Estrogen promotes tumor progression in a genetically defined mouse model of lung adenocarcinoma.

abstract：:Computed tomography (CT; unenhanced, followed by contrast-enhanced examinations) is the cornerstone of imaging of adrenal tumours. Attenuation values of <10 Hounsfield units on an unenhanced CT are practically diagnostic for adenomas. When lesions cannot be characterised adequately with CT, magnetic resonance imaging ...

journal_title：Endocrine-related cancer

authors： Ilias I,Sahdev A,Reznek RH,Grossman AB,Pacak K

更新日期：2007-09-01 00:00:00

abstract：:Mouse models of prostate cancer (PCa) are critical for understanding the biology of PCa initiation, progression, and treatment modalities. Here, we summarize recent advances in PCa mouse models that led to new insights into specific gene functions in PCa. For example, the study of transgenic mice with TMPRSS2/ERG, an ...

journal_title：Endocrine-related cancer

authors： Wu X,Gong S,Roy-Burman P,Lee P,Culig Z

更新日期：2013-06-24 00:00:00

abstract：:Thirty percent of medullary thyroid carcinomas (MTCs) are related to dominant germline pathogenic variants in the RET proto-oncogene. According to their aggressiveness, these pathogenic variants are classified in three risk levels: 'moderate', 'high' and 'highest'. The present study compares the metabolomics profiles ...

journal_title：Endocrine-related cancer

authors： Veyrat-Durebex C,Bouzamondo N,Le Mao M,Chao de la Barca JM,Bris C,Dieu X,Simard G,Gadras C,Tessier L,Drui D,Borson-Chazot F,Barlier A,Reynier P,Prunier-Mirebeau D

更新日期：2019-03-01 00:00:00

abstract：:Endometrial cancer is the most common gynecological malignancy in developed countries and represents the eighth leading cause of cancer related death in women. The growing incidence of endometrial cancer leads scientists and oncologists to identify effective preventive measures and also molecular markers for diagnosis...

journal_title：Endocrine-related cancer

authors： Chaudhry P,Asselin E

更新日期：2009-06-01 00:00:00

abstract：:Carrying excess body fat is a leading cause of cancer. Epidemiologic evidence gives strong clues about the mechanisms that link excess adiposity to risk for several cancer sites. For postmenopausal breast cancer and endometrial cancer, the hyper-estrogenic state that is induced by excess body fatness is the likely cau...

journal_title：Endocrine-related cancer

authors： Byers T,Sedjo RL

更新日期：2015-06-01 00:00:00

abstract：:We undertook this study to estimate an accurate incidence and spread patterns of occult papillary thyroid carcinoma (PTC) in patients with a preoperative diagnosis of solitary PTC by using whole-specimen mapping of all specimens after a total thyroidectomy. Enrolled prospectively in this whole-thyroid mapping study ar...

journal_title：Endocrine-related cancer

authors： Park SY,Jung YS,Ryu CH,Lee CY,Lee YJ,Lee EK,Kim SK,Kim TS,Kim TH,Jang J,Park D,Dong SM,Kang JG,Lee JS,Ryu J

更新日期：2015-08-01 00:00:00

abstract：:Thyroid cancer is on the rise. Novel approaches are needed to improve the outcome of patients with recurrent and advanced metastatic thyroid cancers. FDA approval of suberoylanilide hydroxamic acid (SAHA; vorinostat), an inhibitor of histone deacetylase, for the treatment of hematological malignancies led to the clini...

journal_title：Endocrine-related cancer

authors： Zhu X,Kim DW,Zhao L,Willingham MC,Cheng SY

更新日期：2016-07-01 00:00:00

abstract：:Evidence supports a role of 17&-estradiol (E2) in carcinogenesis and the large majority of breast carcinomas are dependent on estrogen. The anti-estrogen tamoxifen (TAM) is widely used for both treatment and prevention of breast cancer; however, it is also carcinogenic in human uterus and rat liver, highlighting the p...

