当前位置： SCI文献检索 > ENDOCRINE-RELATED CANCER期刊下所有文献 > Prognostic factors of papillary and follicular thyroid cancer: differences in an iodine-replete endemic goiter region.

Prognostic factors of papillary and follicular thyroid cancer: differences in an iodine-replete endemic goiter region.

Abstract：

:Papillary (PTC) and follicular thyroid carcinoma (FTC) are known as differentiated thyroid carcinoma (DTC). Nevertheless, according to the UICC/AJCC (TNM) classification PTC and FTC are frequently analyzed as one cancer. The aim of this study is to show differences in outcome and specific prognostic factors in an iodine-replete endemic goiter region. Six hundred and three patients with DTC treated within a 35-year-period were retrospectively analyzed with respect to carcinoma-specific survival. Prognostic factors were tested for their significance using univariate and multivariate analysis. The histological type (PTC versus FTC) was found to be a highly significant factor - carcinoma-specific survival both in univariate (P<0.001) and multivariate analyses (P=0.003) was significantly different. Univariate analysis revealed patients' age, extra-thyroid tumor spread, lymph node and distant metastases, increasing tumor size, and the tall cell variant to be significant prognostic factors for PTC patients. Age > or =45 years, positive lymph nodes and increasing tumor size were confirmed as independent prognostic factors. Univariate analysis of FTC patients revealed age at presentation, gender, extrathyroidal tumor spread, lymph node and distant metastases, increasing tumor size, multifocality, widely invasive tumor growth and oxyphilic variant to be factors bearing prognostic significance. The presence of distant metastases and increasing tumor size could be identified as independent prognostic factors for FTC patients. This study shows distinctive differences in prognostic factors of PTC and FTC: independent factors predicting poor prognosis are age > or =45 years, positive lymph nodes and increasing tumor size for PTC, and distant metastases and increasing tumor size for FTC. PTC and FTC patients should be analyzed and reported separately.

journal_name

Endocr Relat Cancer

journal_title

Endocrine-related cancer

authors

Passler C,Scheuba C,Prager G,Kaczirek K,Kaserer K,Zettinig G,Niederle B

doi

10.1677/erc.0.0110131

subject

Has Abstract

pub_date

2004-03-01 00:00:00

pages

131-9

issue

1

eissn

1351-0088

issn

1479-6821

journal_volume

11

pub_type

杂志文章

相关文献

ENDOCRINE-RELATED CANCER文献大全
  • miR-205 targets angiogenesis and EMT concurrently in anaplastic thyroid carcinoma.

    abstract：:The current study aims to evaluate for the first time the inhibitory roles of miR-205 in the pathogenesis of anaplastic thyroid carcinoma. In addition, we investigated the mechanisms by which miR-205 regulates angiogenesis and epithelial-to-mesenchymal transition (EMT) in cancer. Two anaplastic thyroid carcinoma cell ...

    journal_title：Endocrine-related cancer

    pub_type： 杂志文章

    doi：10.1530/ERC-17-0497

    authors： Vosgha H,Ariana A,Smith RA,Lam AK

    更新日期：2018-03-01 00:00:00

  • Genomic classification of benign adrenocortical lesions.

    abstract：:Benign adrenal tumors cover a spectrum of lesions with distinct morphology and steroid secretion. Current classification is empirical. Beyond a few driver mutations, pathophysiology is not well understood. Here, a pangenomic characterization of benign adrenocortical tumors is proposed, aiming at unbiased classificatio...

    journal_title：Endocrine-related cancer

    pub_type： 杂志文章

    doi：10.1530/ERC-20-0128

    authors： Faillot S,Foulonneau T,Néou M,Espiard S,Garinet S,Vaczlavik A,Jouinot A,Rondof W,Septier A,Drougat L,Hécale-Perlemoine K,Ragazzon B,Rizk-Rabin M,Sibony M,Bonnet-Serrano F,Guibourdenche J,Libé R,Groussin L,Dousset B,

    更新日期：2021-01-01 00:00:00

  • Human heterochromatin protein 1 isoform HP1beta enhances androgen receptor activity and is implicated in prostate cancer growth.

