Sporadic hypercalcitoninemia: clinical and therapeutic consequences.

abstract：:Evidence supports a role of 17&-estradiol (E2) in carcinogenesis and the large majority of breast carcinomas are dependent on estrogen. The anti-estrogen tamoxifen (TAM) is widely used for both treatment and prevention of breast cancer; however, it is also carcinogenic in human uterus and rat liver, highlighting the p...

journal_title：Endocrine-related cancer

authors： Rondón-Lagos M,Rangel N,Di Cantogno LV,Annaratone L,Castellano I,Russo R,Manetta T,Marchiò C,Sapino A

更新日期：2016-08-01 00:00:00

abstract：:Na(+)/I(-) symporter (NIS)-mediated radioiodide uptake (RAIU) serves as the basis for targeted ablation of thyroid cancer remnants. However, many patients with thyroid cancer have reduced NIS expression/function and hence do not benefit from radioiodine therapy. microRNA (miR) has emerged as a promising therapeutic ta...

journal_title：Endocrine-related cancer

authors： Lakshmanan A,Wojcicka A,Kotlarek M,Zhang X,Jazdzewski K,Jhiang SM

更新日期：2015-02-01 00:00:00

abstract：:Somatostatin-producing neuroendocrine tumors (SOM-NETs) of the duodenum and pancreas appear to be heterogeneous. To determine their clinicopathological profiles, respective data were analyzed on a series of 82 duodenal and 541 pancreatic NETs. In addition, the clinical records of 821 patients with duodenal or pancreat...

journal_title：Endocrine-related cancer

authors： Garbrecht N,Anlauf M,Schmitt A,Henopp T,Sipos B,Raffel A,Eisenberger CF,Knoefel WT,Pavel M,Fottner C,Musholt TJ,Rinke A,Arnold R,Berndt U,Plöckinger U,Wiedenmann B,Moch H,Heitz PU,Komminoth P,Perren A,Klöppel G

更新日期：2008-03-01 00:00:00

abstract：:Androgen deprivation therapy (ADT) is a highly effective treatment used in ∼30% of men with prostate cancer. Adverse effects of ADT on muscle are significant with consistent losses in muscle mass. However, effects of ADT on muscle strength and physical function, of most relevance to the patient, are less well understo...

journal_title：Endocrine-related cancer

authors： de Rooy C,Grossmann M,Zajac JD,Cheung AS

更新日期：2016-01-01 00:00:00

abstract：:Male breast cancer (MBC) is extremely rare and accounts for less than 1% of all breast malignancies. Therefore, clinical management of MBC is currently guided by research on the disease in females. In this study, DNA obtained from 45 formalin-fixed paraffin-embedded (FFPE) MBCs with and 90 MBCs (52 FFPE and 38 fresh-f...

journal_title：Endocrine-related cancer

authors： Moelans CB,de Ligt J,van der Groep P,Prins P,Besselink NJM,Hoogstraat M,Ter Hoeve ND,Lacle MM,Kornegoor R,van der Pol CC,de Leng WWJ,Barbé E,van der Vegt B,Martens J,Bult P,Smit VTHBM,Koudijs MJ,Nijman IJ,Voest EE,S

更新日期：2019-10-01 00:00:00

abstract：:Although the authors of the present review have contributed to genetic discoveries in the field of pheochromocytoma research, we can legitimately ask whether these advances have led to improvements in the diagnosis and management of patients with pheochromocytoma. The answer to this question is an emphatic Yes! In the...

journal_title：Endocrine-related cancer

authors： Neumann HP,Young WF Jr,Krauss T,Bayley JP,Schiavi F,Opocher G,Boedeker CC,Tirosh A,Castinetti F,Ruf J,Beltsevich D,Walz M,Groeben HT,von Dobschuetz E,Gimm O,Wohllk N,Pfeifer M,Lourenço DM Jr,Peczkowska M,Patocs A,

