Apoptosis in breast cancer: relationship with other pathological parameters.

abstract：:Breast and prostate cancer are the most well-characterized cancers of the type that have their development and growth controlled by the endocrine system. These cancers are the leading causes of cancer death in women and men, respectively, in the United States. Being hormone-dependent tumors, antihormone therapies usua...

journal_title：Endocrine-related cancer

authors： Rau KM,Kang HY,Cha TL,Miller SA,Hung MC

更新日期：2005-09-01 00:00:00

abstract：:Mutations of the aryl hydrocarbon receptor interacting protein (AIP) gene are associated with pituitary adenomas that usually occur as familial isolated pituitary adenomas (FIPA). Detailed pathological and tumor genetic data on AIP mutation-related pituitary adenomas are not sufficient. Non-identical twin females pres...

journal_title：Endocrine-related cancer

authors： Villa C,Lagonigro MS,Magri F,Koziak M,Jaffrain-Rea ML,Brauner R,Bouligand J,Junier MP,Di Rocco F,Sainte-Rose C,Beckers A,Roux FX,Daly AF,Chiovato L

更新日期：2011-06-08 00:00:00

abstract：:Although anatomic imaging to assess the precise localization of pheochromocytomas/paragangliomas (PHEOs/PGLs) is unavoidable before any surgical intervention on these tumors, functional imaging is becoming an inseparable portion of the imaging algorithm for these tumors. This review article presents applications of th...

journal_title：Endocrine-related cancer

authors： Castinetti F,Kroiss A,Kumar R,Pacak K,Taieb D

更新日期：2015-08-01 00:00:00

abstract：:Parathyroid carcinoma (PaC) is a rare cause of primary hyperparathyroidism. Though the loss of the oncosuppressor CDC73/HRPT2 gene product, parafibromin, has been involved in the hyperparathyroidism-jaw tumor syndrome and in a consistent set of sporadic PaCs, parathyroid carcinogenesis remains obscure. MicroRNAs are a...

journal_title：Endocrine-related cancer

authors： Corbetta S,Vaira V,Guarnieri V,Scillitani A,Eller-Vainicher C,Ferrero S,Vicentini L,Chiodini I,Bisceglia M,Beck-Peccoz P,Bosari S,Spada A

更新日期：2010-02-18 00:00:00

abstract：:Thyroid cancers are usually surrounded by a significant number of immune-reactive cells. Tumor-associated lymphocytes as well as background lymphocytic thyroiditis are frequently mentioned in pathology reports of patients who have undergone surgery for thyroid cancer. The nature of this lymphocytic reaction is not wel...

journal_title：Endocrine-related cancer

authors： Imam S,Paparodis R,Sharma D,Jaume JC

更新日期：2014-06-01 00:00:00

abstract：:Distant metastases from thyroid cancer of follicular origin are uncommon. Treatment includes levothyroxine administration, focal treatment modalities with surgery, external radiation therapy and thermal ablation, and radioiodine in patients with uptake of 131I in their metastases. Two-thirds of distant metastases beco...

journal_title：Endocrine-related cancer

authors： Berdelou A,Lamartina L,Klain M,Leboulleux S,Schlumberger M

更新日期：2018-04-01 00:00:00

abstract：:Carrying excess body fat is a leading cause of cancer. Epidemiologic evidence gives strong clues about the mechanisms that link excess adiposity to risk for several cancer sites. For postmenopausal breast cancer and endometrial cancer, the hyper-estrogenic state that is induced by excess body fatness is the likely cau...

journal_title：Endocrine-related cancer

authors： Byers T,Sedjo RL

更新日期：2015-06-01 00:00:00

abstract：:Pituitary tumor-transforming gene 1-binding factor (PTTG1IP; PBF) is a multifunctional glycoprotein, which is overexpressed in a wide range of tumours, and significantly associated with poorer oncological outcomes, such as early tumour recurrence, distant metastasis, extramural vascular invasion and decreased disease-...

journal_title：Endocrine-related cancer

authors： Imruetaicharoenchoke W,Fletcher A,Lu W,Watkins RJ,Modasia B,Poole VL,Nieto HR,Thompson RJ,Boelaert K,Read ML,Smith VE,McCabe CJ

更新日期：2017-09-01 00:00:00

abstract：:Medical therapy of pancreatic neuroendocrine tumors (P-NET) may take advantage of Everolimus treatment. However, the extent of therapeutic response cannot be predicted. This study was aimed to identify the possible predictive markers of response to Everolimus in P-NET. We found that Everolimus reduced the cell viabili...

journal_title：Endocrine-related cancer

authors： Falletta S,Partelli S,Rubini C,Nann D,Doria A,Marinoni I,Polenta V,Di Pasquale C,Degli Uberti E,Perren A,Falconi M,Zatelli MC

更新日期：2016-11-01 00:00:00

abstract：:Pituitary adenomas cause significant endocrine and mass-related morbidity. Little is known about the mechanisms that underlie pituitary tumor pathogenesis. In the present study, we searched for a side population (SP) in pituitary tumors representing cells with high efflux capacity and potentially enriched for tumor st...