    abstract：:There are currently few successful therapies for castration-resistant prostate cancer (CRPC). CRPC is thought to result from augmented activation of the androgen/androgen receptor (AR) signaling pathway, which could be enhanced by AR cofactors. In this study, heterochromatin protein 1beta (HP1beta), but not HP1alpha o...

    journal_title：Endocrine-related cancer

    pub_type： 杂志文章

    doi：10.1677/ERC-09-0321

    authors： Shiota M,Song Y,Yokomizo A,Tada Y,Kuroiwa K,Eto M,Oda Y,Inokuchi J,Uchiumi T,Fujimoto N,Seki N,Naito S

    更新日期：2010-05-18 00:00:00

  • Estrogen promotes tumor progression in a genetically defined mouse model of lung adenocarcinoma.

    abstract：:Numerous epidemiological observations point to sex differences in lung cancer etiology and progression. The present study was aimed at understanding the bases of these sex differences. To test the effect of estradiol on tumor progression, we used a mouse model based on conditional Kras expression and concurrent deleti...

    journal_title：Endocrine-related cancer

    pub_type： 杂志文章

    doi：10.1677/ERC-08-0002

    authors： Hammoud Z,Tan B,Badve S,Bigsby RM

    更新日期：2008-06-01 00:00:00

  • Overexpression and activation of EGFR and VEGFR2 in medullary thyroid carcinomas is related to metastasis.

    abstract：:Therapeutic options for patients with metastatic medullary thyroid carcinoma (MTC) are limited due to lack of effective treatments. Thus, there is a need to thoroughly characterize the pathways of molecular pathogenesis and to identify potential targets for therapy in MTC. Since epidermal growth factor receptor (EGFR)...

    journal_title：Endocrine-related cancer

    pub_type： 杂志文章

    doi：10.1677/ERC-08-0304

    authors： Rodríguez-Antona C,Pallares J,Montero-Conde C,Inglada-Pérez L,Castelblanco E,Landa I,Leskelä S,Leandro-García LJ,López-Jiménez E,Letón R,Cascón A,Lerma E,Martin MC,Carralero MC,Mauricio D,Cigudosa JC,Matias-Guiu X,Roble

    更新日期：2010-01-29 00:00:00

  • microRNA-339-5p modulates Na+/I- symporter-mediated radioiodide uptake.

    abstract：:Na(+)/I(-) symporter (NIS)-mediated radioiodide uptake (RAIU) serves as the basis for targeted ablation of thyroid cancer remnants. However, many patients with thyroid cancer have reduced NIS expression/function and hence do not benefit from radioiodine therapy. microRNA (miR) has emerged as a promising therapeutic ta...

    journal_title：Endocrine-related cancer

    pub_type： 杂志文章

    doi：10.1530/ERC-14-0439

    authors： Lakshmanan A,Wojcicka A,Kotlarek M,Zhang X,Jazdzewski K,Jhiang SM

    更新日期：2015-02-01 00:00:00

  • The molecular genetic make-up of male breast cancer.

    abstract：:Male breast cancer (MBC) is extremely rare and accounts for less than 1% of all breast malignancies. Therefore, clinical management of MBC is currently guided by research on the disease in females. In this study, DNA obtained from 45 formalin-fixed paraffin-embedded (FFPE) MBCs with and 90 MBCs (52 FFPE and 38 fresh-f...

    journal_title：Endocrine-related cancer

    pub_type： 杂志文章

    doi：10.1530/ERC-19-0278

    authors： Moelans CB,de Ligt J,van der Groep P,Prins P,Besselink NJM,Hoogstraat M,Ter Hoeve ND,Lacle MM,Kornegoor R,van der Pol CC,de Leng WWJ,Barbé E,van der Vegt B,Martens J,Bult P,Smit VTHBM,Koudijs MJ,Nijman IJ,Voest EE,S

    更新日期：2019-10-01 00:00:00

  • The optimal imaging of adrenal tumours: a comparison of different methods.

