Sporadic hypercalcitoninemia: clinical and therapeutic consequences.

abstract：:The number of individuals who succumb to thyroid cancer has been increasing and those who are refractory to standard care have limited therapeutic options, highlighting the importance of developing new treatments for patients with aggressive forms of the disease. Mutational activation of MAPK signaling, through BRAF a...

journal_title：Endocrine-related cancer

authors： Knippler CM,Saji M,Rajan N,Porter K,La Perle KMD,Ringel MD

更新日期：2019-08-01 00:00:00

abstract：:Therapeutic options for patients with metastatic medullary thyroid carcinoma (MTC) are limited due to lack of effective treatments. Thus, there is a need to thoroughly characterize the pathways of molecular pathogenesis and to identify potential targets for therapy in MTC. Since epidermal growth factor receptor (EGFR)...

journal_title：Endocrine-related cancer

authors： Rodríguez-Antona C,Pallares J,Montero-Conde C,Inglada-Pérez L,Castelblanco E,Landa I,Leskelä S,Leandro-García LJ,López-Jiménez E,Letón R,Cascón A,Lerma E,Martin MC,Carralero MC,Mauricio D,Cigudosa JC,Matias-Guiu X,Roble

更新日期：2010-01-29 00:00:00

abstract：:The etiology and pathogenesis of renal cell carcinoma (RCC) are only partially understood. Key findings in hereditary RCC, which may be site specific or a component of a syndrome, have contributed to our current understanding. Important heritable syndromes of RCC are those associated with pheochromocytoma, especially ...

journal_title：Endocrine-related cancer

authors： Malinoc A,Sullivan M,Wiech T,Schmid KW,Jilg C,Straeter J,Deger S,Hoffmann MM,Bosse A,Rasp G,Eng C,Neumann HP

更新日期：2012-05-03 00:00:00

abstract：:Obesity is associated with a range of health outcomes that are of clinical and public health significance, including cancer. Herein, we summarize epidemiologic and preclinical evidence for an association between obesity and increased risk of breast and prostate cancer incidence and mortality. Moreover, we describe dat...

journal_title：Endocrine-related cancer

authors： Allott EH,Hursting SD

更新日期：2015-12-01 00:00:00

abstract：:Thirty percent of medullary thyroid carcinomas (MTCs) are related to dominant germline pathogenic variants in the RET proto-oncogene. According to their aggressiveness, these pathogenic variants are classified in three risk levels: 'moderate', 'high' and 'highest'. The present study compares the metabolomics profiles ...

journal_title：Endocrine-related cancer

authors： Veyrat-Durebex C,Bouzamondo N,Le Mao M,Chao de la Barca JM,Bris C,Dieu X,Simard G,Gadras C,Tessier L,Drui D,Borson-Chazot F,Barlier A,Reynier P,Prunier-Mirebeau D

更新日期：2019-03-01 00:00:00

abstract：:Long-term culture of MCF-7 wild-type (wt) cells in steroid-depleted medium (LTED) results in hypersensitivity to oestradiol (E2) coinciding with elevated levels of ERalpha and enhanced growth factor signalling. In this study, we aimed to compare the effects of the pure anti-oestrogen ICI 182,780 (ICI) with the competi...

journal_title：Endocrine-related cancer

authors： Martin LA,Pancholi S,Chan CM,Farmer I,Kimberley C,Dowsett M,Johnston SR

更新日期：2005-12-01 00:00:00

abstract：:It is now recognized that transforming growth factor beta (TGF-beta) is an important factor that regulates normal breast development as well as breast cancer. Genetically engineered mouse models have been used to determine the role and mechanism of TGF-beta action in normal development and diseases of the breast. Usin...

journal_title：Endocrine-related cancer

authors： Serra R,Crowley MR

更新日期：2005-12-01 00:00:00

abstract：:Certain members of the thiazolidinedione (TZD) family of the peroxisome proliferator-activated receptor gamma (PPARgamma) agonists, such as troglitazone and ciglitazone, exhibit antitumor activities; however, the underlying mechanism remains inconclusive. Substantial evidence suggests that the antiproliferative effect...

