15 YEARS OF PARAGANGLIOMA: The association of pituitary adenomas and phaeochromocytomas or paragangliomas.

abstract：:Cancers of the reproductive tract account for 12% of all malignancies in women. As previous studies have shown that oestrogen metabolites can cause apoptosis, we characterised the effect of oestrogen and oestrogen metabolites on non-cancerous and cancerous human endometrial cells. Herein, we demonstrate that 2-methoxy...

journal_title：Endocrine-related cancer

authors： Kato S,Sadarangani A,Lange S,Villalón M,Brañes J,Brosens JJ,Owen GI,Cuello M

更新日期：2007-06-01 00:00:00

abstract：:Recent studies have indicated that a high-fat diet (HFD) plays an important role in prostate cancer (PCa) progression. Palmitic acid (PA) is one of the most abundant saturated free fatty acids (FAs) and is associated with carcinogenesis. In this study, we investigated the mechanism underlying the association of dietar...

journal_title：Endocrine-related cancer

authors： Huang M,Narita S,Inoue T,Tsuchiya N,Satoh S,Nanjo H,Sasaki T,Habuchi T

更新日期：2013-12-16 00:00:00

abstract：:Vandetanib is an oral tyrosine kinase inhibitor approved for treatment of advanced symptomatic or progressive medullary thyroid cancer (MTC). The current study (Nbib1496313) evaluated the benefit-risk of two starting doses of vandetanib in patients with symptomatic or progressive MTC. Patients were randomized 1:1 to r...

journal_title：Endocrine-related cancer

authors： Hu MI,Elisei R,Dedecjus M,Popovtzer A,Druce M,Kapiteijn E,Pacini F,Locati L,Krajewska J,Weiss R,Gagel RF

更新日期：2019-02-01 00:00:00

abstract：:Selection of novel molecular markers is an important goal of cancer genomics studies. The aim of our analysis was to apply the multivariate bioinformatical tools to rank the genes - potential markers of papillary thyroid cancer (PTC) according to their diagnostic usefulness. We also assessed the accuracy of benign/mal...

journal_title：Endocrine-related cancer

authors： Fujarewicz K,Jarzab M,Eszlinger M,Krohn K,Paschke R,Oczko-Wojciechowska M,Wiench M,Kukulska A,Jarzab B,Swierniak A

更新日期：2007-09-01 00:00:00

abstract：:The purpose of this study is to investigate the role of carbonic anhydrase IX (CAIX) expression in predicting the response to epirubicin and disease-free survival (DFS) in breast cancer patients enrolled in a single institution trial of primary anthracycline and tamoxifen therapy. CAIX expression was assessed in 183 p...

journal_title：Endocrine-related cancer

authors： Generali D,Fox SB,Berruti A,Brizzi MP,Campo L,Bonardi S,Wigfield SM,Bruzzi P,Bersiga A,Allevi G,Milani M,Aguggini S,Dogliotti L,Bottini A,Harris AL

更新日期：2006-09-01 00:00:00

abstract：:Obestatin was identified as a gut peptide encoded by the ghrelin gene that interacts with the G protein-coupled receptor, GPR39. In this work, a sequential analysis of its transmembrane signalling pathway has been undertaken to characterize the intracellular mechanisms responsible for Akt activation. The results show ...

journal_title：Endocrine-related cancer

authors： Alvarez CJ,Lodeiro M,Theodoropoulou M,Camiña JP,Casanueva FF,Pazos Y

更新日期：2009-06-01 00:00:00

abstract：:Thyroid cancers are usually surrounded by a significant number of immune-reactive cells. Tumor-associated lymphocytes as well as background lymphocytic thyroiditis are frequently mentioned in pathology reports of patients who have undergone surgery for thyroid cancer. The nature of this lymphocytic reaction is not wel...

