A novel role of Shc adaptor proteins in steroid hormone-regulated cancers.

Abstract:

:Tyrosine phosphorylation plays a critical role in growth regulation, and its aberrant regulation can be involved in carcinogenesis. The association of Shc (Src homolog and collagen homolog) adaptor protein family members in tyrosine phosphorylation signaling pathway is well recognized. Shc adaptor proteins transmit activated tyrosine phosphorylation signaling that suggest their plausible role in growth regulation including carcinogenesis and metastasis. In parallel, by sharing a similar mechanism of carcinogenesis, the steroids are involved in the early stage of carcinogenesis as well as the regulation of cancer progression and metastatic processes. Recent evidence indicates a cross-talk between tyrosine phosphorylation signaling and steroid hormone action in epithelial cells, including prostate and breast cancer cells. Therefore, the members of Shc proteins may function as mediators between tyrosine phosphorylation and steroid signaling in steroid-regulated cell proliferation and carcinogenesis. In this communication, we discuss the novel roles of Shc proteins, specifically p52(Shc) and p66(Shc), in steroid hormone-regulated cancers and a novel molecular mechanism by which redox signaling induced by p66(Shc) mediates steroid action via a non-genomic pathway. The p66(Shc) protein may serve as an effective biomarker for predicting cancer prognosis as well as a useful target for treatment.

journal_name

Endocr Relat Cancer

journal_title

Endocrine-related cancer

authors

Alam SM,Rajendran M,Ouyang S,Veeramani S,Zhang L,Lin MF

doi

10.1677/ERC-08-0179

subject

Has Abstract

pub_date

2009-03-01 00:00:00

pages

1-16

issue

1

eissn

1351-0088

issn

1479-6821

pii

ERC-08-0179

journal_volume

16

pub_type

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