorst JA,Sendi-Naderi A,Johnson MK,Cooke CP,Dang SM,Diwan AH

更新日期：2006-12-01 00:00:00

abstract：:Although targeted therapy, including inhibitors of mammalian target of rapamycin (mTOR) and vascular endothelial growth factor, being developed for carcinoids arised from the gastrointestinal tract, treatment for locally advanced or metastatic bronchial carcinoids (BCs) remains lacking. Traditional cytotoxic chemother...

journal_title：Endocrine-related cancer

authors： Dong M,Yao JC

更新日期：2011-04-28 00:00:00

abstract：:This review focuses on the tumour types and symptoms associated with non-islet cell tumour-induced hypoglycaemia (NICTH) as well as the pathogenesis, diagnosis and treatment of this rare paraneoplastic phenomenon. In addition, we report two illustrative cases of patients suffering from NICTH caused by a solid fibrous ...

journal_title：Endocrine-related cancer

authors： de Groot JW,Rikhof B,van Doorn J,Bilo HJ,Alleman MA,Honkoop AH,van der Graaf WT

更新日期：2007-12-01 00:00:00

abstract：:Parathyroid carcinoma (PaC) is a rare cause of primary hyperparathyroidism. Though the loss of the oncosuppressor CDC73/HRPT2 gene product, parafibromin, has been involved in the hyperparathyroidism-jaw tumor syndrome and in a consistent set of sporadic PaCs, parathyroid carcinogenesis remains obscure. MicroRNAs are a...

journal_title：Endocrine-related cancer

authors： Corbetta S,Vaira V,Guarnieri V,Scillitani A,Eller-Vainicher C,Ferrero S,Vicentini L,Chiodini I,Bisceglia M,Beck-Peccoz P,Bosari S,Spada A

更新日期：2010-02-18 00:00:00

abstract：:Dendritic cells (DCs) are highly efficient antigen-presenting cells in the immune system with the potential to regulate the system and induce a cytotoxic T-cell response. As a proof of principle, a multitude of animal and human studies has demonstrated that immunization with antigen-loaded DCs may lead to anti-tumour ...

journal_title：Endocrine-related cancer

authors： Schott M

更新日期：2006-09-01 00:00:00

abstract：:Chemotherapy remains the major treatment option for castration-resistant prostate cancer (CRPC) and limited cytotoxic options are available. Inherent chemotherapy resistance occurs in half of all patients and inevitably develops even in those who initially respond. Docetaxel has been the mainstay of therapy for 6 year...

journal_title：Endocrine-related cancer

authors： Mahon KL,Henshall SM,Sutherland RL,Horvath LG

更新日期：2011-07-04 00:00:00

abstract：:Thyroid cancer is the most common cancer of the endocrine system and is responsible for the majority of deaths from endocrine malignancies. Although a large proportion of thyroid cancers belong to well differentiated histologic subtypes, which in general show a good prognosis after surgery and radioiodine ablation, th...

journal_title：Endocrine-related cancer

authors： Morani F,Titone R,Pagano L,Galetto A,Alabiso O,Aimaretti G,Isidoro C

更新日期：2013-12-16 00:00:00

abstract：:Resistance to chemotherapy is a critical issue in the management of breast cancer patients. The nature of clinical drug resistance is likely to be multifactorial. However, in the last decade considerable attention has been dedicated to the role played by membrane transporter proteins belonging to the ATP binding casse...

journal_title：Endocrine-related cancer

authors： Leonessa F,Clarke R

更新日期：2003-03-01 00:00:00

abstract：:Obesity is associated with a range of health outcomes that are of clinical and public health significance, including cancer. Herein, we summarize epidemiologic and preclinical evidence for an association between obesity and increased risk of breast and prostate cancer incidence and mortality. Moreover, we describe dat...

journal_title：Endocrine-related cancer

authors： Allott EH,Hursting SD

更新日期：2015-12-01 00:00:00

abstract：:This study was designed to address whether simultaneous primary chemo-hormonal therapy provides additional activity compared with chemotherapy alone in breast cancer patients with operable or locally advanced disease. Between January 1997 and January 2002, 211 consecutive patients with T2-4, N0-1, M0 breast cancer wer...

journal_title：Endocrine-related cancer

authors： Bottini A,Berruti A,Brizzi MP,Bersiga A,Generali D,Allevi G,Aguggini S,Bolsi G,Bonardi S,Tondelli B,Vana F,Tampellini M,Alquati P,Dogliotti L

更新日期：2005-06-01 00:00:00

abstract：:Thyroid cancer is rare, but it is the most frequent endocrine malignancy. Its prognosis is generally favorable, especially in cases of well-differentiated thyroid cancers (DTCs), such as papillary and follicular cancers, which have survival rates of approximately 95% at 40 years. However, 15-20% of cases became radioi...

journal_title：Endocrine-related cancer

authors： Viola D,Valerio L,Molinaro E,Agate L,Bottici V,Biagini A,Lorusso L,Cappagli V,Pieruzzi L,Giani C,Sabini E,Passannati P,Puleo L,Matrone A,Pontillo-Contillo B,Battaglia V,Mazzeo S,Vitti P,Elisei R

更新日期：2016-04-01 00:00:00

abstract：:Many clinicians prefer to avoid surgery in patients with carcinoid neoplasia, because of its slow growth and relatively favourable prognosis. Nevertheless, the commonest cause of death in patients with carcinoid is advanced metastatic disease, and both clinical and epidemiological data indicate that the more effective...

journal_title：Endocrine-related cancer

authors： Sutton R,Doran HE,Williams EM,Vora J,Vinjamuri S,Evans J,Campbell F,Raraty MG,Ghaneh P,Hartley M,Poston GJ,Neoptolemos JP

更新日期：2003-12-01 00:00:00

abstract：:The imprinted gene, neuronatin (NNAT), is one of the most abundant transcripts in the pituitary and is thought to be involved in the development and maturation of this gland. In a recent whole-genome approach, exploiting a pituitary tumour cell line, we identified hypermethylation associated loss of NNAT. In this repo...

journal_title：Endocrine-related cancer

authors： Revill K,Dudley KJ,Clayton RN,McNicol AM,Farrell WE

更新日期：2009-06-01 00:00:00