    abstract：:Computed tomography (CT; unenhanced, followed by contrast-enhanced examinations) is the cornerstone of imaging of adrenal tumours. Attenuation values of <10 Hounsfield units on an unenhanced CT are practically diagnostic for adenomas. When lesions cannot be characterised adequately with CT, magnetic resonance imaging ...

    journal_title：Endocrine-related cancer

    pub_type： 杂志文章,评审

    doi：10.1677/ERC-07-0045

    authors： Ilias I,Sahdev A,Reznek RH,Grossman AB,Pacak K

    更新日期：2007-09-01 00:00:00

  • Enriched environment inhibits breast cancer progression in obese models with intact leptin signaling.

    abstract：:Obesity is becoming a global epidemic and is a risk factor for breast cancer. Environmental enrichment (EE), a model recapitulating an active lifestyle, leads to leanness, resistance to diet-induced obesity (DIO) and cancer. One mechanism is the activation of the hypothalamic-sympathoneural-adipocyte (HSA) axis. This ...

    journal_title：Endocrine-related cancer

    pub_type： 杂志文章

    doi：10.1530/ERC-19-0075

    authors： Foglesong GD,Queen NJ,Huang W,Widstrom KJ,Cao L

    更新日期：2019-05-01 00:00:00

  • Germline and somatic SDHx alterations in apparently sporadic differentiated thyroid cancer.

    abstract：:Along with breast and endometrial cancers, thyroid cancer is a major component cancer in Cowden syndrome (CS). Germline variants in SDHB/C/D (SDHx) genes account for subsets of CS/CS-like cases, conferring a higher risk of breast and thyroid cancers over those with only germline PTEN mutations. To investigate whether ...

    journal_title：Endocrine-related cancer

    pub_type： 杂志文章

    doi：10.1530/ERC-14-0537

    authors： Ni Y,Seballos S,Ganapathi S,Gurin D,Fletcher B,Ngeow J,Nagy R,Kloos RT,Ringel MD,LaFramboise T,Eng C

    更新日期：2015-04-01 00:00:00

  • PRKACB variants in skeletal disease or adrenocortical hyperplasia: effects on protein kinase A.

    abstract：:Genetic variants in components of the protein kinase A (PKA) enzyme have been associated with various defects and neoplasms in the context of Carney complex (CNC) and in isolated cases, such as in primary pigmented nodular adrenocortical disease (PPNAD), cortisol-producing adrenal adenomas (CPAs), and various cancers....

    journal_title：Endocrine-related cancer

    pub_type： 杂志文章

    doi：10.1530/ERC-20-0309

    authors： Espiard S,Drougat L,Settas N,Haydar S,Bathon K,London E,Levy I,Faucz FR,Calebiro D,Bertherat J,Li D,Levine MA,Stratakis CA

    更新日期：2020-11-01 00:00:00

  • Diet-induced macrophage inhibitory cytokine 1 promotes prostate cancer progression.

    abstract：:Recent studies have indicated that a high-fat diet (HFD) plays an important role in prostate cancer (PCa) progression. Palmitic acid (PA) is one of the most abundant saturated free fatty acids (FAs) and is associated with carcinogenesis. In this study, we investigated the mechanism underlying the association of dietar...

    journal_title：Endocrine-related cancer

    pub_type： 杂志文章

    doi：10.1530/ERC-13-0227

    authors： Huang M,Narita S,Inoue T,Tsuchiya N,Satoh S,Nanjo H,Sasaki T,Habuchi T

    更新日期：2013-12-16 00:00:00

  • Differential expression of microRNAs in human parathyroid carcinomas compared with normal parathyroid tissue.

    abstract：:Parathyroid carcinoma (PaC) is a rare cause of primary hyperparathyroidism. Though the loss of the oncosuppressor CDC73/HRPT2 gene product, parafibromin, has been involved in the hyperparathyroidism-jaw tumor syndrome and in a consistent set of sporadic PaCs, parathyroid carcinogenesis remains obscure. MicroRNAs are a...

    journal_title：Endocrine-related cancer

    pub_type： 杂志文章

    doi：10.1677/ERC-09-0134

    authors： Corbetta S,Vaira V,Guarnieri V,Scillitani A,Eller-Vainicher C,Ferrero S,Vicentini L,Chiodini I,Bisceglia M,Beck-Peccoz P,Bosari S,Spada A

