Abstract:
:Aromatase inhibitors (AIs) are one of the principal therapeutic approaches for estrogen receptor-positive (ER+) breast cancer in postmenopausal women. They block estrogen biosynthesis through aromatase inhibition, thus preventing tumour progression. Besides the therapeutic success of the third-generation AIs, acquired resistance may develop, leading to tumour relapse. This resistance is thought to be the result of a change in the behaviour of ER in these breast cancer cells, presumably by PI3K/AKT pathway enhancement along with alterations in other signalling pathways. Nevertheless, biological mechanisms, such as apoptosis, autophagy, cell cycle modulation and activation of androgen receptor (AR), are also implicated in acquired resistance. Moreover, clinical evidence demonstrated that there is a lack of cross-resistance among AIs, although the reason is not fully understood. Thus, there is a demand to understand the mechanisms involved in endocrine resistance to each AI, since the search for new strategies to surpass breast cancer acquired resistance is of major concern.
journal_name
Endocr Relat Cancerjournal_title
Endocrine-related cancerauthors
Augusto TV,Correia-da-Silva G,Rodrigues CMP,Teixeira N,Amaral Cdoi
10.1530/ERC-17-0425subject
Has Abstractpub_date
2018-05-01 00:00:00pages
R283-R301issue
5eissn
1351-0088issn
1479-6821pii
ERC-17-0425journal_volume
25pub_type
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