journal_title：Endocrine-related cancer

authors： Imam S,Paparodis R,Sharma D,Jaume JC

更新日期：2014-06-01 00:00:00

abstract：:The majority of metastatic breast cancers cannot be cured and present a major public health problem worldwide. Approximately 70% of breast cancers express the estrogen receptor, and endocrine-based therapies have significantly improved patient outcomes. However, the development of endocrine resistance is extremely com...

journal_title：Endocrine-related cancer

authors： Bullock M

更新日期：2016-02-01 00:00:00

abstract：:The aim of this randomized multicenter phase III trial was to compare chemotherapy and interferon (IFN) in patients with metastatic carcinoid tumors. Patients with documented progressive, unresectable, metastatic carcinoid tumors were randomized between 5-fluorouracil plus streptozotocin (day 1-5) and recombinant IFN-...

journal_title：Endocrine-related cancer

authors： Dahan L,Bonnetain F,Rougier P,Raoul JL,Gamelin E,Etienne PL,Cadiot G,Mitry E,Smith D,Cvitkovic F,Coudert B,Ricard F,Bedenne L,Seitz JF,Fédération Francophone de Cancérologie Digestive (FFCD).,Digestive Tumors Group of the F

更新日期：2009-12-01 00:00:00

abstract：:Genetic variants in components of the protein kinase A (PKA) enzyme have been associated with various defects and neoplasms in the context of Carney complex (CNC) and in isolated cases, such as in primary pigmented nodular adrenocortical disease (PPNAD), cortisol-producing adrenal adenomas (CPAs), and various cancers....

journal_title：Endocrine-related cancer

authors： Espiard S,Drougat L,Settas N,Haydar S,Bathon K,London E,Levy I,Faucz FR,Calebiro D,Bertherat J,Li D,Levine MA,Stratakis CA

更新日期：2020-11-01 00:00:00

abstract：:Thyroid cancer is the most frequent endocrine tumor with a growing incidence worldwide. However, common diagnostic strategy for thyroid cancer classification is hardly to make a proper diagnosis in some cases. To assist classical approach, this study used metabolomics to screen and validate biomarkers from serum and u...

journal_title：Endocrine-related cancer

authors： Chen J,Hu Q,Hou H,Wang S,Zhang Y,Luo Y,Chen H,Deng H,Zhu H,Zhang L,Liu H,Wang A,Liu Y

更新日期：2019-12-01 00:00:00

abstract：:The prognosis remains ill-defined in patients with liver metastases of well-differentiated (WD) digestive endocrine carcinomas (DEC) with high Ki-67 index. The objectives of this study were to determine whether Ki-67 index, tumor differentiation, and extent of liver involvement are independent prognostic factors in pa...

journal_title：Endocrine-related cancer

authors： Hentic O,Couvelard A,Rebours V,Zappa M,Dokmak S,Hammel P,Maire F,O'Toole D,Lévy P,Sauvanet A,Ruszniewski P

更新日期：2010-12-13 00:00:00

abstract：:Because intracellular polyamines have a critical role in cell proliferation and death pathways, the polyamine metabolic pathway represents a potential target for intervention in cancers. A number of polyamine analogues have been identified that downregulate polyamine synthesis and enhance polyamine catabolism, thereby...

journal_title：Endocrine-related cancer

authors： Davidson NE,Hahm HA,McCloskey DE,Woster PM,Casero RA Jr

更新日期：1999-03-01 00:00:00

abstract：:Germline PTEN mutations defining PTEN hamartoma tumor syndrome (PHTS) confer heritable predisposition to breast, endometrial, thyroid and other cancers with known age-related risks, but it remains impossible to predict if any individual will develop cancer. In the general population, gut microbial dysbiosis has been l...

journal_title：Endocrine-related cancer

authors： Byrd V,Getz T,Padmanabhan R,Arora H,Eng C

更新日期：2018-03-01 00:00:00

abstract：:The aim of this systematic review is to study the features of cribriform-morular variant of papillary thyroid carcinoma (CMV-PTC) by analysing the 129 documented cases in the English literature. The disease occurred almost exclusively in women. The median age of presentation for CMV-PTC was 24 years. Slightly over hal...

