Atypical parathyroid adenomas: challenging lesions in the differential diagnosis of endocrine tumors.

abstract：:Approximately 80% of human ovarian and endometrial cancers and 50% of breast cancers express GnRH and its receptor as part of an autocrine regulatory system. After binding of its ligand the tumor GnRH receptor couples to G-protein alphai and activates a variety of intracellular signaling mechanisms. (1) Through activa...

journal_title：Endocrine-related cancer

authors： Emons G,Gründker C,Günthert AR,Westphalen S,Kavanagh J,Verschraegen C

更新日期：2003-06-01 00:00:00

abstract：:Selection of novel molecular markers is an important goal of cancer genomics studies. The aim of our analysis was to apply the multivariate bioinformatical tools to rank the genes - potential markers of papillary thyroid cancer (PTC) according to their diagnostic usefulness. We also assessed the accuracy of benign/mal...

journal_title：Endocrine-related cancer

authors： Fujarewicz K,Jarzab M,Eszlinger M,Krohn K,Paschke R,Oczko-Wojciechowska M,Wiench M,Kukulska A,Jarzab B,Swierniak A

更新日期：2007-09-01 00:00:00

abstract：:Colony-stimulating factor 1 (CSF1) is a key regulator of mammary gland development, and a modulator of tissue macrophages. Expression of the CSF1 receptor gene C-FMS (CSF1R) is strongly associated with poor outcome in breast cancer and results in tumor cell invasiveness and pro-metastatic behavior in vitro. However, C...

journal_title：Endocrine-related cancer

authors： Aharinejad S,Salama M,Paulus P,Zins K,Berger A,Singer CF

更新日期：2013-10-14 00:00:00

abstract：:Bone metastases are common in advanced prostate cancer patients, but mechanisms by which specific pro-metastatic skeletal niches are formed before tumor cell homing are unclear. We aimed to analyze the effects of proteins secreted by primary prostate tumors on the bone microenvironment before the settlement and propag...

journal_title：Endocrine-related cancer

authors： Ardura JA,Álvarez-Carrión L,Gutiérrez-Rojas I,Friedman PA,Gortázar AR,Alonso V

更新日期：2020-07-01 00:00:00

abstract：:Chemotherapy remains the major treatment option for castration-resistant prostate cancer (CRPC) and limited cytotoxic options are available. Inherent chemotherapy resistance occurs in half of all patients and inevitably develops even in those who initially respond. Docetaxel has been the mainstay of therapy for 6 year...

journal_title：Endocrine-related cancer

authors： Mahon KL,Henshall SM,Sutherland RL,Horvath LG

更新日期：2011-07-04 00:00:00

abstract：:Pancreatic neuroendocrine neoplasms (PNENs) constitute a rare tumour entity, and prognosis and treatment options depend on tumour-mediating hallmarks such as angiogenesis, proliferation rate and resistance to apoptosis. The molecular pathways that determine the malignant phenotype are still insufficiently understood a...

journal_title：Endocrine-related cancer

authors： Krug S,Kühnemuth B,Griesmann H,Neesse A,Mühlberg L,Boch M,Kortenhaus J,Fendrich V,Wiese D,Sipos B,Friemel J,Gress TM,Michl P

更新日期：2014-01-01 00:00:00

abstract：:Pancreatic neuroendocrine tumors (PanNETs) are rare in von Hippel-Lindau disease (VHL) but cause serious morbidity and mortality. Management guidelines for VHL-PanNETs continue to be based on limited evidence, and survival data to guide surgical management are lacking. We established the European-American-Asian-VHL-Pa...

journal_title：Endocrine-related cancer

authors： Krauss T,Ferrara AM,Links TP,Wellner U,Bancos I,Kvachenyuk A,Villar Gómez de Las Heras K,Yukina MY,Petrov R,Bullivant G,von Duecker L,Jadhav S,Ploeckinger U,Welin S,Schalin-Jäntti C,Gimm O,Pfeifer M,Ngeow J,Hasse-Laza