journal_title：Endocrine-related cancer

authors： Mertens F,Gremeaux L,Chen J,Fu Q,Willems C,Roose H,Govaere O,Roskams T,Cristina C,Becú-Villalobos D,Jorissen M,Poorten VV,Bex M,van Loon J,Vankelecom H

更新日期：2015-08-01 00:00:00

abstract：:Pancreatic endocrine tumours (PETs) are rare and 'indolent' neoplasms that usually develop metastatic lesions and exhibit poor response to standard medical treatments. Few studies have investigated pathways responsible for PET cell growth and invasion and no alternative therapeutic strategies have been proposed. In a ...

journal_title：Endocrine-related cancer

authors： Di Florio A,Capurso G,Milione M,Panzuto F,Geremia R,Delle Fave G,Sette C

更新日期：2007-03-01 00:00:00

abstract：:Imatinib mesylate (IM), a small molecule that is a selective inhibitor of the ABL, platelet derived growth factor receptor (PDGFR-R) and stem cell ligand receptor (c-kit) tyrosine kinases (TK). IM was also found to inhibit the TK activity of BCR/ABL fusion protein produced in chronic myelogenous leukemia, with marked ...

journal_title：Endocrine-related cancer

authors： Gross DJ,Munter G,Bitan M,Siegal T,Gabizon A,Weitzen R,Merimsky O,Ackerstein A,Salmon A,Sella A,Slavin S,Israel Glivec in Solid Tumors Study Group.

更新日期：2006-06-01 00:00:00

abstract：:The current study aims to evaluate for the first time the inhibitory roles of miR-205 in the pathogenesis of anaplastic thyroid carcinoma. In addition, we investigated the mechanisms by which miR-205 regulates angiogenesis and epithelial-to-mesenchymal transition (EMT) in cancer. Two anaplastic thyroid carcinoma cell ...

journal_title：Endocrine-related cancer

authors： Vosgha H,Ariana A,Smith RA,Lam AK

更新日期：2018-03-01 00:00:00

abstract：:Metastatic duodenopancreatic neuro-endocrine tumors (dpNETs) are the most important disease-related cause of death in patients with multiple endocrine neoplasia type 1 (MEN1). Nonfunctioning pNETs (NF-pNETs) are highly prevalent in MEN1 and clinically heterogeneous. Therefore, management is controversial. Data on prog...

journal_title：Endocrine-related cancer

authors： Sadowski SM,Pieterman CRC,Perrier ND,Triponez F,Valk GD

更新日期：2020-06-01 00:00:00

abstract：:Hormonal therapy leads to improved survival in oestrogen receptor (ER) positive early breast cancer and long-term responses in advanced disease. However, resistance to such therapy is a serious clinical problem. This article considers the data for and against there being a significant role for the oncogene HER-2 in su...

journal_title：Endocrine-related cancer

authors： Dowsett M

更新日期：2001-09-01 00:00:00

abstract：:The potential of aromatase (estrogen synthetase) within the breast to provide a significant source of estrogen mediating tumor proliferation is suggested by studies reporting 4- to 6-fold higher estrogen levels in tumors than in plasma of postmenopausal patients with breast cancer. Recent studies in our laboratory hav...

journal_title：Endocrine-related cancer

authors： Brodie A,Lu Q,Liu Y,Long B

更新日期：1999-06-01 00:00:00

abstract：:Autophagy is an important intracellular process involving the degradation of cytoplasmic components. It is involved in both physiological and pathological conditions, including cancer. The role of autophagy in cancer is described as a 'double-edged sword,' a term that reflects its known participation in tumor suppress...

journal_title：Endocrine-related cancer

authors： Weckman A,Rotondo F,Di Ieva A,Syro LV,Butz H,Cusimano MD,Kovacs K

更新日期：2015-08-01 00:00:00

abstract：:Obesity is associated with a range of health outcomes that are of clinical and public health significance, including cancer. Herein, we summarize epidemiologic and preclinical evidence for an association between obesity and increased risk of breast and prostate cancer incidence and mortality. Moreover, we describe dat...

journal_title：Endocrine-related cancer

authors： Allott EH,Hursting SD

更新日期：2015-12-01 00:00:00

abstract：:Endometrial cancer is the most common gynecological malignancy in developed countries and represents the eighth leading cause of cancer related death in women. The growing incidence of endometrial cancer leads scientists and oncologists to identify effective preventive measures and also molecular markers for diagnosis...

journal_title：Endocrine-related cancer

authors： Chaudhry P,Asselin E

更新日期：2009-06-01 00:00:00

abstract：:177Lu-octreotate is an FDA-approved radionuclide therapy for patients with gastroenteropancreatic neuroendocrine tumours (NETs) expressing somatostatin receptors. The 177Lu-octreotate therapy has shown promising results in clinical trials by prolonging progression-free survival, but complete responses are still uncomm...

