Endocrine complications in long-term survivors of childhood cancers.

abstract：:Resveratrol is a naturally occurring polyphenol that provides a number of anti-aging health benefits including improved metabolism, cardioprotection, and cancer prevention. Much of the work on resveratrol and cancer comes from in vitro studies looking at resveratrol actions on cancer cells and pathways. There are, how...

journal_title：Endocrine-related cancer

authors： Carter LG,D'Orazio JA,Pearson KJ

更新日期：2014-05-06 00:00:00

abstract：:Epidemiologic and experimental evidence suggest that a subset of breast cancer is insulin responsive, but it is unclear whether safe and effective therapies that target the insulin receptor (IR), which is homologous to oncogenes of the tyrosine kinase class, can be developed. We demonstrate that both pharmacologic inh...

journal_title：Endocrine-related cancer

authors： Dool CJ,Mashhedi H,Zakikhani M,David S,Zhao Y,Birman E,Carboni JM,Gottardis M,Blouin MJ,Pollak M

更新日期：2011-11-14 00:00:00

abstract：:Pancreatic neuroendocrine neoplasms (PNENs) constitute a rare tumour entity, and prognosis and treatment options depend on tumour-mediating hallmarks such as angiogenesis, proliferation rate and resistance to apoptosis. The molecular pathways that determine the malignant phenotype are still insufficiently understood a...

journal_title：Endocrine-related cancer

authors： Krug S,Kühnemuth B,Griesmann H,Neesse A,Mühlberg L,Boch M,Kortenhaus J,Fendrich V,Wiese D,Sipos B,Friemel J,Gress TM,Michl P

更新日期：2014-01-01 00:00:00

abstract：:Most endocrine therapies for breast cancer inhibit tumor growth by depriving the cell of estrogen or by blocking its receptor. However, some drugs, such as tamoxifen, can bind to the estrogen receptor (ER) and have both estrogenic and antiestrogenic effects, depending on the tissue, cell, or promoter context. These mi...

journal_title：Endocrine-related cancer

authors： Osborne CK

更新日期：1999-06-01 00:00:00

abstract：:Tyrosine phosphorylation plays a critical role in growth regulation, and its aberrant regulation can be involved in carcinogenesis. The association of Shc (Src homolog and collagen homolog) adaptor protein family members in tyrosine phosphorylation signaling pathway is well recognized. Shc adaptor proteins transmit ac...

journal_title：Endocrine-related cancer

authors： Alam SM,Rajendran M,Ouyang S,Veeramani S,Zhang L,Lin MF

更新日期：2009-03-01 00:00:00

abstract：:There are currently few successful therapies for castration-resistant prostate cancer (CRPC). CRPC is thought to result from augmented activation of the androgen/androgen receptor (AR) signaling pathway, which could be enhanced by AR cofactors. In this study, heterochromatin protein 1beta (HP1beta), but not HP1alpha o...

journal_title：Endocrine-related cancer

authors： Shiota M,Song Y,Yokomizo A,Tada Y,Kuroiwa K,Eto M,Oda Y,Inokuchi J,Uchiumi T,Fujimoto N,Seki N,Naito S

更新日期：2010-05-18 00:00:00

abstract：:Therapeutic options for patients with metastatic medullary thyroid carcinoma (MTC) are limited due to lack of effective treatments. Thus, there is a need to thoroughly characterize the pathways of molecular pathogenesis and to identify potential targets for therapy in MTC. Since epidermal growth factor receptor (EGFR)...

journal_title：Endocrine-related cancer

authors： Rodríguez-Antona C,Pallares J,Montero-Conde C,Inglada-Pérez L,Castelblanco E,Landa I,Leskelä S,Leandro-García LJ,López-Jiménez E,Letón R,Cascón A,Lerma E,Martin MC,Carralero MC,Mauricio D,Cigudosa JC,Matias-Guiu X,Roble