更新日期：2018-09-01 00:00:00

abstract：:Thyroid cancer is on the rise. Novel approaches are needed to improve the outcome of patients with recurrent and advanced metastatic thyroid cancers. FDA approval of suberoylanilide hydroxamic acid (SAHA; vorinostat), an inhibitor of histone deacetylase, for the treatment of hematological malignancies led to the clini...

journal_title：Endocrine-related cancer

authors： Zhu X,Kim DW,Zhao L,Willingham MC,Cheng SY

更新日期：2016-07-01 00:00:00

abstract：:The HIV protease inhibitor Nelfinavir (NFV) inhibits PI3K/AKT and MAPK/ERK signaling pathways, emerging targets in thyroid cancers. We examined the effects of NFV on cancer cells that derived from follicular (FTC), papillary (PTC) and anaplastic (ATC) thyroid cancers. NFV (1-20 µM) was tested in FTC133, BCPAP and SW17...

journal_title：Endocrine-related cancer

authors： Jensen K,Bikas A,Patel A,Kushchayeva Y,Costello J,McDaniel D,Burman K,Vasko V

更新日期：2017-03-01 00:00:00

abstract：:'Calcitonin screening' is not accepted as the standard of care in daily practice. The clinical and surgical consequences of 'calcitonin screening' in a series of patients with mildly elevated basal calcitonin and pentagastrin stimulated calcitonin levels are presented. 260 patients with elevated basal (>10 pg/ml) and ...

journal_title：Endocrine-related cancer

authors： Scheuba C,Kaserer K,Moritz A,Drosten R,Vierhapper H,Bieglmayer C,Haas OA,Niederle B

更新日期：2009-03-01 00:00:00

abstract：:The treatment of hormone hypersecretory syndromes caused by neuroendocrine tumors (NETs) can be a major challenge. NETs originating from the small intestine often secrete serotonin causing flushing, diarrhea and valve fibrosis, leading to dehydration or heart failure in severe cases. NETs from the pancreas can secrete...

journal_title：Endocrine-related cancer

authors： Zandee WT,Kamp K,van Adrichem RC,Feelders RA,de Herder WW

更新日期：2017-07-01 00:00:00

abstract：:Overexpression of human epidermal growth factor receptor 2 (HER2) predicts response to anti-HER2 therapy in breast cancer. We investigated whether hormone receptor (HR) status influences the treatment benefit of trastuzumab in patients with breast cancer. Data from 8338 patients with primary nonmetastatic breast cance...

journal_title：Endocrine-related cancer

authors： Ignatov T,Eggemann H,Burger E,Costa SD,Ignatov A

更新日期：2016-05-01 00:00:00

abstract：:Obesity is associated with a range of health outcomes that are of clinical and public health significance, including cancer. Herein, we summarize epidemiologic and preclinical evidence for an association between obesity and increased risk of breast and prostate cancer incidence and mortality. Moreover, we describe dat...

journal_title：Endocrine-related cancer

authors： Allott EH,Hursting SD

更新日期：2015-12-01 00:00:00

abstract：:The aim of this randomized multicenter phase III trial was to compare chemotherapy and interferon (IFN) in patients with metastatic carcinoid tumors. Patients with documented progressive, unresectable, metastatic carcinoid tumors were randomized between 5-fluorouracil plus streptozotocin (day 1-5) and recombinant IFN-...

journal_title：Endocrine-related cancer

authors： Dahan L,Bonnetain F,Rougier P,Raoul JL,Gamelin E,Etienne PL,Cadiot G,Mitry E,Smith D,Cvitkovic F,Coudert B,Ricard F,Bedenne L,Seitz JF,Fédération Francophone de Cancérologie Digestive (FFCD).,Digestive Tumors Group of the F

更新日期：2009-12-01 00:00:00

abstract：:Most endocrine therapies for breast cancer inhibit tumor growth by depriving the cell of estrogen or by blocking its receptor. However, some drugs, such as tamoxifen, can bind to the estrogen receptor (ER) and have both estrogenic and antiestrogenic effects, depending on the tissue, cell, or promoter context. These mi...