journal_title：Endocrine-related cancer

authors： Weng JR,Chen CY,Pinzone JJ,Ringel MD,Chen CS

更新日期：2006-06-01 00:00:00

abstract：:Autotaxin is a secreted enzyme that converts extracellular lysophosphatidylcholine to lysophosphatidate (LPA). In cancers, LPA increases tumour growth, metastasis and chemoresistance by activating six G-protein coupled receptors. We examined >200 human thyroid biopsies. Autotaxin expression in metastatic deposits and ...

journal_title：Endocrine-related cancer

authors： Benesch MG,Ko YM,Tang X,Dewald J,Lopez-Campistrous A,Zhao YY,Lai R,Curtis JM,Brindley DN,McMullen TP

更新日期：2015-08-01 00:00:00

abstract：:The molecular pathways leading to thyroid follicular neoplasia are incompletely understood, and the diagnosis of follicular tumors is a clinical challenge. To provide leads to the pathogenesis and diagnosis of the tumors, we examined the global transcriptome signatures of follicular thyroid carcinoma (FC) and normofol...

journal_title：Endocrine-related cancer

authors： Borup R,Rossing M,Henao R,Yamamoto Y,Krogdahl A,Godballe C,Winther O,Kiss K,Christensen L,Høgdall E,Bennedbaek F,Nielsen FC

更新日期：2010-07-28 00:00:00

abstract：:Administration of the microtubule inhibitor docetaxel is a common treatment for metastatic castration-resistant prostate cancer (mCRPC) and results in prolonged patient overall survival. Usually, after a short period of time chemotherapy resistance emerges and there is urgent need to find new therapeutic targets to ov...

journal_title：Endocrine-related cancer

authors： Gruber M,Ferrone L,Puhr M,Santer FR,Furlan T,Eder IE,Sampson N,Schäfer G,Handle F,Culig Z

更新日期：2020-03-01 00:00:00

abstract：:The potential of aromatase (estrogen synthetase) within the breast to provide a significant source of estrogen mediating tumor proliferation is suggested by studies reporting 4- to 6-fold higher estrogen levels in tumors than in plasma of postmenopausal patients with breast cancer. Recent studies in our laboratory hav...

journal_title：Endocrine-related cancer

authors： Brodie A,Lu Q,Liu Y,Long B

更新日期：1999-06-01 00:00:00

abstract：:Forty years ago, physicians caring for the J-kindred, a 100+ member family with multiple endocrine neoplasia type 2A (MEN2A), hypothesized that early thyroidectomy based on measurement of the biomarker calcitonin could cure patients at risk for development of medullary thyroid carcinoma (MTC). We re-evaluated 22 famil...

journal_title：Endocrine-related cancer

authors： Grubbs EG,Lechan RM,Edeiken-Monroe B,Cote GJ,Trotter C,Tischler AS,Gagel RF

更新日期：2020-08-01 00:00:00

abstract：:Most endocrine therapies for breast cancer inhibit tumor growth by depriving the cell of estrogen or by blocking its receptor. However, some drugs, such as tamoxifen, can bind to the estrogen receptor (ER) and have both estrogenic and antiestrogenic effects, depending on the tissue, cell, or promoter context. These mi...

journal_title：Endocrine-related cancer

authors： Osborne CK

更新日期：1999-06-01 00:00:00

abstract：:In the CLARINET study, lanreotide Autogel (depot in USA) significantly prolonged progression-free survival (PFS) in patients with metastatic pancreatic/intestinal neuroendocrine tumours (NETs). We report long-term safety and additional efficacy data from the open-label extension (OLE). Patients with metastatic grade 1...

journal_title：Endocrine-related cancer

authors： Caplin ME,Pavel M,Ćwikła JB,Phan AT,Raderer M,Sedláčková E,Cadiot G,Wolin EM,Capdevila J,Wall L,Rindi G,Langley A,Martinez S,Gomez-Panzani E,Ruszniewski P,CLARINET Investigators.