更新日期：2010-01-29 00:00:00

abstract：:Resistance to chemotherapy is a critical issue in the management of breast cancer patients. The nature of clinical drug resistance is likely to be multifactorial. However, in the last decade considerable attention has been dedicated to the role played by membrane transporter proteins belonging to the ATP binding casse...

journal_title：Endocrine-related cancer

authors： Leonessa F,Clarke R

更新日期：2003-03-01 00:00:00

abstract：:Small-intestinal carcinoids (SIC) are the most common small-bowel malignancies. We sought to determine the risk of developing SIC before and after other primary malignancies (PM) and the prognosis of patients with SIC, with and without another PM. We used the Surveillance, Epidemiology, and End Results database to ide...

journal_title：Endocrine-related cancer

authors： Amin S,Warner RR,Itzkowitz SH,Kim MK

更新日期：2012-05-24 00:00:00

abstract：:Non-functioning pituitary adenomas, recently alternatively termed pituitary neuroendocrine tumours (NFpitNETs), are mostly benign neoplasms that are not associated with a hormonal hypersecretory syndrome. The clinical spectrum of NFpitNETs varies from completely asymptomatic to the development of panhypopituitarism an...

journal_title：Endocrine-related cancer

authors： Yavropoulou MP,Tsoli M,Barkas K,Kaltsas G,Grossman A

更新日期：2020-10-01 00:00:00

abstract：:Obesity is associated with a range of health outcomes that are of clinical and public health significance, including cancer. Herein, we summarize epidemiologic and preclinical evidence for an association between obesity and increased risk of breast and prostate cancer incidence and mortality. Moreover, we describe dat...

journal_title：Endocrine-related cancer

authors： Allott EH,Hursting SD

更新日期：2015-12-01 00:00:00

abstract：:Imatinib mesylate (IM), a small molecule that is a selective inhibitor of the ABL, platelet derived growth factor receptor (PDGFR-R) and stem cell ligand receptor (c-kit) tyrosine kinases (TK). IM was also found to inhibit the TK activity of BCR/ABL fusion protein produced in chronic myelogenous leukemia, with marked ...

journal_title：Endocrine-related cancer

authors： Gross DJ,Munter G,Bitan M,Siegal T,Gabizon A,Weitzen R,Merimsky O,Ackerstein A,Salmon A,Sella A,Slavin S,Israel Glivec in Solid Tumors Study Group.

更新日期：2006-06-01 00:00:00

abstract：:The function of estrogen receptor beta (ER-beta) in mammary tissue is not completely understood. While early observations were often conflicting, more recent data suggest an important role as a tumor-suppressor gene. A decrease of ER-beta expression has been observed in ductal carcinoma in situ and invasive carcinoma ...

journal_title：Endocrine-related cancer

authors： Rody A,Holtrich U,Solbach C,Kourtis K,von Minckwitz G,Engels K,Kissler S,Gätje R,Karn T,Kaufmann M

更新日期：2005-12-01 00:00:00

abstract：:Vandetanib is an oral tyrosine kinase inhibitor approved for treatment of advanced symptomatic or progressive medullary thyroid cancer (MTC). The current study (Nbib1496313) evaluated the benefit-risk of two starting doses of vandetanib in patients with symptomatic or progressive MTC. Patients were randomized 1:1 to r...

journal_title：Endocrine-related cancer

authors： Hu MI,Elisei R,Dedecjus M,Popovtzer A,Druce M,Kapiteijn E,Pacini F,Locati L,Krajewska J,Weiss R,Gagel RF

更新日期：2019-02-01 00:00:00

abstract：:Ghrelin is a hormone with multiple physiologic functions, including promotion of growth hormone release, stimulation of appetite and regulation of energy homeostasis. Treatment with ghrelin/ghrelin-receptor agonists is a prospective therapy for disease-related cachexia and malnutrition. In vitro studies have shown hig...