journal_title：Endocrine-related cancer

authors： Rondón-Lagos M,Rangel N,Di Cantogno LV,Annaratone L,Castellano I,Russo R,Manetta T,Marchiò C,Sapino A

更新日期：2016-08-01 00:00:00

abstract：:Germline mutations in codon 918 of exon 16 of the RET gene (M918T) are classically associated with multiple endocrine neoplasia type 2B (MEN 2B) with highly aggressive medullary thyroid cancer (MTC), pheochromocytoma and a unique phenotype. The objectives of this study are to describe the rare M918V RET mutation disco...

journal_title：Endocrine-related cancer

authors： Martins-Costa MC,Cunha LL,Lindsey SC,Camacho CP,Dotto RP,Furuzawa GK,Sousa MS,Kasamatsu TS,Kunii IS,Martins MM,Machado AL,Martins JR,Dias-da-Silva MR,Maciel RM

更新日期：2016-12-01 00:00:00

abstract：:Tumor necrosis factor receptor-associated protein 1 (TRAP1) is a heat shock protein 90 (HSP90) molecular chaperone upregulated in several human malignancies and involved in protection from apoptosis and drug resistance, cell cycle progression, cell metabolism and quality control of specific client proteins. TRAP1 role...

journal_title：Endocrine-related cancer

authors： Palladino G,Notarangelo T,Pannone G,Piscazzi A,Lamacchia O,Sisinni L,Spagnoletti G,Toti P,Santoro A,Storto G,Bufo P,Cignarelli M,Esposito F,Landriscina M

更新日期：2016-09-01 00:00:00

abstract：:Carcinoid syndrome (CS) is a debilitating disease caused by functional neuroendocrine tumors. Several treatment options are available to alleviate the hormonal symptoms, but their relative efficacy is unknown. Online databases were searched for publications on the treatment of CS symptoms. Independent reviewers assess...

journal_title：Endocrine-related cancer

authors： Hofland J,Herrera-Martínez AD,Zandee WT,de Herder WW

更新日期：2019-03-01 00:00:00

abstract：:Resistance to chemotherapy is a critical issue in the management of breast cancer patients. The nature of clinical drug resistance is likely to be multifactorial. However, in the last decade considerable attention has been dedicated to the role played by membrane transporter proteins belonging to the ATP binding casse...

journal_title：Endocrine-related cancer

authors： Leonessa F,Clarke R

更新日期：2003-03-01 00:00:00

abstract：:Genetic alteration is the driving force for thyroid tumorigenesis and progression, based upon which novel approaches to the management of thyroid cancer can be developed. A recent important genetic finding in thyroid cancer is the oncogenic T1799A transversion mutation of BRAF (the gene for the B-type Raf kinase, BRAF...

journal_title：Endocrine-related cancer

authors： Xing M

更新日期：2005-06-01 00:00:00

abstract：:Medical therapy of pancreatic neuroendocrine tumors (P-NET) may take advantage of Everolimus treatment. However, the extent of therapeutic response cannot be predicted. This study was aimed to identify the possible predictive markers of response to Everolimus in P-NET. We found that Everolimus reduced the cell viabili...

journal_title：Endocrine-related cancer

authors： Falletta S,Partelli S,Rubini C,Nann D,Doria A,Marinoni I,Polenta V,Di Pasquale C,Degli Uberti E,Perren A,Falconi M,Zatelli MC

更新日期：2016-11-01 00:00:00

abstract：:Paragangliomas (PGLs) have widely different metastastic potentials. Two different types of PGLs can be defined by expression profiling. Cluster 1 PGLs exhibit VHL and/or succinate dehydrogenase (SDH) mutations and a pseudohypoxic phenotype. RET and neurofibromatosis type 1 (NF1) mutations occur in cluster 2 tumors cha...

journal_title：Endocrine-related cancer

authors： Span PN,Rao JU,Oude Ophuis SB,Lenders JW,Sweep FC,Wesseling P,Kusters B,van Nederveen FH,de Krijger RR,Hermus AR,Timmers HJ