journal_title：Endocrine-related cancer

authors： Osborne CK

更新日期：1999-06-01 00:00:00

abstract：:Androgen deprivation therapy (ADT) is a highly effective treatment used in ∼30% of men with prostate cancer. Adverse effects of ADT on muscle are significant with consistent losses in muscle mass. However, effects of ADT on muscle strength and physical function, of most relevance to the patient, are less well understo...

journal_title：Endocrine-related cancer

authors： de Rooy C,Grossmann M,Zajac JD,Cheung AS

更新日期：2016-01-01 00:00:00

abstract：:We report the case of an 8-year-old child who presented with severe hyperinsulinaemic hypoglycaemia due to a pancreatic islet cell adenoma. In vivo, there was no beneficial response to the hyperglycaemia-inducing agent diazoxide and as a consequence the child underwent a subtotal pancreatectomy. In vitro studies of ad...

journal_title：Endocrine-related cancer

authors： Hussain K,Cosgrove KE,Shepherd RM,Chapman JC,Swift SM,Smith VV,Kassem SA,Glaser B,Lindley KJ,Aynsley-Green A,Dunne MJ

更新日期：2002-12-01 00:00:00

abstract：:Male breast cancer (MBC) is extremely rare and accounts for less than 1% of all breast malignancies. Therefore, clinical management of MBC is currently guided by research on the disease in females. In this study, DNA obtained from 45 formalin-fixed paraffin-embedded (FFPE) MBCs with and 90 MBCs (52 FFPE and 38 fresh-f...

journal_title：Endocrine-related cancer

authors： Moelans CB,de Ligt J,van der Groep P,Prins P,Besselink NJM,Hoogstraat M,Ter Hoeve ND,Lacle MM,Kornegoor R,van der Pol CC,de Leng WWJ,Barbé E,van der Vegt B,Martens J,Bult P,Smit VTHBM,Koudijs MJ,Nijman IJ,Voest EE,S

更新日期：2019-10-01 00:00:00

abstract：:It has been proposed that knowledge of estrogen receptor beta (ER-beta) expression may refine estrogen receptor alpha (ER-alpha) predictivity of response to endocrine therapy. We challenged this hypothesis in ER-alpha-positive breast cancers subjected to preoperative antiestrogen treatment. Forty-seven elderly (> or =...

journal_title：Endocrine-related cancer

authors： Cappelletti V,Celio L,Bajetta E,Allevi A,Longarini R,Miodini P,Villa R,Fabbri A,Mariani L,Giovanazzi R,Galante E,Greco M,Grazia Daidone M

更新日期：2004-12-01 00:00:00

abstract：:Anaplastic thyroid cancer is one of the most lethal diseases, and a curative therapy does not exist. Doxorubicin, the only drug approved for anaplastic thyroid cancer treatment, has a very low response rate and causes numerous side effects among which cardiotoxicity is the most prominent. Thus, doxorubicin delivery to...

journal_title：Endocrine-related cancer

authors： Marano F,Frairia R,Rinella L,Argenziano M,Bussolati B,Grange C,Mastrocola R,Castellano I,Berta L,Cavalli R,Catalano MG

更新日期：2017-06-01 00:00:00

abstract：:Dendritic cells (DCs) are highly efficient antigen-presenting cells in the immune system with the potential to regulate the system and induce a cytotoxic T-cell response. As a proof of principle, a multitude of animal and human studies has demonstrated that immunization with antigen-loaded DCs may lead to anti-tumour ...

journal_title：Endocrine-related cancer

authors： Schott M

更新日期：2006-09-01 00:00:00

abstract：:The imprinted gene, neuronatin (NNAT), is one of the most abundant transcripts in the pituitary and is thought to be involved in the development and maturation of this gland. In a recent whole-genome approach, exploiting a pituitary tumour cell line, we identified hypermethylation associated loss of NNAT. In this repo...

