The LRIG family: enigmatic regulators of growth factor receptor signaling.

abstract：:ThyroSeq v2 claims high positive (PPV) and negative (NPV) predictive values in a wide range of pretest risks of malignancy in indeterminate thyroid nodules (ITNs) (categories B-III and B-IV of the Bethesda system). We evaluated ThyroSeq v2 performance in a cohort of patients with ITNs seen at our Academic Cancer Cente...

journal_title：Endocrine-related cancer

authors： Valderrabano P,Khazai L,Leon ME,Thompson ZJ,Ma Z,Chung CH,Hallanger-Johnson JE,Otto KJ,Rogers KD,Centeno BA,McIver B

更新日期：2017-03-01 00:00:00

abstract：:Neuroendocrine tumours (NET) of the gastroenteropancreatic system comprise a malignant entity with a low incidence. Only limited information is available on long-term clinical outcome and clinically applicable prognostic factors. We performed a retrospective analysis of a large, well-characterized centre-based patient...

journal_title：Endocrine-related cancer

authors： Pape UF,Berndt U,Müller-Nordhorn J,Böhmig M,Roll S,Koch M,Willich SN,Wiedenmann B

更新日期：2008-12-01 00:00:00

abstract：:The realization that microRNAs (miRNAs) are frequently deregulated in malignancy has had a major impact on cancer research. In particular, the recent finding that highly stable forms of miRNAs can be accurately measured in body fluids, including blood, has generated considerable excitement. Here, we discuss the potent...

journal_title：Endocrine-related cancer

authors： Selth LA,Tilley WD,Butler LM

更新日期：2012-06-18 00:00:00

abstract：:Tropomyosin receptor kinase (Trk) inhibitors are investigated as a novel targeted therapy in various cancers. We investigated the in vitro effects of the pan-Trk inhibitor GNF-5837 in human neuroendocrine tumor (NET) cells. The human neuroendocrine pancreatic BON1, bronchopulmonary NCI-H727 and ileal GOT1 cell lines w...

journal_title：Endocrine-related cancer

authors： Aristizabal Prada ET,Heinzle V,Knösel T,Nölting S,Spöttl G,Maurer J,Spitzweg C,Angele M,Schmidt N,Beuschlein F,Stalla GK,Blaser R,Kuhn KA,Auernhammer CJ

更新日期：2018-05-01 00:00:00

abstract：:Endocrine disturbances are among the most frequently reported complications in childhood cancer survivors, affecting between 20 and 50% of individuals who survive into adulthood. Most endocrine complications are the result of prior cancer treatments, especially radiotherapy. The objective of the present review is to d...

journal_title：Endocrine-related cancer

authors： Chemaitilly W,Sklar CA

更新日期：2010-06-03 00:00:00

abstract：:Distant metastases from thyroid cancer of follicular origin are uncommon. Treatment includes levothyroxine administration, focal treatment modalities with surgery, external radiation therapy and thermal ablation, and radioiodine in patients with uptake of 131I in their metastases. Two-thirds of distant metastases beco...

journal_title：Endocrine-related cancer

authors： Berdelou A,Lamartina L,Klain M,Leboulleux S,Schlumberger M

更新日期：2018-04-01 00:00:00

abstract：:Pheochromocytomas (PCCs) and paragangliomas (PGLs) are rare neuroendocrine tumors of the adrenal glands and the sympathetic and parasympathetic paraganglia. They can occur sporadically or as a part of different hereditary tumor syndromes. About 30% of PCCs and PGLs are currently believed to be caused by germline mutat...

journal_title：Endocrine-related cancer

authors： Welander J,Söderkvist P,Gimm O

更新日期：2011-12-01 00:00:00

abstract：:Deubiquitinases (DUBs) play important roles and therefore are potential drug targets in various diseases including cancer and neurodegeneration. In this review, we recapitulate structure-function studies of the most studied DUBs including USP7, USP22, CYLD, UCHL1, BAP1, A20, as well as ataxin 3 and connect them to reg...

journal_title：Endocrine-related cancer

authors： Pfoh R,Lacdao IK,Saridakis V

更新日期：2015-02-01 00:00:00

abstract：:Tumor necrosis factor receptor-associated protein 1 (TRAP1) is a heat shock protein 90 (HSP90) molecular chaperone upregulated in several human malignancies and involved in protection from apoptosis and drug resistance, cell cycle progression, cell metabolism and quality control of specific client proteins. TRAP1 role...

