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CD62L on neutrophil granulocytes, a useful, complementary marker for the prediction of ventriculitis in blood-containing CSF.

Abstract：

OBJECTIVES:Presence of residual blood is a common problem in cerebrospinal fluid (CSF) diagnostics of ventriculitis. We hypothesised that neutrophil granulocytes in infected, blood-containing CSF lose CD62L expression. Therefore CD62L expression on neutrophils may present a complementary marker to distinguish between patients with residual blood and infection. DESIGNS AND METHODS:Evaluation was performed in 64 ventricular CSF samples sent to the laboratory for diagnostic investigation. Cell count, microbiological culture, total protein and flow cytometric analysis of CSF were performed. RESULTS:Cell counts and CD62L expression were significantly different between the culture positive and negative group. ROC-analysis revealed a significant predictive value for cell count and CD62L expression. Optimal cut-offs were calculated and a decision tree was established to predict a positive culture. CONCLUSIONS:Cell count and CD62L expression were predictive for a positive culture and the combination helped to increase specificity and sensitivity for the detection of ventriculitis in blood-containing CSF.

journal_name

Clin Biochem

journal_title

Clinical biochemistry

authors

Boer K,Vogelsang H,Deufel T,Pfister W,Kiehntopf M

doi

10.1016/j.clinbiochem.2010.07.003

subject

Has Abstract

pub_date

2010-11-01 00:00:00

pages

1351-5

issue

16-17

eissn

0009-9120

issn

1873-2933

pii

S0009-9120(10)00318-8

journal_volume

43

pub_type

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