更新日期：2018-08-01 00:00:00

abstract：:The treatment of hormone hypersecretory syndromes caused by neuroendocrine tumors (NETs) can be a major challenge. NETs originating from the small intestine often secrete serotonin causing flushing, diarrhea and valve fibrosis, leading to dehydration or heart failure in severe cases. NETs from the pancreas can secrete...

journal_title：Endocrine-related cancer

authors： Zandee WT,Kamp K,van Adrichem RC,Feelders RA,de Herder WW

更新日期：2017-07-01 00:00:00

abstract：:Quantitative reverse transcription-polymerase chain reaction (RT-PCR) used to detect minor changes in specific mRNA concentrations may be associated with poor reproducibility. Stringent quality control is therefore essential at each step of the protocol, including the PCR procedure. We performed inter-laboratory quali...

journal_title：Endocrine-related cancer

authors： de Cremoux P,Bieche I,Tran-Perennou C,Vignaud S,Boudou E,Asselain B,Lidereau R,Magdelénat H,Becette V,Sigal-Zafrani B,Spyratos F

更新日期：2004-09-01 00:00:00

abstract：:Novel strategies are needed for the treatment of adrenocortical tumors that are usually resistant to chemotherapy. Hecate, a 23-amino acid lytic peptide, was conjugated to the 15-amino acid (81-95) fragment of the human chorionic gonadotropin beta (CGbeta) chain, which would selectively kill cancer cells expressing th...

journal_title：Endocrine-related cancer

authors： Vuorenoja S,Rivero-Müller A,Ziecik AJ,Huhtaniemi I,Toppari J,Rahman NA

更新日期：2008-06-01 00:00:00

abstract：:Insulin-like growth factors (IGFs) are thought to promote tumour progression and metastasis in part by stimulating cell migration. Insulin receptor substrate-1 (IRS-1) and IRS-2 are multisite docking proteins positioned immediately downstream from the type I IGF and insulin receptors. IRS-2 but not IRS-1 has been repo...

journal_title：Endocrine-related cancer

authors： de Blaquière GE,May FE,Westley BR

更新日期：2009-06-01 00:00:00

abstract：:Over the past years there have been significant advances in breast cancer treatment and early detection. For the first time, a decrease in cancer mortality has been observed. Recently, much progress has been made in the understanding of carcinogenesis partly due to available new technologies to detect early molecular ...

journal_title：Endocrine-related cancer

authors： Arun B,Hortobagyi GN

更新日期：2002-03-01 00:00:00

abstract：:Ghrelin is a hormone with multiple physiologic functions, including promotion of growth hormone release, stimulation of appetite and regulation of energy homeostasis. Treatment with ghrelin/ghrelin-receptor agonists is a prospective therapy for disease-related cachexia and malnutrition. In vitro studies have shown hig...

journal_title：Endocrine-related cancer

authors： Sever S,White DL,Garcia JM

更新日期：2016-09-01 00:00:00

abstract：:The phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway is a key signaling pathway that has been linked to both tumorigenesis and resistance to therapy in prostate cancer and other solid tumors. Given the significance of the PI3K/Akt/mTOR pathway in integrating cell survival signals a...

journal_title：Endocrine-related cancer

authors： Bitting RL,Armstrong AJ

更新日期：2013-05-20 00:00:00

abstract：:We have reported a high prevalence of hypothyroidism in the cutaneous melanoma population, suggesting that the pathologic hormonal environment of hypothyroidism promotes melanoma growth. The objective of this study was to test the hypothesis that TSH, which circulates at elevated levels in hypothyroid individuals, sti...

journal_title：Endocrine-related cancer

authors： Ellerhorst JA,Sendi-Naderi A,Johnson MK,Cooke CP,Dang SM,Diwan AH

更新日期：2006-12-01 00:00:00

abstract：:Hypoxia occurs in solid tumours due to a mismatch between tumour growth and angiogenesis. Hypoxia in solid tumours is associated with an aggressive phenotype and resistance to radiation therapy and chemotherapy leading to poor patient prognosis. Hypoxia-inducible factor-1 (HIF-1) is a transcription factor, which is ac...