journal_title：Endocrine-related cancer

authors： Lam AK,Saremi N

更新日期：2017-04-01 00:00:00

abstract：:The imprinted gene, neuronatin (NNAT), is one of the most abundant transcripts in the pituitary and is thought to be involved in the development and maturation of this gland. In a recent whole-genome approach, exploiting a pituitary tumour cell line, we identified hypermethylation associated loss of NNAT. In this repo...

journal_title：Endocrine-related cancer

authors： Revill K,Dudley KJ,Clayton RN,McNicol AM,Farrell WE

更新日期：2009-06-01 00:00:00

abstract：:Endometrial cancer risk is strongly influenced by obesity, but the mechanisms of action remain unclear. Leptin and adiponectin, secreted from adipose tissue, reportedly play a role in such carcinogenic processes as cell proliferation, angiogenesis, and insulin regulation. In this case-control study, nested within the ...

journal_title：Endocrine-related cancer

authors： Dallal CM,Brinton LA,Bauer DC,Buist DS,Cauley JA,Hue TF,Lacroix A,Tice JA,Chia VM,Falk R,Pfeiffer R,Pollak M,Veenstra TD,Xu X,Lacey JV Jr,B~FIT Research Group.

更新日期：2013-02-18 00:00:00

abstract：:Chemotherapy remains the major treatment option for castration-resistant prostate cancer (CRPC) and limited cytotoxic options are available. Inherent chemotherapy resistance occurs in half of all patients and inevitably develops even in those who initially respond. Docetaxel has been the mainstay of therapy for 6 year...

journal_title：Endocrine-related cancer

authors： Mahon KL,Henshall SM,Sutherland RL,Horvath LG

更新日期：2011-07-04 00:00:00

abstract：:FOXE1 is a thyroid-specific transcription factor essential for thyroid gland development and maintenance of the differentiated state. Interestingly, a strong association has been recently described between FOXE1 expression and susceptibility to thyroid cancer, but little is known about the mechanisms underlying FOXE1-...

journal_title：Endocrine-related cancer

authors： Morillo-Bernal J,Fernández LP,Santisteban P

更新日期：2020-03-01 00:00:00

abstract：:Tumor necrosis factor receptor-associated protein 1 (TRAP1) is a heat shock protein 90 (HSP90) molecular chaperone upregulated in several human malignancies and involved in protection from apoptosis and drug resistance, cell cycle progression, cell metabolism and quality control of specific client proteins. TRAP1 role...

journal_title：Endocrine-related cancer

authors： Palladino G,Notarangelo T,Pannone G,Piscazzi A,Lamacchia O,Sisinni L,Spagnoletti G,Toti P,Santoro A,Storto G,Bufo P,Cignarelli M,Esposito F,Landriscina M

更新日期：2016-09-01 00:00:00

abstract：:Neuroendocrine neoplasms (NEN) are a class of tumours heterogeneous in terms of their anatomical sites of origin and clinical behaviour. Outdated perspectives of indolence have been superseded by appreciation for their myriad clinical challenges, such as the high rates of regional and distant metastases at initial dia...

journal_title：Endocrine-related cancer

authors： Clift AK,Frilling A

更新日期：2020-09-01 00:00:00

abstract：:With few exceptions, the almost 30,000 prostate cancer deaths annually in the United States are due to failure of androgen deprivation therapy. Androgen deprivation therapy prevents ligand-activation of the androgen receptor. Despite initial remission after androgen deprivation therapy, prostate cancer almost invariab...

journal_title：Endocrine-related cancer

authors： Kumari S,Senapati D,Heemers HV

更新日期：2017-08-01 00:00:00

abstract：:Apoptosis is a frequent phenomenon in breast cancer and it can be detected by light microscopy in conventional histopathological sections or by special staining techniques. The number of apoptotic cells as a percentage of cells present, or the number of apoptotic cells per square millimetre of neoplastic tissue, is us...