更新日期：2011-04-28 00:00:00

abstract：:Selection of novel molecular markers is an important goal of cancer genomics studies. The aim of our analysis was to apply the multivariate bioinformatical tools to rank the genes - potential markers of papillary thyroid cancer (PTC) according to their diagnostic usefulness. We also assessed the accuracy of benign/mal...

journal_title：Endocrine-related cancer

authors： Fujarewicz K,Jarzab M,Eszlinger M,Krohn K,Paschke R,Oczko-Wojciechowska M,Wiench M,Kukulska A,Jarzab B,Swierniak A

更新日期：2007-09-01 00:00:00

abstract：:Because intracellular polyamines have a critical role in cell proliferation and death pathways, the polyamine metabolic pathway represents a potential target for intervention in cancers. A number of polyamine analogues have been identified that downregulate polyamine synthesis and enhance polyamine catabolism, thereby...

journal_title：Endocrine-related cancer

authors： Davidson NE,Hahm HA,McCloskey DE,Woster PM,Casero RA Jr

更新日期：1999-03-01 00:00:00

abstract：:Sialic acid immunoglobulin-like lectin (Siglec)-6 is a transmembrane receptor that binds leptin. Leptin is an obesity-associated peptide hormone overexpressed in gestational trophoblastic disease (GTD). GTD encompasses several placental abnormalities that range from benign to malignant. Among GTD, molar placentas are ...

journal_title：Endocrine-related cancer

authors： Rumer KK,Post MD,Larivee RS,Zink M,Uyenishi J,Kramer A,Teoh D,Bogart K,Winn VD

更新日期：2012-11-19 00:00:00

abstract：:Thyroid cancer is the most common cancer of the endocrine system and is responsible for the majority of deaths from endocrine malignancies. Although a large proportion of thyroid cancers belong to well differentiated histologic subtypes, which in general show a good prognosis after surgery and radioiodine ablation, th...

journal_title：Endocrine-related cancer

authors： Morani F,Titone R,Pagano L,Galetto A,Alabiso O,Aimaretti G,Isidoro C

更新日期：2013-12-16 00:00:00

abstract：:Insulin-like growth factors (IGFs) are thought to promote tumour progression and metastasis in part by stimulating cell migration. Insulin receptor substrate-1 (IRS-1) and IRS-2 are multisite docking proteins positioned immediately downstream from the type I IGF and insulin receptors. IRS-2 but not IRS-1 has been repo...

journal_title：Endocrine-related cancer

authors： de Blaquière GE,May FE,Westley BR

更新日期：2009-06-01 00:00:00

abstract：:The androgen receptor (AR) is well known to play a central role in the pathogenesis of prostate cancer (PCa). In several studies, AR was overexpressed in castration-resistant PCa (CRPC). However, the mechanism of AR overexpression in CRPC is not fully elucidated. Y-box binding protein-1 (YB-1) is a pleiotropic transcr...

journal_title：Endocrine-related cancer

authors： Shiota M,Takeuchi A,Song Y,Yokomizo A,Kashiwagi E,Uchiumi T,Kuroiwa K,Tatsugami K,Fujimoto N,Oda Y,Naito S

更新日期：2011-07-11 00:00:00

abstract：:Pancreatic endocrine tumours (PETs) are rare and 'indolent' neoplasms that usually develop metastatic lesions and exhibit poor response to standard medical treatments. Few studies have investigated pathways responsible for PET cell growth and invasion and no alternative therapeutic strategies have been proposed. In a ...

journal_title：Endocrine-related cancer

authors： Di Florio A,Capurso G,Milione M,Panzuto F,Geremia R,Delle Fave G,Sette C

更新日期：2007-03-01 00:00:00

abstract：:Chitinase 3-like 1 (CHI3L1 or YKL40) is a secreted glycoprotein highly expressed in tumours from patients with advanced stage cancers, including prostate cancer (PCa). The exact function of YKL40 is poorly understood, but it has been shown to play an important role in promoting tumour angiogenesis and metastasis. The ...