journal_title：Endocrine-related cancer

authors： Patiar S,Harris AL

更新日期：2006-12-01 00:00:00

abstract：:FOXE1 is a thyroid-specific transcription factor essential for thyroid gland development and maintenance of the differentiated state. Interestingly, a strong association has been recently described between FOXE1 expression and susceptibility to thyroid cancer, but little is known about the mechanisms underlying FOXE1-...

journal_title：Endocrine-related cancer

authors： Morillo-Bernal J,Fernández LP,Santisteban P

更新日期：2020-03-01 00:00:00

abstract：:This study analyzes the uptake and antiproliferative effect of two different chemical forms of iodine, iodide (I-) and molecular iodine (I2), in MCF-7 cells, which are inducible for the Na+/I- symporter (NIS) and positive for pendrin (PDS). The mouse fibroblast cell line NIH3T3 was used as control. Our results show th...

journal_title：Endocrine-related cancer

authors： Arroyo-Helguera O,Anguiano B,Delgado G,Aceves C

更新日期：2006-12-01 00:00:00

abstract：:The concentrations of endogenous hormones differ between women with twin and singleton births, with a possible influence on the risk of cancer. We used the nationwide Swedish Family-Cancer Database, including 30,409 women with a twin birth, to examine the subsequent risks of breast, endometrial, and ovarian cancers. R...

journal_title：Endocrine-related cancer

authors： Ji J,Försti A,Sundquist J,Hemminki K

更新日期：2007-09-01 00:00:00

abstract：:The tumour microenvironment is known to be acidic due to high glycolytic rates of tumour cells. Monocarboxylate transporters (MCTs) play a role in extracellular acidification, which is widely known to be involved in tumour progression. Recently, we have described the upregulation of MCT1 in breast carcinomas and its a...

journal_title：Endocrine-related cancer

authors： Morais-Santos F,Miranda-Gonçalves V,Pinheiro S,Vieira AF,Paredes J,Schmitt FC,Baltazar F,Pinheiro C

更新日期：2013-12-16 00:00:00

abstract：:Thyroid cancer is the most common cancer of the endocrine system and is responsible for the majority of deaths from endocrine malignancies. Although a large proportion of thyroid cancers belong to well differentiated histologic subtypes, which in general show a good prognosis after surgery and radioiodine ablation, th...

journal_title：Endocrine-related cancer

authors： Morani F,Titone R,Pagano L,Galetto A,Alabiso O,Aimaretti G,Isidoro C

更新日期：2013-12-16 00:00:00

abstract：:Obestatin was identified as a gut peptide encoded by the ghrelin gene that interacts with the G protein-coupled receptor, GPR39. In this work, a sequential analysis of its transmembrane signalling pathway has been undertaken to characterize the intracellular mechanisms responsible for Akt activation. The results show ...

journal_title：Endocrine-related cancer

authors： Alvarez CJ,Lodeiro M,Theodoropoulou M,Camiña JP,Casanueva FF,Pazos Y

更新日期：2009-06-01 00:00:00

abstract：:The thyroid hormones T3 and T4 have emerged as pro-angiogenic hormones with important implications for cancer management. Endogenous circulating hormone levels may help stimulate cancer progression and limit the effectiveness of anticancer therapy, though clinical data remain inconclusive. The capacity of thyroid horm...

journal_title：Endocrine-related cancer

authors： Schmohl KA,Nelson PJ,Spitzweg C

更新日期：2019-06-01 00:00:00

abstract：:Breast and prostate cancer are the most well-characterized cancers of the type that have their development and growth controlled by the endocrine system. These cancers are the leading causes of cancer death in women and men, respectively, in the United States. Being hormone-dependent tumors, antihormone therapies usua...