更新日期：2016-03-01 00:00:00

abstract：:177Lu-octreotate is an FDA-approved radionuclide therapy for patients with gastroenteropancreatic neuroendocrine tumours (NETs) expressing somatostatin receptors. The 177Lu-octreotate therapy has shown promising results in clinical trials by prolonging progression-free survival, but complete responses are still uncomm...

journal_title：Endocrine-related cancer

authors： Hofving T,Sandblom V,Arvidsson Y,Shubbar E,Altiparmak G,Swanpalmer J,Almobarak B,Elf AK,Johanson V,Elias E,Kristiansson E,Forssell-Aronsson E,Nilsson O

更新日期：2019-04-01 00:00:00

abstract：:The androgen receptor (AR) is well known to play a central role in the pathogenesis of prostate cancer (PCa). In several studies, AR was overexpressed in castration-resistant PCa (CRPC). However, the mechanism of AR overexpression in CRPC is not fully elucidated. Y-box binding protein-1 (YB-1) is a pleiotropic transcr...

journal_title：Endocrine-related cancer

authors： Shiota M,Takeuchi A,Song Y,Yokomizo A,Kashiwagi E,Uchiumi T,Kuroiwa K,Tatsugami K,Fujimoto N,Oda Y,Naito S

更新日期：2011-07-11 00:00:00

abstract：:Paragangliomas (PGLs) have widely different metastastic potentials. Two different types of PGLs can be defined by expression profiling. Cluster 1 PGLs exhibit VHL and/or succinate dehydrogenase (SDH) mutations and a pseudohypoxic phenotype. RET and neurofibromatosis type 1 (NF1) mutations occur in cluster 2 tumors cha...

journal_title：Endocrine-related cancer

authors： Span PN,Rao JU,Oude Ophuis SB,Lenders JW,Sweep FC,Wesseling P,Kusters B,van Nederveen FH,de Krijger RR,Hermus AR,Timmers HJ

更新日期：2011-04-28 00:00:00

abstract：:ThyroSeq v2 claims high positive (PPV) and negative (NPV) predictive values in a wide range of pretest risks of malignancy in indeterminate thyroid nodules (ITNs) (categories B-III and B-IV of the Bethesda system). We evaluated ThyroSeq v2 performance in a cohort of patients with ITNs seen at our Academic Cancer Cente...

journal_title：Endocrine-related cancer

authors： Valderrabano P,Khazai L,Leon ME,Thompson ZJ,Ma Z,Chung CH,Hallanger-Johnson JE,Otto KJ,Rogers KD,Centeno BA,McIver B

更新日期：2017-03-01 00:00:00

abstract：:Obesity increases both the risk and mortality associated with many types of cancer including that of the breast. In mice, obesity increases both incidence of spontaneous tumors and burden of transplanted tumors. Our findings identify leptin, an adipose secreted cytokine, in promoting increased mammary tumor burden in ...

journal_title：Endocrine-related cancer

authors： Zheng Q,Dunlap SM,Zhu J,Downs-Kelly E,Rich J,Hursting SD,Berger NA,Reizes O

更新日期：2011-07-11 00:00:00

abstract：:Non-functioning pituitary adenomas, recently alternatively termed pituitary neuroendocrine tumours (NFpitNETs), are mostly benign neoplasms that are not associated with a hormonal hypersecretory syndrome. The clinical spectrum of NFpitNETs varies from completely asymptomatic to the development of panhypopituitarism an...

journal_title：Endocrine-related cancer

authors： Yavropoulou MP,Tsoli M,Barkas K,Kaltsas G,Grossman A

更新日期：2020-10-01 00:00:00

abstract：:Medullary thyroid cancer (MTC) is a rare tumor arising from the calcitonin-producing parafollicular C cells of the thyroid gland, occurring either sporadically or alternatively in a hereditary form based on germline RET mutations in approximately one-third of cases. Historically, patients with advanced, metastasized M...

journal_title：Endocrine-related cancer

authors： Spitzweg C,Morris JC,Bible KC

更新日期：2016-06-01 00:00:00

abstract：:The clinical course of medullary thyroid carcinoma (MTC) associated with the MEN2A syndrome as well as of sporadic MTC shows considerable heterogeneity. The disease picture varies not only between the same RET proto-oncogene mutation carriers but also among sporadic MTC patients with no RET germinal mutations, which s...