    更新日期：2010-02-18 00:00:00

  • Leptin deficiency suppresses MMTV-Wnt-1 mammary tumor growth in obese mice and abrogates tumor initiating cell survival.

    abstract：:Obesity increases both the risk and mortality associated with many types of cancer including that of the breast. In mice, obesity increases both incidence of spontaneous tumors and burden of transplanted tumors. Our findings identify leptin, an adipose secreted cytokine, in promoting increased mammary tumor burden in ...

    journal_title：Endocrine-related cancer

    pub_type： 杂志文章

    doi：10.1530/ERC-11-0102

    authors： Zheng Q,Dunlap SM,Zhu J,Downs-Kelly E,Rich J,Hursting SD,Berger NA,Reizes O

    更新日期：2011-07-11 00:00:00

  • Molecular signatures of thyroid follicular neoplasia.

    abstract：:The molecular pathways leading to thyroid follicular neoplasia are incompletely understood, and the diagnosis of follicular tumors is a clinical challenge. To provide leads to the pathogenesis and diagnosis of the tumors, we examined the global transcriptome signatures of follicular thyroid carcinoma (FC) and normofol...

    journal_title：Endocrine-related cancer

    pub_type： 杂志文章

    doi：10.1677/ERC-09-0288

    authors： Borup R,Rossing M,Henao R,Yamamoto Y,Krogdahl A,Godballe C,Winther O,Kiss K,Christensen L,Høgdall E,Bennedbaek F,Nielsen FC

    更新日期：2010-07-28 00:00:00

  • SHH pathway inhibition is protumourigenic in adamantinomatous craniopharyngioma.

    abstract：:Pharmacological inhibition of the sonic hedgehog (SHH) pathway can be beneficial against certain cancers but detrimental in others. Adamantinomatous craniopharyngioma (ACP) is a relevant pituitary tumour, affecting children and adults, that is associated with high morbidity and increased mortality in long-term follow-...

    journal_title：Endocrine-related cancer

    pub_type： 杂志文章

    doi：10.1530/ERC-18-0538

    authors： Carreno G,Boult JKR,Apps J,Gonzalez-Meljem JM,Haston S,Guiho R,Stache C,Danielson LS,Koers A,Smith LM,Virasami A,Panousopoulos L,Buchfelder M,Jacques TS,Chesler L,Robinson SP,Martinez-Barbera JP

    更新日期：2019-03-01 00:00:00

  • 15 YEARS OF PARAGANGLIOMA: Imaging and imaging-based treatment of pheochromocytoma and paraganglioma.

    abstract：:Although anatomic imaging to assess the precise localization of pheochromocytomas/paragangliomas (PHEOs/PGLs) is unavoidable before any surgical intervention on these tumors, functional imaging is becoming an inseparable portion of the imaging algorithm for these tumors. This review article presents applications of th...

    journal_title：Endocrine-related cancer

    pub_type： 杂志文章,评审

    doi：10.1530/ERC-15-0175

    authors： Castinetti F,Kroiss A,Kumar R,Pacak K,Taieb D

    更新日期：2015-08-01 00:00:00

  • Endothelins and hypoxia-inducible factor in cancer.

    abstract：:The endothelin system is a family of three similar small peptides, two G-protein-coupled receptors and two proteinases. Endothelins have several physiological roles, notably in embryonic differentiation and vascular homeostasis. Numerous types of tumour express endothelins and their regulation is often aberrant when c...

    journal_title：Endocrine-related cancer

    pub_type： 杂志文章,评审

    doi：10.1677/ERC-07-0057

    authors： Grimshaw MJ

    更新日期：2007-06-01 00:00:00

  • Human melanoma cells express functional receptors for thyroid-stimulating hormone.

    abstract：:We have reported a high prevalence of hypothyroidism in the cutaneous melanoma population, suggesting that the pathologic hormonal environment of hypothyroidism promotes melanoma growth. The objective of this study was to test the hypothesis that TSH, which circulates at elevated levels in hypothyroid individuals, sti...