journal_title：Endocrine-related cancer

authors： Rau KM,Kang HY,Cha TL,Miller SA,Hung MC

更新日期：2005-09-01 00:00:00

abstract：:The clinical course of medullary thyroid carcinoma (MTC) associated with the MEN2A syndrome as well as of sporadic MTC shows considerable heterogeneity. The disease picture varies not only between the same RET proto-oncogene mutation carriers but also among sporadic MTC patients with no RET germinal mutations, which s...

journal_title：Endocrine-related cancer

authors： Kaczmarek-Ryś M,Ziemnicka K,Pławski A,Budny B,Michalak M,Hryhorowicz S,Hoppe-Gołębiewska J,Boruń P,Gołąb M,Czetwertyńska M,Sromek M,Szalata M,Ruchała M,Słomski R

更新日期：2018-04-01 00:00:00

abstract：:The HIV protease inhibitor Nelfinavir (NFV) inhibits PI3K/AKT and MAPK/ERK signaling pathways, emerging targets in thyroid cancers. We examined the effects of NFV on cancer cells that derived from follicular (FTC), papillary (PTC) and anaplastic (ATC) thyroid cancers. NFV (1-20 µM) was tested in FTC133, BCPAP and SW17...

journal_title：Endocrine-related cancer

authors： Jensen K,Bikas A,Patel A,Kushchayeva Y,Costello J,McDaniel D,Burman K,Vasko V

更新日期：2017-03-01 00:00:00

abstract：:We studied the psychological performance and the quality of life in patients with differentiated thyroid carcinoma, either during treatment with chronic suppressive doses of levothyroxine, or during the withdrawal of levothyroxine needed to perform whole-body scanning with radioactive iodine, with those of appropriate...

journal_title：Endocrine-related cancer

authors： Botella-Carretero JI,Galán JM,Caballero C,Sancho J,Escobar-Morreale HF

更新日期：2003-12-01 00:00:00

abstract：:Tumor-induced osteomalacia (TIO) is a rare and fascinating paraneoplastic syndrome in which patients present with bone pain, fractures, and muscle weakness. The cause is high blood levels of the recently identified phosphate and vitamin D-regulating hormone, fibroblast growth factor 23 (FGF23). In TIO, FGF23 is secret...

journal_title：Endocrine-related cancer

authors： Chong WH,Molinolo AA,Chen CC,Collins MT

更新日期：2011-06-08 00:00:00

abstract：:The potential of aromatase (estrogen synthetase) within the breast to provide a significant source of estrogen mediating tumor proliferation is suggested by studies reporting 4- to 6-fold higher estrogen levels in tumors than in plasma of postmenopausal patients with breast cancer. Recent studies in our laboratory hav...

journal_title：Endocrine-related cancer

authors： Brodie A,Lu Q,Liu Y,Long B

更新日期：1999-06-01 00:00:00

abstract：:The androgen receptor (AR) mediates the effects of male steroid hormones (androgens) and contributes to a wide variety of physiological and pathophysiological conditions. As such, the regulatory mechanisms governing AR activity are of high significance. Concerted effort has been placed on delineating the mechanisms th...

journal_title：Endocrine-related cancer

authors： Burd CJ,Morey LM,Knudsen KE

更新日期：2006-12-01 00:00:00

abstract：:Along with breast and endometrial cancers, thyroid cancer is a major component cancer in Cowden syndrome (CS). Germline variants in SDHB/C/D (SDHx) genes account for subsets of CS/CS-like cases, conferring a higher risk of breast and thyroid cancers over those with only germline PTEN mutations. To investigate whether ...

journal_title：Endocrine-related cancer

authors： Ni Y,Seballos S,Ganapathi S,Gurin D,Fletcher B,Ngeow J,Nagy R,Kloos RT,Ringel MD,LaFramboise T,Eng C

更新日期：2015-04-01 00:00:00