journal_title：Endocrine-related cancer

authors： Palladino G,Notarangelo T,Pannone G,Piscazzi A,Lamacchia O,Sisinni L,Spagnoletti G,Toti P,Santoro A,Storto G,Bufo P,Cignarelli M,Esposito F,Landriscina M

更新日期：2016-09-01 00:00:00

abstract：:Components of the tumour microenvironment initiate and promote cancer development. In this study, we investigated the stromal component of parathyroid neoplasia. Immunohistochemistry for alpha-smooth muscle actin (α-SMA) showed an abundant periacinar distribution of α-SMA(+) cells in normal parathyroid glands (n=3). T...

journal_title：Endocrine-related cancer

authors： Verdelli C,Avagliano L,Creo P,Guarnieri V,Scillitani A,Vicentini L,Steffano GB,Beretta E,Soldati L,Costa E,Spada A,Bulfamante GP,Corbetta S

更新日期：2015-02-01 00:00:00

abstract：:Thyroid carcinomas derived from follicular cells comprise papillary thyroid carcinoma (PTC), follicular thyroid carcinoma, poorly differentiated thyroid carcinoma (PDTC) and undifferentiated anaplastic thyroid carcinoma (ATC). PTC, the most frequent thyroid carcinoma histotype, is associated with gene rearrangements t...

journal_title：Endocrine-related cancer

authors： Degl'Innocenti D,Romeo P,Tarantino E,Sensi M,Cassinelli G,Catalano V,Lanzi C,Perrone F,Pilotti S,Seregni E,Pierotti MA,Greco A,Borrello MG

更新日期：2013-01-21 00:00:00

abstract：:Mouse models of prostate cancer (PCa) are critical for understanding the biology of PCa initiation, progression, and treatment modalities. Here, we summarize recent advances in PCa mouse models that led to new insights into specific gene functions in PCa. For example, the study of transgenic mice with TMPRSS2/ERG, an ...

journal_title：Endocrine-related cancer

authors： Wu X,Gong S,Roy-Burman P,Lee P,Culig Z

更新日期：2013-06-24 00:00:00

abstract：:Epidemiologic and experimental evidence suggest that a subset of breast cancer is insulin responsive, but it is unclear whether safe and effective therapies that target the insulin receptor (IR), which is homologous to oncogenes of the tyrosine kinase class, can be developed. We demonstrate that both pharmacologic inh...

journal_title：Endocrine-related cancer

authors： Dool CJ,Mashhedi H,Zakikhani M,David S,Zhao Y,Birman E,Carboni JM,Gottardis M,Blouin MJ,Pollak M

更新日期：2011-11-14 00:00:00

abstract：:Our main objective was to search for mutations in candidate genes and for paired box gene 8-peroxisome proliferator-activated receptor gamma (PAX8-PPARgamma) rearrangement in a well-differentiated angioinvasive follicular thyroid carcinoma (FTC) causing hyperthyroidism. DNA and RNA were extracted from the patient's th...

journal_title：Endocrine-related cancer

authors： Lado-Abeal J,Celestino R,Bravo SB,Garcia-Rendueles ME,de la Calzada J,Castro I,Castro P,Espadinha C,Palos F,Soares P,Alvarez CV,Sobrinho-Simões M,Cameselle-Teijeiro J

更新日期：2010-06-03 00:00:00

abstract：:Prostate cancer is the most common cancer in men, resulting in over 10 000 deaths/year in the UK. Sequencing and copy number analysis of primary tumours has revealed heterogeneity within tumours and an absence of recurrent founder mutations, consistent with non-genetic disease initiating events. Using methylation prof...

journal_title：Endocrine-related cancer

authors： Massie CE,Spiteri I,Ross-Adams H,Luxton H,Kay J,Whitaker HC,Dunning MJ,Lamb AD,Ramos-Montoya A,Brewer DS,Cooper CS,Eeles R,UK Prostate ICGC Group.,Warren AY,Tavaré S,Neal DE,Lynch AG

更新日期：2015-04-01 00:00:00

abstract：:Resistance to anoikis (matrix deprivation-induced apoptosis) is a critical component of the metastatic cascade. Molecular mechanisms underlying resistance to anoikis have not been reported in thyroid cancer cells. For an in vitro model of anoikis, we cultured follicular, papillary, and anaplastic thyroid cancer cell l...