journal_title：Endocrine-related cancer

authors： Jeet V,Tevz G,Lehman M,Hollier B,Nelson C

更新日期：2014-10-01 00:00:00

abstract：:FOXE1 is a thyroid-specific transcription factor essential for thyroid gland development and maintenance of the differentiated state. Interestingly, a strong association has been recently described between FOXE1 expression and susceptibility to thyroid cancer, but little is known about the mechanisms underlying FOXE1-...

journal_title：Endocrine-related cancer

authors： Morillo-Bernal J,Fernández LP,Santisteban P

更新日期：2020-03-01 00:00:00

abstract：:Elevated circulating chromogranin A (CgA) levels are found in neuroendocrine tumors (NETs), but the diagnostic usefulness of this marker is still debatable. To assess the role of CgA for the diagnosis of gastroenteropancreatic (GEP) NETs and the identification of metastatic patients, an Italian multicenter observation...

journal_title：Endocrine-related cancer

authors： Zatelli MC,Torta M,Leon A,Ambrosio MR,Gion M,Tomassetti P,De Braud F,Delle Fave G,Dogliotti L,degli Uberti EC,Italian CromaNet Working Group.

更新日期：2007-06-01 00:00:00

abstract：:The aim of this randomized multicenter phase III trial was to compare chemotherapy and interferon (IFN) in patients with metastatic carcinoid tumors. Patients with documented progressive, unresectable, metastatic carcinoid tumors were randomized between 5-fluorouracil plus streptozotocin (day 1-5) and recombinant IFN-...

journal_title：Endocrine-related cancer

authors： Dahan L,Bonnetain F,Rougier P,Raoul JL,Gamelin E,Etienne PL,Cadiot G,Mitry E,Smith D,Cvitkovic F,Coudert B,Ricard F,Bedenne L,Seitz JF,Fédération Francophone de Cancérologie Digestive (FFCD).,Digestive Tumors Group of the F

更新日期：2009-12-01 00:00:00

abstract：:The purpose of this study is to investigate the role of carbonic anhydrase IX (CAIX) expression in predicting the response to epirubicin and disease-free survival (DFS) in breast cancer patients enrolled in a single institution trial of primary anthracycline and tamoxifen therapy. CAIX expression was assessed in 183 p...

journal_title：Endocrine-related cancer

authors： Generali D,Fox SB,Berruti A,Brizzi MP,Campo L,Bonardi S,Wigfield SM,Bruzzi P,Bersiga A,Allevi G,Milani M,Aguggini S,Dogliotti L,Bottini A,Harris AL

更新日期：2006-09-01 00:00:00

abstract：:The anaplastic lymphoma kinase (ALK) gene is frequently rearranged in various types of cancer and is highly responsive to targeted therapeutics. We developed a system to detect rearrangement of ALK in a large group of Korean thyroid cancer patients. We screened 474 malignant or benign thyroid tumor cases to identify A...

journal_title：Endocrine-related cancer

authors： Park G,Kim TH,Lee HO,Lim JA,Won JK,Min HS,Lee KE,Park DJ,Park YJ,Park WY

更新日期：2015-02-01 00:00:00

abstract：:Metastatic duodenopancreatic neuro-endocrine tumors (dpNETs) are the most important disease-related cause of death in patients with multiple endocrine neoplasia type 1 (MEN1). Nonfunctioning pNETs (NF-pNETs) are highly prevalent in MEN1 and clinically heterogeneous. Therefore, management is controversial. Data on prog...

journal_title：Endocrine-related cancer

authors： Sadowski SM,Pieterman CRC,Perrier ND,Triponez F,Valk GD

更新日期：2020-06-01 00:00:00

abstract：:Tumor-induced osteomalacia (TIO) is a rare and fascinating paraneoplastic syndrome in which patients present with bone pain, fractures, and muscle weakness. The cause is high blood levels of the recently identified phosphate and vitamin D-regulating hormone, fibroblast growth factor 23 (FGF23). In TIO, FGF23 is secret...

journal_title：Endocrine-related cancer

authors： Chong WH,Molinolo AA,Chen CC,Collins MT

更新日期：2011-06-08 00:00:00