Abstract：
:Appropriate combinations of immunotherapy and gene therapy promise to be more effective in the treatment of cancer patients than either of these therapeutic approaches alone. One such treatment is based on the application of patients' cytotoxic T cells, which can be activated, expanded, and genetically engineered to recognize particular tumor-associated antigens (TAAs). Because T cells recognizing TAAs might become unresponsive in the process of tumor development as a result of tumor evasion strategies, immunogenic viral antigens or alloantigens could be used for the expansion of cytotoxic T cells and then redirected through genetic engineering. This therapeutic approach has already demonstrated promising results in melanoma patients and could be used in the treatment of many other tumors. The graft-versus-leukemia, or more generally graft-versus-tumor, reaction based on the application of a donor lymphocyte infusion can also be ameliorated through the incorporation of suicide genes into donor lymphocytes. Such lymphocytes could be safely and more extensively used in tumor patients because they could be eliminated should a severe graft-versus-host reaction develop.
journal_name
Arch Immunol Ther Exp (Warsz)journal_title
Archivum immunologiae et therapiae experimentalisauthors
Jakóbisiak M,Gołab Jdoi
10.1007/s00005-010-0091-0subject
Has Abstractpub_date
2010-10-01 00:00:00pages
347-54issue
5eissn
0004-069Xissn
1661-4917journal_volume
58pub_type
杂志文章,评审abstract：:Herpes simplex and zoster are frequent skin diseases of viral origin and the mechanism of their development as well as their course are not yet fully known. Fully effective methods of treating these diseases are not known. The authors evaluated the results of the externally applied ITCL preparation in the form of a 2%...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1983-01-01 00:00:00
abstract：:We have reported earlier that human T lymphocytes from blood or spleens of normal donors can be propagated in long-term culture in the presence of IL-2, after stimulation either with wheat germ agglutinin (WGA) or phytohemagglutinin (PHA) and with the use of repeated restimulation with supernatants collected after 24 ...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：:The influence of antibiotics and purine and pyrimidine analogues on cells forming rosettes EA and EAC was evaluated in vitro. At the same time pH of solutions of examined immunosuppressors was estimated and a series of experiments with a buffer of appropriate pH was carried out. It was estimated that the effect inhibi...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1980-01-01 00:00:00
abstract：:Sustained chronic inflammation induces activation of genes involved in cellular proliferation and apoptosis, thereby causing skeletal muscle degeneration. To investigate in vitro effects of isolated pentacyclic triterpenes from Eugenia punicifolia (Ep-CM) upon signaling pathways involved in the regulation of skeletal ...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：10.1007/s00005-014-0291-0
更新日期：2014-12-01 00:00:00
abstract：:Antibacterial, antifungal and antitumor activity of 15 newly synthetized compounds were investigated in vitro. These compounds were mainly 1-[4-pyridyl]-pyridinium salts, dipyridyl sulphides and corresponding sulphones. Antitumor activity was evaluated in a model of leukemia L1210, P388, Sarcoma 180, Ehrlich carcinoma...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：:The idea that vaccination can be used to fight cancer is not new. Approximately 100 years ago, researchers attempted to stimulate a tumor-specific, therapeutic immune response to tumors by injecting patients with cells and extracts from their own tumors, or tumors of the same type from different individuals. During th...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章,评审
doi：10.1007/s00005-011-0129-y
更新日期：2011-08-01 00:00:00
abstract：:Approximately one third of the world's population is infected with Mycobacterium tuberculosis,yet each year a small proportion of those individuals progress to an active disease state. Early identification and treatment of such individuals is essential to reduce transmission; however, genetic and immunological correla...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章,评审
doi：
更新日期：2005-11-01 00:00:00
abstract：:Both TG and TnonG subpopulations from human peripheral blood were found to secrete helper and suppressor factors for the PHA-induced T cell proliferative response. The TnonG subpopulation contained cells which were both able to secrete helper factor and to respond by proliferation, whereas in the TG subpopulation cell...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
abstract：:A study on the influence of cystamine on the kinetics and dynamics of the action of thioridazine has been carried out. Higher levels of this drug in the blood and lower levels in the brain tissue than those in unpremedicated rats were determined. Half-life of thioridazine underwent shortening from 2-55 hr to 1-05 hr. ...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1976-01-01 00:00:00
abstract：:In 51 cases with non-Hodgkin's lymphoma and in 25 healthy subjects, immunological state was determined by resorting to values of the following parameters of nonspecific immunity: the levels of G, A and M immunoglobulins, antistreptolysins, complement, T and B lymphocytes, monocytes, granulocytes and the skin test with...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1983-01-01 00:00:00
abstract：:Working on the problem entitled "Synthesis of cysteine derivatives of immunotropic activity" the following compounds were synthesized; cysteine hydrazide and its hydrochloride, S-methylcysteine hydrazide hydrochloride, S, N, N-trimethylcysteine and S-benzylcysteinyl-S-benzylcysteine. We modified the synthesis of cyste...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1978-01-01 00:00:00
abstract：:Mesenchymal stromal cells (MSCs) show significant immune-suppressive properties both in vitro and in vivo. Based on their immune-stealth properties, allogeneic MSCs are used to treat several diseases, for example the injection of MSCs in infarcted heart tissue or their use in bone-cartilage regeneration. The most spec...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章,评审
doi：10.1007/s00005-008-0036-z
更新日期：2008-09-01 00:00:00
abstract：:New treatment strategies for HIV/AIDS are very successful in reducing viral load. However, reconstitution of the immune system takes about one year and may be insufficient or remain incomplete. During this time the patient remains prone to opportunistic infections as a result of the complex immune dysfunction caused b...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章,评审
doi：
更新日期：2002-01-01 00:00:00
abstract：:Recently, the role of small heat shock proteins (HSPs) has been widely recognized in cancer research. Small HSPs are tumorprotective via numerous, independent mechanisms such as: oxidative stress, protection preventing protein denaturation, anti-apoptotic activity, and likely direct suppression of the immune system. H...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章,评审
doi：10.1007/s00005-006-0013-3
更新日期：2006-03-01 00:00:00
abstract：:The role of antibodies in immunity to intravenous infection with dysentery bacilli was studied in mice. Serum from animals immunized with a single dose of live dysentery bacilli obtained at a varying intervals of time after immunization transferred immunity to other mice infected with lethal doses of the same bacilli....