journal_title：Endocrine-related cancer

authors： Kaczmarek-Ryś M,Ziemnicka K,Pławski A,Budny B,Michalak M,Hryhorowicz S,Hoppe-Gołębiewska J,Boruń P,Gołąb M,Czetwertyńska M,Sromek M,Szalata M,Ruchała M,Słomski R

更新日期：2018-04-01 00:00:00

abstract：:Along with breast and endometrial cancers, thyroid cancer is a major component cancer in Cowden syndrome (CS). Germline variants in SDHB/C/D (SDHx) genes account for subsets of CS/CS-like cases, conferring a higher risk of breast and thyroid cancers over those with only germline PTEN mutations. To investigate whether ...

journal_title：Endocrine-related cancer

authors： Ni Y,Seballos S,Ganapathi S,Gurin D,Fletcher B,Ngeow J,Nagy R,Kloos RT,Ringel MD,LaFramboise T,Eng C

更新日期：2015-04-01 00:00:00

abstract：:Recent studies have indicated that a high-fat diet (HFD) plays an important role in prostate cancer (PCa) progression. Palmitic acid (PA) is one of the most abundant saturated free fatty acids (FAs) and is associated with carcinogenesis. In this study, we investigated the mechanism underlying the association of dietar...

journal_title：Endocrine-related cancer

authors： Huang M,Narita S,Inoue T,Tsuchiya N,Satoh S,Nanjo H,Sasaki T,Habuchi T

更新日期：2013-12-16 00:00:00

abstract：:Prostate cancer development and progression is largely dependent on androgen receptor (AR) signaling. AR is a hormone-dependent transcription factor, which binds to thousands of sites throughout the human genome to regulate expression of directly responsive genes, including pro-survival genes that enable tumor cells t...

journal_title：Endocrine-related cancer

authors： Stelloo S,Linder S,Nevedomskaya E,Valle-Encinas E,de Rink I,Wessels LFA,van der Poel H,Bergman AM,Zwart W

更新日期：2020-02-01 00:00:00

abstract：:Pancreatic neuroendocrine neoplasms (PNENs) constitute a rare tumour entity, and prognosis and treatment options depend on tumour-mediating hallmarks such as angiogenesis, proliferation rate and resistance to apoptosis. The molecular pathways that determine the malignant phenotype are still insufficiently understood a...

journal_title：Endocrine-related cancer

authors： Krug S,Kühnemuth B,Griesmann H,Neesse A,Mühlberg L,Boch M,Kortenhaus J,Fendrich V,Wiese D,Sipos B,Friemel J,Gress TM,Michl P

更新日期：2014-01-01 00:00:00

abstract：:Chitinase 3-like 1 (CHI3L1 or YKL40) is a secreted glycoprotein highly expressed in tumours from patients with advanced stage cancers, including prostate cancer (PCa). The exact function of YKL40 is poorly understood, but it has been shown to play an important role in promoting tumour angiogenesis and metastasis. The ...

journal_title：Endocrine-related cancer

authors： Jeet V,Tevz G,Lehman M,Hollier B,Nelson C

更新日期：2014-10-01 00:00:00

abstract：:Carrying excess body fat is a leading cause of cancer. Epidemiologic evidence gives strong clues about the mechanisms that link excess adiposity to risk for several cancer sites. For postmenopausal breast cancer and endometrial cancer, the hyper-estrogenic state that is induced by excess body fatness is the likely cau...

journal_title：Endocrine-related cancer

authors： Byers T,Sedjo RL

更新日期：2015-06-01 00:00:00

abstract：:Deubiquitinases (DUBs) play important roles and therefore are potential drug targets in various diseases including cancer and neurodegeneration. In this review, we recapitulate structure-function studies of the most studied DUBs including USP7, USP22, CYLD, UCHL1, BAP1, A20, as well as ataxin 3 and connect them to reg...

journal_title：Endocrine-related cancer

authors： Pfoh R,Lacdao IK,Saridakis V

更新日期：2015-02-01 00:00:00