journal_title：Endocrine-related cancer

authors： Jensen K,Patel A,Klubo-Gwiezdzinska J,Bauer A,Vasko V

更新日期：2011-09-20 00:00:00

abstract：:Colony-stimulating factor 1 (CSF1) is a key regulator of mammary gland development, and a modulator of tissue macrophages. Expression of the CSF1 receptor gene C-FMS (CSF1R) is strongly associated with poor outcome in breast cancer and results in tumor cell invasiveness and pro-metastatic behavior in vitro. However, C...

journal_title：Endocrine-related cancer

authors： Aharinejad S,Salama M,Paulus P,Zins K,Berger A,Singer CF

更新日期：2013-10-14 00:00:00

abstract：:Benign adrenal tumors cover a spectrum of lesions with distinct morphology and steroid secretion. Current classification is empirical. Beyond a few driver mutations, pathophysiology is not well understood. Here, a pangenomic characterization of benign adrenocortical tumors is proposed, aiming at unbiased classificatio...

journal_title：Endocrine-related cancer

authors： Faillot S,Foulonneau T,Néou M,Espiard S,Garinet S,Vaczlavik A,Jouinot A,Rondof W,Septier A,Drougat L,Hécale-Perlemoine K,Ragazzon B,Rizk-Rabin M,Sibony M,Bonnet-Serrano F,Guibourdenche J,Libé R,Groussin L,Dousset B,

更新日期：2021-01-01 00:00:00

abstract：:We undertook this study to estimate an accurate incidence and spread patterns of occult papillary thyroid carcinoma (PTC) in patients with a preoperative diagnosis of solitary PTC by using whole-specimen mapping of all specimens after a total thyroidectomy. Enrolled prospectively in this whole-thyroid mapping study ar...

journal_title：Endocrine-related cancer

authors： Park SY,Jung YS,Ryu CH,Lee CY,Lee YJ,Lee EK,Kim SK,Kim TS,Kim TH,Jang J,Park D,Dong SM,Kang JG,Lee JS,Ryu J

更新日期：2015-08-01 00:00:00

abstract：:Ovarian cancer remains one of the leading causes of cancer deaths. Thus, new biomarkers predictive of response to the standard paclitaxel-carboplatin treatment are needed to improve chemotherapy strategies. MicroRNAs have the potential to modify drug outcomes. Based on this, we have demonstrated in this study that pat...

journal_title：Endocrine-related cancer

authors： Leskelä S,Leandro-García LJ,Mendiola M,Barriuso J,Inglada-Pérez L,Muñoz I,Martínez-Delgado B,Redondo A,de Santiago J,Robledo M,Hardisson D,Rodríguez-Antona C

更新日期：2010-12-21 00:00:00

abstract：:The androgen receptor (AR) is well known to play a central role in the pathogenesis of prostate cancer (PCa). In several studies, AR was overexpressed in castration-resistant PCa (CRPC). However, the mechanism of AR overexpression in CRPC is not fully elucidated. Y-box binding protein-1 (YB-1) is a pleiotropic transcr...

journal_title：Endocrine-related cancer

authors： Shiota M,Takeuchi A,Song Y,Yokomizo A,Kashiwagi E,Uchiumi T,Kuroiwa K,Tatsugami K,Fujimoto N,Oda Y,Naito S

更新日期：2011-07-11 00:00:00

abstract：:Overexpression of human epidermal growth factor receptor 2 (HER2) predicts response to anti-HER2 therapy in breast cancer. We investigated whether hormone receptor (HR) status influences the treatment benefit of trastuzumab in patients with breast cancer. Data from 8338 patients with primary nonmetastatic breast cance...

journal_title：Endocrine-related cancer

authors： Ignatov T,Eggemann H,Burger E,Costa SD,Ignatov A

更新日期：2016-05-01 00:00:00

abstract：:Pancreatic endocrine tumours (PETs) are rare and 'indolent' neoplasms that usually develop metastatic lesions and exhibit poor response to standard medical treatments. Few studies have investigated pathways responsible for PET cell growth and invasion and no alternative therapeutic strategies have been proposed. In a ...

journal_title：Endocrine-related cancer

authors： Di Florio A,Capurso G,Milione M,Panzuto F,Geremia R,Delle Fave G,Sette C