journal_title：Endocrine-related cancer

authors： Sever S,White DL,Garcia JM

更新日期：2016-09-01 00:00:00

abstract：:Overexpression of human epidermal growth factor receptor 2 (HER2) predicts response to anti-HER2 therapy in breast cancer. We investigated whether hormone receptor (HR) status influences the treatment benefit of trastuzumab in patients with breast cancer. Data from 8338 patients with primary nonmetastatic breast cance...

journal_title：Endocrine-related cancer

authors： Ignatov T,Eggemann H,Burger E,Costa SD,Ignatov A

更新日期：2016-05-01 00:00:00

abstract：:Pituitary adenomas cause significant endocrine and mass-related morbidity. Little is known about the mechanisms that underlie pituitary tumor pathogenesis. In the present study, we searched for a side population (SP) in pituitary tumors representing cells with high efflux capacity and potentially enriched for tumor st...

journal_title：Endocrine-related cancer

authors： Mertens F,Gremeaux L,Chen J,Fu Q,Willems C,Roose H,Govaere O,Roskams T,Cristina C,Becú-Villalobos D,Jorissen M,Poorten VV,Bex M,van Loon J,Vankelecom H

更新日期：2015-08-01 00:00:00

abstract：:We studied the psychological performance and the quality of life in patients with differentiated thyroid carcinoma, either during treatment with chronic suppressive doses of levothyroxine, or during the withdrawal of levothyroxine needed to perform whole-body scanning with radioactive iodine, with those of appropriate...

journal_title：Endocrine-related cancer

authors： Botella-Carretero JI,Galán JM,Caballero C,Sancho J,Escobar-Morreale HF

更新日期：2003-12-01 00:00:00

abstract：:Medullary thyroid carcinomas (MTC) arise from thyroid parafollicular, calcitonin-producing C-cells and can occur either as sporadic or as hereditary diseases in the context of familial syndromes, including multiple endocrine neoplasia 2A (MEN2A), multiple endocrine neoplasia 2B (MEN2B) and familial MTC (FMTC). In a la...

journal_title：Endocrine-related cancer

authors： Castellone MD,Melillo RM

更新日期：2018-02-01 00:00:00

abstract：:PD-L1 expression is being considered a potential biomarker for response of anti-PD-1 or anti-PD-L1 agents in various tumors. The reported frequency of PD-L1 positivity varies in thyroid carcinomas, and multiple factors may contribute to the variability in PD-L1 positivity. We evaluated the PD-L1 expression in various ...

journal_title：Endocrine-related cancer

authors： Ahn S,Kim TH,Kim SW,Ki CS,Jang HW,Kim JS,Kim JH,Choe JH,Shin JH,Hahn SY,Oh YL,Chung JH

更新日期：2017-02-01 00:00:00

abstract：:Administration of the microtubule inhibitor docetaxel is a common treatment for metastatic castration-resistant prostate cancer (mCRPC) and results in prolonged patient overall survival. Usually, after a short period of time chemotherapy resistance emerges and there is urgent need to find new therapeutic targets to ov...

journal_title：Endocrine-related cancer

authors： Gruber M,Ferrone L,Puhr M,Santer FR,Furlan T,Eder IE,Sampson N,Schäfer G,Handle F,Culig Z

更新日期：2020-03-01 00:00:00

abstract：:Aromatase inhibitors (AIs) are one of the principal therapeutic approaches for estrogen receptor-positive (ER+) breast cancer in postmenopausal women. They block estrogen biosynthesis through aromatase inhibition, thus preventing tumour progression. Besides the therapeutic success of the third-generation AIs, acquired...

journal_title：Endocrine-related cancer

authors： Augusto TV,Correia-da-Silva G,Rodrigues CMP,Teixeira N,Amaral C

更新日期：2018-05-01 00:00:00

abstract：:Thyroid cancer is on the rise. Novel approaches are needed to improve the outcome of patients with recurrent and advanced metastatic thyroid cancers. FDA approval of suberoylanilide hydroxamic acid (SAHA; vorinostat), an inhibitor of histone deacetylase, for the treatment of hematological malignancies led to the clini...