journal_title：Endocrine-related cancer

authors： Lipponen P

更新日期：1999-03-01 00:00:00

abstract：:It is well known that sex steroids play important roles in the development of invasive ductal carcinoma (IDC) of the human breast. However, biological significance of sex steroids remains largely unclear in ductal carcinoma in situ (DCIS), regarded as a precursor lesion of IDC, which is partly due to the fact that the...

journal_title：Endocrine-related cancer

authors： Shibuya R,Suzuki T,Miki Y,Yoshida K,Moriya T,Ono K,Akahira J,Ishida T,Hirakawa H,Evans DB,Sasano H

更新日期：2008-03-01 00:00:00

abstract：:Although targeted therapy, including inhibitors of mammalian target of rapamycin (mTOR) and vascular endothelial growth factor, being developed for carcinoids arised from the gastrointestinal tract, treatment for locally advanced or metastatic bronchial carcinoids (BCs) remains lacking. Traditional cytotoxic chemother...

journal_title：Endocrine-related cancer

authors： Dong M,Yao JC

更新日期：2011-04-28 00:00:00

abstract：:PD-L1 expression is being considered a potential biomarker for response of anti-PD-1 or anti-PD-L1 agents in various tumors. The reported frequency of PD-L1 positivity varies in thyroid carcinomas, and multiple factors may contribute to the variability in PD-L1 positivity. We evaluated the PD-L1 expression in various ...

journal_title：Endocrine-related cancer

authors： Ahn S,Kim TH,Kim SW,Ki CS,Jang HW,Kim JS,Kim JH,Choe JH,Shin JH,Hahn SY,Oh YL,Chung JH

更新日期：2017-02-01 00:00:00

abstract：:The concentrations of endogenous hormones differ between women with twin and singleton births, with a possible influence on the risk of cancer. We used the nationwide Swedish Family-Cancer Database, including 30,409 women with a twin birth, to examine the subsequent risks of breast, endometrial, and ovarian cancers. R...

journal_title：Endocrine-related cancer

authors： Ji J,Försti A,Sundquist J,Hemminki K

更新日期：2007-09-01 00:00:00

abstract：:The leucine-rich repeats and immunoglobulin-like domains (LRIG) family of transmembrane proteins contains three vertebrate members (LRIG1, LRIG2 and LRIG3) and one member each in flies (Lambik) and worms (Sma-10). LRIGs have stepped into the spotlight as essential regulators of growth factor receptors, including recep...

journal_title：Endocrine-related cancer

authors： Simion C,Cedano-Prieto ME,Sweeney C

更新日期：2014-01-01 00:00:00

abstract：:Mutations of the aryl hydrocarbon receptor interacting protein (AIP) gene are associated with pituitary adenomas that usually occur as familial isolated pituitary adenomas (FIPA). Detailed pathological and tumor genetic data on AIP mutation-related pituitary adenomas are not sufficient. Non-identical twin females pres...

journal_title：Endocrine-related cancer

authors： Villa C,Lagonigro MS,Magri F,Koziak M,Jaffrain-Rea ML,Brauner R,Bouligand J,Junier MP,Di Rocco F,Sainte-Rose C,Beckers A,Roux FX,Daly AF,Chiovato L

更新日期：2011-06-08 00:00:00

abstract：:Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterized in man by parathyroid, pancreatic, pituitary and adrenal tumours. The MEN1 gene encodes a 610-amino acid protein (menin) which is a tumour suppressor. To investigate the in vivo role of menin, we developed a mouse model, by dele...

journal_title：Endocrine-related cancer

authors： Harding B,Lemos MC,Reed AA,Walls GV,Jeyabalan J,Bowl MR,Tateossian H,Sullivan N,Hough T,Fraser WD,Ansorge O,Cheeseman MT,Thakker RV

更新日期：2009-12-01 00:00:00