journal_title：Endocrine-related cancer

authors： Revill K,Dudley KJ,Clayton RN,McNicol AM,Farrell WE

更新日期：2009-06-01 00:00:00

abstract：:Neuroendocrine neoplasms (NENs) are a relatively rare group of heterogeneous tumours originating from neuroendocrine cells found throughout the body. Pancreatic NENs (PanNENs) are the second most common pancreatic malignancy accounting for 1-3% of all neoplasms developing in the pancreas. Despite having a low backgrou...

journal_title：Endocrine-related cancer

authors： Pipinikas CP,Berner AM,Sposito T,Thirlwell C

更新日期：2019-08-01 00:00:00

abstract：:Over the past years there have been significant advances in breast cancer treatment and early detection. For the first time, a decrease in cancer mortality has been observed. Recently, much progress has been made in the understanding of carcinogenesis partly due to available new technologies to detect early molecular ...

journal_title：Endocrine-related cancer

authors： Arun B,Hortobagyi GN

更新日期：2002-03-01 00:00:00

abstract：:The tumour microenvironment is known to be acidic due to high glycolytic rates of tumour cells. Monocarboxylate transporters (MCTs) play a role in extracellular acidification, which is widely known to be involved in tumour progression. Recently, we have described the upregulation of MCT1 in breast carcinomas and its a...

journal_title：Endocrine-related cancer

authors： Morais-Santos F,Miranda-Gonçalves V,Pinheiro S,Vieira AF,Paredes J,Schmitt FC,Baltazar F,Pinheiro C

更新日期：2013-12-16 00:00:00

abstract：:FOXE1 is a thyroid-specific transcription factor essential for thyroid gland development and maintenance of the differentiated state. Interestingly, a strong association has been recently described between FOXE1 expression and susceptibility to thyroid cancer, but little is known about the mechanisms underlying FOXE1-...

journal_title：Endocrine-related cancer

authors： Morillo-Bernal J,Fernández LP,Santisteban P

更新日期：2020-03-01 00:00:00

abstract：:Endometrial cancer risk is strongly influenced by obesity, but the mechanisms of action remain unclear. Leptin and adiponectin, secreted from adipose tissue, reportedly play a role in such carcinogenic processes as cell proliferation, angiogenesis, and insulin regulation. In this case-control study, nested within the ...

journal_title：Endocrine-related cancer

authors： Dallal CM,Brinton LA,Bauer DC,Buist DS,Cauley JA,Hue TF,Lacroix A,Tice JA,Chia VM,Falk R,Pfeiffer R,Pollak M,Veenstra TD,Xu X,Lacey JV Jr,B~FIT Research Group.

更新日期：2013-02-18 00:00:00

abstract：:Transformation-related protein 63 (Trp63), the predominant member of the Trp53 family, contributes to epithelial differentiation and is expressed in breast neoplasia. Trp63 features two distinct promoters yielding specific mRNAs encoding two major TRP63 isoforms, a transactivating transcription factor and a dominant n...

journal_title：Endocrine-related cancer

authors： Assefnia S,Kang K,Groeneveld S,Yamaji D,Dabydeen S,Alamri A,Liu X,Hennighausen L,Furth PA

更新日期：2014-05-06 00:00:00

abstract：:The fight against cancer has seen major breakthroughs in recent years. More than a decade ago, tyrosine kinase inhibitors targeting constitutively activated signaling cascades within the tumor inaugurated a new era of oncological therapy. Recently, immunotherapy with immune checkpoint inhibitors has started to revolut...

journal_title：Endocrine-related cancer

authors： Latteyer S,Tiedje V,Schilling B,Führer D

更新日期：2016-10-01 00:00:00

abstract：:The majority of metastatic breast cancers cannot be cured and present a major public health problem worldwide. Approximately 70% of breast cancers express the estrogen receptor, and endocrine-based therapies have significantly improved patient outcomes. However, the development of endocrine resistance is extremely com...

journal_title：Endocrine-related cancer

authors： Bullock M

更新日期：2016-02-01 00:00:00