    journal_title：Endocrine-related cancer

    pub_type： 杂志文章

    doi：10.1677/erc.1.01239

    authors： Ellerhorst JA,Sendi-Naderi A,Johnson MK,Cooke CP,Dang SM,Diwan AH

    更新日期：2006-12-01 00:00:00

  • Tetrac as an anti-angiogenic agent in cancer.

    abstract：:The thyroid hormones T3 and T4 have emerged as pro-angiogenic hormones with important implications for cancer management. Endogenous circulating hormone levels may help stimulate cancer progression and limit the effectiveness of anticancer therapy, though clinical data remain inconclusive. The capacity of thyroid horm...

    journal_title：Endocrine-related cancer

    pub_type： 杂志文章,评审

    doi：10.1530/ERC-19-0058

    authors： Schmohl KA,Nelson PJ,Spitzweg C

    更新日期：2019-06-01 00:00:00

  • The microbiome in PTEN hamartoma tumor syndrome.

    abstract：:Germline PTEN mutations defining PTEN hamartoma tumor syndrome (PHTS) confer heritable predisposition to breast, endometrial, thyroid and other cancers with known age-related risks, but it remains impossible to predict if any individual will develop cancer. In the general population, gut microbial dysbiosis has been l...

    journal_title：Endocrine-related cancer

    pub_type： 杂志文章

    doi：10.1530/ERC-17-0442

    authors： Byrd V,Getz T,Padmanabhan R,Arora H,Eng C

    更新日期：2018-03-01 00:00:00

  • Perspectives for immunotherapy in endocrine cancer.

    abstract：:The fight against cancer has seen major breakthroughs in recent years. More than a decade ago, tyrosine kinase inhibitors targeting constitutively activated signaling cascades within the tumor inaugurated a new era of oncological therapy. Recently, immunotherapy with immune checkpoint inhibitors has started to revolut...

    journal_title：Endocrine-related cancer

    pub_type： 杂志文章,评审

    doi：10.1530/ERC-16-0169

    authors： Latteyer S,Tiedje V,Schilling B,Führer D

    更新日期：2016-10-01 00:00:00

  • Obesity and menopause modify the epigenomic profile of breast cancer.

    abstract：:Obesity is a high risk factor for breast cancer. This relationship could be marked by a specific methylome. The current work was aimed to explore the impact of obesity and menopausal status on variation in breast cancer methylomes. Data from Infinium 450K array-based methylomes of 64 breast tumors were coupled with in...

    journal_title：Endocrine-related cancer

    pub_type： 杂志文章

    doi：10.1530/ERC-16-0565

    authors： Crujeiras AB,Diaz-Lagares A,Stefansson OA,Macias-Gonzalez M,Sandoval J,Cueva J,Lopez-Lopez R,Moran S,Jonasson JG,Tryggvadottir L,Olafsdottir E,Tinahones FJ,Carreira MC,Casanueva FF,Esteller M

    更新日期：2017-07-01 00:00:00

  • Somatostatin receptor subtype 5 (SSTR5) mRNA expression is related to histopathological features of cell proliferation in insulinomas.

    abstract：:Insulinomas are rare endocrine neoplasias that constitute the most frequent islet cell tumours. Somatostatin (SST) analogs are tentatively used to inhibit insulin secretion and control tumour growth in patients with local invasion or inoperative metastasis, but variable responses have been reported. Data regarding som...

    journal_title：Endocrine-related cancer

    pub_type： 杂志文章

    doi：10.1677/erc.1.00962

    authors： de Sá SV,Corrêa-Giannella ML,Machado MC,de Souza JJ,Pereira MA,Patzina RA,Siqueira SA,Machado MC,Giannella-Neto D

    更新日期：2006-03-01 00:00:00

  • New drugs for medullary thyroid cancer: new promises?

    abstract：:Medullary thyroid cancer (MTC) is a rare tumor arising from the calcitonin-producing parafollicular C cells of the thyroid gland, occurring either sporadically or alternatively in a hereditary form based on germline RET mutations in approximately one-third of cases. Historically, patients with advanced, metastasized M...