journal_title：Endocrine-related cancer

authors： Hofving T,Sandblom V,Arvidsson Y,Shubbar E,Altiparmak G,Swanpalmer J,Almobarak B,Elf AK,Johanson V,Elias E,Kristiansson E,Forssell-Aronsson E,Nilsson O

更新日期：2019-04-01 00:00:00

abstract：:Metastatic tumor cells can interfere directly with the function of bone cells involved in normal bone remodeling or indirectly by influencing the behavior of hematopoietic, stromal and other cells in bone marrow that interact with bone cells. Recent studies of metastatic cancer have revealed that tumor cells interact ...

journal_title：Endocrine-related cancer

authors： Boyce BF,Yoneda T,Guise TA

更新日期：1999-09-01 00:00:00

abstract：:Atypical parathyroid adenomas represent a group of intermediate form of parathyroid neoplasms of uncertain malignant potential which show some atypical histological features that represent a challenge for the differential diagnosis with parathyroid carcinomas. They may occur as sporadic or as a part of hereditary synd...

journal_title：Endocrine-related cancer

authors： Cetani F,Marcocci C,Torregrossa L,Pardi E

更新日期：2019-07-01 00:00:00

abstract：:With increasing numbers of childhood cancer survivors who were treated with radiation, there is a need to evaluate potential biomarkers that could signal an increased risk of developing thyroid cancer. We aimed to examine the relationships between thyrotropin and thyroglobulin levels and the risk of developing thyroid...

journal_title：Endocrine-related cancer

authors： Shulan JM,Vydro L,Schneider AB,Mihailescu DV

更新日期：2018-04-01 00:00:00

abstract：:Pheochromocytomas (PCCs) and paragangliomas (PGLs) are rare neuroendocrine tumors of the adrenal glands and the sympathetic and parasympathetic paraganglia. They can occur sporadically or as a part of different hereditary tumor syndromes. About 30% of PCCs and PGLs are currently believed to be caused by germline mutat...

journal_title：Endocrine-related cancer

authors： Welander J,Söderkvist P,Gimm O

更新日期：2011-12-01 00:00:00

abstract：:Ghrelin is a hormone with multiple physiologic functions, including promotion of growth hormone release, stimulation of appetite and regulation of energy homeostasis. Treatment with ghrelin/ghrelin-receptor agonists is a prospective therapy for disease-related cachexia and malnutrition. In vitro studies have shown hig...

journal_title：Endocrine-related cancer

authors： Sever S,White DL,Garcia JM

更新日期：2016-09-01 00:00:00

abstract：:ThyroSeq v2 claims high positive (PPV) and negative (NPV) predictive values in a wide range of pretest risks of malignancy in indeterminate thyroid nodules (ITNs) (categories B-III and B-IV of the Bethesda system). We evaluated ThyroSeq v2 performance in a cohort of patients with ITNs seen at our Academic Cancer Cente...

journal_title：Endocrine-related cancer

authors： Valderrabano P,Khazai L,Leon ME,Thompson ZJ,Ma Z,Chung CH,Hallanger-Johnson JE,Otto KJ,Rogers KD,Centeno BA,McIver B

更新日期：2017-03-01 00:00:00

abstract：:Epidemiologic and experimental evidence suggest that a subset of breast cancer is insulin responsive, but it is unclear whether safe and effective therapies that target the insulin receptor (IR), which is homologous to oncogenes of the tyrosine kinase class, can be developed. We demonstrate that both pharmacologic inh...

journal_title：Endocrine-related cancer

authors： Dool CJ,Mashhedi H,Zakikhani M,David S,Zhao Y,Birman E,Carboni JM,Gottardis M,Blouin MJ,Pollak M

更新日期：2011-11-14 00:00:00

abstract：:Medullary thyroid cancer (MTC) is a rare tumor arising from the calcitonin-producing parafollicular C cells of the thyroid gland, occurring either sporadically or alternatively in a hereditary form based on germline RET mutations in approximately one-third of cases. Historically, patients with advanced, metastasized M...

journal_title：Endocrine-related cancer

authors： Spitzweg C,Morris JC,Bible KC

更新日期：2016-06-01 00:00:00

abstract：:Transformation-related protein 63 (Trp63), the predominant member of the Trp53 family, contributes to epithelial differentiation and is expressed in breast neoplasia. Trp63 features two distinct promoters yielding specific mRNAs encoding two major TRP63 isoforms, a transactivating transcription factor and a dominant n...

journal_title：Endocrine-related cancer

authors： Assefnia S,Kang K,Groeneveld S,Yamaji D,Dabydeen S,Alamri A,Liu X,Hennighausen L,Furth PA

更新日期：2014-05-06 00:00:00

abstract：:The expression of estrogen receptor α (ERα) in breast cancer identifies patients most likely to respond to endocrine treatment. The second ER, ERβ, is also expressed in breast tumors, but its function and therapeutic potential need further study. Although in vitro studies have established that ERβ opposes transcriptio...

journal_title：Endocrine-related cancer

authors： Jonsson P,Katchy A,Williams C

更新日期：2014-01-30 00:00:00