更新日期：2007-03-01 00:00:00

abstract：:Type 3 deiodinase (DIO3, D3) is reactivated in human neoplasias. Increased D3 levels in papillary thyroid carcinoma (PTC) have been associated with tumor size and metastatic disease. The objective of this study is to investigate the signaling pathways involved in DIO3 upregulation in PTC. Experiments were performed in...

journal_title：Endocrine-related cancer

authors： Romitti M,Wajner SM,Ceolin L,Ferreira CV,Ribeiro RV,Rohenkohl HC,Weber Sde S,Lopez PL,Fuziwara CS,Kimura ET,Maia AL

更新日期：2016-03-01 00:00:00

abstract：:Administration of the microtubule inhibitor docetaxel is a common treatment for metastatic castration-resistant prostate cancer (mCRPC) and results in prolonged patient overall survival. Usually, after a short period of time chemotherapy resistance emerges and there is urgent need to find new therapeutic targets to ov...

journal_title：Endocrine-related cancer

authors： Gruber M,Ferrone L,Puhr M,Santer FR,Furlan T,Eder IE,Sampson N,Schäfer G,Handle F,Culig Z

更新日期：2020-03-01 00:00:00

abstract：:Endocrine therapy has become the most important treatment option for women with estrogen receptor (ER)-positive breast cancer. Urgently needed are prognostic assays that can identify those who need additional adjuvant therapy, such as signal transduction inhibitors or chemotherapy, for ER-positive early breast cancer....

journal_title：Endocrine-related cancer

authors： Yamashita H,Nishio M,Toyama T,Sugiura H,Kondo N,Kobayashi S,Fujii Y,Iwase H

更新日期：2008-09-01 00:00:00

abstract：:Imatinib mesylate (IM), a small molecule that is a selective inhibitor of the ABL, platelet derived growth factor receptor (PDGFR-R) and stem cell ligand receptor (c-kit) tyrosine kinases (TK). IM was also found to inhibit the TK activity of BCR/ABL fusion protein produced in chronic myelogenous leukemia, with marked ...

journal_title：Endocrine-related cancer

authors： Gross DJ,Munter G,Bitan M,Siegal T,Gabizon A,Weitzen R,Merimsky O,Ackerstein A,Salmon A,Sella A,Slavin S,Israel Glivec in Solid Tumors Study Group.

更新日期：2006-06-01 00:00:00

abstract：:Long-term culture of MCF-7 wild-type (wt) cells in steroid-depleted medium (LTED) results in hypersensitivity to oestradiol (E2) coinciding with elevated levels of ERalpha and enhanced growth factor signalling. In this study, we aimed to compare the effects of the pure anti-oestrogen ICI 182,780 (ICI) with the competi...

journal_title：Endocrine-related cancer

authors： Martin LA,Pancholi S,Chan CM,Farmer I,Kimberley C,Dowsett M,Johnston SR

更新日期：2005-12-01 00:00:00

abstract：:Paragangliomas (PGLs) have widely different metastastic potentials. Two different types of PGLs can be defined by expression profiling. Cluster 1 PGLs exhibit VHL and/or succinate dehydrogenase (SDH) mutations and a pseudohypoxic phenotype. RET and neurofibromatosis type 1 (NF1) mutations occur in cluster 2 tumors cha...

journal_title：Endocrine-related cancer

authors： Span PN,Rao JU,Oude Ophuis SB,Lenders JW,Sweep FC,Wesseling P,Kusters B,van Nederveen FH,de Krijger RR,Hermus AR,Timmers HJ

更新日期：2011-04-28 00:00:00

abstract：:Somatostatin-producing neuroendocrine tumors (SOM-NETs) of the duodenum and pancreas appear to be heterogeneous. To determine their clinicopathological profiles, respective data were analyzed on a series of 82 duodenal and 541 pancreatic NETs. In addition, the clinical records of 821 patients with duodenal or pancreat...

journal_title：Endocrine-related cancer

authors： Garbrecht N,Anlauf M,Schmitt A,Henopp T,Sipos B,Raffel A,Eisenberger CF,Knoefel WT,Pavel M,Fottner C,Musholt TJ,Rinke A,Arnold R,Berndt U,Plöckinger U,Wiedenmann B,Moch H,Heitz PU,Komminoth P,Perren A,Klöppel G

更新日期：2008-03-01 00:00:00