    journal_title：Endocrine-related cancer

    pub_type： 杂志文章,评审

    doi：10.1530/ERC-16-0104

    authors： Spitzweg C,Morris JC,Bible KC

    更新日期：2016-06-01 00:00:00

  • Hyperplasia-adenoma sequence in pituitary tumorigenesis related to aryl hydrocarbon receptor interacting protein gene mutation.

    abstract：:Mutations of the aryl hydrocarbon receptor interacting protein (AIP) gene are associated with pituitary adenomas that usually occur as familial isolated pituitary adenomas (FIPA). Detailed pathological and tumor genetic data on AIP mutation-related pituitary adenomas are not sufficient. Non-identical twin females pres...

    journal_title：Endocrine-related cancer

    pub_type： 杂志文章

    doi：10.1530/ERC-11-0059

    authors： Villa C,Lagonigro MS,Magri F,Koziak M,Jaffrain-Rea ML,Brauner R,Bouligand J,Junier MP,Di Rocco F,Sainte-Rose C,Beckers A,Roux FX,Daly AF,Chiovato L

    更新日期：2011-06-08 00:00:00

  • Chromogranin A as a marker of neuroendocrine neoplasia: an Italian Multicenter Study.

    abstract：:Elevated circulating chromogranin A (CgA) levels are found in neuroendocrine tumors (NETs), but the diagnostic usefulness of this marker is still debatable. To assess the role of CgA for the diagnosis of gastroenteropancreatic (GEP) NETs and the identification of metastatic patients, an Italian multicenter observation...

    journal_title：Endocrine-related cancer

    pub_type： 杂志文章,多中心研究

    doi：10.1677/ERC-07-0001

    authors： Zatelli MC,Torta M,Leon A,Ambrosio MR,Gion M,Tomassetti P,De Braud F,Delle Fave G,Dogliotti L,degli Uberti EC,Italian CromaNet Working Group.

    更新日期：2007-06-01 00:00:00

  • Androgen receptor signaling in castration-resistant prostate cancer: a lesson in persistence.

    abstract：:The androgen receptor (AR) signaling axis drives all stages of prostate cancer, including the lethal, drug-resistant form of the disease termed castration-resistant prostate cancer (CRPC), which arises after failure of androgen deprivation therapy (ADT). Persistent AR activity in spite of ADT and the second-generation...

    journal_title：Endocrine-related cancer

    pub_type： 杂志文章,评审

    doi：10.1530/ERC-16-0422

    authors： Coutinho I,Day TK,Tilley WD,Selth LA

    更新日期：2016-12-01 00:00:00

  • Prospective evaluation of estrogen receptor-beta in predicting response to neoadjuvant antiestrogen therapy in elderly breast cancer patients.

    abstract：:It has been proposed that knowledge of estrogen receptor beta (ER-beta) expression may refine estrogen receptor alpha (ER-alpha) predictivity of response to endocrine therapy. We challenged this hypothesis in ER-alpha-positive breast cancers subjected to preoperative antiestrogen treatment. Forty-seven elderly (> or =...

    journal_title：Endocrine-related cancer

    pub_type： 临床试验,杂志文章

    doi：10.1677/erc.1.00822

    authors： Cappelletti V,Celio L,Bajetta E,Allevi A,Longarini R,Miodini P,Villa R,Fabbri A,Mariani L,Giovanazzi R,Galante E,Greco M,Grazia Daidone M

    更新日期：2004-12-01 00:00:00

  • Overview of tyrosine kinase inhibitors in clinical breast cancer.

    abstract：:Studies of cell models and profiling of clinical breast cancer material to reveal the mechanisms of resistance to anti-oestrogen therapy, and to tamoxifen in particular, have reported that this phenomenon can be associated with increased expression and signalling through erbB Type 1 growth factor receptors, notably th...

    journal_title：Endocrine-related cancer

    pub_type： 杂志文章,评审

    doi：10.1677/erc.1.01059

    authors： Agrawal A,Gutteridge E,Gee JM,Nicholson RI,Robertson JF

    更新日期：2005-07-01 00:00:00