journal_title：Endocrine-related cancer

authors： Zhu X,Kim DW,Zhao L,Willingham MC,Cheng SY

更新日期：2016-07-01 00:00:00

abstract：:Genetic alteration is the driving force for thyroid tumorigenesis and progression, based upon which novel approaches to the management of thyroid cancer can be developed. A recent important genetic finding in thyroid cancer is the oncogenic T1799A transversion mutation of BRAF (the gene for the B-type Raf kinase, BRAF...

journal_title：Endocrine-related cancer

authors： Xing M

更新日期：2005-06-01 00:00:00

abstract：:The tumour microenvironment is known to be acidic due to high glycolytic rates of tumour cells. Monocarboxylate transporters (MCTs) play a role in extracellular acidification, which is widely known to be involved in tumour progression. Recently, we have described the upregulation of MCT1 in breast carcinomas and its a...

journal_title：Endocrine-related cancer

authors： Morais-Santos F,Miranda-Gonçalves V,Pinheiro S,Vieira AF,Paredes J,Schmitt FC,Baltazar F,Pinheiro C

更新日期：2013-12-16 00:00:00

abstract：:The combination of pituitary adenomas (PA) and phaeochromocytomas (phaeo) or paragangliomas (PGL) is a rare event. Although these endocrine tumours may occur together by coincidence, there is mounting evidence that, in at least some cases, classical phaeo/PGL-predisposing genes may also play a role in pituitary tumori...

journal_title：Endocrine-related cancer

authors： O'Toole SM,Dénes J,Robledo M,Stratakis CA,Korbonits M

更新日期：2015-08-01 00:00:00

abstract：:Sialic acid immunoglobulin-like lectin (Siglec)-6 is a transmembrane receptor that binds leptin. Leptin is an obesity-associated peptide hormone overexpressed in gestational trophoblastic disease (GTD). GTD encompasses several placental abnormalities that range from benign to malignant. Among GTD, molar placentas are ...

journal_title：Endocrine-related cancer

authors： Rumer KK,Post MD,Larivee RS,Zink M,Uyenishi J,Kramer A,Teoh D,Bogart K,Winn VD

更新日期：2012-11-19 00:00:00

abstract：:Anaplastic thyroid cancer (ATC) is an aggressive malignancy with limited treatment options. We explored novel treatment modalities by targeting epigenetic modifications using inhibitors of BET (e.g. BRD4) activity. We evaluated the efficacy in the treatment of ATC of a novel BET inhibitor, PLX51107 (PLX), currently in...

journal_title：Endocrine-related cancer

authors： Zhu X,Park S,Lee WK,Cheng SY

更新日期：2019-09-01 00:00:00

abstract：:The 16th International Multiple Endocrine Neoplasia Workshop (MEN2019) held in Houston, TX, USA, focused on emerging topics in the pathogenesis and therapy of malignant endocrine tumors associated with MEN syndromes. With MEN-2 syndromes, the most common malignancy is medullary thyroid carcinoma (MTC). In the spirit o...

journal_title：Endocrine-related cancer

authors： Dadu R,Bagheri-Yarmand R,Ringel MD,Grubbs EG,Zafereo M,Cote G,Gagel RF,Robinson BG,Shaw KR,Hu MI

更新日期：2020-08-01 00:00:00

abstract：:Apoptosis is a frequent phenomenon in breast cancer and it can be detected by light microscopy in conventional histopathological sections or by special staining techniques. The number of apoptotic cells as a percentage of cells present, or the number of apoptotic cells per square millimetre of neoplastic tissue, is us...

journal_title：Endocrine-related cancer

authors： Lipponen P

更新日期：1999-03-01 00:00:00