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1976-01-01 00:00:00
abstract：:The effect of heparin on generation and activity of NK cells in vitro were studied. Heparin decreased NK cytotoxicity when present in the assay. In contrast, the agent increased generation of NK cytotoxicity and showed synergistic action with recombinant IL2. ...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：:In this work the biocompatibility of porous bioceramic implanted to the rabbit femoral bone was studied. The animals were killed 3, 6, 9, 14, 18 and 30 days after implantation and the callus with surrounding periosteum from the site of implant was taken for the studies. Morphological investigations of the callus were ...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：:The investigation was carried on mice infected with influenza A/053/74/H3N2 virus. 129/Ao/Boy, inbred mice, were inoculated intranasally with influenza virus. The alveolar and peritoneal cells from infected and uninfected animals were induced in vitro with Newcastle disease virus. It was shown that the alveolar cells ...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1980-01-01 00:00:00
abstract：:The respiratory burst of polymorphonuclear leukocytes depends on activation of many enzymes and generation of variety of second messengers. One of important links leading to polymorphonuclear leukocytes (PMNL) activation is a transient rise in intracellular free calcium concentration ([Ca2+]i). Serine proteinase inhib...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：:Crude burn toxin was obtained from human skin scalded for 1 min at 90 degrees C in vitro. The toxin solubilized with 8 M urea was administered to rabbits to obtain antiserum. The antigenic analysis carried out by immunodiffusion and immunoelectrophoresis demonstrated that urea-extractable toxin solution differed from ...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1981-01-01 00:00:00
abstract：:Regulation of monocyte/macrophage function is important in coordinating immune responses. Their contact with invading pathogens activates signaling pathways that provoke pro-inflammatory gene expression and thus causing a locally restricted inflammation. Recently, the peroxisome proliferator-activated receptor gamma (...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章,评审
doi：
更新日期：2003-01-01 00:00:00
abstract：:Ecothiopate (Etp), 10 mug injected into the lateral cerebral ventricle (ivtr), diminished spontaneous motility and open-field performance, lowered body temperature, inhibited amphetamine-induced hypermotility and stereotypy, prolonged hexobarbital anesthesia and did not induce catalepsy. These behavioral symptoms were...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1975-01-01 00:00:00
abstract：:Diabetes and cancer are diseases which take the size of an epidemic spread across the globe. Those diseases are influenced by many factors, both genetic and environmental. Precise knowledge of the complex relationships and interactions between these two conditions is of great importance for their prevention and treatm...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章,评审
doi：10.1007/s00005-011-0119-0
更新日期：2011-06-01 00:00:00
abstract：:In this study we have examined the influence of ABO and Rh blood groups as well as the effect of cigarette smoking on the level of NK activity in healthy men. Blood bank donors and age-matched non-donors have been evaluated independently. As far as ABO blood groups are concerned, higher NK activity in individuals with...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:Recent years of research have shed a new light on the role of IgE in immune reactions. It seems to be more than just a contribution to immediate type of allergic response. It appears that monomeric IgE may enhance mast cell activity without cross-linking of FcεRI by IgE specific allergen or autoreactive IgG anti-IgE a...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章,评审
doi：10.1007/s00005-016-0417-7
更新日期：2017-04-01 00:00:00
abstract：:Measurements of interferons, their inhibitors and/or inactivators and tumor necrosis factor-like activities in sera from patients with neoplasias were performed. Interferon activity could not be detected in 96% of the sera samples examined. In contrast, both interferon inhibitors and/or inactivators and tumor necrosis...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
abstract：:Tuberculosis (TB) is a chronic infectious disease which essentially affects the lungs and produces profound abnormalities on the immune system. Although most people infected by the tubercle bacillus (90%) do not develop the disease during their lifetime, when there are alterations in the immune system, such as co-infe...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章,评审
doi：10.1007/s00005-009-0042-9
更新日期：2009-09-01 00:00:00
abstract：:It was found that intravenous application of thiosulfate increased non-specifically immunoglobulin concentration in mice sera. Thiosulfate stimulated the immune response to T-dependent antigens. ...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：
更新日期：1978-01-01 00:00:00
abstract：:Human cathelicidin, LL-37, is small antimicrobial peptide, which reveals also some immunomodulatory and proangiogenic properties and, therefore, may promote wound healing. The expression of LL-37 is controlled by various factors, including vitamin D. Thus, any disturbances in vitamin D level may influence LL-37 produc...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章
doi：10.1007/s00005-016-0423-9
更新日期：2017-10-01 00:00:00
abstract：:After more than two decades of investigation, the biological role of the gammadelta T-cell receptors (TCRs) remains elusive. In fact, a theory of ligand recognition is still lacking that accounts for their adaptable structure, their peripheral selection, and the observed responses of gammadelta T cells, which do not r...
journal_title：Archivum immunologiae et therapiae experimentalis
pub_type： 杂志文章,评审
doi：10.1007/s00005-009-0017-x
更新日期：2009-03-01 00:00:00
