Abstract:
:Approximately one third of the world's population is infected with Mycobacterium tuberculosis,yet each year a small proportion of those individuals progress to an active disease state. Early identification and treatment of such individuals is essential to reduce transmission; however, genetic and immunological correlates of disease progression have not been well established in man. The murine model has been a central tool for the elucidation of protective immune mechanisms that are essential for controlling M. tuberculosis infection. Additionally, the study of inbred mice has revealed significant divergence in the susceptibility and disease progression of individual mouse strains to an infection with M.tuberculosis. The continued study of genetically disparate mouse strains has the potential to identify immune mechanisms that correlate with increasing susceptibility to tuberculosis. These mechanisms will be highly applicable to studies in man and assist in the early detection of individuals that are more vulnerable to the development of reactivation tuberculosis.
journal_name
Arch Immunol Ther Exp (Warsz)journal_title
Archivum immunologiae et therapiae experimentalisauthors
Beamer GL,Turner Jsubject
Has Abstractpub_date
2005-11-01 00:00:00pages
469-83issue
6eissn
0004-069Xissn
1661-4917pii
8421journal_volume
53pub_type
杂志文章,评审abstract::Until recently, the traditional view was that tolerance to self antigens was maintained by a combination of physical deletion, in the thymus, and functional deletion, in the periphery, of autoreactive T cells. There is now, however, abundant evidence that the normal T cell repertoire contains overtly autoreactive T ce...
journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章,评审
doi:
更新日期:2000-01-01 00:00:00
abstract::Two week old chickens were treated once daily for 5 days with AE8--1-pyridyl-1,2-benzisoselenazol-3(2H)-one, AE22--bis-2-(N-phenyle-carboxamido) 1 pyridyl diselenide and AE31--bis(phenylo-diselenide with R3 = CONHC18H37). Their whole blood alone or blood mixed with thymus cells were used to generate graft versus host ...
journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
abstract::The results of treatment with intrauterine transfusion are presented. The analysis comprised 48 successful transfusions into 29 foetuses. The reference group consisted of 11 transfusions which proved nonfeasible or ineffective and 54 untreated cases. Following blood treatment, the newborn mortality rate dropped more t...
journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1987-01-01 00:00:00
abstract::Investigations were carried out on an influence of phospholipids from L. monocytogenes and A. fumigatus on the degradation of Streptococcus faecalis cell walls by mouse peritoneal macrophages. It has been found, that macrophages from mice stimulated with phospholipids under studies degraded streptococcal cell walls la...
journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1985-01-01 00:00:00
abstract::The carbohydrate and amino acid compositions of the purified Fc receptor from human placental trophoblasts are described. The placental receptor is a glycoprotein. The total content of carbohydrates in the receptor is 30% (w/w). The major carbohydrate components are galactose, N-acetylglucosamine, fucose, and mannose....
journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1985-01-01 00:00:00
abstract::The key of the immune system is to protect the host from foreign threat posed by pathogens and from the internal threat posed by self-attacking lymphocytes. The ability to discriminate self versus non-self ensures that only "non-self" pathogens, but not the self antigens, are attacked. Such tolerance to "self" arises ...
journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章,评审
doi:10.1007/s00005-008-0015-4
更新日期:2008-03-01 00:00:00
abstract::The immune system responds vigorously to invading pathogens (non-self, foreign), while remaining unresponsive (tolerant) to the body's own components and circulating constituents (self). This indifference to self components is a result of finely orchestrated events of thymic negative selection (central tolerance) of d...
journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章,评审
doi:10.1007/s00005-006-0035-x
更新日期:2006-09-01 00:00:00
abstract::Use of a four-step method of purification from human kidneys yielded gamma-glutamyl transpeptidase with specific activity 330 times higher than activity in the homogenate. The enzyme from human liver was also purified, and from urine two fractions of it were separated. From rabbits immunized with the enzyme from human...
journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1977-01-01 00:00:00
abstract::Over the last 18 years of study in one of our laboratories, we have observed the development of residual disease and latent reservoirs as major problems in the long-term therapy of HIV-1-infected individuals on highly active antiretroviral therapy (HAART). It was shown in the early 1990 's that HAART, as it is present...
journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章,评审
doi:
更新日期:2004-09-01 00:00:00
abstract::Peripheral blood T lymphocytes and T cell subsets were analyzed in 19 patients with chronic active hepatitis B virus infection. The T cell subpopulations were defined by indirect immuno-fluorescence using monoclonal antibodies, and additionally, natural killer cell activity against K 562 human erythroleukemic cell has...
journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
abstract::Lymphocytes cultured for three days with PHA or Con A were capable of inducing vigorous proliferation of autologous or allogeneic lymphocytes. Kinetics of the response varied with mitogen dose used for obtaining stimulating cells and with the ratio of stimulating to responder cells. A requirement for viable, mitogen-r...
journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1978-01-01 00:00:00
abstract::Recently, the role of small heat shock proteins (HSPs) has been widely recognized in cancer research. Small HSPs are tumorprotective via numerous, independent mechanisms such as: oxidative stress, protection preventing protein denaturation, anti-apoptotic activity, and likely direct suppression of the immune system. H...
journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章,评审
doi:10.1007/s00005-006-0013-3
更新日期:2006-03-01 00:00:00
abstract::Intravenous and subcutaneous immunoglobulin preparations, consisting of IgG class antibodies, are increasingly used to treat a broad range of pathological conditions, including humoral immune deficiencies, as well as acute and chronic inflammatory or autoimmune disorders. A plethora of Fab- or Fc-mediated immune regul...
journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章,评审
doi:10.1007/s00005-016-0422-x
更新日期:2017-06-01 00:00:00
abstract::The innate immune system is essential for the first line of host defense against micropathogens. In virus-infected cells, exposed viral nucleotides are sensed by pattern recognition receptors (PRRs), resulting in the induction of type I interferon. Retinoic acid-inducible gene-I-like receptors (RLRs) are a member of P...
journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章,评审
doi:10.1007/s00005-010-0107-9
更新日期:2011-02-01 00:00:00
abstract::The occurrence of circulating immune complexes was studied in 28 patients suffering from uveitis. The presence of complexes was found in 18 patients including 6 out of 10 patients with iridocyclitis and in 12 out of 18 patients with chronic total uveitis. ...
journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1987-01-01 00:00:00
abstract::Umbilical cord blood transplantation (UCBT) is known to be associated with increased risk of infections, compared to bone marrow or peripheral blood stem cell transplantation. In viral diseases for which specific treatment is available, real-time PCR assays are reliable diagnostic tools for timely initiation of approp...
journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章
doi:10.1007/s00005-010-0096-8
更新日期:2010-12-01 00:00:00
abstract::The induction of plasmacytomas in BALB/c mice by Bayol F or Pristan is described. In some experiments mice treated with Bayol F were antigenically stimulated by repeated injections of allogenic C57BL/6 spleen cells. The incidence of plasmacytoma was 57% in Bayol F treated mice and 59% in the mice subjected to sustaine...
journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1980-01-01 00:00:00
abstract::The effects of the mixtures of human, porcine and murine interferons (IFNs) alpha, beta and gamma and bovine IFN-alpha were studied in human, porcine and murine cells. The synergistic action of the mixtures of IFN-alpha/beta and IFN-gamma occurred not only in the homologous but also in the heterologous systems. The sy...
journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1987-01-01 00:00:00
abstract:INTRODUCTION:Rheumatism has been treated using whole-body cryotherapy (WBCT) since the 1970s. The aim of this study was to assess the efficacy of WBCT as an experimental, adjunctive method of treating depressive and anxiety disorders. MATERIALS AND METHODS:A control (n=34) and a study group (n=26), both consisting of ...
journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章
doi:10.1007/s00005-008-0006-5
更新日期:2008-01-01 00:00:00
abstract:INTRODUCTION:The aim of the study was to evaluate whether vascular endothelial growth factor (VEGF) serum level is associated with systemic organ involvement, microvascular changes as determined by nailfold capillaroscopy, and disease activity of systemic lupus erythematosus (SLE). MATERIALS AND METHODS:Serum levels o...
journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章
doi:10.1007/s00005-007-0017-7
更新日期:2007-05-01 00:00:00
abstract::A preliminary study of six hairy cell leukemia patients treated with one course of 2-chloro-2'-deoxyadenosine (2-CdA) is presented. 2-CdA was administered 0.1 mg/kg/daily by intravenous infusion over 7 days. Two patients achieved CR and four PR. ...
journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 临床试验,杂志文章
doi:
更新日期:1994-01-01 00:00:00
abstract::ADCC activity in 27 cadaver renal allograft recipients was studied. All the patients were given standard immunosuppressive treatment. Significant positive correlation between high ADCC activity during first 5 days after grafting and accelerated rjection crisis was found. The high positive ADCC test may signalize the p...
journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1978-01-01 00:00:00
abstract::The aim of the study was to investigate the influence of verapamil on anti-IgE induced histamine release from basophils isolated from the blood of 10 atopic asthma patients. The results of the investigations showed that verapamil in concentration of 10(-2)M - 10(-6)M significantly inhibits histamine release from basop...
journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
abstract::Distribution of esterase D types was studied in a sample of the Polish population numbering 885 subjects. Frequency of EsDl-1 type was 0.810, EsD2-1 -- 0.174, and EsD2-2 -- 0.16. Frequency of the genes EsD1 and EsD2, which determine this system, were 0.897 and 0.103 respectively. A study of 613 mother-child pairs reve...
journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1979-01-01 00:00:00
abstract::Determinations of the blood serum levels of interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-alpha) and their soluble receptors (sIL-6R, sTNFR) in denture stomatitis patients (DS) were performed. Serum levels of interleukins and their soluble receptors were measured using the ELISA method. In all examined patien...
journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章
doi:
更新日期:2000-01-01 00:00:00
abstract::The activity of neutral glucoamylase and alpha-amylase were determined in the myocardium and skeletal muscle after in vivo pharmacologic stimulation of adrenergic receptors. The activity changes of these enzymes were found to not always occur parallelly. The activity of both these enzymes is decreased under beta-agoni...
journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1976-01-01 00:00:00
abstract::The dry thermal glycation method was used to conjugate D-glucose and D-fructose with bovine serum albumin. Reactions were conducted at 50-104 degrees C for 30 min. Depending on temperature, different levels of substitution were achieved. In the case of D-glucose, average substitution levels of up to 53 mol glucose/mol...
journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章
doi:
更新日期:2002-01-01 00:00:00
abstract::Cytokines are small proteins or glycoproteins that transmit information from one cell to another. Most cells in the body secrete and respond to cytokines and their effects have been described on a myriad of cellular functions. Cytokine interactions may not be linear, thus making the system extremely intricate and with...
journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章,评审
doi:
更新日期:2000-01-01 00:00:00
abstract::In a previous study, anticataleptic action of cyproheptadine was reported. The present investigation deals with the influence of WA-335 (9,10-dihydro-10-(1-methyl-4-piperidylidene)-9-anthrol), another antagonist of serotonin, on catalepsy induced in rats with spiroperidol, pimozide, fluphenazine and reserpine. WA-335 ...
journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章
doi:
更新日期:1976-01-01 00:00:00
abstract::Phage display of many nanobodies via filamentous phage in combination with helper phage has been reported by many scientists. The aim of this study was to produce lambda (λ) bacteriophage displaying high-affinity nanobody against HER-2 expressing breast carcinoma cells. Bacteriophage λ is a temperate phage with inhere...
journal_title:Archivum immunologiae et therapiae experimentalis
pub_type: 杂志文章
doi:10.1007/s00005-012-0206-x
更新日期:2013-02-01 00:00:00